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New insights into innate immune mechanisms underlying allergenicity.

Abstract：

:Allergic diseases, which have reached epidemic proportions, are caused by inappropriate immune responses to a relatively small number of environmental proteins. The molecular basis for the propensity of specific proteins to promote maladaptive, allergic responses has been difficult to define. Recent data suggest that the ability of such proteins to promote allergic responses in susceptible hosts is a function of their ability to interact with diverse pathways of innate immune recognition and activation at mucosal surfaces. This review highlights recent insights into innate immune activation by allergens--through proteolytic activity, engagement of pattern recognition receptors, molecular mimicry of TLR signaling complex molecules, lipid-binding activity, and oxidant potential--and the role of such activation in inducing allergic disease. A greater understanding of the fundamental origins of allergenicity should help define new preventive and therapeutic targets in allergic disease.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Wills-Karp M,Nathan A,Page K,Karp CL

doi

10.1038/mi.2009.138

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

104-10

issue

2

eissn

1933-0219

issn

1935-3456

pii

mi2009138

journal_volume

3

pub_type

杂志文章,评审

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