Abstract：
:Therapy of cryptococcal meningitis has been focused primarily on optimizing the antifungal regimen to improve the previously high treatment failure rates. Until recently, relatively little attention has been paid to the impact of increased intracranial pressure, which is a frequent problem that complicates management of patients with cryptococcal meningitis. Patients with elevated baseline opening pressures have higher titers of cerebrospinal fluid cryptococcal capsular polysaccharide antigen, more frequent headaches, meningismus, papilledema, hearing loss, and pathologic reflexes, as well as increased morbidity and mortality compared with those patients with normal opening pressures. Optimal therapy has not yet been firmly established, but the diagnostic evaluation and available treatment options are reviewed here, including frequent high volume lumbar punctures, lumbar drains, ventriculoperitoneal shunting, and corticosteroids.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Gambarin KJ,Hamill RJdoi
10.1007/s11908-002-0026-ykeywords:
subject
Has Abstractpub_date
2002-08-01 00:00:00pages
332-338issue
4eissn
1523-3847issn
1534-3146journal_volume
4pub_type
杂志文章abstract：:A broad range of disorders can cause inflammation of the thyroid gland. True thyroid infections are rare and can result from a variety of microorganisms, of which bacteria are the most common. Other rarer pathogens include fungi, parasites, and viruses. Gram-positive bacteria, especially staphylococci, predominate as ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0027-7
更新日期：2000-04-01 00:00:00
abstract：:Urinary tract infections are common, especially among women, and cause significant morbidity. While prognosis is probably more dependent on whether or not an episode of urinary tract infection is complicated (ie, associated with functional, metabolic, or anatomic abnormalities of the urinary tract) or uncomplicated, a...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-001-0090-8
更新日期：2001-12-01 00:00:00
abstract：PURPOSE OF REVIEW:The infectious complications of transplantation can have devastating consequences for patients. Early and accurate diagnosis is essential to good outcomes. This review describes recent advances in pathogen-directed diagnostic testing and discusses the role of new methods for transplant infectious dise...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-019-0704-7
更新日期：2019-11-26 00:00:00
abstract：:The incidence of end-stage liver disease (ESLD) is increasing and many of these patients may be considered for orthotopic liver transplantation. As patients with ESLD are at risk of a number of infections, infectious disease physicians should be aware of the management of these infections in order to provide optimal p...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0514-5
更新日期：2016-01-01 00:00:00
abstract：:Bacterial meningitis remains a feared diagnosis that may lead to significant mortality and morbidity in both the developed and developing world; case fatality rates range from 10% to 50% among all age groups. Several vaccines are available (including the Haemophilus influenzae type B polysaccharide conjugate vaccine) ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-009-0045-z
更新日期：2009-07-01 00:00:00
abstract：:Pulmonary nocardiosis is an uncommon but serious infection that is increasingly found in immunosuppressed persons, especially transplant recipients and persons with AIDS. The Nocardia species are denizens of soil and decaying plants that gain entry to humans through inhalation or inoculation. Pulmonary nocardiosis typ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-001-0032-5
更新日期：2001-06-01 00:00:00
abstract：PURPOSE OF REVIEW:The increase in drug-resistant community-acquired pneumonia (CAP) is an important problem all over the world. This article explores the current state of antimicrobial resistance of different bacteria that cause CAP and also assesses risk factors to identify those pathogens. RECENT FINDINGS:In the las...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0565-x
更新日期：2017-03-01 00:00:00
abstract：:Although waterborne pathogens are relatively uncommon causes of cutaneous infections, these agents are being recognized with increasing frequency. Humans are exposed to water through a variety of recreational and occupational activities. Poor sanitary conditions in developing nations place the human populations at con...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-003-0020-z
更新日期：2003-10-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Patients with COPD are at increased risk for community-acquired pneumonia (CAP). COPD has been reported as a comorbidity in at least one third of the hospitalized patients with CAP. There is a controversy that the pre...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-014-0444-7
更新日期：2015-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Acinetobacter baumannii (AB) is an infamous nosocomial pathogen with a seemingly limitless capacity for antimicrobial resistance, leading to few treatment options and poor clinical outcomes. The debatably low pathogenicity and virulence of AB are juxtaposed by its exceptionally high rate of infection-...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-019-0706-5
更新日期：2019-11-16 00:00:00
abstract：:Determining the microbiologic etiology of enteric infection remains an elusive goal. Conventional approaches, including culture, microscopy, and antigen-based tests have significant limitations such as limit of detection and the need for multiple procedures. Molecular diagnostics, especially PCR based tests, are rapid...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-011-0223-7
更新日期：2012-02-01 00:00:00
abstract：:Lower respiratory tract infections (LRTIs) are a global burden to public health and are frequently caused by respiratory viruses. Advances in molecular diagnostic techniques have allowed the identification of previously undetected viral pathogens and have improved our understanding of respiratory virus infections. Her...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-012-0258-4
更新日期：2012-06-01 00:00:00
abstract：:Community-acquired pneumonia (CAP) is one of the most common causes of morbidity and mortality in elderly and children. Vitamin C is known as a physiological antioxidant, regulating innate immune system in the lung. Vitamin C has been used to prevent and treat CAP. However, the use of vitamin C for preventing and trea...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-016-0530-0
更新日期：2016-08-01 00:00:00
abstract：:Skin and soft tissue infections vary widely in their nature and severity, and their nomenclature is complex. Most are readily recognized and easily treated, but more severe infections may masquerade in forms similar to those of more innocent infections, causing delay in diagnosis and treatment that may result in loss ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-002-0010-6
