The immune reconstitution inflammatory syndrome: a clinical update.

Abstract:

:The immune reconstitution inflammatory syndrome (IRIS) is a well-described phenomenon in HIV-infected patients following initiation of antiretroviral therapy and can lead to significant morbidity and mortality in some patients. Risk for IRIS is enhanced in those with low CD4 counts and preexisting opportunistic infections. The development of pathogen-specific definitions of IRIS has aided classification of patients and has facilitated research. Newer data on optimal timing of ART initiation, with additional data in the setting of tuberculosis and cryptococcal meningitis, will help guide strategies to decrease the risk of IRIS but must balance the risks of HIV disease progression. Managing patients with IRIS can be challenging. Treatment options include pathogen-specific therapy, antiinflammatory therapies, and other novel approaches.

journal_name

Curr Infect Dis Rep

authors

Armstrong WS

doi

10.1007/s11908-012-0308-y

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

39-45

issue

1

eissn

1523-3847

issn

1534-3146

journal_volume

15

pub_type

杂志文章
  • Skin infections in returned travelers: an update.

    abstract::Dermatologic manifestations of travel-related illness are particularly vexing due to the broad differential diagnosis and clinicians' unfamiliarity with uncommonly seen diseases. This paper aims to educate and update the reader on selected infectious diseases in the returned traveler whose disease manifestations are p...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-015-0467-8

    authors: Zimmerman RF,Belanger ES,Pfeiffer CD

    更新日期:2015-03-01 00:00:00

  • Changing epidemiology of bacterial meningitis.

    abstract::Immunization against the most common meningeal pathogens is the leading factor associated with decreased incidence of bacterial meningitis in countries where routine vaccination is available. This is most dramatically illustrated by the reduction in the incidence of Haemophilus influenzae type b meningitis. The incide...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-007-0047-7

    authors: Dery MA,Hasbun R

    更新日期:2007-07-01 00:00:00

  • Infectious Complications of Novel Multiple Sclerosis Therapies.

    abstract:PURPOSE OF REVIEW:Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system most often characterized by clinical relapses and periods of remission. RECENT FINDINGS:The past decade has seen a dramatic increase in disease-modifying therapies for MS. Fourteen FDA-approved immunomodulato...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11908-017-0562-0

    authors: Levin SN,Kaplan TB

    更新日期:2017-02-01 00:00:00

  • Infections of the Central Nervous System in Returning Travelers and Immigrants.

    abstract:PURPOSE OF REVIEW:This review highlights current knowledge in travel-related neuroinfectious diseases, providing insight on approaches to prevention, diagnosis, and treatment of infections of the central nervous system (CNS) in travelers and immigrants. RECENT FINDINGS:Updates on travel vaccine recommendations includi...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11908-017-0594-5

    authors: Thompson H,Thakur K

    更新日期:2017-10-03 00:00:00

  • Update on the pathogenesis and management of pouchitis.

    abstract::Pouchitis is an inflammatory complication after restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA). IPAA is the surgical treatment of choice in patients with ulcerative colitis (UC) who require colectomy. Initial episodes of acute pouchitis generally respond to antibiotics but significant numbers of c...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-014-0442-9

    authors: Chowdhry S,Katz JA

    更新日期:2014-12-01 00:00:00

  • A 2015 Update on Ventilator-Associated Pneumonia: New Insights on Its Prevention, Diagnosis, and Treatment.

    abstract::Ventilator-associated pneumonia (VAP), an infection of the lower respiratory tract which occurs in association with mechanical ventilation, is one of the most common causes of nosocomial infection in the intensive care unit (ICU). VAP causes significant morbidity and mortality in critically ill patients including incr...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-015-0496-3

    authors: Waters B,Muscedere J

    更新日期:2015-08-01 00:00:00

  • Management and Prevention of Clostridium difficile-Associated Diarrhea.

    abstract::Clostridium difficile is a major cause of antibiotic-associated diarrhea. While treatment regimens for C. difficile have been available for decades, they remain less than optimal due to the frequent recurrences that occur after therapy is completed. Moreover, the morbidity and expense associated with C. difficile have...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-996-0032-6

    authors: Ciesla WP,Bobak DA

    更新日期:2001-04-01 00:00:00

  • Clinical Challenges in an Outbreak of COVID-19 in Wuhan, China: Concerns from Frontiers.

    abstract:Purpose of Review:In December 2019, outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected pneumonia patients were discovered in Wuhan City, Hubei Province, China. With the spread of the epidemic, new cases have been found in other regions of China and abroad. This review summarizes the curr...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11908-020-00738-7

    authors: Wang Y,Wang L,Li X,Gong Z

    更新日期:2020-01-01 00:00:00

  • Renal Transplantation in HIV-Positive Recipients.

