Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease.

abstract：:AIDS is mainly a sexually transmitted disease, and accordingly, mucosal tissues are the primary sites of natural human immunodeficiency virus type-1 (HIV-1) transmission. Mucosal immunoglobulin A (IgA) antibody specific for HIV-1 envelope gp41 subunit is one correlate of protection in individuals who are highly sexual...

journal_title：Mucosal immunology

authors： Tudor D,Derrien M,Diomede L,Drillet AS,Houimel M,Moog C,Reynes JM,Lopalco L,Bomsel M

更新日期：2009-09-01 00:00:00

abstract：:Dectin-1 (gene symbol: Clec7a) is a receptor for β-glucans that play an important role for the host defense against fungi. Recently, we showed that Clec7a-/- mice are resistant against dextran sodium sulfate (DSS)-induced colitis because of regulatory T-cell population expansion in the colon. The regulatory T-cell exp...

journal_title：Mucosal immunology

authors： Kamiya T,Tang C,Kadoki M,Oshima K,Hattori M,Saijo S,Adachi Y,Ohno N,Iwakura Y

更新日期：2018-05-01 00:00:00

abstract：:Celiac disease is a multifactorial disorder and provides a privileged model to decipher how the interplay between environmental and genetic factors can alter mucosal tolerance to a food antigen, lead to chronic intestinal inflammation, and ultimately promote T-cell lymphomagenesis. Here we summarize how HLA-DQ2/8 mole...

journal_title：Mucosal immunology

authors： Meresse B,Ripoche J,Heyman M,Cerf-Bensussan N

更新日期：2009-01-01 00:00:00

abstract：:IFN-γ is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-γ rapidly induced Noxa expression and that extent of inflammation by repeated house dust mite exposure was enhanced in noxa-/- compared ...

journal_title：Mucosal immunology

authors： Zhang C,Jones JT,Chand HS,Wathelet MG,Evans CM,Dickey B,Xiang J,Mebratu YA,Tesfaigzi Y

更新日期：2018-05-01 00:00:00

abstract：:Specific components of the intestinal microbiota are capable of influencing immune responses such that a mutualistic relationship is established. In mice, colonization with segmented filamentous bacteria (SFB) induces T-helper-17 (Th17) cell differentiation in the intestine, yet the effector functions of interleukin (...

journal_title：Mucosal immunology

authors： Flannigan KL,Ngo VL,Geem D,Harusato A,Hirota SA,Parkos CA,Lukacs NW,Nusrat A,Gaboriau-Routhiau V,Cerf-Bensussan N,Gewirtz AT,Denning TL

更新日期：2017-05-01 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a natural and major ingredient of green tea, has been shown to have anti-inflammation and anti-HIV-1 properties. We demonstrated that the intrarectal administration of EGCG could protect rhesus macaques from repetitive, intrarectal challenges with low-dose SHIVSF162P3N. This protecti...

journal_title：Mucosal immunology

authors： Liu JB,Li JL,Zhuang K,Liu H,Wang X,Xiao QH,Li XD,Zhou RH,Zhou L,Ma TC,Zhou W,Liu MQ,Ho WZ

更新日期：2018-07-01 00:00:00

abstract：:Intestinal CD8αα intraepithelial T lymphocytes (T-IELs) have a key role in mucosal immunity and, unlike other T cells, were proposed to differentiate locally. In apparent contradiction, these cells were also shown to originate from a wave of thymus migrants colonizing the gut in the first 3 weeks after birth. We here ...

journal_title：Mucosal immunology

authors： Peaudecerf L,dos Santos PR,Boudil A,Ezine S,Pardigon N,Rocha B

更新日期：2011-01-01 00:00:00

abstract：:Bacterial-induced intestinal inflammation is crucially dependent on interleukin (IL)-23 and is associated with CD4(+) T helper type 1 (Th1) and Th17 responses. However, the relative contributions of these subsets during the induction and resolution of colitis in T-cell-sufficient hosts remain unknown. We report that H...

