当前位置： SCI文献检索 > Mucosal Immunology期刊下所有文献 > Neutrophils express pro- and anti-inflammatory cytokines in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques.

Neutrophils express pro- and anti-inflammatory cytokines in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques.

Abstract：

:Neutrophils are implicated in the pathogenesis of tuberculosis (TB), a disease caused by Mycobacterium tuberculosis infection, but the mechanisms by which they promote disease are not fully understood. Neutrophils can express cytokines that influence TB progression, and so we compared neutrophil and T-cell expression of the Th1 cytokines IFNγ and TNF, the Th2 cytokine IL-4, and regulatory cytokine IL-10 in M. tuberculosis-infected macaques to determine if neutrophil cytokine expression contributes to dysregulated immunity in TB. We found that peripheral blood neutrophils produced cytokines after stimulation by mycobacterial antigens and inactive and viable M. tuberculosis. M. tuberculosis antigen-stimulated neutrophils inhibited antigen-specific T-cell IFNγ production. In lung granulomas, neutrophil cytokine expression resembled T-cell cytokine expression, and although there was histologic evidence for neutrophil interaction with T cells, neutrophil cytokine expression was not correlated with T-cell cytokine expression or bacteria load. There was substantial overlap in the spatial arrangement of cytokine-expressing neutrophils and T cells, but IL-10-expressing neutrophils were also abundant in bacteria-rich areas between caseum and epithelioid macrophages. These results suggest that neutrophils contribute to the cytokine milieu in granulomas and may be important immunoregulatory cells in TB granulomas.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Gideon HP,Phuah J,Junecko BA,Mattila JT

doi

10.1038/s41385-019-0195-8

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

1370-1381

issue

6

eissn

1933-0219

issn

1935-3456

pii

10.1038/s41385-019-0195-8

journal_volume

12

pub_type

杂志文章

相关文献

Mucosal Immunology文献大全
  • IL-17-mediated antifungal defense in the oral mucosa is independent of neutrophils.

    abstract：:Interleukin-17 (IL-17)-mediated immunity has emerged as a crucial host defense mechanism against Candida albicans infections in mucosal tissues and the skin. The precise mechanism by which the IL-17 pathway prevents fungal outgrowth has not been clarified. Neutrophils are critical for limiting fungal dissemination and...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2014.57

    authors： Trautwein-Weidner K,Gladiator A,Nur S,Diethelm P,LeibundGut-Landmann S

    更新日期：2015-03-01 00:00:00

  • Mechanism of NKT cell activation by intranasal coadministration of alpha-galactosylceramide, which can induce cross-protection against influenza viruses.

    abstract：:In a nasal vaccine against influenza, the activation of natural killer T (NKT) cells by intranasal coadministration of alpha-galactosylceramide (alpha-GalCer) can potently enhance protective immune responses. The results of this study show that the NKT cell-activated nasal vaccine can induce an effective cross-protect...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2008.2

    authors： Kamijuku H,Nagata Y,Jiang X,Ichinohe T,Tashiro T,Mori K,Taniguchi M,Hase K,Ohno H,Shimaoka T,Yonehara S,Odagiri T,Tashiro M,Sata T,Hasegawa H,Seino KI

    更新日期：2008-05-01 00:00:00

  • Pulmonary monocytes interact with effector T cells in the lung tissue to drive TRM differentiation following viral infection.

    abstract：:Lung resident memory CD8 T cells (TRM) are critical for protection against respiratory viruses, but the cellular interactions required for their development are poorly understood. Herein we describe the necessity of classical monocytes for the establishment of lung TRM following influenza infection. We find that, duri...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-019-0224-7

    authors： Dunbar PR,Cartwright EK,Wein AN,Tsukamoto T,Tiger Li ZR,Kumar N,Uddbäck IE,Hayward SL,Ueha S,Takamura S,Kohlmeier JE

    更新日期：2020-01-01 00:00:00

  • Anti-CXCL13 antibody can inhibit the formation of gastric lymphoid follicles induced by Helicobacter infection.

    abstract：:Helicobacter suis infects the stomachs of both animals and humans, and can induce gastric mucosa-associated lymphoid tissue (MALT) lymphomas. It is known that CXC chemokine ligand 13 (CXCL13) is highly expressed in the Helicobacter-infected mice and gastric MALT lymphoma patients, but the pathway that links the activa...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2014.14

    authors： Yamamoto K,Nishiumi S,Yang L,Klimatcheva E,Pandina T,Takahashi S,Matsui H,Nakamura M,Zauderer M,Yoshida M,Azuma T

    更新日期：2014-09-01 00:00:00

  • Mucosal immunity: aliment and ailments.

    abstract：:The development of the primitive gut in the multicellular aquatic eukaryote was driven by the insufficient absorption of nutrients from the oceanic soup. The anatomy of this evolving specialized system invited its colonization by environmental prokaryotes and resulted in the establishment of the intestinal microflora....

