Abstract:
PURPOSE OF REVIEW:Post-transplant infections present a formidable challenge to the physician due to their varied presentation. Many of these infections begin by inoculation following skin compromise or disseminate to the skin hematogenously, making cutaneous manifestations of infection an important diagnostic clue in the immunocompromised. Quality research in this field is lacking, and this articles seeks to review the literature and present a guide to physicians in order for them to suspect certain infections by their cutaneous presentation. RECENT FINDINGS:The cutaneous presentation of opportunistic infections in transplant patients is extremely varied. However, as more case reports are published, certain patterns specific to individual organisms are emerging. In addition, early recognition is improving outcomes and systemic antibiotic therapy success. Early and correct recognition of disseminated infection in the immunocompromised host can be aided by close attention to cutaneous findings. This allows early and correct antibiotic therapy and improves outcomes.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Pettit CJ,Mazurek K,Kaffenberger Bdoi
10.1007/s11908-018-0621-1subject
Has Abstractpub_date
2018-05-22 00:00:00pages
16issue
7eissn
1523-3847issn
1534-3146pii
10.1007/s11908-018-0621-1journal_volume
20pub_type
杂志文章,评审abstract::Pulmonary nocardiosis is an uncommon but serious infection that is increasingly found in immunosuppressed persons, especially transplant recipients and persons with AIDS. The Nocardia species are denizens of soil and decaying plants that gain entry to humans through inhalation or inoculation. Pulmonary nocardiosis typ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-001-0032-5
更新日期:2001-06-01 00:00:00
abstract::Combination antifungal therapy has been an area of great research and clinical interest since antifungals became available decades ago, in part driven by the severe morbidity and mortality associated with invasive fungal infections. Because of the availability of newer antifungal agents including echinocandins and exp...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-007-0069-1
更新日期:2007-11-01 00:00:00
abstract::Therapy of cryptococcal meningitis has been focused primarily on optimizing the antifungal regimen to improve the previously high treatment failure rates. Until recently, relatively little attention has been paid to the impact of increased intracranial pressure, which is a frequent problem that complicates management ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0026-y
更新日期:2002-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to investigate the evolution and epidemiology of Klebsiella pneumoniae carbapenemase (KPC)-producing organisms and the current and future treatment options for infections caused by KPC-producing isolates. RECENT FINDINGS:The emergence of resistance in Enterobacteriaceae ...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-018-0617-x
更新日期:2018-05-05 00:00:00
abstract::Primary infection of humans with varicella zoster virus (VZV) causes varicella (chickenpox), after which the virus becomes latent in cranial nerve ganglia, dorsal root ganglia and autonomic ganglia along the entire neuraxis. As VZV-specific cell-mediated immunity declines in elderly and immunocompromised individuals, ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0407-z
更新日期:2014-06-01 00:00:00
abstract::Streptococcus bovis is a rare, but important cause of bacterial meningitis in children. Since its discovery in the early 1970s, the pathogen has undergone multiple taxonomic changes producing four distinct subspecies today, the most prevalent of which is S. gallolyticus subsp pasteurianus in infants and children. Whil...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-016-0519-8
更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to discuss the unique pathways of biofilm formation utilized by respiratory pathogens and current and future therapeutic strategies to inhibit biofilm formation or eradicate established biofilm in the context of these pathogens. Both nonselective and selective strategies ...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-019-0657-x
更新日期:2019-03-02 00:00:00
abstract::The ability to predict efficacy and toxicity during antiretroviral therapy for HIV would be of obvious advantage. The substantial variability between patients in terms of bioavailability and distribution of current regimens is likely driven by genetic and environmental factors. Protease inhibitors and nucleoside/nucle...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-006-0052-2
更新日期:2006-09-01 00:00:00
abstract::Treatment of chronic rhinosinusitis still represents an unmet medical need. Presently, the US Food and Drug Administration has not approved any drugs for the treatment of this common condition. Various inflammatory processes are involved in the pathogenesis of chronic rhinosinusitis. Treatment of infection and surgica...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-007-0031-2
更新日期:2007-05-01 00:00:00
abstract::Solid organ and hematopoietic stem cell transplant recipients may be exposed to diseases which may be prevented through live attenuated virus vaccines (LAVV). Because of their immunosuppression, these diseases can lead to severe complications in transplant recipients. Despite increasing evidence regarding the safety a...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-015-0472-y
更新日期:2015-04-01 00:00:00
abstract::The immune reconstitution inflammatory syndrome (IRIS) is a well-described phenomenon in HIV-infected patients following initiation of antiretroviral therapy and can lead to significant morbidity and mortality in some patients. Risk for IRIS is enhanced in those with low CD4 counts and preexisting opportunistic infect...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-012-0308-y
更新日期:2013-02-01 00:00:00
abstract:PURPOSE OF REVIEW:This review attempts to understand the reasons for the successes and failures of the two novel strategies that have slowly begun to emerge as potential counters for anti-malarial drug resistance-"Triple Combination Therapy" and "Drug Cycling." RECENT FINDINGS:Recent reports have suggested that increa...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0579-4
更新日期:2017-07-01 00:00:00
abstract::Skin lesions provide an important clue to the diagnoses of many infections in returned travelers. New information related to epidemiology, recognition, diagnosis, or management is described for the systemic infections--dengue fever, several of the rickettsial infections, African trypanosomiasis, and coccidioidomycosis...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-004-0025-2
更新日期:2004-02-01 00:00:00
