Abstract：
:Although an enrichment of orally derived bacteria is reported in the gut microbiota of patients with several diseases, it is mostly unknown whether oral bacteria can colonize and induce intestinal inflammation. In a recent paper in Science, Atarashi et al.1 from Kenya Honda's laboratory show that a subset of orally derived bacteria colonizes and persists in the gut, leading to activation of the intestinal immune system and subsequent chronic inflammation in a susceptible host. The impact of oral health status as a potential contributor to inflammatory diseases at distal sites of the body deserves consideration.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Lira-Junior R,Boström EAdoi
10.1038/mi.2017.116subject
Has Abstractpub_date
2018-03-01 00:00:00pages
316-318issue
2eissn
1933-0219issn
1935-3456pii
mi2017116journal_volume
11pub_type
评论,杂志文章abstract：:Intestinal epithelial Na+/H+ exchange facilitated by the apical NHE3 (Slc9a3) is a highly regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3-/- mice develop spontaneous, bacterially mediated colitis, and IBD-like dysbiosis. Disruption of epithelial Na+/H+ exchange in IBD may t...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-018-0035-2
更新日期：2018-09-01 00:00:00
abstract：:Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3-4 million cases globally with 100,000-150,000 deaths reported annually. Mostly confined to developing nations, current strategies to control the spread of cholera include the provision of safe drinking water a...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0159-z
更新日期：2019-07-01 00:00:00
abstract：:Cellular inhibitors of apoptosis proteins (cIAPs) are critical arbiters of cell death and key mediators of inflammation and innate immunity. cIAP2 is frequently overexpressed in colorectal cancer and in regenerating crypts of ulcerative colitis patients. However, its corresponding functions in intestinal homeostasis a...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.46
更新日期：2016-01-01 00:00:00
abstract：:The tight connection between intestinal inflammation and arthritis in spondyloarthritis (SpA) has been studied extensively. Subclinical gut inflammation, which can be considered as a model for early Crohn's disease, was shown to be strongly associated with joint inflammation. Several early mucosal abnormalities were u...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2008.24
更新日期：2008-09-01 00:00:00
abstract：:The extent to which tissue-specific viral infections generate memory T cells specifically adapted to and maintained within the target infection site is unknown. Here, we show that respiratory virus-specific memory T cells in mice and humans are generated and maintained in compartmentalized niches in lungs, distinct fr...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2013.67
更新日期：2014-05-01 00:00:00
abstract：:This corrects the article DOI: 10.1038/mi.2017.46. ...
journal_title：Mucosal immunology
pub_type： 杂志文章,已发布勘误
doi：10.1038/mi.2017.79
更新日期：2018-01-01 00:00:00
abstract：:The mechanism regulating the gastrointestinal epithelial barrier remains poorly understood. We herein demonstrate that Absent in melanoma-2 (AIM2) contributes to the maintenance of intestinal barrier integrity and defense against bacterial infection. AIM2-deficient mice displayed an increased susceptibility to mucosal...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.142
更新日期：2016-09-01 00:00:00
abstract：:The generation of tissue-resident memory T cells (TRM) is an essential aspect of immunity at mucosal surfaces, and it has been suggested that preferential generation of TRM is one of the principal advantages of mucosally administered vaccines. We have previously shown that antigen-specific, IL-17-producing CD4+ T cell...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0218-5
更新日期：2020-01-01 00:00:00
abstract：:Mycobacterium tuberculosis (M.tb) is deposited into the alveolus where it first encounters the alveolar lining fluid (ALF) prior contacts host cells. We demonstrated that M.tb-exposure to human ALF alters its cell surface, driving better M.tb infection control by professional phagocytes. Contrary to these findings, ou...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0156-2
更新日期：2019-05-01 00:00:00
abstract：:De novo differentiation of CD4(+)Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo follo...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.102
更新日期：2013-05-01 00:00:00
abstract：:In a nasal vaccine against influenza, the activation of natural killer T (NKT) cells by intranasal coadministration of alpha-galactosylceramide (alpha-GalCer) can potently enhance protective immune responses. The results of this study show that the NKT cell-activated nasal vaccine can induce an effective cross-protect...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2008.2
更新日期：2008-05-01 00:00:00
abstract：:Induction of mucosal immunoglobulin-A (IgA) capable of providing a first line of defense against bacterial and viral pathogens remains a major goal of needle-free vaccines given via mucosal routes. Innate immune cells are known to play a central role in induction of IgA responses by mucosal vaccines, but the relative ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2014.105
更新日期：2015-07-01 00:00:00
abstract：:Effector T-cell contraction is one of the primary means by which immune homeostasis in the peripheral tissues is reestablished following an inflammatory response. In this issue of Mucosal Immunology, Hashimoto-Hill et al.1 show that retinoic acid (RA) transcriptionally upregulates P2X7 primarily in effector T cells of...
journal_title：Mucosal immunology
pub_type： 评论,杂志文章
doi：10.1038/mi.2016.117
更新日期：2017-07-01 00:00:00
abstract：:The mechanisms underlying the massive gastrointestinal tract CD4 T-cell depletion in human immunodeficiency virus (HIV) infection are not well understood nor is it clear whether similar depletion is manifest at other mucosal surfaces. Studies of T-cell and virus dynamics in different anatomical sites have begun to ill...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2007.5
更新日期：2008-01-01 00:00:00
abstract：:Celiac disease is a multifactorial disorder and provides a privileged model to decipher how the interplay between environmental and genetic factors can alter mucosal tolerance to a food antigen, lead to chronic intestinal inflammation, and ultimately promote T-cell lymphomagenesis. Here we summarize how HLA-DQ2/8 mole...