journal_title：Mucosal immunology

authors： Morrison PJ,Bending D,Fouser LA,Wright JF,Stockinger B,Cooke A,Kullberg MC

更新日期：2013-11-01 00:00:00

abstract：:How the immune system senses aeroallergens and triggers an aberrant inflammation is poorly understood. Dectin-2 is a house dust mite (HDM)-sensing pattern recognition receptor. In a 3-week mouse model of repeated intranasal HDM challenge, anti-Dectin-2 potently attenuated the characteristic allergic inflammation and a...

journal_title：Mucosal immunology

authors： Clarke DL,Davis NH,Campion CL,Foster ML,Heasman SC,Lewis AR,Anderson IK,Corkill DJ,Sleeman MA,May RD,Robinson MJ

更新日期：2014-05-01 00:00:00

abstract：:Intestinal dendritic cells (DCs) continuously migrate through lymphatics to mesenteric lymph nodes where they initiate immunity or tolerance. Recent research has focused on populations of intestinal DCs expressing CD103. Here we demonstrate, for the first time, the presence of two distinct CD103(-) DC subsets in intes...

journal_title：Mucosal immunology

authors： Cerovic V,Houston SA,Scott CL,Aumeunier A,Yrlid U,Mowat AM,Milling SW

更新日期：2013-01-01 00:00:00

abstract：:Malaria-associated acute respiratory distress syndrome (MA-ARDS) and acute lung injury (ALI) are complications that cause lung damage and often leads to death. The MA-ARDS/ALI is associated with a Type 1 inflammatory response mediated by T lymphocytes and IFN-γ. Here, we used the Plasmodium berghei NK65 (PbN)-induced ...

journal_title：Mucosal immunology

authors： Galvão-Filho B,de Castro JT,Figueiredo MM,Rosmaninho CG,Antonelli LRDV,Gazzinelli RT

更新日期：2019-03-01 00:00:00

abstract：:Intranasal inoculation with influenza hemagglutinin subunit with polyinosine-polycytidylic (polyI:C), a synthetic analog for double-stranded RNA, enhances production of vaccine-specific immunoglobulin (Ig) A, which is superior to IgG in prophylactic immunity. The mechanism whereby polyI:C skews to IgA production in th...

journal_title：Mucosal immunology

authors： Takaki H,Kure S,Oshiumi H,Sakoda Y,Suzuki T,Ainai A,Hasegawa H,Matsumoto M,Seya T

更新日期：2018-01-01 00:00:00

abstract：:Nedd4 family interacting protein 1 (Ndfip1) is an adaptor protein that regulates Itch, an E3 ubiquitin ligase that ubiquitylates JunB, thereby preventing interleukin (IL)-4 and IL-5 production. Mice lacking Ndfip1 or Itch develop T helper type 2 (T(H)2)-mediated inflammation in the skin and lungs and die prematurely. ...

journal_title：Mucosal immunology

authors： Ramon HE,Riling CR,Bradfield J,Yang B,Hakonarson H,Oliver PM

更新日期：2011-05-01 00:00:00

abstract：:Periostin is an extracellular matrix protein that has been primarily studied in the context of the heart, where it has been shown to promote cardiac repair and remodeling. In this study, we focused on the role of periostin in an allergic eosinophilic inflammatory disease (eosinophilic esophagitis (EE)) known to involv...

journal_title：Mucosal immunology

authors： Blanchard C,Mingler MK,McBride M,Putnam PE,Collins MH,Chang G,Stringer K,Abonia JP,Molkentin JD,Rothenberg ME

更新日期：2008-07-01 00:00:00

abstract：:The gut mucosa is an important site of HIV immunopathogenesis with severe depletion of CD4+ T cells occurring during acute infection. The effect of prolonged anti-retroviral therapy (ART) on cycling and restoration of T lymphocytes in the gut remains unclear. Colon and terminal ileal biopsies and peripheral blood samp...

