abstract：Purpose of Review:In December 2019, outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected pneumonia patients were discovered in Wuhan City, Hubei Province, China. With the spread of the epidemic, new cases have been found in other regions of China and abroad. This review summarizes the curr...

journal_title：Current infectious disease reports

authors： Wang Y,Wang L,Li X,Gong Z

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The infectious complications of transplantation can have devastating consequences for patients. Early and accurate diagnosis is essential to good outcomes. This review describes recent advances in pathogen-directed diagnostic testing and discusses the role of new methods for transplant infectious dise...

journal_title：Current infectious disease reports

authors： Young BA,Hanson KE,Gomez CA

更新日期：2019-11-26 00:00:00

abstract：PURPOSE OF REVIEW:The global emergence of antifungal resistance among Candida spp. and Aspergillus spp. is a growing threat to public health, driven largely by the expanding use of antifungals in both the clinical and agricultural settings. As treatment options remain limited, understanding mechanisms and risk factors ...

journal_title：Current infectious disease reports

authors： Hendrickson JA,Hu C,Aitken SL,Beyda N

更新日期：2019-11-16 00:00:00

abstract：PURPOSE OF REVIEW:Acinetobacter baumannii (AB) is an infamous nosocomial pathogen with a seemingly limitless capacity for antimicrobial resistance, leading to few treatment options and poor clinical outcomes. The debatably low pathogenicity and virulence of AB are juxtaposed by its exceptionally high rate of infection-...

journal_title：Current infectious disease reports

authors： Butler DA,Biagi M,Tan X,Qasmieh S,Bulman ZP,Wenzler E

更新日期：2019-11-16 00:00:00

abstract：PURPOSE OF REVIEW:Suppressive therapy and periodic presumptive treatment (PPT) are distinct but related strategies that have been used to reduce the incidence of bacterial vaginosis (BV). Here, we review clinical trial evidence of the effectiveness of suppressive therapy and PPT to reduce BV, and discuss their roles fo...

journal_title：Current infectious disease reports

authors： Balkus JE,Carter KA,McClelland RS

更新日期：2019-08-31 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this article is to perform a systematic review over the past 5 years on the role and effectiveness of clinical decision support systems (CDSSs) on antibiotic stewardship. RECENT FINDINGS:CDDS interventions found a significant impact on multiple outcomes relevant to antibiotic stewardsh...

journal_title：Current infectious disease reports

authors： Rittmann B,Stevens MP

更新日期：2019-07-24 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to discuss the unique pathways of biofilm formation utilized by respiratory pathogens and current and future therapeutic strategies to inhibit biofilm formation or eradicate established biofilm in the context of these pathogens. Both nonselective and selective strategies ...

journal_title：Current infectious disease reports

authors： Hamilos DL

更新日期：2019-03-02 00:00:00

abstract：PURPOSE OF REVIEW:Modern advances in malaria rapid diagnostic test (RDT) technology have increased demand for low-cost, easy-to-use assays in areas endemic for malaria. Substantial developments in diagnostic sensitivity and specificity, improvements in non-falciparum RDTs, and novel biotechnological innovations are gra...

journal_title：Current infectious disease reports

authors： Mukkala AN,Kwan J,Lau R,Harris D,Kain D,Boggild AK

更新日期：2018-10-23 00:00:00

abstract：PURPOSE OF REVIEW:Post-transplant infections present a formidable challenge to the physician due to their varied presentation. Many of these infections begin by inoculation following skin compromise or disseminate to the skin hematogenously, making cutaneous manifestations of infection an important diagnostic clue in t...

journal_title：Current infectious disease reports

authors： Pettit CJ,Mazurek K,Kaffenberger B

更新日期：2018-05-22 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to investigate the evolution and epidemiology of Klebsiella pneumoniae carbapenemase (KPC)-producing organisms and the current and future treatment options for infections caused by KPC-producing isolates. RECENT FINDINGS:The emergence of resistance in Enterobacteriaceae ...

