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Cycling of gut mucosal CD4+ T cells decreases after prolonged anti-retroviral therapy and is associated with plasma LPS levels.

Abstract：

:The gut mucosa is an important site of HIV immunopathogenesis with severe depletion of CD4+ T cells occurring during acute infection. The effect of prolonged anti-retroviral therapy (ART) on cycling and restoration of T lymphocytes in the gut remains unclear. Colon and terminal ileal biopsies and peripheral blood samples were collected from viremic, untreated, HIV-infected participants, patients treated with prolonged ART (>5 years), and uninfected controls and analyzed by flow cytometry. In the gut, the proportion of cycling T cells decreased and the number of CD4+ T cells normalized in treated patients in parallel with beta 7 expression on CD4+ T cells in blood. Cycling of gut T cells in viremic patients was associated with increased plasma LPS levels, but not colonic HIV-RNA. These data suggest that gut T-cell activation and microbial translocation may be interconnected whereas prolonged ART may decrease activation and restore gut CD4+ T cells.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Ciccone EJ,Read SW,Mannon PJ,Yao MD,Hodge JN,Dewar R,Chairez CL,Proschan MA,Kovacs JA,Sereti I

doi

10.1038/mi.2009.129

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

172-81

issue

2

eissn

1933-0219

issn

1935-3456

pii

mi2009129

journal_volume

3

pub_type

杂志文章

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