Molecular Diagnostic Advances in Transplant Infectious Diseases.

Abstract:

PURPOSE OF REVIEW:The infectious complications of transplantation can have devastating consequences for patients. Early and accurate diagnosis is essential to good outcomes. This review describes recent advances in pathogen-directed diagnostic testing and discusses the role of new methods for transplant infectious diseases. RECENT FINDINGS:Several molecular assays have been introduced into clinical practice in recent years. When the results of rapid testing are linked to patient-specific interventions, improved outcomes can be realized. Syndromic testing along with metagenomic next-generation sequencing (mNGS) represents novel approaches to infection diagnosis. However, the optimal use of these tests for transplant patients along with an overall assessment of cost-effectiveness demands further study. Molecular diagnostics are revolutionizing transplant care. Clinicians need to be aware of the current diagnostic landscape and have a working knowledge of the nuances related to test performance, result interpretation, and cost.

journal_name

Curr Infect Dis Rep

authors

Young BA,Hanson KE,Gomez CA

doi

10.1007/s11908-019-0704-7

subject

Has Abstract

pub_date

2019-11-26 00:00:00

pages

52

issue

12

eissn

1523-3847

issn

1534-3146

pii

10.1007/s11908-019-0704-7

journal_volume

21

pub_type

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