Abstract:
:Induction of mucosal immunity is critical for protection from enteric pathogens. Heat shock protein gp96 is one of the primary peptide and protein chaperones located in the endoplasmic reticulum. We reported previously that a cell-secreted gp96-Ig fusion protein (gp96-Ig) mediated strong systemic, antigen-specific CD8-CTL expansion in vivo. We now evaluate the mucosal immune response to stimulation by secreted gp96 using allogeneic NIH-3T3 transfected with ovalbumin (OVA) and gp96-Ig. A single intraperitoneal NIH-3T3-OVA-gp96-Ig immunization caused significant homing of OVA-specific TCR transgenic CD8 cells (OT-I) to Peyer's patches, to the intraepithelial compartment and to the lamina propria. Intraperitoneal immunization with cells secreting gp96-Ig provided stronger mucosal immunity than the same dose instilled vaginally or rectally or injected subcutaneously or intradermally. Our results provide the first evidence that cell-based gp96-Ig-secreting vaccines may serve as a potent modality to induce mucosal immunity.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Strbo N,Pahwa S,Kolber MA,Gonzalez L,Fisher E,Podack ERdoi
10.1038/mi.2009.127subject
Has Abstractpub_date
2010-03-01 00:00:00pages
182-92issue
2eissn
1933-0219issn
1935-3456pii
mi2009127journal_volume
3pub_type
杂志文章abstract::IFN-γ is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-γ rapidly induced Noxa expression and that extent of inflammation by repeated house dust mite exposure was enhanced in noxa-/- compared ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2017.117
更新日期:2018-05-01 00:00:00
abstract::Malaria-associated acute respiratory distress syndrome (MA-ARDS) and acute lung injury (ALI) are complications that cause lung damage and often leads to death. The MA-ARDS/ALI is associated with a Type 1 inflammatory response mediated by T lymphocytes and IFN-γ. Here, we used the Plasmodium berghei NK65 (PbN)-induced ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-018-0093-5
更新日期:2019-03-01 00:00:00
abstract::As the Bacillus Calmette-Guérin (BCG) vaccine does not confer long-lasting protection against lung Mycobacterium tuberculosis infection, the development of more efficient vaccines is greatly needed. Here, we used mycobacterial low-molecular weight proteins of the 6-kDa Early Secreted Antigenic Target (ESAT-6) protein ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.92
更新日期:2013-05-01 00:00:00
abstract::Alpha B-crystallin (CRYAB) is an important member of the small heat shock protein family, and plays a protective and therapeutic role in neurological inflammation. CRYAB expression was assessed in cultured HT29 and Caco-2 cells and inflamed mucosa of patients with inflammatory bowel disease (IBD) and colitis models in...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0198-5
更新日期:2019-11-01 00:00:00
abstract::HIV prevention mandates an understanding of the mechanisms of mucosal immunity with attention to some unique features of the epidemic and mucosal environment in the developing world. An effective vaccine will have to induce mucosal protection against a highly diverse virus, which is equipped with a number of immune ev...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2009.23
更新日期:2009-07-01 00:00:00
abstract::The extent to which tissue-specific viral infections generate memory T cells specifically adapted to and maintained within the target infection site is unknown. Here, we show that respiratory virus-specific memory T cells in mice and humans are generated and maintained in compartmentalized niches in lungs, distinct fr...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2013.67
更新日期:2014-05-01 00:00:00
abstract::Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6Chi monocytes, but the factors driving this tissue-specific process are not understood. ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2016.142
更新日期:2017-11-01 00:00:00
abstract::Post influenza bacterial pneumonia is associated with significant mortality and morbidity. Dendritic cells (DCs) play a crucial role in host defense against bacterial pneumonia, but their contribution to post influenza-susceptibility to secondary bacterial pneumonia is incompletely understood. WT and CCR2-/- mice were...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-018-0106-4
更新日期:2019-03-01 00:00:00
abstract::Epidemiological data indicate a link between rheumatoid arthritis (RA) and periodontal disease (PD). In vitro and in vivo studies have sought to dissect potential mechanisms by which PD may contribute to initiation and progression of RA. However, these are both multifactorial, chronic diseases, and their complex etiol...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2011.66
更新日期:2012-03-01 00:00:00
abstract::Effector T-cell contraction is one of the primary means by which immune homeostasis in the peripheral tissues is reestablished following an inflammatory response. In this issue of Mucosal Immunology, Hashimoto-Hill et al.1 show that retinoic acid (RA) transcriptionally upregulates P2X7 primarily in effector T cells of...