    abstract::About 1% of all patients with end-stage renal disease in the United States are infected with HIV. With the introduction of highly active antiretroviral therapy (HAART), HIV death rates have declined 80%, and chronic diseases resulting from HIV have replaced opportunistic infections as the leading cause of death among ...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-009-0078-3

    authors: Locke JE,Segev DL

    更新日期:2010-01-01 00:00:00

  • The Microbiology and Management of Acute and Chronic Rhinosinusitis.

    abstract::Although most cases of rhinosinusitis are benign, the disruption of quality of life due to disease symptoms leads patients to seek early medical care. Ongoing debates dispute the definition, bacteriology, and medical management of chronic sinusitis, while the criteria for acute sinusitis are relatively well establishe...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-001-0022-7

    authors: Hadley JA

    更新日期:2001-06-01 00:00:00

  • Update on the Management of Hepatitis C in Liver Transplant Recipients.

    abstract::Hepatic failure due to hepatitis C is the leading indicator for orthotopic liver transplantation (OLT) in the United States. Unfortunately, recurrent hepatitis C virus infection is essentially universal following orthotopic liver transplantation. Although significant advances have been made in the past decade for the ...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-002-0049-4

    authors: A Bobak D,Yadavalli G

    更新日期:2002-04-01 00:00:00

  • Healthcare-associated bacterial meningitis.

    abstract::Healthcare-associated bacterial meningitis may occur after neurosurgical procedures, head trauma, and following placement of external or internal ventricular catheters. The likely microorganisms that cause meningitis in this setting (ie, staphylococci and gram-negative bacilli) are different from those that cause meni...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-011-0190-z

    authors: Laxmi S,Tunkel AR

    更新日期:2011-08-01 00:00:00

  • Ventilatory strategies in patients with sepsis and respiratory failure.

    abstract::Patients with sepsis may require mechanical ventilation due to the acute respiratory distress syndrome (ARDS). It has become increasingly accepted that mechanical ventilation can contribute to lung injury in these patients. The modern concept of ventilator-induced lung injury is described in the context of alveolar ov...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-005-0007-z

    authors: Hess DR,Thompson BT

    更新日期:2005-09-01 00:00:00

  • Management of HIV-infected Patients with Multidrug-resistant Virus.

    abstract::Heavily pretreated HIV-infected patients with multidrug-resistant virus remain a clinical challenge to the treating physician. While the goal of therapy in such patients is still controversial, sustained immunologic and clinical benefit have only been demonstrated with complete suppression of plasma viral load below d...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-002-0089-9

    authors: Montaner JS,Harris M

    更新日期:2002-06-01 00:00:00

  • Lessons from Suppressive Therapy and Periodic Presumptive Treatment for Bacterial Vaginosis.

    abstract:PURPOSE OF REVIEW:Suppressive therapy and periodic presumptive treatment (PPT) are distinct but related strategies that have been used to reduce the incidence of bacterial vaginosis (BV). Here, we review clinical trial evidence of the effectiveness of suppressive therapy and PPT to reduce BV, and discuss their roles fo...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11908-019-0688-3

    authors: Balkus JE,Carter KA,McClelland RS

    更新日期:2019-08-31 00:00:00

  • Diagnosis and Management of Candida and Other Fungal Infections of the Head and Neck.

    abstract::Fungi are common inhabitants of the oral and nasal mucosa, and therefore the differentiation between colonization and pathogenicity in the setting of upper respiratory tract infection symptoms can be difficult. Fungal head and neck infections occur in both immunocompetent and immunocompromised persons, and patients wi...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-002-0078-z

    authors: Miller DJ

    更新日期:2002-06-01 00:00:00

  • Rotavirus Vaccines: Current Controversies and Future Directions.

    abstract::Rotaviruses are the most important cause of pediatric gastroenteritis worldwide. In August 1998, a new rotavirus vaccine was licensed for general use in the United States. However, 14 months later, the vaccine was withdrawn from the market because of serious gastrointestinal side effects. This paper discusses the need...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-000-0090-0

    authors: Coffin SE

    更新日期:2000-02-01 00:00:00

  • Urinary Tract Infection in Postmenopausal Women.

    abstract::Urinary tract infection (UTI) is common in postmenopausal women; the estimated incidence ranges from 4% to 15%. The clinical presentation of UTI is somewhat different in postmenopausal older women than it is in younger women: postmenopausal women are less likely to report frequency, dysuria, hematuria, and fever, but ...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-999-0043-1

    authors: Foxman B

    更新日期:1999-10-01 00:00:00

  • Rapid Detection and Diagnosis of Group A Streptococcal Pharyngitis.

