Redox signaling regulates commensal-mediated mucosal homeostasis and restitution and requires formyl peptide receptor 1.

abstract：:Although an enrichment of orally derived bacteria is reported in the gut microbiota of patients with several diseases, it is mostly unknown whether oral bacteria can colonize and induce intestinal inflammation. In a recent paper in Science, Atarashi et al.1 from Kenya Honda's laboratory show that a subset of orally de...

journal_title：Mucosal immunology

authors： Lira-Junior R,Boström EA

更新日期：2018-03-01 00:00:00

abstract：:Annual epidemics and unexpected pandemics of influenza are threats to human health. Lung immune and inflammatory responses, such as those induced by respiratory infection influenza virus, determine the outcome of pulmonary pathogenesis. Platelet-derived chemokine (C-X-C motif) ligand 4 (CXCL4) has an immunoregulatory ...

journal_title：Mucosal immunology

authors： Guo L,Feng K,Wang YC,Mei JJ,Ning RT,Zheng HW,Wang JJ,Worthen GS,Wang X,Song J,Li QH,Liu LD

更新日期：2017-11-01 00:00:00

abstract：:The communities of bacteria that reside in the intestinal tract are in constant competition within this dynamic and densely colonized environment. At homeostasis, the equilibrium that exists between these species and strains is shaped by their metabolism and also by pathways of active antagonism, which drive competiti...

journal_title：Mucosal immunology

authors： Sorbara MT,Pamer EG

更新日期：2019-01-01 00:00:00

abstract：:Human type-2 CD8+ T cells are a cell population with potentially important roles in allergic disease. We investigated this in the context of severe asthma with persistent airway eosinophilia-a phenotype associated with high exacerbation risk and responsiveness to type-2 cytokine-targeted therapies. In two independent ...

journal_title：Mucosal immunology

authors： Hilvering B,Hinks TSC,Stöger L,Marchi E,Salimi M,Shrimanker R,Liu W,Chen W,Luo J,Go S,Powell T,Cane J,Thulborn S,Kurioka A,Leng T,Matthews J,Connolly C,Borg C,Bafadhel M,Willberg CB,Ramasamy A,Djukanović R,Ogg

更新日期：2018-09-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections, especially in infants. Lung neutrophilia is a hallmark of RSV disease but the mechanism by which neutrophils are recruited and activated is unclear. Here, we investigate the innate immune signaling pathways underlying ne...

journal_title：Mucosal immunology

authors： Kirsebom FCM,Kausar F,Nuriev R,Makris S,Johansson C

更新日期：2019-09-01 00:00:00

abstract：:Human papillomaviruses (HPV)-related cervical cancer is the second leading cause of cancer death in women worldwide. Despite active development, HPV E6/E7 oncogene-specific therapeutic vaccines have had limited clinical efficacy to date. Here, we report that intravaginal (IVAG) instillation of CpG-ODN (TLR9 agonist) o...

journal_title：Mucosal immunology

authors： Domingos-Pereira S,Decrausaz L,Derré L,Bobst M,Romero P,Schiller JT,Jichlinski P,Nardelli-Haefliger D

更新日期：2013-03-01 00:00:00

abstract：:While recent studies suggest that interleukin (IL)-1β production is modulated by macroautophagy or sensors of endoplasmic reticulum (ER) stress upon pro-inflammatory insult, autophagy and IL-1β production during viral infection has not been fully investigated. This was addressed using respiratory syncytial virus (RSV)...

journal_title：Mucosal immunology

authors： Reed M,Morris SH,Owczarczyk AB,Lukacs NW

更新日期：2015-09-01 00:00:00

abstract：:Intestinal epithelial Na+/H+ exchange facilitated by the apical NHE3 (Slc9a3) is a highly regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3-/- mice develop spontaneous, bacterially mediated colitis, and IBD-like dysbiosis. Disruption of epithelial Na+/H+ exchange in IBD may t...