journal_title：Mucosal immunology
pub_type： 评论,杂志文章,评审
doi：10.1038/mi.2008.75
更新日期：2009-01-01 00:00:00
abstract：:Our studies have focused on understanding the mechanisms of interactions between the indigenous intestinal flora and the mammalian host in both physiological and nonphysiological conditions. In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of ...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2008.49
更新日期：2008-11-01 00:00:00
abstract：:Oral tolerance refers to the observation that prior feeding of an antigen induces local and systemic immune tolerance to that antigen. Physiologically, this process is probably of central importance for preventing inflammatory responses to the numerous dietary and microbial antigens present in the gut. Defective oral ...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2010.25
更新日期：2010-07-01 00:00:00
abstract：:Neutrophils clear viruses, but excessive neutrophil responses induce tissue injury and worsen disease. Aging increases mortality to influenza infection; however, whether this is due to impaired viral clearance or a pathological host immune response is unknown. Here we show that aged mice have higher levels of lung neu...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-018-0115-3
更新日期：2019-03-01 00:00:00
abstract：:IFN-γ is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-γ rapidly induced Noxa expression and that extent of inflammation by repeated house dust mite exposure was enhanced in noxa-/- compared ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2017.117
更新日期：2018-05-01 00:00:00
abstract：:Cigarette smoke has been associated with susceptibility to different pulmonary and airway diseases. Impaired alveolar macrophages (AMs) that are major phagocytes in the lung have been associated with patients with airway diseases and active smokers. In the current report, we show that exposure to second-hand cigarette...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.120
更新日期：2016-07-01 00:00:00
abstract：:Epidemiological data indicate a link between rheumatoid arthritis (RA) and periodontal disease (PD). In vitro and in vivo studies have sought to dissect potential mechanisms by which PD may contribute to initiation and progression of RA. However, these are both multifactorial, chronic diseases, and their complex etiol...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2011.66
更新日期：2012-03-01 00:00:00
abstract：:Periostin is an extracellular matrix protein that has been primarily studied in the context of the heart, where it has been shown to promote cardiac repair and remodeling. In this study, we focused on the role of periostin in an allergic eosinophilic inflammatory disease (eosinophilic esophagitis (EE)) known to involv...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2008.15
更新日期：2008-07-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) is a highly prevalent respiratory disease characterized by airflow limitation and chronic inflammation. MiR-155 is described as an ancient regulator of the immune system. Our objective was to establish a role for miR-155 in cigarette smoke (CS)-induced inflammation and COPD...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0241-6
更新日期：2020-05-01 00:00:00
abstract：:The ultimate goal for vaccination is to stimulate protective immunological memory. Protection against infectious diseases not only relies on the magnitude of the humoral immune response, but more importantly on the quality and longevity of it. Adjuvants are critical components of most non-living vaccines. Although lit...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2010.54
更新日期：2010-11-01 00:00:00
abstract：:Lung resident memory CD8 T cells (TRM) are critical for protection against respiratory viruses, but the cellular interactions required for their development are poorly understood. Herein we describe the necessity of classical monocytes for the establishment of lung TRM following influenza infection. We find that, duri...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0224-7
更新日期：2020-01-01 00:00:00
abstract：:Chronic beryllium disease (CBD) is a granulomatous lung disorder that is associated with the accumulation of beryllium (Be)-specific CD4(+) T cells into the lung. Genetic susceptibility is linked to HLA-DPB1 alleles that possess a glutamic acid at position 69 (βGlu69), and HLA-DPB1*02:01 is the most prevalent βGlu69-c...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.54
更新日期：2016-01-01 00:00:00
abstract：:Development of effective tuberculosis vaccines is hampered by insufficient understanding of protective immunity. Here, Woodworth et al.1 show secondary effector CD4 T cells generated after Mtb challenge of H56/CAF01 vaccinated mice display superior lung homing compared with primary effectors. Vaccination generates lar...
journal_title：Mucosal immunology
pub_type： 评论,杂志文章
doi：10.1038/mi.2016.110
更新日期：2017-03-01 00:00:00
abstract：:The roles of macrophages in type 2-driven inflammation and fibrosis remain unclear. Here, using CD11b-diphtheria toxin receptor (DTR) transgenic mice and three models of interleukin 13 (IL-13)-dependent inflammation, fibrosis, and immunity, we show that CD11b(+) F4/80(+) Ly6C(+) macrophages are required for the mainte...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.34
更新日期：2016-01-01 00:00:00
abstract：:Dectin-1 (gene symbol: Clec7a) is a receptor for β-glucans that play an important role for the host defense against fungi. Recently, we showed that Clec7a-/- mice are resistant against dextran sodium sulfate (DSS)-induced colitis because of regulatory T-cell population expansion in the colon. The regulatory T-cell exp...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2017.86
更新日期：2018-05-01 00:00:00
abstract：:Treatment of post-transplant patients with immunosuppressive drugs targeting the calcineurin-nuclear factor of activated T cells (NFAT) pathway, including cyclosporine A or tacrolimus, is commonly associated with a higher incidence of opportunistic infections, such as Aspergillus fumigatus, which can lead to severe li...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2016.52
更新日期：2017-03-01 00:00:00