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2009.123

    authors： Raz E

    更新日期：2010-01-01 00:00:00

  • Selective deletion of MyD88 signaling in α-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation.

    abstract：:Intestinal fibrosis leading to strictures remains a significant clinical problem in inflammatory bowel diseases (IBD). The role of bacterial components in activating intestinal mesenchymal cells and driving fibrogenesis is largely unexplored. Tamoxifen-inducible α-SMA promoter Cre mice crossed with floxed MyD88 mice w...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-020-0259-9

    authors： Zhao S,Dejanovic D,Yao P,Bhilocha S,Sadler T,Schirbel A,West G,Doyon G,Lopez R,Mao R,Kurada S,El Ouali S,Grassl G,Fox PL,Cruise M,Worthley DL,de la Motte C,Fiocchi C,Rieder F

    更新日期：2020-07-01 00:00:00

  • BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses.

    abstract：:Leukotriene B4 receptor 1 (BLT1) triggers the migration of granulocytes and activated T cells; however, its role in B-cell function remains unclear. Here we report that BLT1 is required to induce the production of antigen-specific IgA against oral vaccine through mediating innate immune signals from commensal bacteria...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-019-0175-z

    authors： Nagatake T,Hirata SI,Koga T,Kuroda E,Kobari S,Suzuki H,Hosomi K,Matsumoto N,Yanrismet Y,Shimojou M,Morimoto S,Sasaki F,Ishii KJ,Yokomizo T,Kunisawa J

    更新日期：2019-09-01 00:00:00

  • Cross-protective mucosal immunity mediated by memory Th17 cells against Streptococcus pneumoniae lung infection.

    abstract：:Pneumonia caused by Streptococcus pneumoniae (Sp) remains a leading cause of serious illness and death worldwide. Immunization with conjugated pneumococcal vaccine has lowered the colonization rate and consequently invasive diseases by inducing serotype-specific antibodies. However, many of the current pneumonia cases...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2016.41

    authors： Wang Y,Jiang B,Guo Y,Li W,Tian Y,Sonnenberg GF,Weiser JN,Ni X,Shen H

    更新日期：2017-01-01 00:00:00

  • IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue.

    abstract：:T helper type (Th17) cytokines such as interleukin (IL)-17A and IL-22 are important in maintaining mucosal barrier function and may be important in the pathogenesis of inflammatory bowel diseases (IBDs). Here, we analyzed cells from the colon of IBD patients and show that Crohn's disease (CD) patients had significantl...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2013.31

    authors： Leung JM,Davenport M,Wolff MJ,Wiens KE,Abidi WM,Poles MA,Cho I,Ullman T,Mayer L,Loke P

    更新日期：2014-01-01 00:00:00

  • Neutrophil recruitment and activation are differentially dependent on MyD88/TRIF and MAVS signaling during RSV infection.

    abstract：:Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections, especially in infants. Lung neutrophilia is a hallmark of RSV disease but the mechanism by which neutrophils are recruited and activated is unclear. Here, we investigate the innate immune signaling pathways underlying ne...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-019-0190-0

    authors： Kirsebom FCM,Kausar F,Nuriev R,Makris S,Johansson C

    更新日期：2019-09-01 00:00:00

  • Innate lymphoid cells: models of plasticity for immune homeostasis and rapid responsiveness in protection.

    abstract：:Innate lymphoid cells (ILCs) have stormed onto the immune landscape as "newly discovered" cell types. These tissue-resident sentinels are enriched at mucosal surfaces and engage in complex cross talk with elements of the adaptive immune system and microenvironment to orchestrate immune homeostasis. Many parallels exis...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2016.64

    authors： Almeida FF,Belz GT

    更新日期：2016-09-01 00:00:00

  • Differential effect of vitamin D on NOD2- and TLR-induced cytokines in Crohn's disease.

    abstract：:Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn's disease (CD). Ineffectual NOD2 (nucleotide-binding oligomerization domain 2) is the most common susceptibility gene contributing to CD. Vitamin D (vD), a potent modulator of innate and adaptive immunity, induces NOD2 gene express...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2014.30

    authors： Dionne S,Calderon MR,White JH,Memari B,Elimrani I,Adelson B,Piccirillo C,Seidman EG

    更新日期：2014-11-01 00:00:00

  • Oral-gut connection: one step closer to an integrated view of the gastrointestinal tract?

    abstract：:Although an enrichment of orally derived bacteria is reported in the gut microbiota of patients with several diseases, it is mostly unknown whether oral bacteria can colonize and induce intestinal inflammation. In a recent paper in Science, Atarashi et al.1 from Kenya Honda's laboratory show that a subset of orally de...