journal_title：Current infectious disease reports

authors： Porreca AM,Sullivan KV,Gallagher JC

更新日期：2018-05-05 00:00:00

abstract：:Starting from 2010, the 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in several countries. This paper discusses some of the problems recently emerged after PCV13 use and their clinical impact. The impact of PCV13 has been relevant and has saved millions of children and adults by severe infectious di...

journal_title：Current infectious disease reports

authors： Principi N,Di Cara G,Bizzarri I,Isidori C,Borgia P,Mignini C,Saponara M,Argentiero A,Esposito S

更新日期：2018-01-24 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights current knowledge in travel-related neuroinfectious diseases, providing insight on approaches to prevention, diagnosis, and treatment of infections of the central nervous system (CNS) in travelers and immigrants. RECENT FINDINGS:Updates on travel vaccine recommendations includi...

journal_title：Current infectious disease reports

authors： Thompson H,Thakur K

更新日期：2017-10-03 00:00:00

abstract：PURPOSE OF REVIEW:Since the treatment of acute diverticulitis has become more conservative over the last years, knowledge of conservative treatment strategies is increasingly important. RECENT FINDINGS:Several treatment strategies that previously have been imposed as routine treatment are now obsolete. Uncomplicated d...

journal_title：Current infectious disease reports

authors： van Dijk ST,Rottier SJ,van Geloven AAW,Boermeester MA

更新日期：2017-09-23 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this paper is to review therapies with new mechanisms of action for the treatment of HIV that are at least in phase 2 clinical trials. RECENT FINDINGS:There are several new mechanisms of action being represented within clinical development, including histone deacetylase (HDAC) inhibito...

journal_title：Current infectious disease reports

authors： Gravatt LAH,Leibrand CR,Patel S,McRae M

更新日期：2017-09-19 00:00:00

abstract：PURPOSE OF THE REVIEW:Community-acquired pneumonia (CAP) is still associated with a large burden and causes significant morbidity and mortality. Besides universal vaccination and antibiotic treatment, statins as adjunctive therapy may also have a beneficial role in the prevention and treatment of CAP. Our goal from thi...

journal_title：Current infectious disease reports

authors： Batais MA,Khan AR,Bin Abdulhak AA

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review attempts to understand the reasons for the successes and failures of the two novel strategies that have slowly begun to emerge as potential counters for anti-malarial drug resistance-"Triple Combination Therapy" and "Drug Cycling." RECENT FINDINGS:Recent reports have suggested that increa...

journal_title：Current infectious disease reports

authors： Dipanjan B,Shivaprakash G,Balaji O

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The increase in drug-resistant community-acquired pneumonia (CAP) is an important problem all over the world. This article explores the current state of antimicrobial resistance of different bacteria that cause CAP and also assesses risk factors to identify those pathogens. RECENT FINDINGS:In the las...

journal_title：Current infectious disease reports

authors： Arancibia F,Ruiz M

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system most often characterized by clinical relapses and periods of remission. RECENT FINDINGS:The past decade has seen a dramatic increase in disease-modifying therapies for MS. Fourteen FDA-approved immunomodulato...

journal_title：Current infectious disease reports

authors： Levin SN,Kaplan TB

更新日期：2017-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to determine the effectiveness of the use of syndrome diagnosis in the evaluation of vaginitis and to make suggestions based on the review findings. RECENT FINDINGS:Vaginal discharge as the main symptom of vaginitis is unspecific. A randomized study of symptom-based diagnosis and tre...

journal_title：Current infectious disease reports

authors： Nwankwo TO,Aniebue UU,Umeh UA

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Community-acquired pneumonia (CAP) is the cause of a considerable burden of morbidity and mortality among HIV-infected patients. The purpose of this study was to review recent literature for epidemiological trends and management of CAP in HIV patients. RECENT FINDINGS:While the specific infectious et...