journal_title：Mucosal immunology

authors： Ciccone EJ,Read SW,Mannon PJ,Yao MD,Hodge JN,Dewar R,Chairez CL,Proschan MA,Kovacs JA,Sereti I

更新日期：2010-03-01 00:00:00

abstract：:Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn's disease (CD). Ineffectual NOD2 (nucleotide-binding oligomerization domain 2) is the most common susceptibility gene contributing to CD. Vitamin D (vD), a potent modulator of innate and adaptive immunity, induces NOD2 gene express...

journal_title：Mucosal immunology

authors： Dionne S,Calderon MR,White JH,Memari B,Elimrani I,Adelson B,Piccirillo C,Seidman EG

更新日期：2014-11-01 00:00:00

abstract：:Celiac disease (CD) is a chronic small intestinal inflammation precipitated by gluten ingestion. According to case reports, interferon (IFN)-α administration may induce development of overt CD. Plasmacytoid dendritic cells (PDCs) were thought to be the source of IFN-α and promote a T helper type 1 response leading to ...

journal_title：Mucosal immunology

authors： Ráki M,Beitnes AC,Lundin KE,Jahnsen J,Jahnsen FL,Sollid LM

更新日期：2013-09-01 00:00:00

abstract：:Secondary bacterial pneumonia is a significant complication of severe influenza infection and Staphylococcus aureus and Streptococcus pneumoniae are the primary pathogens of interest. IL-22 promotes S. aureus and S. pneumoniae host defense in the lung through epithelial integrity and induction of antimicrobial peptide...

journal_title：Mucosal immunology

authors： Abood RN,McHugh KJ,Rich HE,Ortiz MA,Tobin JM,Ramanan K,Robinson KM,Bomberger JM,Kolls JK,Manni ML,Pociask DA,Alcorn JF

更新日期：2019-09-01 00:00:00

abstract：:Molecular mechanisms regulating transforming growth factor-beta (TGF-beta) induction of Foxp3 (forkhead box P3) expression and thus induction of induced regulatory T cells (Tregs) have been the focus of a great deal of study in recent years. It has become clear that this process is influenced by a number of factors as...

journal_title：Mucosal immunology

authors： Xu L,Kitani A,Strober W

更新日期：2010-05-01 00:00:00

abstract：:FoxP3+ regulatory T cells (Tregs) control inflammation and maintain mucosal homeostasis, but their functions during infection are poorly understood. Th1, Th2, and Th17 cells can be identified by master transcription factors (TFs) T-bet, GATA3, and RORγT; Tregs also express these TFs. While T-bet+ Tregs can selectively...

journal_title：Mucosal immunology

authors： Clay SL,Bravo-Blas A,Wall DM,MacLeod MKL,Milling SWF

更新日期：2020-11-01 00:00:00

abstract：:Women with asymptomatic Neisseria gonorrhoeae infection are at risk of developing pelvic inflammatory disease (PID) if the bacteria ascend from the endocervix into the uterus and oviducts. Factors that affect disease severity, ranging from mild discomfort to severe inflammation, pain, and infertility, remain elusive. ...

journal_title：Mucosal immunology

authors： Islam EA,Shaik-Dasthagirisaheb Y,Kaushic C,Wetzler LM,Gray-Owen SD

更新日期：2016-07-01 00:00:00

abstract：:The study of animal immune physiology and animal models of human disease have accelerated many aspects of translational research by allowing direct, definitive investigations. In particular, the use of mice has allowed genetic manipulation, adoptive transfer, immunization, and focused cell and tissue sampling, which w...

journal_title：Mucosal immunology

authors： Gibbons DL,Spencer J

更新日期：2011-03-01 00:00:00

abstract：:Regulation of respiratory mucosal immunity by microbial-derived metabolites has been a proposed mechanism that may provide airway protection. Here we examine the effect of oral Lactobacillus johnsonii supplementation on metabolic and immune response dynamics during respiratory syncytial virus (RSV) infection. L. johns...