    journal_title：Mucosal immunology

    pub_type： 评论,杂志文章

    doi：10.1038/mi.2017.116

    authors： Lira-Junior R,Boström EA

    更新日期：2018-03-01 00:00:00

  • Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling.

    abstract：:Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6Chi monocytes, but the factors driving this tissue-specific process are not understood. ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2016.142

    authors： Schridde A,Bain CC,Mayer JU,Montgomery J,Pollet E,Denecke B,Milling SWF,Jenkins SJ,Dalod M,Henri S,Malissen B,Pabst O,Mcl Mowat A

    更新日期：2017-11-01 00:00:00

  • Nod1, but not the ASC inflammasome, contributes to induction of IL-1β secretion in human trophoblasts after sensing of Chlamydia trachomatis.

    abstract：:Chlamydia trachomatis (Ct) is an obligate intracellular bacterial pathogen. Previously, we showed that infection of human trophoblast cells by Ct triggers the secretion of the pro-inflammatory cytokine, interleukin (IL)-1β. The aim of this study was to understand the innate immune pathways involved in trophoblast prod...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2012.63

    authors： Kavathas PB,Boeras CM,Mulla MJ,Abrahams VM

    更新日期：2013-03-01 00:00:00

  • Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality.

    abstract：:Neutrophils clear viruses, but excessive neutrophil responses induce tissue injury and worsen disease. Aging increases mortality to influenza infection; however, whether this is due to impaired viral clearance or a pathological host immune response is unknown. Here we show that aged mice have higher levels of lung neu...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-018-0115-3

    authors： Kulkarni U,Zemans RL,Smith CA,Wood SC,Deng JC,Goldstein DR

    更新日期：2019-03-01 00:00:00

  • The reproductive cycle is a pathogenic determinant during gonococcal pelvic inflammatory disease in mice.

    abstract：:Women with asymptomatic Neisseria gonorrhoeae infection are at risk of developing pelvic inflammatory disease (PID) if the bacteria ascend from the endocervix into the uterus and oviducts. Factors that affect disease severity, ranging from mild discomfort to severe inflammation, pain, and infertility, remain elusive. ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.122

    authors： Islam EA,Shaik-Dasthagirisaheb Y,Kaushic C,Wetzler LM,Gray-Owen SD

    更新日期：2016-07-01 00:00:00

  • Celiac disease: from oral tolerance to intestinal inflammation, autoimmunity and lymphomagenesis.

    abstract：:Celiac disease is a multifactorial disorder and provides a privileged model to decipher how the interplay between environmental and genetic factors can alter mucosal tolerance to a food antigen, lead to chronic intestinal inflammation, and ultimately promote T-cell lymphomagenesis. Here we summarize how HLA-DQ2/8 mole...

    journal_title：Mucosal immunology

    pub_type： 评论,杂志文章,评审

    doi：10.1038/mi.2008.75

    authors： Meresse B,Ripoche J,Heyman M,Cerf-Bensussan N

    更新日期：2009-01-01 00:00:00

  • The ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility.

    abstract：:Nedd4 family interacting protein 1 (Ndfip1) is an adaptor protein that regulates Itch, an E3 ubiquitin ligase that ubiquitylates JunB, thereby preventing interleukin (IL)-4 and IL-5 production. Mice lacking Ndfip1 or Itch develop T helper type 2 (T(H)2)-mediated inflammation in the skin and lungs and die prematurely. ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2010.69

    authors： Ramon HE,Riling CR,Bradfield J,Yang B,Hakonarson H,Oliver PM

    更新日期：2011-05-01 00:00:00

  • Toll-like receptor 3 in nasal CD103+ dendritic cells is involved in immunoglobulin A production.

    abstract：:Intranasal inoculation with influenza hemagglutinin subunit with polyinosine-polycytidylic (polyI:C), a synthetic analog for double-stranded RNA, enhances production of vaccine-specific immunoglobulin (Ig) A, which is superior to IgG in prophylactic immunity. The mechanism whereby polyI:C skews to IgA production in th...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2017.48

    authors： Takaki H,Kure S,Oshiumi H,Sakoda Y,Suzuki T,Ainai A,Hasegawa H,Matsumoto M,Seya T

    更新日期：2018-01-01 00:00:00

  • An African perspective on mucosal immunity and HIV-1.

    abstract：:HIV prevention mandates an understanding of the mechanisms of mucosal immunity with attention to some unique features of the epidemic and mucosal environment in the developing world. An effective vaccine will have to induce mucosal protection against a highly diverse virus, which is equipped with a number of immune ev...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2009.23

    authors： Pala P,Gomez-Roman VR,Gilmour J,Kaleebu P

    更新日期：2009-07-01 00:00:00

  • Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity.

