Abstract:
PURPOSE OF REVIEW:The increase in drug-resistant community-acquired pneumonia (CAP) is an important problem all over the world. This article explores the current state of antimicrobial resistance of different bacteria that cause CAP and also assesses risk factors to identify those pathogens. RECENT FINDINGS:In the last two decades, it has been documented that there is a significant increase in drug-resistant Streptococcus pneumoniae and other bacteria causing CAP. The most important risk factors are overuse of antibiotics, prior hospitalization, and lung comorbidities. The direct consequences can be severe, including prolonged stays in hospital, increased costs, and morbi-mortality. However, drug-resistant CAP declined after the introduction of the pneumococcal conjugate vaccine. This review found an increase in resistance to the antibiotics used in CAP, and the risk factor can be used for identifying patients with drug-resistant CAP and initiate appropriate treatment. Judicious use of antibiotics and the development of effective new vaccines are needed.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Arancibia F,Ruiz Mdoi
10.1007/s11908-017-0565-xsubject
Has Abstractpub_date
2017-03-01 00:00:00pages
11issue
3eissn
1523-3847issn
1534-3146pii
10.1007/s11908-017-0565-xjournal_volume
19pub_type
杂志文章,评审abstract::Streptococcus bovis is a rare, but important cause of bacterial meningitis in children. Since its discovery in the early 1970s, the pathogen has undergone multiple taxonomic changes producing four distinct subspecies today, the most prevalent of which is S. gallolyticus subsp pasteurianus in infants and children. Whil...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-016-0519-8
更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Community-acquired pneumonia (CAP) is still associated with a large burden and causes significant morbidity and mortality. Besides universal vaccination and antibiotic treatment, statins as adjunctive therapy may also have a beneficial role in the prevention and treatment of CAP. Our goal from thi...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0581-x
更新日期:2017-08-01 00:00:00
abstract::Malaria is a devastating disease, inflicting epidemic morbidity and mortality with an estimated 500 million cases and 2.5 million deaths annually. Children suffer the most severe morbidity; one child dies of malaria every 30 seconds, accounting for over 1 million of the deaths annually. There continues to be a tremend...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-003-0064-0
更新日期:2003-02-01 00:00:00
abstract::Pyoderma gangrenosum (PG) is a rare cause of purulent vulvovaginal ulceration. Six recent cases of vulvovaginal pyoderma gangrenosum associated with rituximab are described. All cases were seen in the setting of rituximab used for the treatment of B cell non Hodgkin's lymphoma (NHL). Age range was 50-74; symptoms were...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-015-0478-5
更新日期:2015-05-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Patients with COPD are at increased risk for community-acquired pneumonia (CAP). COPD has been reported as a comorbidity in at least one third of the hospitalized patients with CAP. There is a controversy that the pre...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0444-7
更新日期:2015-01-01 00:00:00
abstract::Community-acquired pneumonia (CAP) is one of the most common causes of morbidity and mortality in elderly and children. Vitamin C is known as a physiological antioxidant, regulating innate immune system in the lung. Vitamin C has been used to prevent and treat CAP. However, the use of vitamin C for preventing and trea...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-016-0530-0
更新日期:2016-08-01 00:00:00
abstract::Neuroimaging studies have revealed that neurocysticercosis is a major cause of neurologic disease in most developing countries and is an emerging disease in industrialized areas. Patients with neurocysticercosis present mainly with seizures (parenchymal form) or intracranial hypertension (ventricular/subarachnoid form...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-999-0055-x
更新日期:1999-12-01 00:00:00
abstract::Although mixed infections are known to be clinically relevant in conditions such as nosocomial pneumonia and ventilator-related pneumonia, it is increasingly recognized that a substantial number of community-acquired lower respiratory tract infections may also be attributed to more than one pathogenic organism. A bett...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-007-0017-0
更新日期:2007-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The global emergence of antifungal resistance among Candida spp. and Aspergillus spp. is a growing threat to public health, driven largely by the expanding use of antifungals in both the clinical and agricultural settings. As treatment options remain limited, understanding mechanisms and risk factors ...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-019-0702-9
更新日期:2019-11-16 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-008-0045-4
更新日期:2008-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Since the treatment of acute diverticulitis has become more conservative over the last years, knowledge of conservative treatment strategies is increasingly important. RECENT FINDINGS:Several treatment strategies that previously have been imposed as routine treatment are now obsolete. Uncomplicated d...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0600-y
更新日期:2017-09-23 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-012-0278-0
更新日期:2012-10-01 00:00:00
abstract::Diarrhea is one of the most common health problems among travelers. Although enterotoxigenic Escherichia coli is implicated most commonly, enteroaggregative E. coli has recently been described as a major pathogen. Shigella, Campylobacter, and Salmonella organisms are less common causes of acute diarrhea, and intestina...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0070-7
更新日期:2002-02-01 00:00:00
abstract::Skin and soft tissue infections vary widely in their nature and severity, and their nomenclature is complex. Most are readily recognized and easily treated, but more severe infections may masquerade in forms similar to those of more innocent infections, causing delay in diagnosis and treatment that may result in loss ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0010-6
更新日期:2002-10-01 00:00:00