journal_title：Mucosal immunology

authors： Harrison CA,Laubitz D,Ohland CL,Midura-Kiela MT,Patil K,Besselsen DG,Jamwal DR,Jobin C,Ghishan FK,Kiela PR

更新日期：2018-09-01 00:00:00

abstract：:Mesenteric lymph nodes (MLNs), that drain the large and small intestine, are critical sites for the induction of oral tolerance. Although depletion of CD4 T cells in the intestinal lamina propria is a hallmark of HIV infection, CD4 T cell dynamics in MLNs is less known due to the lack of accessibility to these LNs. We...

journal_title：Mucosal immunology

authors： Moukambi F,Rabezanahary H,Fortier Y,Rodrigues V,Clain J,Benmadid-Laktout G,Zghidi-Abouzid O,Soundaramourty C,Laforge M,Estaquier J

更新日期：2019-07-01 00:00:00

abstract：:Alpha B-crystallin (CRYAB) is an important member of the small heat shock protein family, and plays a protective and therapeutic role in neurological inflammation. CRYAB expression was assessed in cultured HT29 and Caco-2 cells and inflamed mucosa of patients with inflammatory bowel disease (IBD) and colitis models in...

journal_title：Mucosal immunology

authors： Xu W,Guo Y,Huang Z,Zhao H,Zhou M,Huang Y,Wen D,Song J,Zhu Z,Sun M,Liu CY,Chen Y,Cui L,Wang X,Liu Z,Yang Y,Du P

更新日期：2019-11-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/mi.2017.46. ...

journal_title：Mucosal immunology

authors： Kinnear E,Lambert L,McDonald JU,Cheeseman HM,Caproni LJ,Tregoning JS

更新日期：2018-01-01 00:00:00

abstract：:The mechanisms underlying the massive gastrointestinal tract CD4 T-cell depletion in human immunodeficiency virus (HIV) infection are not well understood nor is it clear whether similar depletion is manifest at other mucosal surfaces. Studies of T-cell and virus dynamics in different anatomical sites have begun to ill...

journal_title：Mucosal immunology

authors： Brenchley JM,Knox KS,Asher AI,Price DA,Kohli LM,Gostick E,Hill BJ,Hage CA,Brahmi Z,Khoruts A,Twigg HL 3rd,Schacker TW,Douek DC

更新日期：2008-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-γ (PPAR-γ) is widely expressed in macrophages and has been identified as a putative target for the development of novel therapies against inflammatory bowel disease (IBD). Computational simulations identified macrophages as key targets for therapeutic interventions against IB...

journal_title：Mucosal immunology

authors： Hontecillas R,Horne WT,Climent M,Guri AJ,Evans C,Zhang Y,Sobral BW,Bassaganya-Riera J

更新日期：2011-05-01 00:00:00

abstract：:T helper (Th)1 and Th2 cells play decisive roles in the regulation of resistance vs. susceptibility to pulmonary cryptococcosis. To study the function of interleukin (IL)-4 receptor (IL-4R) on Th cells in pulmonary cryptococcosis, we infected mice specifically lacking IL-4Rα on CD4(+) T cells (Lck(Cre)IL-4Rα(-/lox) mi...

journal_title：Mucosal immunology

authors： Müller U,Piehler D,Stenzel W,Köhler G,Frey O,Held J,Grahnert A,Richter T,Eschke M,Kamradt T,Brombacher F,Alber G

更新日期：2012-05-01 00:00:00

abstract：:HIV prevention mandates an understanding of the mechanisms of mucosal immunity with attention to some unique features of the epidemic and mucosal environment in the developing world. An effective vaccine will have to induce mucosal protection against a highly diverse virus, which is equipped with a number of immune ev...

