Abstract：
:Viral respiratory tract infections (RTI) pose a high burden on the youngest members of our society. Several risk factors are known for severe viral respiratory disease. However, a large proportion of the severe RTI cannot be explained by these risk factors. A growing body of evidence shows that the composition of the microbiota has a major influence on the training of both the mucosal and the systemic immune response and can thus potentially determine susceptibility for severe viral infections. In this review, we discuss the current evidence regarding the influence of bacterial colonization on the severity of viral respiratory infections.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Vissers M,de Groot R,Ferwerda Gdoi
10.1038/mi.2013.93subject
Has Abstractpub_date
2014-03-01 00:00:00pages
227-38issue
2eissn
1933-0219issn
1935-3456pii
mi201393journal_volume
7pub_type
杂志文章,评审abstract：:Human papillomaviruses (HPV)-related cervical cancer is the second leading cause of cancer death in women worldwide. Despite active development, HPV E6/E7 oncogene-specific therapeutic vaccines have had limited clinical efficacy to date. Here, we report that intravaginal (IVAG) instillation of CpG-ODN (TLR9 agonist) o...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.83
更新日期：2013-03-01 00:00:00
abstract：:Previously we have extensively characterized Salmonella enterica serovar Typhi (S. Typhi)-specific cell-mediated immune (CMI) responses in volunteers orally immunized with the licensed Ty21a typhoid vaccine. In this study we measured Salmonella-specific multifunctional (MF) CD8+ T-cell responses to further investigate...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.24
更新日期：2015-11-01 00:00:00
abstract：:The ultimate goal for vaccination is to stimulate protective immunological memory. Protection against infectious diseases not only relies on the magnitude of the humoral immune response, but more importantly on the quality and longevity of it. Adjuvants are critical components of most non-living vaccines. Although lit...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2010.54
更新日期：2010-11-01 00:00:00
abstract：:Intestinal CD8αα intraepithelial T lymphocytes (T-IELs) have a key role in mucosal immunity and, unlike other T cells, were proposed to differentiate locally. In apparent contradiction, these cells were also shown to originate from a wave of thymus migrants colonizing the gut in the first 3 weeks after birth. We here ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2010.47
更新日期：2011-01-01 00:00:00
abstract：:Nedd4 family interacting protein 1 (Ndfip1) is an adaptor protein that regulates Itch, an E3 ubiquitin ligase that ubiquitylates JunB, thereby preventing interleukin (IL)-4 and IL-5 production. Mice lacking Ndfip1 or Itch develop T helper type 2 (T(H)2)-mediated inflammation in the skin and lungs and die prematurely. ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2010.69
更新日期：2011-05-01 00:00:00
abstract：:Chlamydia trachomatis (Ct) is an obligate intracellular bacterial pathogen. Previously, we showed that infection of human trophoblast cells by Ct triggers the secretion of the pro-inflammatory cytokine, interleukin (IL)-1β. The aim of this study was to understand the innate immune pathways involved in trophoblast prod...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.63
更新日期：2013-03-01 00:00:00
abstract：:Beryllium exposure results in beryllium hypersensitivity in a subset of exposed individuals, leading to granulomatous inflammation and fibrosis in the lung. In addition to its antigenic properties, beryllium has potent adjuvant activity that contributes to sensitization via unknown pathways. Here we show that berylliu...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.14
更新日期：2015-11-01 00:00:00
abstract：:Effector T-cell contraction is one of the primary means by which immune homeostasis in the peripheral tissues is reestablished following an inflammatory response. In this issue of Mucosal Immunology, Hashimoto-Hill et al.1 show that retinoic acid (RA) transcriptionally upregulates P2X7 primarily in effector T cells of...
journal_title：Mucosal immunology
pub_type： 评论,杂志文章
doi：10.1038/mi.2016.117
更新日期：2017-07-01 00:00:00
abstract：:Oral tolerance refers to the observation that prior feeding of an antigen induces local and systemic immune tolerance to that antigen. Physiologically, this process is probably of central importance for preventing inflammatory responses to the numerous dietary and microbial antigens present in the gut. Defective oral ...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2010.25
更新日期：2010-07-01 00:00:00
abstract：:Women with asymptomatic Neisseria gonorrhoeae infection are at risk of developing pelvic inflammatory disease (PID) if the bacteria ascend from the endocervix into the uterus and oviducts. Factors that affect disease severity, ranging from mild discomfort to severe inflammation, pain, and infertility, remain elusive. ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.122
更新日期：2016-07-01 00:00:00
abstract：:Intranasal inoculation with influenza hemagglutinin subunit with polyinosine-polycytidylic (polyI:C), a synthetic analog for double-stranded RNA, enhances production of vaccine-specific immunoglobulin (Ig) A, which is superior to IgG in prophylactic immunity. The mechanism whereby polyI:C skews to IgA production in th...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2017.48
更新日期：2018-01-01 00:00:00
abstract：:The development of the primitive gut in the multicellular aquatic eukaryote was driven by the insufficient absorption of nutrients from the oceanic soup. The anatomy of this evolving specialized system invited its colonization by environmental prokaryotes and resulted in the establishment of the intestinal microflora....
