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Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis.

Abstract：

:Association mapping and candidate gene studies within inflammatory bowel diseases (IBD) linkage regions, as well as genome-wide association studies in Crohn's disease (CD) have led to the discovery of multiple risk genes, but these explain only a fraction of the genetic susceptibility observed in IBD. We have thus been pursuing a region on chromosome 3p21-22 showing linkage to CD and ulcerative colitis (UC) using a gene-centric association mapping approach. We identified 12 functional candidate genes by searching for literature cocitations with relevant keywords and for gene expression patterns consistent with immune/intestinal function. We then performed an association study composed of a screening phase, where tagging single nucleotide polymorphisms (SNPs) were evaluated in 1,020 IBD patients, and an independent replication phase in 745 IBD patients. These analyses identified and replicated significant association with IBD for four SNPs within a 1.2 Mb linkage disequilibrium region. We then identified a non-synonymous coding variant (rs3197999, R689C) in the macrophage-stimulating 1 (MST1) gene (P-value 3.62 x 10(-6)) that accounts for the association signal, and shows association with both CD and UC. MST1 encodes macrophage-stimulating protein (MSP), a protein regulating the innate immune responses to bacterial ligands. R689C is predicted to interfere with MSP binding to its receptor, suggesting a role for this gene in the pathogenesis of IBD.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Goyette P,Lefebvre C,Ng A,Brant SR,Cho JH,Duerr RH,Silverberg MS,Taylor KD,Latiano A,Aumais G,Deslandres C,Jobin G,Annese V,Daly MJ,Xavier RJ,Rioux JD

doi

10.1038/mi.2007.15

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

131-8

issue

2

eissn

1933-0219

issn

1935-3456

pii

mi200715

journal_volume

1

pub_type

杂志文章,多中心研究

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