Abstract：
:Helminth infection leads to the local proliferation and accumulation of macrophages in tissues. However, the function of macrophages during helminth infection remains unclear. SH2-containing inositol 5'-phosphatase 1 (Ship1, Inpp5d) is a lipid phosphatase that has been shown to play a critical role in macrophage function. Here, we identify a critical role for Ship1 in the negative regulation of interleukin (IL)-12/23p40 production by macrophages during infection with the intestinal helminth parasite Trichuris muris. Mice with myeloid cell-specific deletion of Ship1 (Ship1(ΔLysM) mice) develop a non-protective T-helper type 1 cell response and fail to expel parasites. Ship1-deficient macrophages produce heightened levels of IL-12/23p40 in vitro and in vivo and antibody blockade of IL-12/23p40 renders Ship1(ΔLysM) mice resistant to Trichuris infection. Our results identify a critical role for the negative regulation of IL-12/23p40 production by macrophages in the development of a protective T(H)2 cell response.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Hadidi S,Antignano F,Hughes MR,Wang SK,Snyder K,Sammis GM,Kerr WG,McNagny KM,Zaph Cdoi
10.1038/mi.2012.29subject
Has Abstractpub_date
2012-09-01 00:00:00pages
535-43issue
5eissn
1933-0219issn
1935-3456pii
mi201229journal_volume
5pub_type
杂志文章abstract：:Innate lymphoid cells (ILCs) have stormed onto the immune landscape as "newly discovered" cell types. These tissue-resident sentinels are enriched at mucosal surfaces and engage in complex cross talk with elements of the adaptive immune system and microenvironment to orchestrate immune homeostasis. Many parallels exis...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2016.64
更新日期：2016-09-01 00:00:00
abstract：:Development of effective tuberculosis vaccines is hampered by insufficient understanding of protective immunity. Here, Woodworth et al.1 show secondary effector CD4 T cells generated after Mtb challenge of H56/CAF01 vaccinated mice display superior lung homing compared with primary effectors. Vaccination generates lar...
journal_title：Mucosal immunology
pub_type： 评论,杂志文章
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abstract：:Leptin is an adipocytokine that links nutrition to immunity. Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that leptin signaling has a protective role during intestinal amebic infection. In this study we show tha...
journal_title：Mucosal immunology
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abstract：:Bacterial-induced intestinal inflammation is crucially dependent on interleukin (IL)-23 and is associated with CD4(+) T helper type 1 (Th1) and Th17 responses. However, the relative contributions of these subsets during the induction and resolution of colitis in T-cell-sufficient hosts remain unknown. We report that H...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2013.11
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abstract：:Group 3 innate lymphoid cells (ILC3s), a subset of the innate lymphoid cells, are abundantly present in the intestine and are crucial regulators of intestinal inflammation. Brg1 (Brahma-related gene 1), a catalytic subunit of the mammalian SWI-SNF-like chromatin-remodeling BAF complex, regulates the development and fu...
journal_title：Mucosal immunology
pub_type： 杂志文章
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journal_title：Mucosal immunology
pub_type： 杂志文章
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journal_title：Mucosal immunology
pub_type： 杂志文章
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journal_title：Mucosal immunology
pub_type： 杂志文章
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更新日期：2017-11-01 00:00:00
abstract：:As the Bacillus Calmette-Guérin (BCG) vaccine does not confer long-lasting protection against lung Mycobacterium tuberculosis infection, the development of more efficient vaccines is greatly needed. Here, we used mycobacterial low-molecular weight proteins of the 6-kDa Early Secreted Antigenic Target (ESAT-6) protein ...
journal_title：Mucosal immunology
pub_type： 杂志文章
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更新日期：2013-05-01 00:00:00
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journal_title：Mucosal immunology
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journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-018-0049-9
更新日期：2018-09-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.53
更新日期：2013-01-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 杂志文章,多中心研究
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更新日期：2008-03-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2011-03-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 评论,杂志文章,评审
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更新日期：2009-01-01 00:00:00
abstract：:Human papillomaviruses (HPV)-related cervical cancer is the second leading cause of cancer death in women worldwide. Despite active development, HPV E6/E7 oncogene-specific therapeutic vaccines have had limited clinical efficacy to date. Here, we report that intravaginal (IVAG) instillation of CpG-ODN (TLR9 agonist) o...
journal_title：Mucosal immunology
pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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journal_title：Mucosal immunology
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更新日期：2019-03-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
abstract：:Induction of mucosal immunoglobulin-A (IgA) capable of providing a first line of defense against bacterial and viral pathogens remains a major goal of needle-free vaccines given via mucosal routes. Innate immune cells are known to play a central role in induction of IgA responses by mucosal vaccines, but the relative ...
journal_title：Mucosal immunology
pub_type： 杂志文章
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更新日期：2015-07-01 00:00:00
abstract：:The interleukin-23 (IL-23) pathway has emerged as a promising therapeutic target for inflammatory bowel disease. Although the pathogenic role of IL-23 receptor (IL-23R) on T lymphocytes is well established, its function on innate immune cells has not been thoroughly examined. Here we investigate the consequence of IL-...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2011.54
更新日期：2012-01-01 00:00:00
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journal_title：Mucosal immunology
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更新日期：2016-01-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
abstract：:Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn's disease (CD). Ineffectual NOD2 (nucleotide-binding oligomerization domain 2) is the most common susceptibility gene contributing to CD. Vitamin D (vD), a potent modulator of innate and adaptive immunity, induces NOD2 gene express...
journal_title：Mucosal immunology
pub_type： 杂志文章
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更新日期：2014-11-01 00:00:00
abstract：:This corrects the article DOI: 10.1038/mi.2017.66. ...
journal_title：Mucosal immunology
pub_type： 杂志文章,已发布勘误
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更新日期：2018-03-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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journal_title：Mucosal immunology
pub_type： 杂志文章
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