    abstract：:Group 3 innate lymphoid cells (ILC3s), a subset of the innate lymphoid cells, are abundantly present in the intestine and are crucial regulators of intestinal inflammation. Brg1 (Brahma-related gene 1), a catalytic subunit of the mammalian SWI-SNF-like chromatin-remodeling BAF complex, regulates the development and fu...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-020-0317-3

    authors： Qi X,Qiu J,Chang J,Ji Y,Yang Q,Cui G,Sun L,Chai Q,Qin J,Qiu J

    更新日期：2021-01-01 00:00:00

  • Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation.

    abstract：:IFN-γ is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-γ rapidly induced Noxa expression and that extent of inflammation by repeated house dust mite exposure was enhanced in noxa-/- compared ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2017.117

    authors： Zhang C,Jones JT,Chand HS,Wathelet MG,Evans CM,Dickey B,Xiang J,Mebratu YA,Tesfaigzi Y

    更新日期：2018-05-01 00:00:00

  • Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis.

    abstract：:Association mapping and candidate gene studies within inflammatory bowel diseases (IBD) linkage regions, as well as genome-wide association studies in Crohn's disease (CD) have led to the discovery of multiple risk genes, but these explain only a fraction of the genetic susceptibility observed in IBD. We have thus bee...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1038/mi.2007.15

    authors： Goyette P,Lefebvre C,Ng A,Brant SR,Cho JH,Duerr RH,Silverberg MS,Taylor KD,Latiano A,Aumais G,Deslandres C,Jobin G,Annese V,Daly MJ,Xavier RJ,Rioux JD

    更新日期：2008-03-01 00:00:00

  • Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma.

    abstract：:Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as t...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2012.14

    authors： Han H,Xu W,Headley MB,Jessup HK,Lee KS,Omori M,Comeau MR,Marshak-Rothstein A,Ziegler SF

    更新日期：2012-05-01 00:00:00

  • Restoring cigarette smoke-induced impairment of efferocytosis in alveolar macrophages.

    abstract：:Cigarette smoke has been associated with susceptibility to different pulmonary and airway diseases. Impaired alveolar macrophages (AMs) that are major phagocytes in the lung have been associated with patients with airway diseases and active smokers. In the current report, we show that exposure to second-hand cigarette...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.120

    authors： Subramaniam R,Mukherjee S,Chen H,Keshava S,Neuenschwander P,Shams H

    更新日期：2016-07-01 00:00:00

  • AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection.

    abstract：:The mechanism regulating the gastrointestinal epithelial barrier remains poorly understood. We herein demonstrate that Absent in melanoma-2 (AIM2) contributes to the maintenance of intestinal barrier integrity and defense against bacterial infection. AIM2-deficient mice displayed an increased susceptibility to mucosal...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.142

    authors： Hu GQ,Song PX,Li N,Chen W,Lei QQ,Yu SX,Zhang XJ,Du CT,Deng XM,Han WY,Yang YJ

    更新日期：2016-09-01 00:00:00

  • A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways.

    abstract：:Cellular inhibitors of apoptosis proteins (cIAPs) are critical arbiters of cell death and key mediators of inflammation and innate immunity. cIAP2 is frequently overexpressed in colorectal cancer and in regenerating crypts of ulcerative colitis patients. However, its corresponding functions in intestinal homeostasis a...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.46

    authors： Dagenais M,Dupaul-Chicoine J,Champagne C,Skeldon A,Morizot A,Saleh M

    更新日期：2016-01-01 00:00:00

  • Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease.

    abstract：:The sphingosine-1-phosphate receptor-1 (S1P1) agonist ozanimod ameliorates ulcerative colitis, yet its mechanism of action is unknown. Here, we examine the cell subsets that express S1P1 in intestine using S1P1-eGFP mice, the regulation of S1P1 expression in lymphocytes after administration of dextran sulfate sodium (...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2016.35

    authors： Karuppuchamy T,Behrens EH,González-Cabrera P,Sarkisyan G,Gima L,Boyer JD,Bamias G,Jedlicka P,Veny M,Clark D,Peach R,Scott F,Rosen H,Rivera-Nieves J

    更新日期：2017-01-01 00:00:00

  • CD4(+) T-cell survival in the GI tract requires dectin-1 during fungal infection.

    abstract：:Dectin-1 is an innate antifungal C-type lectin receptor necessary for protective antifungal immunity. We recently discovered that Dectin-1 is involved in controlling fungal infections of the gastrointestinal (GI) tract, but how this C-type lectin receptor mediates these activities is unknown. Here, we show that Dectin...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.79

    authors： Drummond RA,Dambuza IM,Vautier S,Taylor JA,Reid DM,Bain CC,Underhill DM,Masopust D,Kaplan DH,Brown GD

    更新日期：2016-03-01 00:00:00