Abstract：
:Specific components of the intestinal microbiota are capable of influencing immune responses such that a mutualistic relationship is established. In mice, colonization with segmented filamentous bacteria (SFB) induces T-helper-17 (Th17) cell differentiation in the intestine, yet the effector functions of interleukin (IL)-17A in response to SFB remain incompletely understood. Here we report that colonization of mice with SFB-containing microbiota induced IL-17A- and CXCR2-dependent recruitment of neutrophils to the ileum. This response required adaptive immunity, as Rag-deficient mice colonized with SFB-containing microbiota failed to induce IL-17A, CXCL1 and CXCL2, and displayed defective neutrophil recruitment to the ileum. Interestingly, neutrophil depletion in wild-type mice resulted in significantly augmented Th17 responses and SFB expansion, which correlated with impaired expression of IL-22 and antimicrobial peptides. These data provide novel insight into a dynamic IL-17A-CXCR2-neutrophil axis during acute SFB colonization and demonstrate a central role for neutrophils in limiting SFB expansion.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Flannigan KL,Ngo VL,Geem D,Harusato A,Hirota SA,Parkos CA,Lukacs NW,Nusrat A,Gaboriau-Routhiau V,Cerf-Bensussan N,Gewirtz AT,Denning TLdoi
10.1038/mi.2016.80subject
Has Abstractpub_date
2017-05-01 00:00:00pages
673-684issue
3eissn
1933-0219issn
1935-3456pii
mi201680journal_volume
10pub_type
杂志文章abstract：:Colonization of the nasopharyngeal mucosa by meningococcus and other polysaccharide (PS)-encapsulated bacteria precedes invasion. PS-conjugate vaccines induce PS-specific B-cell memory (B(MEM)) and also prevent colonization, thus blocking person-to-person transmission, generating herd protection. However, in isolation...
journal_title：Mucosal immunology
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journal_title：Mucosal immunology
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journal_title：Mucosal immunology
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journal_title：Mucosal immunology
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journal_title：Mucosal immunology
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journal_title：Mucosal immunology
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abstract：:Chlamydia trachomatis (Ct) is an obligate intracellular bacterial pathogen. Previously, we showed that infection of human trophoblast cells by Ct triggers the secretion of the pro-inflammatory cytokine, interleukin (IL)-1β. The aim of this study was to understand the innate immune pathways involved in trophoblast prod...
journal_title：Mucosal immunology
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journal_title：Mucosal immunology
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journal_title：Mucosal immunology
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journal_title：Mucosal immunology
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journal_title：Mucosal immunology
pub_type： 杂志文章
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journal_title：Mucosal immunology
pub_type： 杂志文章
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journal_title：Mucosal immunology
pub_type： 评论,杂志文章
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更新日期：2017-07-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 杂志文章
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更新日期：2019-09-01 00:00:00
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journal_title：Mucosal immunology
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更新日期：2015-07-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 杂志文章,评审
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更新日期：2008-09-01 00:00:00
abstract：:Development of effective tuberculosis vaccines is hampered by insufficient understanding of protective immunity. Here, Woodworth et al.1 show secondary effector CD4 T cells generated after Mtb challenge of H56/CAF01 vaccinated mice display superior lung homing compared with primary effectors. Vaccination generates lar...
journal_title：Mucosal immunology
pub_type： 评论,杂志文章
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更新日期：2017-03-01 00:00:00
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journal_title：Mucosal immunology
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journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.14
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abstract：:Pneumonia caused by Streptococcus pneumoniae (Sp) remains a leading cause of serious illness and death worldwide. Immunization with conjugated pneumococcal vaccine has lowered the colonization rate and consequently invasive diseases by inducing serotype-specific antibodies. However, many of the current pneumonia cases...
journal_title：Mucosal immunology
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journal_title：Mucosal immunology
pub_type： 杂志文章,评审
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更新日期：2008-11-01 00:00:00
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journal_title：Mucosal immunology
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更新日期：2011-09-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 杂志文章,评审
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更新日期：2010-05-01 00:00:00
abstract：:Children born by cesarean section (CS) have an increased risk of developing inflammatory bowel disease (IBD), possibly due to skewed microbial colonization during birth and consequently impaired bacterial stimulation of the developing immune system. The aim of this study was to investigate the association between CS a...
journal_title：Mucosal immunology
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更新日期：2019-11-01 00:00:00
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journal_title：Mucosal immunology
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更新日期：2015-01-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
abstract：:Group 3 innate lymphoid cells (ILC3s), a subset of the innate lymphoid cells, are abundantly present in the intestine and are crucial regulators of intestinal inflammation. Brg1 (Brahma-related gene 1), a catalytic subunit of the mammalian SWI-SNF-like chromatin-remodeling BAF complex, regulates the development and fu...
journal_title：Mucosal immunology
pub_type： 杂志文章
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更新日期：2021-01-01 00:00:00
abstract：:Cells of the mononuclear phagocyte system (MPS) are found in large numbers in every organ of the body, where they contribute to innate and acquired immunity and homeostasis. This review considers the locations of MPS cells, surface markers that distinguish subsets of monocytes and macrophages, the pathways of MPS diff...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
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更新日期：2008-11-01 00:00:00
abstract：:Intranasal (IN) immunization with a Plasmodium circumsporozoite (CS) protein conjugated to flagellin, a Toll-like receptor 5 agonist, was found to elicit antibody-mediated protective immunity in our previous murine studies. To better understand IN-elicited immune responses, we examined the nasopharynx-associated lymph...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2013.48
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