abstract::Hepatitis delta virus (HDV) is a unique human virus, showing similarities with plant viroids. Although impressive knowledge on virus structure and replication has been achieved, several questions like HBV/HDV interaction and post translational modifications of HD antigens remain to be answered. Potential targets for t...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0233-5
更新日期:2012-02-01 00:00:00
abstract::Pouchitis is an inflammatory complication after restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA). IPAA is the surgical treatment of choice in patients with ulcerative colitis (UC) who require colectomy. Initial episodes of acute pouchitis generally respond to antibiotics but significant numbers of c...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0442-9
更新日期:2014-12-01 00:00:00
abstract::Infectious myositis is defined as an infection of a skeletal muscle. Infectious myositis is most commonly caused by bacteria; however, a variety of viral, parasitic, and fungal agents may also cause myositis. The pathogenesis of nonbacterial infectious myositis is via direct or hematogenous infection of the musculatur...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-010-0118-z
更新日期:2010-09-01 00:00:00
abstract::The 2009 pandemic influenza A (H1N1) was responsible for the first influenza pandemic of the 21st century. The virus- a previously unknown triple-reassortant virus containing segments of avian, human, and swine origins- generally caused mild disease. Unlike seasonal influenza, 2009 pandemic influenza A (H1N1) primaril...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-010-0157-5
更新日期:2011-04-01 00:00:00
abstract::Healthcare-associated bacterial meningitis may occur after neurosurgical procedures, head trauma, and following placement of external or internal ventricular catheters. The likely microorganisms that cause meningitis in this setting (ie, staphylococci and gram-negative bacilli) are different from those that cause meni...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0190-z
更新日期:2011-08-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Patients with COPD are at increased risk for community-acquired pneumonia (CAP). COPD has been reported as a comorbidity in at least one third of the hospitalized patients with CAP. There is a controversy that the pre...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0444-7
更新日期:2015-01-01 00:00:00
abstract::Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have been reported with increasing frequency from many parts of the world. Most infections involve the skin and soft tissue structures, and CA-MRSA is now the most commonly identifiable cause of purulent skin and soft tissue infectio...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-007-0061-9
更新日期:2007-09-01 00:00:00
abstract::The first description of acute respiratory distress syndrome (ARDS) in adults appeared in 1967 and was characterized by dyspnea, hypoxemia, diffuse alveolar infiltrates, and reduced respiratory system compliance. ARDS and acute lung injury (ALI) syndrome have no specific treatment, only supportive care: treating the u...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-009-0052-0
更新日期:2009-09-01 00:00:00
abstract::Bacterial vaginosis (BV) is a common cause of vaginal discharge in women of childbearing age. In some individuals, it recurs frequently after treatment, frustrating both the patient and the physician. Standard BV treatment--metronidazole or clindamycin, administered either intravaginally or orally--is followed by rela...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0053-5
更新日期:2000-12-01 00:00:00
abstract::Rotaviruses are the most important cause of pediatric gastroenteritis worldwide. In August 1998, a new rotavirus vaccine was licensed for general use in the United States. However, 14 months later, the vaccine was withdrawn from the market because of serious gastrointestinal side effects. This paper discusses the need...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0090-0
更新日期:2000-02-01 00:00:00
abstract::Arthroplasty of the knee and hip is a common procedure. There is a risk of infection with primary arthroplasty, with an incidence of 1% to 2%. Significant cost and morbidity are associated with infection of the prosthetic joint. Most infections (60% to 70%) are caused by staphylococci, but approximately 10% are caused...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-004-0038-x
更新日期:2004-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Since the treatment of acute diverticulitis has become more conservative over the last years, knowledge of conservative treatment strategies is increasingly important. RECENT FINDINGS:Several treatment strategies that previously have been imposed as routine treatment are now obsolete. Uncomplicated d...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0600-y
更新日期:2017-09-23 00:00:00
abstract::Acute otitis media (AOM), when associated with a bulging or full tympanic membrane, has a bacterial etiology in more than 90% of cases. Not infrequently, the organisms present express resistance mechanisms to commonly prescribed antibiotic therapy. Tympanocentesis is a procedure advocated by several national guideline...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-006-0058-9
更新日期:2006-05-01 00:00:00
abstract::Starting from 2010, the 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in several countries. This paper discusses some of the problems recently emerged after PCV13 use and their clinical impact. The impact of PCV13 has been relevant and has saved millions of children and adults by severe infectious di...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-018-0607-z
更新日期:2018-01-24 00:00:00
abstract::Neuroimaging studies have revealed that neurocysticercosis is a major cause of neurologic disease in most developing countries and is an emerging disease in industrialized areas. Patients with neurocysticercosis present mainly with seizures (parenchymal form) or intracranial hypertension (ventricular/subarachnoid form...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-999-0055-x
更新日期:1999-12-01 00:00:00
abstract::Although highly active antiretroviral therapy suppresses HIV replication resulting in extraordinary clinical benefits, toxicity, adherence difficulties, and the monetary cost of medications limit the long-term effectiveness and availability of therapy for many HIV-infected individuals. Strategies to interrupt therapy ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0059-2
更新日期:2002-04-01 00:00:00
abstract::A broad range of disorders can cause inflammation of the thyroid gland. True thyroid infections are rare and can result from a variety of microorganisms, of which bacteria are the most common. Other rarer pathogens include fungi, parasites, and viruses. Gram-positive bacteria, especially staphylococci, predominate as ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0027-7
更新日期:2000-04-01 00:00:00