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Intestinal CD103(-) dendritic cells migrate in lymph and prime effector T cells.

Abstract：

:Intestinal dendritic cells (DCs) continuously migrate through lymphatics to mesenteric lymph nodes where they initiate immunity or tolerance. Recent research has focused on populations of intestinal DCs expressing CD103. Here we demonstrate, for the first time, the presence of two distinct CD103(-) DC subsets in intestinal lymph. Similar to CD103(+) DCs, these intestine-derived CD103(-) DCs are responsive to Flt3 and they efficiently prime and confer a gut-homing phenotype to naive T cells. However, uniquely among intestinal DCs, CD103(-) CD11b(+) CX(3)CR1(int) lymph DCs induce the differentiation of both interferon-γ and interleukin-17-producing effector T cells, even in the absence of overt stimulation. Priming by CD103(-) CD11b(+) DCs represents a novel mechanism for the rapid generation of effector T-cell responses in the gut. Therefore, these cells may prove to be valuable targets for the treatment of intestinal inflammation or in the development of effective oral vaccines.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Cerovic V,Houston SA,Scott CL,Aumeunier A,Yrlid U,Mowat AM,Milling SW

doi

10.1038/mi.2012.53

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

104-13

issue

1

eissn

1933-0219

issn

1935-3456

pii

mi201253

journal_volume

6

pub_type

杂志文章

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