journal_title：Mucosal immunology

authors： Fonseca W,Lucey K,Jang S,Fujimura KE,Rasky A,Ting HA,Petersen J,Johnson CC,Boushey HA,Zoratti E,Ownby DR,Levine AM,Bobbit KR,Lynch SV,Lukacs NW

更新日期：2017-11-01 00:00:00

abstract：:Induction of mucosal immunoglobulin-A (IgA) capable of providing a first line of defense against bacterial and viral pathogens remains a major goal of needle-free vaccines given via mucosal routes. Innate immune cells are known to play a central role in induction of IgA responses by mucosal vaccines, but the relative ...

journal_title：Mucosal immunology

authors： Jee J,Bonnegarde-Bernard A,Duverger A,Iwakura Y,Cormet-Boyaka E,Martin TL,Steiner HE,Bachman RC,Boyaka PN

更新日期：2015-07-01 00:00:00

abstract：:Alpha B-crystallin (CRYAB) is an important member of the small heat shock protein family, and plays a protective and therapeutic role in neurological inflammation. CRYAB expression was assessed in cultured HT29 and Caco-2 cells and inflamed mucosa of patients with inflammatory bowel disease (IBD) and colitis models in...

journal_title：Mucosal immunology

authors： Xu W,Guo Y,Huang Z,Zhao H,Zhou M,Huang Y,Wen D,Song J,Zhu Z,Sun M,Liu CY,Chen Y,Cui L,Wang X,Liu Z,Yang Y,Du P

更新日期：2019-11-01 00:00:00

abstract：:The mucosal immune system is charged with defending the host's vast interfaces with the outside world from the enormous and diverse group of microbes that colonizes these surfaces. A key means by which the mucosal immune system protects the host from such diverse microbes is using germ-line-encoded receptors that targ...

journal_title：Mucosal immunology

authors： Vijay-Kumar M,Gewirtz AT

更新日期：2009-05-01 00:00:00

abstract：:Cells of the mononuclear phagocyte system (MPS) are found in large numbers in every organ of the body, where they contribute to innate and acquired immunity and homeostasis. This review considers the locations of MPS cells, surface markers that distinguish subsets of monocytes and macrophages, the pathways of MPS diff...

journal_title：Mucosal immunology

authors： Hume DA

更新日期：2008-11-01 00:00:00

abstract：:Leptin is an adipocytokine that links nutrition to immunity. Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that leptin signaling has a protective role during intestinal amebic infection. In this study we show tha...

journal_title：Mucosal immunology

authors： Guo X,Roberts MR,Becker SM,Podd B,Zhang Y,Chua SC Jr,Myers MG Jr,Duggal P,Houpt ER,Petri WA Jr

更新日期：2011-05-01 00:00:00

abstract：:Cross-presentation of cellular antigens is crucial for priming CD8(+) T cells, and generating immunity to intracellular pathogens--particularly viruses. It is unclear which intestinal phagocytes perform this function in vivo. To address this, we examined dendritic cells (DCs) from the intestinal lymph of IFABP-tOVA 23...

journal_title：Mucosal immunology

authors： Cerovic V,Houston SA,Westlund J,Utriainen L,Davison ES,Scott CL,Bain CC,Joeris T,Agace WW,Kroczek RA,Mowat AM,Yrlid U,Milling SW

更新日期：2015-01-01 00:00:00

abstract：:The sphingosine-1-phosphate receptor-1 (S1P1) agonist ozanimod ameliorates ulcerative colitis, yet its mechanism of action is unknown. Here, we examine the cell subsets that express S1P1 in intestine using S1P1-eGFP mice, the regulation of S1P1 expression in lymphocytes after administration of dextran sulfate sodium (...

journal_title：Mucosal immunology

authors： Karuppuchamy T,Behrens EH,González-Cabrera P,Sarkisyan G,Gima L,Boyer JD,Bamias G,Jedlicka P,Veny M,Clark D,Peach R,Scott F,Rosen H,Rivera-Nieves J

更新日期：2017-01-01 00:00:00