Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection.

abstract：:Viral respiratory tract infections (RTI) pose a high burden on the youngest members of our society. Several risk factors are known for severe viral respiratory disease. However, a large proportion of the severe RTI cannot be explained by these risk factors. A growing body of evidence shows that the composition of the ...

journal_title：Mucosal immunology

authors： Vissers M,de Groot R,Ferwerda G

更新日期：2014-03-01 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a natural and major ingredient of green tea, has been shown to have anti-inflammation and anti-HIV-1 properties. We demonstrated that the intrarectal administration of EGCG could protect rhesus macaques from repetitive, intrarectal challenges with low-dose SHIVSF162P3N. This protecti...

journal_title：Mucosal immunology

authors： Liu JB,Li JL,Zhuang K,Liu H,Wang X,Xiao QH,Li XD,Zhou RH,Zhou L,Ma TC,Zhou W,Liu MQ,Ho WZ

更新日期：2018-07-01 00:00:00

abstract：:Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3-4 million cases globally with 100,000-150,000 deaths reported annually. Mostly confined to developing nations, current strategies to control the spread of cholera include the provision of safe drinking water a...

journal_title：Mucosal immunology

authors： Davitt CJH,Longet S,Albutti A,Aversa V,Nordqvist S,Hackett B,McEntee CP,Rosa M,Coulter IS,Lebens M,Tobias J,Holmgren J,Lavelle EC

更新日期：2019-07-01 00:00:00

abstract：:Rotaviruses (RV) are the leading cause of gastroenteritis in infants and children worldwide and are associated with high mortality predominately in low-income settings. The virus is classified into G and P serotypes and further into P genotypes based on differences in the surface-exposed proteins VP7 and VP4, respecti...

journal_title：Mucosal immunology

authors： Clarke E,Desselberger U

更新日期：2015-01-01 00:00:00

abstract：:Chlamydia trachomatis (Ct) is an obligate intracellular bacterial pathogen. Previously, we showed that infection of human trophoblast cells by Ct triggers the secretion of the pro-inflammatory cytokine, interleukin (IL)-1β. The aim of this study was to understand the innate immune pathways involved in trophoblast prod...

journal_title：Mucosal immunology

authors： Kavathas PB,Boeras CM,Mulla MJ,Abrahams VM

更新日期：2013-03-01 00:00:00

abstract：:Post influenza bacterial pneumonia is associated with significant mortality and morbidity. Dendritic cells (DCs) play a crucial role in host defense against bacterial pneumonia, but their contribution to post influenza-susceptibility to secondary bacterial pneumonia is incompletely understood. WT and CCR2-/- mice were...

journal_title：Mucosal immunology

authors： Gurczynski SJ,Nathani N,Warheit-Niemi HI,Hult EM,Podsiad A,Deng J,Zemans RL,Bhan U,Moore BB

更新日期：2019-03-01 00:00:00

abstract：:As the Bacillus Calmette-Guérin (BCG) vaccine does not confer long-lasting protection against lung Mycobacterium tuberculosis infection, the development of more efficient vaccines is greatly needed. Here, we used mycobacterial low-molecular weight proteins of the 6-kDa Early Secreted Antigenic Target (ESAT-6) protein ...

journal_title：Mucosal immunology

authors： Dong H,Stanek O,Salvador FR,Länger U,Morillon E,Ung C,Sebo P,Leclerc C,Majlessi L

更新日期：2013-05-01 00:00:00

abstract：:Pneumonia caused by Streptococcus pneumoniae (Sp) remains a leading cause of serious illness and death worldwide. Immunization with conjugated pneumococcal vaccine has lowered the colonization rate and consequently invasive diseases by inducing serotype-specific antibodies. However, many of the current pneumonia cases...

journal_title：Mucosal immunology

authors： Wang Y,Jiang B,Guo Y,Li W,Tian Y,Sonnenberg GF,Weiser JN,Ni X,Shen H

更新日期：2017-01-01 00:00:00

abstract：:T helper type (Th17) cytokines such as interleukin (IL)-17A and IL-22 are important in maintaining mucosal barrier function and may be important in the pathogenesis of inflammatory bowel diseases (IBDs). Here, we analyzed cells from the colon of IBD patients and show that Crohn's disease (CD) patients had significantl...

journal_title：Mucosal immunology

authors： Leung JM,Davenport M,Wolff MJ,Wiens KE,Abidi WM,Poles MA,Cho I,Ullman T,Mayer L,Loke P

更新日期：2014-01-01 00:00:00

abstract：:Development of effective tuberculosis vaccines is hampered by insufficient understanding of protective immunity. Here, Woodworth et al.1 show secondary effector CD4 T cells generated after Mtb challenge of H56/CAF01 vaccinated mice display superior lung homing compared with primary effectors. Vaccination generates lar...

journal_title：Mucosal immunology

authors： Barber DL

更新日期：2017-03-01 00:00:00

abstract：:Chronic beryllium disease (CBD) is a granulomatous lung disorder that is associated with the accumulation of beryllium (Be)-specific CD4(+) T cells into the lung. Genetic susceptibility is linked to HLA-DPB1 alleles that possess a glutamic acid at position 69 (βGlu69), and HLA-DPB1*02:01 is the most prevalent βGlu69-c...