journal_title：Mucosal immunology

authors： Pala P,Gomez-Roman VR,Gilmour J,Kaleebu P

更新日期：2009-07-01 00:00:00

abstract：:The tight connection between intestinal inflammation and arthritis in spondyloarthritis (SpA) has been studied extensively. Subclinical gut inflammation, which can be considered as a model for early Crohn's disease, was shown to be strongly associated with joint inflammation. Several early mucosal abnormalities were u...

journal_title：Mucosal immunology

authors： Jacques P,Elewaut D

更新日期：2008-09-01 00:00:00

abstract：:Intranasal inoculation with influenza hemagglutinin subunit with polyinosine-polycytidylic (polyI:C), a synthetic analog for double-stranded RNA, enhances production of vaccine-specific immunoglobulin (Ig) A, which is superior to IgG in prophylactic immunity. The mechanism whereby polyI:C skews to IgA production in th...

journal_title：Mucosal immunology

authors： Takaki H,Kure S,Oshiumi H,Sakoda Y,Suzuki T,Ainai A,Hasegawa H,Matsumoto M,Seya T

更新日期：2018-01-01 00:00:00

abstract：:Post influenza bacterial pneumonia is associated with significant mortality and morbidity. Dendritic cells (DCs) play a crucial role in host defense against bacterial pneumonia, but their contribution to post influenza-susceptibility to secondary bacterial pneumonia is incompletely understood. WT and CCR2-/- mice were...

journal_title：Mucosal immunology

authors： Gurczynski SJ,Nathani N,Warheit-Niemi HI,Hult EM,Podsiad A,Deng J,Zemans RL,Bhan U,Moore BB

更新日期：2019-03-01 00:00:00

abstract：:The sphingosine-1-phosphate receptor-1 (S1P1) agonist ozanimod ameliorates ulcerative colitis, yet its mechanism of action is unknown. Here, we examine the cell subsets that express S1P1 in intestine using S1P1-eGFP mice, the regulation of S1P1 expression in lymphocytes after administration of dextran sulfate sodium (...

journal_title：Mucosal immunology

authors： Karuppuchamy T,Behrens EH,González-Cabrera P,Sarkisyan G,Gima L,Boyer JD,Bamias G,Jedlicka P,Veny M,Clark D,Peach R,Scott F,Rosen H,Rivera-Nieves J

更新日期：2017-01-01 00:00:00

abstract：:Previously we have extensively characterized Salmonella enterica serovar Typhi (S. Typhi)-specific cell-mediated immune (CMI) responses in volunteers orally immunized with the licensed Ty21a typhoid vaccine. In this study we measured Salmonella-specific multifunctional (MF) CD8+ T-cell responses to further investigate...

journal_title：Mucosal immunology

authors： Wahid R,Fresnay S,Levine MM,Sztein MB

更新日期：2015-11-01 00:00:00

abstract：:The impact of topical antiretrovirals for pre-exposure prophylaxis on humoral responses following HIV infection is unknown. Using a binding antibody multiplex assay, we investigated HIV-specific IgG and IgA responses to envelope glycoproteins, p24 Gag and p66, in the genital tract (GT) and plasma following HIV acquisi...

journal_title：Mucosal immunology

authors： Archary D,Seaton KE,Passmore JS,Werner L,Deal A,Dunphy LJ,Arnold KB,Yates NL,Lauffenburger DA,Bergin P,Liebenberg LJ,Samsunder N,Mureithi MW,Altfeld M,Garrett N,Karim QA,Karim SA,Morris L,Tomaras GD

更新日期：2016-05-01 00:00:00

abstract：:Interleukin-17 (IL-17)-mediated immunity has emerged as a crucial host defense mechanism against Candida albicans infections in mucosal tissues and the skin. The precise mechanism by which the IL-17 pathway prevents fungal outgrowth has not been clarified. Neutrophils are critical for limiting fungal dissemination and...