journal_title：Current infectious disease reports

authors： Almeida A,Boattini M

更新日期：2017-01-01 00:00:00

abstract：:Carbapenems are the broadest spectrum antimicrobials utilized in the treatment of serious infections since the 1980s. Soon after their introduction, the discovery of carbapenem-resistant Enterobacteriaceae (CRE) was reported in the 1990s. Invasive CRE infections are associated with high mortality and limited treatment...

journal_title：Current infectious disease reports

authors： Bowers DR,Huang V

更新日期：2016-12-01 00:00:00

abstract：:Community-acquired pneumonia (CAP) is one of the most common causes of morbidity and mortality in elderly and children. Vitamin C is known as a physiological antioxidant, regulating innate immune system in the lung. Vitamin C has been used to prevent and treat CAP. However, the use of vitamin C for preventing and trea...

journal_title：Current infectious disease reports

authors： Li Y,Li G

更新日期：2016-08-01 00:00:00

abstract：:Noroviruses are among the most common cause of diarrhea in transplant recipients. The clinical spectrum of norovirus infection after transplant is increasingly being recognized. As substantial morbidity is now associated with norovirus infections in this population; the quest for rapid diagnostic modalities and newer ...

journal_title：Current infectious disease reports

authors： Angarone MP,Sheahan A,Kamboj M

更新日期：2016-06-01 00:00:00

abstract：:Streptococcus bovis is a rare, but important cause of bacterial meningitis in children. Since its discovery in the early 1970s, the pathogen has undergone multiple taxonomic changes producing four distinct subspecies today, the most prevalent of which is S. gallolyticus subsp pasteurianus in infants and children. Whil...

journal_title：Current infectious disease reports

authors： Hede SV

更新日期：2016-03-01 00:00:00

abstract：:The incidence of end-stage liver disease (ESLD) is increasing and many of these patients may be considered for orthotopic liver transplantation. As patients with ESLD are at risk of a number of infections, infectious disease physicians should be aware of the management of these infections in order to provide optimal p...

journal_title：Current infectious disease reports

authors： Mah A,Wright A

更新日期：2016-01-01 00:00:00

abstract：:Elderly are at high risk for hospitalization for community-acquired pneumonia (CAP), especially due to Streptococcus pneumoniae, and seasonal influenza viruses. Data suggest PPV23's influence on various CAP-related outcomes among the elderly may depend upon how many years have elapsed since they received this vaccine....

journal_title：Current infectious disease reports

authors： Gubbins PO,Li C

更新日期：2015-12-01 00:00:00

abstract：:Reduction of microbial contamination of the hospital environment is a challenge, yet has potential impacts on infection prevention efforts. Fumigation and UV light devices for environmental cleaning have expanded into the health care setting with the goal of decontamination of difficult to clean or overlooked surfaces...

journal_title：Current infectious disease reports

authors： Doll M,Morgan DJ,Anderson D,Bearman G

更新日期：2015-09-01 00:00:00

abstract：:Ventilator-associated pneumonia (VAP), an infection of the lower respiratory tract which occurs in association with mechanical ventilation, is one of the most common causes of nosocomial infection in the intensive care unit (ICU). VAP causes significant morbidity and mortality in critically ill patients including incr...

journal_title：Current infectious disease reports

authors： Waters B,Muscedere J

更新日期：2015-08-01 00:00:00

abstract：:Pyoderma gangrenosum (PG) is a rare cause of purulent vulvovaginal ulceration. Six recent cases of vulvovaginal pyoderma gangrenosum associated with rituximab are described. All cases were seen in the setting of rituximab used for the treatment of B cell non Hodgkin's lymphoma (NHL). Age range was 50-74; symptoms were...

journal_title：Current infectious disease reports

authors： Selva-Nayagam P,Fischer G,Hamann I,Sobel J,James C

更新日期：2015-05-01 00:00:00

abstract：:Solid organ and hematopoietic stem cell transplant recipients may be exposed to diseases which may be prevented through live attenuated virus vaccines (LAVV). Because of their immunosuppression, these diseases can lead to severe complications in transplant recipients. Despite increasing evidence regarding the safety a...