journal_title:Mucosal immunology
pub_type: 评论,杂志文章
doi:10.1038/mi.2016.117
更新日期:2017-07-01 00:00:00
abstract::Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as t...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.14
更新日期:2012-05-01 00:00:00
abstract::Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3-4 million cases globally with 100,000-150,000 deaths reported annually. Mostly confined to developing nations, current strategies to control the spread of cholera include the provision of safe drinking water a...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0159-z
更新日期:2019-07-01 00:00:00
abstract::The gut mucosa is an important site of HIV immunopathogenesis with severe depletion of CD4+ T cells occurring during acute infection. The effect of prolonged anti-retroviral therapy (ART) on cycling and restoration of T lymphocytes in the gut remains unclear. Colon and terminal ileal biopsies and peripheral blood samp...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2009.129
更新日期:2010-03-01 00:00:00
abstract::The sphingosine-1-phosphate receptor-1 (S1P1) agonist ozanimod ameliorates ulcerative colitis, yet its mechanism of action is unknown. Here, we examine the cell subsets that express S1P1 in intestine using S1P1-eGFP mice, the regulation of S1P1 expression in lymphocytes after administration of dextran sulfate sodium (...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2016.35
更新日期:2017-01-01 00:00:00
abstract::De novo differentiation of CD4(+)Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo follo...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.102
更新日期:2013-05-01 00:00:00
abstract::Children born by cesarean section (CS) have an increased risk of developing inflammatory bowel disease (IBD), possibly due to skewed microbial colonization during birth and consequently impaired bacterial stimulation of the developing immune system. The aim of this study was to investigate the association between CS a...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0207-8
更新日期:2019-11-01 00:00:00
abstract::Newborns are highly susceptible to pathogenic infections with significant worldwide morbidity possibly due to an immature immune system. Recently, we reported that Propionibacterium strain, P. UF1, isolated from the gut microbiota of preterm infants, induced the differentiation of bacteria-specific Th17 cells. Here, w...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-018-0125-1
更新日期:2019-03-01 00:00:00
abstract::Nedd4 family interacting protein 1 (Ndfip1) is an adaptor protein that regulates Itch, an E3 ubiquitin ligase that ubiquitylates JunB, thereby preventing interleukin (IL)-4 and IL-5 production. Mice lacking Ndfip1 or Itch develop T helper type 2 (T(H)2)-mediated inflammation in the skin and lungs and die prematurely. ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2010.69
更新日期:2011-05-01 00:00:00
abstract::Intestinal epithelial Na+/H+ exchange facilitated by the apical NHE3 (Slc9a3) is a highly regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3-/- mice develop spontaneous, bacterially mediated colitis, and IBD-like dysbiosis. Disruption of epithelial Na+/H+ exchange in IBD may t...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-018-0035-2
更新日期:2018-09-01 00:00:00
abstract::While recent studies suggest that interleukin (IL)-1β production is modulated by macroautophagy or sensors of endoplasmic reticulum (ER) stress upon pro-inflammatory insult, autophagy and IL-1β production during viral infection has not been fully investigated. This was addressed using respiratory syncytial virus (RSV)...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2015.3
更新日期:2015-09-01 00:00:00
abstract::Association mapping and candidate gene studies within inflammatory bowel diseases (IBD) linkage regions, as well as genome-wide association studies in Crohn's disease (CD) have led to the discovery of multiple risk genes, but these explain only a fraction of the genetic susceptibility observed in IBD. We have thus bee...
journal_title:Mucosal immunology
pub_type: 杂志文章,多中心研究
doi:10.1038/mi.2007.15
更新日期:2008-03-01 00:00:00
abstract::Specific components of the intestinal microbiota are capable of influencing immune responses such that a mutualistic relationship is established. In mice, colonization with segmented filamentous bacteria (SFB) induces T-helper-17 (Th17) cell differentiation in the intestine, yet the effector functions of interleukin (...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2016.80
更新日期:2017-05-01 00:00:00
abstract::Vaccine-mediated prevention of primary infection with human immunodeficiency virus (HIV) may require the sustained production of antibody at mucosal portals of entry. Here, we describe a novel approach of repeated mucosal immunization by delivering an HIV-1 envelope glycoprotein (gp) in a gel formulated for intravagin...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2009.110
更新日期:2010-01-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a highly prevalent respiratory disease characterized by airflow limitation and chronic inflammation. MiR-155 is described as an ancient regulator of the immune system. Our objective was to establish a role for miR-155 in cigarette smoke (CS)-induced inflammation and COPD...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0241-6
更新日期:2020-05-01 00:00:00
abstract::Classical Whipple's disease (CWD) affects the gastrointestinal tract and rather elicits regulatory than inflammatory immune reactions. Mechanisms of malabsorption, diarrhea, and systemic immune activation are unknown. We here analyzed mucosal architecture, barrier function, and immune activation as potential diarrheal...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2017.6
更新日期:2017-11-01 00:00:00
abstract::The seasonal burden of influenza coupled with the pandemic outbreaks of more pathogenic strains underscore a critical need to understand the pathophysiology of influenza injury in the lung. Interleukin-22 (IL-22) is a promising cytokine that is critical in protecting the lung during infection. This cytokine is strongl...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0206-9
更新日期:2020-01-01 00:00:00
abstract::The impact of topical antiretrovirals for pre-exposure prophylaxis on humoral responses following HIV infection is unknown. Using a binding antibody multiplex assay, we investigated HIV-specific IgG and IgA responses to envelope glycoproteins, p24 Gag and p66, in the genital tract (GT) and plasma following HIV acquisi...
journal_title:Mucosal immunology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/mi.2015.145
更新日期:2016-05-01 00:00:00
abstract::This corrects the article DOI: 10.1038/mi.2017.46. ...
journal_title:Mucosal immunology
pub_type: 杂志文章,已发布勘误
doi:10.1038/mi.2017.79
更新日期:2018-01-01 00:00:00
abstract::Pneumonia caused by Streptococcus pneumoniae (Sp) remains a leading cause of serious illness and death worldwide. Immunization with conjugated pneumococcal vaccine has lowered the colonization rate and consequently invasive diseases by inducing serotype-specific antibodies. However, many of the current pneumonia cases...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2016.41
更新日期:2017-01-01 00:00:00
abstract::Nucleotide oligomerization domain (NOD)2 is a member of the NOD-like receptor family of proteins that initiate inflammatory responses when exposed to ligands derived from bacterial components that gain access to the intracellular milieu. It is thus somewhat paradoxical that polymorphisms in the gene that encode NOD2 (...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2008.42
更新日期:2008-11-01 00:00:00