Update on the pathogenesis and management of pouchitis.

Abstract:

:Pouchitis is an inflammatory complication after restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA). IPAA is the surgical treatment of choice in patients with ulcerative colitis (UC) who require colectomy. Initial episodes of acute pouchitis generally respond to antibiotics but significant numbers of cases eventually become dependent on or refractory to antibiotics. Management of chronic antibiotic refractory pouchitis is challenging and can ultimately lead to pouch failure. The etiopathogenesis is unknown though recent studies have implicated bacterial dysbiosis of the pouch microbiota, NOD2 polymorphism, and Clostridium difficile infection in the development of severe pouchitis. Early identification of risk factors can help in tailoring therapy and reducing cases of chronic pouchitis.

journal_name

Curr Infect Dis Rep

authors

Chowdhry S,Katz JA

doi

10.1007/s11908-014-0442-9

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

442

issue

12

eissn

1523-3847

issn

1534-3146

journal_volume

16

pub_type

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