journal_title：Current infectious disease reports

authors： Verolet CM,Posfay-Barbe KM

更新日期：2015-04-01 00:00:00

abstract：:Dermatologic manifestations of travel-related illness are particularly vexing due to the broad differential diagnosis and clinicians' unfamiliarity with uncommonly seen diseases. This paper aims to educate and update the reader on selected infectious diseases in the returned traveler whose disease manifestations are p...

journal_title：Current infectious disease reports

authors： Zimmerman RF,Belanger ES,Pfeiffer CD

更新日期：2015-03-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Patients with COPD are at increased risk for community-acquired pneumonia (CAP). COPD has been reported as a comorbidity in at least one third of the hospitalized patients with CAP. There is a controversy that the pre...

journal_title：Current infectious disease reports

authors： Cilli A

更新日期：2015-01-01 00:00:00

abstract：:Pouchitis is an inflammatory complication after restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA). IPAA is the surgical treatment of choice in patients with ulcerative colitis (UC) who require colectomy. Initial episodes of acute pouchitis generally respond to antibiotics but significant numbers of c...

journal_title：Current infectious disease reports

authors： Chowdhry S,Katz JA

更新日期：2014-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a significant cause of chronic liver disease with substantial long-term sequelae. Until very recently, therapies to cure HCV were hindered by high nonresponse rates and severe side effects. The first-generation protease inhibitor-containing regimens provided superior cure rates for...

journal_title：Current infectious disease reports

authors： Moore C,Levitsky J

更新日期：2014-08-01 00:00:00

abstract：:Primary infection of humans with varicella zoster virus (VZV) causes varicella (chickenpox), after which the virus becomes latent in cranial nerve ganglia, dorsal root ganglia and autonomic ganglia along the entire neuraxis. As VZV-specific cell-mediated immunity declines in elderly and immunocompromised individuals, ...

journal_title：Current infectious disease reports

authors： Nagel MA,Gilden D

更新日期：2014-06-01 00:00:00

abstract：:Antiretroviral therapy (ART) does not eliminate HIV-1 from latently infected reservoirs, and this remains the critical obstacle to the eradication of infection. Although ART is effective in suppressing viral load, life-long ART is burdensome in many respects. Given expanding numbers of HIV-infected individuals on ART ...

journal_title：Current infectious disease reports

authors： Margolis DM

更新日期：2014-03-01 00:00:00

abstract：:Community-acquired pneumonia is a common reason for hospitalization and leads to significant morbidity and mortality. There are published evidence-based guidelines for the diagnosis, treatment, and management of community-acquired pneumonia. Many countries, including the US, have developed national, publically reporte...

journal_title：Current infectious disease reports

authors： Richey EA,Dudley L,Liu SK

更新日期：2014-02-01 00:00:00

abstract：:It is well established that the immunological response to the seasonal trivalent influenza vaccine is attenuated in cancer patients. Furthermore, rates of seroprotection and seroconversion vary by malignancy type and are higher in patients with solid tumors, as compared either with those with hematologic malignancies ...

journal_title：Current infectious disease reports

authors： Baluch A,Pasikhova Y

更新日期：2013-12-01 00:00:00

abstract：:All of the endemic mycoses have cutaneous and mucocutaneous manifestations that are most commonly seen when patients have disseminated infection. Biopsy of skin lesions is simple and safe and can assist in making a timely diagnosis of disseminated infection. Primary cutaneous inoculation infection has been reported wi...

journal_title：Current infectious disease reports

authors： Smith JA,Riddell J 4th,Kauffman CA

更新日期：2013-10-01 00:00:00

abstract：:In most high-income countries, fewer children now acquire meningitis, and many of those who do will survive. Globally, however, meningitis still remains a significant cause of child morbidity and mortality. In this article, the authors review recent evidence on the morbidity faced by childhood survivors of bacterial m...

journal_title：Current infectious disease reports

authors： Hudson LD,Viner RM,Christie D

更新日期：2013-06-01 00:00:00