abstract::Intensive care unit (ICU) patients present several unusual pharmacokinetic (PK) characteristics compared with less seriously ill patients, including increased distribution volume and variable clearance. Interpatient PK variability is often considerable and can produce a wide range of values for PK parameters and major...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-009-0003-9
更新日期:2009-01-01 00:00:00
abstract::The deadly combination of tuberculosis (TB) and human immunodeficiency virus (HIV) currently ravaging the world, taking a toll of about 0.35 million people every year, is one of the major public health crises of the decade. Throughout the course of HIV infection, the risk of acquisition, reactivation, and reinfection ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-012-0311-3
更新日期:2013-02-01 00:00:00
abstract::Combination antifungal therapy has been an area of great research and clinical interest since antifungals became available decades ago, in part driven by the severe morbidity and mortality associated with invasive fungal infections. Because of the availability of newer antifungal agents including echinocandins and exp...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-007-0069-1
更新日期:2007-11-01 00:00:00
abstract::Patients with sepsis may require mechanical ventilation due to the acute respiratory distress syndrome (ARDS). It has become increasingly accepted that mechanical ventilation can contribute to lung injury in these patients. The modern concept of ventilator-induced lung injury is described in the context of alveolar ov...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-005-0007-z
更新日期:2005-09-01 00:00:00
abstract::Healthcare-associated bacterial meningitis may occur after neurosurgical procedures, head trauma, and following placement of external or internal ventricular catheters. The likely microorganisms that cause meningitis in this setting (ie, staphylococci and gram-negative bacilli) are different from those that cause meni...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0190-z
更新日期:2011-08-01 00:00:00
abstract::Invasive fungal infection (IFI) is an important cause of morbidity and mortality in patients with hematologic malignancy, prolonged neutropenia, or after hematopoietic stem cell transplant. Antifungal prophylaxis prevents IFI in high-risk hematology patients. This article discusses recent developments in antifungal pr...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-009-0061-z
更新日期:2009-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Acinetobacter baumannii (AB) is an infamous nosocomial pathogen with a seemingly limitless capacity for antimicrobial resistance, leading to few treatment options and poor clinical outcomes. The debatably low pathogenicity and virulence of AB are juxtaposed by its exceptionally high rate of infection-...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-019-0706-5
更新日期:2019-11-16 00:00:00
abstract::Endocarditis pathogens colonize valves with pre-existing sterile vegetations or valves with minimal endothelial lesions. Inflamed endothelia produce cytokines, integrins, and tissue factor, which in turn attract fibronectin, monocytes, and platelets. Bacteria attaching to such structures further activate the cascade, ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-006-0071-z
更新日期:2006-06-01 00:00:00
abstract::Noroviruses are among the most common cause of diarrhea in transplant recipients. The clinical spectrum of norovirus infection after transplant is increasingly being recognized. As substantial morbidity is now associated with norovirus infections in this population; the quest for rapid diagnostic modalities and newer ...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-016-0524-y
更新日期:2016-06-01 00:00:00
abstract::Coronary heart disease (CHD) is an inflammatory process that takes decades to develop. In HIV-seronegative persons, high-sensitivity C-reactive protein is a biologic marker of CHD risk. HIV infection induces chronic inflammation, despite adequate suppression of HIV replication with antiretroviral therapy, resulting in...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-010-0153-9
更新日期:2011-02-01 00:00:00
abstract::In the United States each year, influenza accounts for an estimated 20,000 to 40,000 deaths, nearly 300,000 hospitalizations, and millions of days lost from work. In the past few years, there has been an explosion of information in the medical literature related to influenza. This paper reviews these latest developmen...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0039-3
更新日期:2000-06-01 00:00:00
abstract:Purpose of Review:In December 2019, outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected pneumonia patients were discovered in Wuhan City, Hubei Province, China. With the spread of the epidemic, new cases have been found in other regions of China and abroad. This review summarizes the curr...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-020-00738-7
更新日期:2020-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this paper is to review therapies with new mechanisms of action for the treatment of HIV that are at least in phase 2 clinical trials. RECENT FINDINGS:There are several new mechanisms of action being represented within clinical development, including histone deacetylase (HDAC) inhibito...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0601-x
更新日期:2017-09-19 00:00:00
abstract::Skin lesions provide an important clue to the diagnoses of many infections in returned travelers. New information related to epidemiology, recognition, diagnosis, or management is described for the systemic infections--dengue fever, several of the rickettsial infections, African trypanosomiasis, and coccidioidomycosis...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-004-0025-2
更新日期:2004-02-01 00:00:00
abstract::Therapy of cryptococcal meningitis has been focused primarily on optimizing the antifungal regimen to improve the previously high treatment failure rates. Until recently, relatively little attention has been paid to the impact of increased intracranial pressure, which is a frequent problem that complicates management ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0026-y
更新日期:2002-08-01 00:00:00
abstract::Hepatitis C virus (HCV) infection is a significant cause of chronic liver disease with substantial long-term sequelae. Until very recently, therapies to cure HCV were hindered by high nonresponse rates and severe side effects. The first-generation protease inhibitor-containing regimens provided superior cure rates for...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0413-1
更新日期:2014-08-01 00:00:00