更新日期：2002-10-01 00:00:00
abstract：:Heavily pretreated HIV-infected patients with multidrug-resistant virus remain a clinical challenge to the treating physician. While the goal of therapy in such patients is still controversial, sustained immunologic and clinical benefit have only been demonstrated with complete suppression of plasma viral load below d...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-002-0089-9
更新日期：2002-06-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this article is to perform a systematic review over the past 5 years on the role and effectiveness of clinical decision support systems (CDSSs) on antibiotic stewardship. RECENT FINDINGS:CDDS interventions found a significant impact on multiple outcomes relevant to antibiotic stewardsh...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-019-0683-8
更新日期：2019-07-24 00:00:00
abstract：:There is strong evidence that preoperative nasal S. aureus screening/decolonization will significantly reduce surgical site infections (SSIs) after joint prostheses implantation. There is some evidence that antibiotic-containing bone cement may lower SSI rates. Timely administration of perioperative systemic antibioti...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-012-0278-0
更新日期：2012-10-01 00:00:00
abstract：:The possibility that infection with Chlamydia pneumoniae may somehow contribute to the pathogenesis of atherosclerosis continues to be explored by researchers worldwide. A direct cause-and-effect relationship between the bacterium and subsequent development of atherosclerosis has yet to be proved. However, compelling ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-996-0021-9
更新日期：1999-06-01 00:00:00
abstract：:Although mixed infections are known to be clinically relevant in conditions such as nosocomial pneumonia and ventilator-related pneumonia, it is increasingly recognized that a substantial number of community-acquired lower respiratory tract infections may also be attributed to more than one pathogenic organism. A bett...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0017-0
更新日期：2007-01-01 00:00:00
abstract：:Solid organ and hematopoietic stem cell transplant recipients may be exposed to diseases which may be prevented through live attenuated virus vaccines (LAVV). Because of their immunosuppression, these diseases can lead to severe complications in transplant recipients. Despite increasing evidence regarding the safety a...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0472-y
更新日期：2015-04-01 00:00:00
abstract：:The outcome for HIV-infected patients with cancer has dramatically improved in the highly active antiretroviral therapy (HAART) era, probably due to improvements in immune status and bone marrow function that allow the possibility of increased drug-dose intensity with a higher complete remission rate. Although data re...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-008-0026-7
更新日期：2008-05-01 00:00:00
abstract：:All of the endemic mycoses have cutaneous and mucocutaneous manifestations that are most commonly seen when patients have disseminated infection. Biopsy of skin lesions is simple and safe and can assist in making a timely diagnosis of disseminated infection. Primary cutaneous inoculation infection has been reported wi...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-013-0352-2
更新日期：2013-10-01 00:00:00
abstract：:Eosinophilia in patients exposed to tropical or subtropical environments is caused most commonly by helminth (worm) infections. Besides a detailed exposure history, the diagnostic approach must consider other infections and noninfectious causes of eosinophilia, as treatments for many of these disorders differ. ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-006-0034-4
更新日期：2006-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Modern advances in malaria rapid diagnostic test (RDT) technology have increased demand for low-cost, easy-to-use assays in areas endemic for malaria. Substantial developments in diagnostic sensitivity and specificity, improvements in non-falciparum RDTs, and novel biotechnological innovations are gra...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-018-0655-4
更新日期：2018-10-23 00:00:00
abstract：:The dogma is that the higher risk of pyelonephritis in pregnant women is explained entirely by anatomic/obstructive changes. If so, gestational pyelonephritis should be caused by random, nonpathogenic bacteria. Instead, gestational pyelonephritis is associated with a narrow group of genetically related Escherichia col...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-002-0041-z
更新日期：2002-12-01 00:00:00
abstract：:Two million of the 15 million (13.3%) new cases of sexually transmitted infections (STIs) among persons 15 to 49 years old occur in pregnant women. Access to care and a provider's ability to assess risk, screen, and treat STIs are critical factors in preventing adverse pregnancy outcomes. Significant variations in pro...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0008-1
更新日期：2007-03-01 00:00:00
abstract：:Drotrecogin alfa (activated) (DrotAA) has been approved for therapy of severe sepsis and septic shock for 7 years, but controversy persists regarding efficacy and safety. Only a single randomized, controlled trial (Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis; PROWESS) has shown evidence...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-008-0060-5
更新日期：2008-09-01 00:00:00
abstract：:Pyoderma gangrenosum (PG) is a rare cause of purulent vulvovaginal ulceration. Six recent cases of vulvovaginal pyoderma gangrenosum associated with rituximab are described. All cases were seen in the setting of rituximab used for the treatment of B cell non Hodgkin's lymphoma (NHL). Age range was 50-74; symptoms were...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0478-5
更新日期：2015-05-01 00:00:00
abstract：:Endocarditis pathogens colonize valves with pre-existing sterile vegetations or valves with minimal endothelial lesions. Inflamed endothelia produce cytokines, integrins, and tissue factor, which in turn attract fibronectin, monocytes, and platelets. Bacteria attaching to such structures further activate the cascade, ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-006-0071-z
更新日期：2006-06-01 00:00:00
abstract：:Immunization against the most common meningeal pathogens is the leading factor associated with decreased incidence of bacterial meningitis in countries where routine vaccination is available. This is most dramatically illustrated by the reduction in the incidence of Haemophilus influenzae type b meningitis. The incide...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0047-7
更新日期：2007-07-01 00:00:00
