Abstract:
:The study of animal immune physiology and animal models of human disease have accelerated many aspects of translational research by allowing direct, definitive investigations. In particular, the use of mice has allowed genetic manipulation, adoptive transfer, immunization, and focused cell and tissue sampling, which would obviously be unthinkable for studies in humans. However, the disease relevance of some animal models may be uncertain and difficulties in interpretation may occur as a consequence of immunological differences between the two species. In this review, we will consider general differences in the structure and development of human and mouse mucosal lymphoid microenvironments and then discuss species differences in mucosal B- and T-cell biology that relate to the current concepts of intestinal immune function.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Gibbons DL,Spencer Jdoi
10.1038/mi.2010.85subject
Has Abstractpub_date
2011-03-01 00:00:00pages
148-57issue
2eissn
1933-0219issn
1935-3456pii
mi201085journal_volume
4pub_type
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