journal_title：Mucosal immunology

authors： Falta MT,Tinega AN,Mack DG,Bowerman NA,Crawford F,Kappler JW,Pinilla C,Fontenot AP

更新日期：2016-01-01 00:00:00

abstract：:Leukotriene B4 receptor 1 (BLT1) triggers the migration of granulocytes and activated T cells; however, its role in B-cell function remains unclear. Here we report that BLT1 is required to induce the production of antigen-specific IgA against oral vaccine through mediating innate immune signals from commensal bacteria...

journal_title：Mucosal immunology

authors： Nagatake T,Hirata SI,Koga T,Kuroda E,Kobari S,Suzuki H,Hosomi K,Matsumoto N,Yanrismet Y,Shimojou M,Morimoto S,Sasaki F,Ishii KJ,Yokomizo T,Kunisawa J

更新日期：2019-09-01 00:00:00

abstract：:Sonic hedgehog (SHH) is abundantly expressed and critical for morphogenesis in embryonic lungs; however, SHH expression drops to a much lower level in mice from E17.5 and in humans from the 21st gestational week. We find that SHH expression is robustly upregulated in the airway epithelia of children with asthma or mou...

journal_title：Mucosal immunology

authors： Xu C,Zou C,Hussain M,Shi W,Shao Y,Jiang Z,Wu X,Lu M,Wu J,Xie Q,Ke Y,Long F,Tang L,Wu X

更新日期：2018-09-01 00:00:00

abstract：:Levels of reactive free radicals are elevated in the airway during asthmatic exacerbations, but their roles in the pathophysiology of asthma remain unclear. We have identified subsets of myeloid-derived suppressor-like cells as key sources of nitric oxide and superoxide in the lungs of mice with evolving experimental ...

journal_title：Mucosal immunology

authors： Deshane J,Zmijewski JW,Luther R,Gaggar A,Deshane R,Lai JF,Xu X,Spell M,Estell K,Weaver CT,Abraham E,Schwiebert LM,Chaplin DD

更新日期：2011-09-01 00:00:00

abstract：:The tight connection between intestinal inflammation and arthritis in spondyloarthritis (SpA) has been studied extensively. Subclinical gut inflammation, which can be considered as a model for early Crohn's disease, was shown to be strongly associated with joint inflammation. Several early mucosal abnormalities were u...

journal_title：Mucosal immunology

authors： Jacques P,Elewaut D

更新日期：2008-09-01 00:00:00

abstract：:Eosinophils are granulocytes, typically implicated as end-stage effector cells in type-II immune responses. They are capable of producing a wide array of pre-formed molecules which render them with vast potential to influence a wide variety of processes. Nonetheless, eosinophil research has traditionally focused on th...

journal_title：Mucosal immunology

authors： Shah K,Ignacio A,McCoy KD,Harris NL

更新日期：2020-07-01 00:00:00

abstract：:Cross-presentation of cellular antigens is crucial for priming CD8(+) T cells, and generating immunity to intracellular pathogens--particularly viruses. It is unclear which intestinal phagocytes perform this function in vivo. To address this, we examined dendritic cells (DCs) from the intestinal lymph of IFABP-tOVA 23...

journal_title：Mucosal immunology

authors： Cerovic V,Houston SA,Westlund J,Utriainen L,Davison ES,Scott CL,Bain CC,Joeris T,Agace WW,Kroczek RA,Mowat AM,Yrlid U,Milling SW

更新日期：2015-01-01 00:00:00

abstract：:Crohn's disease (CD) is often accompanied by the complications of intestinal strictures and fistulas. These complications remain obstacles in CD treatment. In recent years, the importance of epithelial-mesenchymal transition in the pathogenesis of CD-associated fistulas and intestinal fibrosis has become apparent. Epi...

journal_title：Mucosal immunology

authors： Jiang H,Shen J,Ran Z

更新日期：2018-03-01 00:00:00

abstract：:Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn's disease (CD). Ineffectual NOD2 (nucleotide-binding oligomerization domain 2) is the most common susceptibility gene contributing to CD. Vitamin D (vD), a potent modulator of innate and adaptive immunity, induces NOD2 gene express...

journal_title：Mucosal immunology

authors： Dionne S,Calderon MR,White JH,Memari B,Elimrani I,Adelson B,Piccirillo C,Seidman EG

更新日期：2014-11-01 00:00:00

abstract：:The gut mucosa is an important site of HIV immunopathogenesis with severe depletion of CD4+ T cells occurring during acute infection. The effect of prolonged anti-retroviral therapy (ART) on cycling and restoration of T lymphocytes in the gut remains unclear. Colon and terminal ileal biopsies and peripheral blood samp...

journal_title：Mucosal immunology

authors： Ciccone EJ,Read SW,Mannon PJ,Yao MD,Hodge JN,Dewar R,Chairez CL,Proschan MA,Kovacs JA,Sereti I

