Abstract:
:The immune reconstitution inflammatory syndrome (IRIS) is a well-described phenomenon in HIV-infected patients following initiation of antiretroviral therapy and can lead to significant morbidity and mortality in some patients. Risk for IRIS is enhanced in those with low CD4 counts and preexisting opportunistic infections. The development of pathogen-specific definitions of IRIS has aided classification of patients and has facilitated research. Newer data on optimal timing of ART initiation, with additional data in the setting of tuberculosis and cryptococcal meningitis, will help guide strategies to decrease the risk of IRIS but must balance the risks of HIV disease progression. Managing patients with IRIS can be challenging. Treatment options include pathogen-specific therapy, antiinflammatory therapies, and other novel approaches.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Armstrong WSdoi
10.1007/s11908-012-0308-ysubject
Has Abstractpub_date
2013-02-01 00:00:00pages
39-45issue
1eissn
1523-3847issn
1534-3146journal_volume
15pub_type
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