Abstract:
:Induction of mucosal immunoglobulin-A (IgA) capable of providing a first line of defense against bacterial and viral pathogens remains a major goal of needle-free vaccines given via mucosal routes. Innate immune cells are known to play a central role in induction of IgA responses by mucosal vaccines, but the relative contribution of myeloid cell subsets to these responses has not firmly been established. Using an in vivo model of sublingual vaccination with Bacillus anthracis edema toxin (EdTx) as adjuvant, we examined the role of myeloid cell subsets for mucosal secretory IgA responses. Sublingual immunization of wild-type mice resulted in a transient increase of neutrophils in sublingual tissues and cervical lymph nodes. These mice later developed Ag-specific serum IgG responses, but not serum or mucosal IgA. Interestingly, EdTx failed to increase neutrophils in sublingual tissues and cervical lymph nodes of IKKβ(ΔMye) mice, and these mice developed IgA responses. Partial depletion of neutrophils before immunization of wild-type mice allowed the development of both mucosal and serum IgA responses. Finally, co-culture of B cells with neutrophils from either wild-type or IKKβ(ΔMye) mice suppressed secretion of IgA, but not IgM or IgG. These results identify a new role for neutrophils as negative regulators of IgA responses.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Jee J,Bonnegarde-Bernard A,Duverger A,Iwakura Y,Cormet-Boyaka E,Martin TL,Steiner HE,Bachman RC,Boyaka PNdoi
10.1038/mi.2014.105subject
Has Abstractpub_date
2015-07-01 00:00:00pages
735-45issue
4eissn
1933-0219issn
1935-3456pii
mi2014105journal_volume
8pub_type
杂志文章abstract::Effector T-cell contraction is one of the primary means by which immune homeostasis in the peripheral tissues is reestablished following an inflammatory response. In this issue of Mucosal Immunology, Hashimoto-Hill et al.1 show that retinoic acid (RA) transcriptionally upregulates P2X7 primarily in effector T cells of...
journal_title:Mucosal immunology
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journal_title:Mucosal immunology
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journal_title:Mucosal immunology
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journal_title:Mucosal immunology
pub_type: 杂志文章
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journal_title:Mucosal immunology
pub_type: 杂志文章
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journal_title:Mucosal immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Mucosal immunology
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Mucosal immunology
pub_type: 杂志文章,多中心研究
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