更新日期：2010-03-01 00:00:00

abstract：:IFN-γ is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-γ rapidly induced Noxa expression and that extent of inflammation by repeated house dust mite exposure was enhanced in noxa-/- compared ...

journal_title：Mucosal immunology

authors： Zhang C,Jones JT,Chand HS,Wathelet MG,Evans CM,Dickey B,Xiang J,Mebratu YA,Tesfaigzi Y

更新日期：2018-05-01 00:00:00

abstract：:Nucleotide oligomerization domain (NOD)2 is a member of the NOD-like receptor family of proteins that initiate inflammatory responses when exposed to ligands derived from bacterial components that gain access to the intracellular milieu. It is thus somewhat paradoxical that polymorphisms in the gene that encode NOD2 (...

journal_title：Mucosal immunology

authors： Strober W,Kitani A,Fuss I,Asano N,Watanabe T

更新日期：2008-11-01 00:00:00

abstract：:Previously we have extensively characterized Salmonella enterica serovar Typhi (S. Typhi)-specific cell-mediated immune (CMI) responses in volunteers orally immunized with the licensed Ty21a typhoid vaccine. In this study we measured Salmonella-specific multifunctional (MF) CD8+ T-cell responses to further investigate...

journal_title：Mucosal immunology

authors： Wahid R,Fresnay S,Levine MM,Sztein MB

更新日期：2015-11-01 00:00:00

abstract：:Mycobacterium tuberculosis (M.tb) is deposited into the alveolus where it first encounters the alveolar lining fluid (ALF) prior contacts host cells. We demonstrated that M.tb-exposure to human ALF alters its cell surface, driving better M.tb infection control by professional phagocytes. Contrary to these findings, ou...

journal_title：Mucosal immunology

authors： Scordo JM,Olmo-Fontánez AM,Kelley HV,Sidiki S,Arcos J,Akhter A,Wewers MD,Torrelles JB

更新日期：2019-05-01 00:00:00

abstract：:Although an enrichment of orally derived bacteria is reported in the gut microbiota of patients with several diseases, it is mostly unknown whether oral bacteria can colonize and induce intestinal inflammation. In a recent paper in Science, Atarashi et al.1 from Kenya Honda's laboratory show that a subset of orally de...

journal_title：Mucosal immunology

authors： Lira-Junior R,Boström EA

更新日期：2018-03-01 00:00:00

abstract：:Intranasal inoculation with influenza hemagglutinin subunit with polyinosine-polycytidylic (polyI:C), a synthetic analog for double-stranded RNA, enhances production of vaccine-specific immunoglobulin (Ig) A, which is superior to IgG in prophylactic immunity. The mechanism whereby polyI:C skews to IgA production in th...

journal_title：Mucosal immunology

authors： Takaki H,Kure S,Oshiumi H,Sakoda Y,Suzuki T,Ainai A,Hasegawa H,Matsumoto M,Seya T

更新日期：2018-01-01 00:00:00

abstract：:The mucosal immune system is charged with defending the host's vast interfaces with the outside world from the enormous and diverse group of microbes that colonizes these surfaces. A key means by which the mucosal immune system protects the host from such diverse microbes is using germ-line-encoded receptors that targ...

journal_title：Mucosal immunology

authors： Vijay-Kumar M,Gewirtz AT

更新日期：2009-05-01 00:00:00

abstract：:Specific components of the intestinal microbiota are capable of influencing immune responses such that a mutualistic relationship is established. In mice, colonization with segmented filamentous bacteria (SFB) induces T-helper-17 (Th17) cell differentiation in the intestine, yet the effector functions of interleukin (...

journal_title：Mucosal immunology

authors： Flannigan KL,Ngo VL,Geem D,Harusato A,Hirota SA,Parkos CA,Lukacs NW,Nusrat A,Gaboriau-Routhiau V,Cerf-Bensussan N,Gewirtz AT,Denning TL

更新日期：2017-05-01 00:00:00

abstract：:The interleukin-23 (IL-23) pathway has emerged as a promising therapeutic target for inflammatory bowel disease. Although the pathogenic role of IL-23 receptor (IL-23R) on T lymphocytes is well established, its function on innate immune cells has not been thoroughly examined. Here we investigate the consequence of IL-...

journal_title：Mucosal immunology

authors： Cox JH,Kljavin NM,Ota N,Leonard J,Roose-Girma M,Diehl L,Ouyang W,Ghilardi N

更新日期：2012-01-01 00:00:00

abstract：:Sphingolipids play a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, little is known about the precise roles of sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, and its receptor modulation in COPD. In this study, we demonstrated that the S1P receptor modula...

journal_title：Mucosal immunology

authors： Asakura T,Ishii M,Namkoong H,Suzuki S,Kagawa S,Yagi K,Komiya T,Hashimoto T,Okamori S,Kamata H,Tasaka S,Kihara A,Hegab AE,Hasegawa N,Betsuyaku T

更新日期：2018-11-01 00:00:00