journal_title：Mucosal immunology

authors： Trautwein-Weidner K,Gladiator A,Nur S,Diethelm P,LeibundGut-Landmann S

更新日期：2015-03-01 00:00:00

abstract：:Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but has limited efficacy against pulmonary TB disease development and modest protection against extrapulmonary TB. Preventative antibiotic treatment for Mycobacterium tuberculosis (Mtb) infections in high-prevalence settings is unfeasible du...

journal_title：Mucosal immunology

authors： Young C,Walzl G,Du Plessis N

更新日期：2020-03-01 00:00:00

abstract：:IFN-γ is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-γ rapidly induced Noxa expression and that extent of inflammation by repeated house dust mite exposure was enhanced in noxa-/- compared ...

journal_title：Mucosal immunology

authors： Zhang C,Jones JT,Chand HS,Wathelet MG,Evans CM,Dickey B,Xiang J,Mebratu YA,Tesfaigzi Y

更新日期：2018-05-01 00:00:00

abstract：:The development of the primitive gut in the multicellular aquatic eukaryote was driven by the insufficient absorption of nutrients from the oceanic soup. The anatomy of this evolving specialized system invited its colonization by environmental prokaryotes and resulted in the establishment of the intestinal microflora....

journal_title：Mucosal immunology

authors： Raz E

更新日期：2010-01-01 00:00:00

abstract：:Intestinal dendritic cells (DCs) continuously migrate through lymphatics to mesenteric lymph nodes where they initiate immunity or tolerance. Recent research has focused on populations of intestinal DCs expressing CD103. Here we demonstrate, for the first time, the presence of two distinct CD103(-) DC subsets in intes...

journal_title：Mucosal immunology

authors： Cerovic V,Houston SA,Scott CL,Aumeunier A,Yrlid U,Mowat AM,Milling SW

更新日期：2013-01-01 00:00:00

abstract：:Induction of mucosal immunoglobulin-A (IgA) capable of providing a first line of defense against bacterial and viral pathogens remains a major goal of needle-free vaccines given via mucosal routes. Innate immune cells are known to play a central role in induction of IgA responses by mucosal vaccines, but the relative ...

journal_title：Mucosal immunology

authors： Jee J,Bonnegarde-Bernard A,Duverger A,Iwakura Y,Cormet-Boyaka E,Martin TL,Steiner HE,Bachman RC,Boyaka PN

更新日期：2015-07-01 00:00:00

abstract：:Sonic hedgehog (SHH) is abundantly expressed and critical for morphogenesis in embryonic lungs; however, SHH expression drops to a much lower level in mice from E17.5 and in humans from the 21st gestational week. We find that SHH expression is robustly upregulated in the airway epithelia of children with asthma or mou...

journal_title：Mucosal immunology

authors： Xu C,Zou C,Hussain M,Shi W,Shao Y,Jiang Z,Wu X,Lu M,Wu J,Xie Q,Ke Y,Long F,Tang L,Wu X

更新日期：2018-09-01 00:00:00

abstract：:The generation of tissue-resident memory T cells (TRM) is an essential aspect of immunity at mucosal surfaces, and it has been suggested that preferential generation of TRM is one of the principal advantages of mucosally administered vaccines. We have previously shown that antigen-specific, IL-17-producing CD4+ T cell...

journal_title：Mucosal immunology

authors： O'Hara JM,Redhu NS,Cheung E,Robertson NG,Patik I,Sayed SE,Thompson CM,Herd M,Lucas KB,Conaway E,Morton CC,Farber DL,Malley R,Horwitz BH

更新日期：2020-01-01 00:00:00

abstract：:Intestinal CD8αα intraepithelial T lymphocytes (T-IELs) have a key role in mucosal immunity and, unlike other T cells, were proposed to differentiate locally. In apparent contradiction, these cells were also shown to originate from a wave of thymus migrants colonizing the gut in the first 3 weeks after birth. We here ...

journal_title：Mucosal immunology

authors： Peaudecerf L,dos Santos PR,Boudil A,Ezine S,Pardigon N,Rocha B

更新日期：2011-01-01 00:00:00