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2009.123
更新日期：2010-01-01 00:00:00
abstract：:The mechanisms underlying the massive gastrointestinal tract CD4 T-cell depletion in human immunodeficiency virus (HIV) infection are not well understood nor is it clear whether similar depletion is manifest at other mucosal surfaces. Studies of T-cell and virus dynamics in different anatomical sites have begun to ill...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2007.5
更新日期：2008-01-01 00:00:00
abstract：:T helper type (Th17) cytokines such as interleukin (IL)-17A and IL-22 are important in maintaining mucosal barrier function and may be important in the pathogenesis of inflammatory bowel diseases (IBDs). Here, we analyzed cells from the colon of IBD patients and show that Crohn's disease (CD) patients had significantl...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2013.31
更新日期：2014-01-01 00:00:00
abstract：:Cellular inhibitors of apoptosis proteins (cIAPs) are critical arbiters of cell death and key mediators of inflammation and innate immunity. cIAP2 is frequently overexpressed in colorectal cancer and in regenerating crypts of ulcerative colitis patients. However, its corresponding functions in intestinal homeostasis a...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.46
更新日期：2016-01-01 00:00:00
abstract：:De novo differentiation of CD4(+)Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo follo...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.102
更新日期：2013-05-01 00:00:00
abstract：:Dectin-1 is an innate antifungal C-type lectin receptor necessary for protective antifungal immunity. We recently discovered that Dectin-1 is involved in controlling fungal infections of the gastrointestinal (GI) tract, but how this C-type lectin receptor mediates these activities is unknown. Here, we show that Dectin...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.79
更新日期：2016-03-01 00:00:00
abstract：:The mechanism regulating the gastrointestinal epithelial barrier remains poorly understood. We herein demonstrate that Absent in melanoma-2 (AIM2) contributes to the maintenance of intestinal barrier integrity and defense against bacterial infection. AIM2-deficient mice displayed an increased susceptibility to mucosal...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.142
更新日期：2016-09-01 00:00:00
abstract：:Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6Chi monocytes, but the factors driving this tissue-specific process are not understood. ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2016.142
更新日期：2017-11-01 00:00:00
abstract：:The seasonal burden of influenza coupled with the pandemic outbreaks of more pathogenic strains underscore a critical need to understand the pathophysiology of influenza injury in the lung. Interleukin-22 (IL-22) is a promising cytokine that is critical in protecting the lung during infection. This cytokine is strongl...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0206-9
更新日期：2020-01-01 00:00:00
abstract：:Classical Whipple's disease (CWD) affects the gastrointestinal tract and rather elicits regulatory than inflammatory immune reactions. Mechanisms of malabsorption, diarrhea, and systemic immune activation are unknown. We here analyzed mucosal architecture, barrier function, and immune activation as potential diarrheal...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2017.6
更新日期：2017-11-01 00:00:00
abstract：:There continues to be a major need for more effective inflammatory bowel disease (IBD) therapies. IL-13Rα2 is a decoy receptor that binds the cytokine IL-13 with high affinity and diminishes its STAT6-mediated effector functions. Previously, we found that IL-13Rα2 was necessary for IBD in mice deficient in the anti-in...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0189-6
更新日期：2019-09-01 00:00:00
abstract：:Most HIV transmissions among men who have sex with men (MSM), the group that accounted for 67% of new US infections in 2014, occur via exposure to the rectal mucosa. However, it is unclear how the act of condomless receptive anal intercourse (CRAI) may alter the mucosal immune environment in HIV-negative MSM. Here, we...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2016.97
更新日期：2017-07-01 00:00:00
abstract：:Intestinal epithelial Na+/H+ exchange facilitated by the apical NHE3 (Slc9a3) is a highly regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3-/- mice develop spontaneous, bacterially mediated colitis, and IBD-like dysbiosis. Disruption of epithelial Na+/H+ exchange in IBD may t...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-018-0035-2
更新日期：2018-09-01 00:00:00
abstract：:In a nasal vaccine against influenza, the activation of natural killer T (NKT) cells by intranasal coadministration of alpha-galactosylceramide (alpha-GalCer) can potently enhance protective immune responses. The results of this study show that the NKT cell-activated nasal vaccine can induce an effective cross-protect...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2008.2
更新日期：2008-05-01 00:00:00
abstract：:Leptin is an adipocytokine that links nutrition to immunity. Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that leptin signaling has a protective role during intestinal amebic infection. In this study we show tha...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2010.76
更新日期：2011-05-01 00:00:00
abstract：:Secondary bacterial pneumonia is a significant complication of severe influenza infection and Staphylococcus aureus and Streptococcus pneumoniae are the primary pathogens of interest. IL-22 promotes S. aureus and S. pneumoniae host defense in the lung through epithelial integrity and induction of antimicrobial peptide...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0188-7
更新日期：2019-09-01 00:00:00
abstract：:Over the past 25 years, studies led in humans have considerably improved our understanding of celiac disease, a complex disease that is generally defined as an autoimmune-like enteropathy induced by dietary gluten in genetically predisposed individuals. Recently, large efforts were also invested in the development of ...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2014.102
更新日期：2015-01-01 00:00:00
abstract：:The communities of bacteria that reside in the intestinal tract are in constant competition within this dynamic and densely colonized environment. At homeostasis, the equilibrium that exists between these species and strains is shaped by their metabolism and also by pathways of active antagonism, which drive competiti...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/s41385-018-0053-0
更新日期：2019-01-01 00:00:00
abstract：:Mesenteric lymph nodes (MLNs), that drain the large and small intestine, are critical sites for the induction of oral tolerance. Although depletion of CD4 T cells in the intestinal lamina propria is a hallmark of HIV infection, CD4 T cell dynamics in MLNs is less known due to the lack of accessibility to these LNs. We...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0174-0
更新日期：2019-07-01 00:00:00