    abstract::This article reviews techniques of rapid testing and the effective diagnosis of streptococcal pharyngitis. Despite 50 years' study of streptococcal pharyngitis and 20 years' experience with rapid tests for its diagnosis, the subject continues to evolve. Rapid diagnostic tests have become more sensitive. Experts now co...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-004-0006-5

    authors: Corneli HM

    更新日期:2004-06-01 00:00:00

  • Management of Increased Intracranial Pressure in Cryptococcal Meningitis.

    abstract::Therapy of cryptococcal meningitis has been focused primarily on optimizing the antifungal regimen to improve the previously high treatment failure rates. Until recently, relatively little attention has been paid to the impact of increased intracranial pressure, which is a frequent problem that complicates management ...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-002-0026-y

    authors: Gambarin KJ,Hamill RJ

    更新日期:2002-08-01 00:00:00

  • Clinical Decision Support Systems and Their Role in Antibiotic Stewardship: a Systematic Review.

    abstract:PURPOSE OF REVIEW:The purpose of this article is to perform a systematic review over the past 5 years on the role and effectiveness of clinical decision support systems (CDSSs) on antibiotic stewardship. RECENT FINDINGS:CDDS interventions found a significant impact on multiple outcomes relevant to antibiotic stewardsh...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-019-0683-8

    authors: Rittmann B,Stevens MP

    更新日期:2019-07-24 00:00:00

  • Syndromic Diagnosis in Evaluation of Women with Symptoms of Vaginitis.

    abstract:PURPOSE OF REVIEW:This review aims to determine the effectiveness of the use of syndrome diagnosis in the evaluation of vaginitis and to make suggestions based on the review findings. RECENT FINDINGS:Vaginal discharge as the main symptom of vaginitis is unspecific. A randomized study of symptom-based diagnosis and tre...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11908-017-0558-9

    authors: Nwankwo TO,Aniebue UU,Umeh UA

    更新日期:2017-01-01 00:00:00

  • HIV in Africa: Challenges and Directions for the Next Decade.

    abstract::Africa carries a disproportionate burden of the global HIV endemic, accounting for two thirds of the global 33.3 million people living with HIV. While tremendous advances have been made in addressing the HIV epidemic in Africa, considerable challenges remain. Testing for HIV increased by 86% from 2007 to 2009 but more...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-011-0230-8

    authors: Gilliam BL,Patel D,Talwani R,Temesgen Z

    更新日期:2012-02-01 00:00:00

  • Probiotics and prebiotics for the prevention of necrotizing enterocolitis.

    abstract::Necrotizing enterocolitis (NEC) continues to be a major cause of morbidity and mortality in premature infants. Although the pathogenesis of NEC remains unclear, abnormal bacterial colonization has been postulated as playing a central role. Various factors impact bacterial colonization following delivery. Compared to t...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-010-0156-6

    authors: Stenger MR,Reber KM,Giannone PJ,Nankervis CA

    更新日期:2011-02-01 00:00:00

  • New Drugs in the Pipeline for the Treatment of HIV: a Review.

    abstract:PURPOSE OF REVIEW:The purpose of this paper is to review therapies with new mechanisms of action for the treatment of HIV that are at least in phase 2 clinical trials. RECENT FINDINGS:There are several new mechanisms of action being represented within clinical development, including histone deacetylase (HDAC) inhibito...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11908-017-0601-x

    authors: Gravatt LAH,Leibrand CR,Patel S,McRae M

    更新日期:2017-09-19 00:00:00

  • Cyclosporiasis: an update.

    abstract::Cyclosporiasis is a food- and water-borne infection that affects healthy and immunocompromised individuals. Awareness of the disease has increased, and outbreaks continue to be reported among vulnerable hosts and now among local residents in endemic areas. Advances in molecular techniques have improved identification ...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-009-0016-4

    authors: Warren CA

    更新日期:2009-03-01 00:00:00

  • Biofilm Formations in Pediatric Respiratory Tract Infection Part 2: Mucosal Biofilm Formation by Respiratory Pathogens and Current and Future Therapeutic Strategies to Inhibit Biofilm Formation or Eradicate Established Biofilm.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to discuss the unique pathways of biofilm formation utilized by respiratory pathogens and current and future therapeutic strategies to inhibit biofilm formation or eradicate established biofilm in the context of these pathogens. Both nonselective and selective strategies ...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11908-019-0657-x

    authors: Hamilos DL

    更新日期:2019-03-02 00:00:00

  • Combination antifungal therapy for the treatment of invasive yeast and mold infections.

    abstract::Combination antifungal therapy has been an area of great research and clinical interest since antifungals became available decades ago, in part driven by the severe morbidity and mortality associated with invasive fungal infections. Because of the availability of newer antifungal agents including echinocandins and exp...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-007-0069-1

    authors: Baddley JW,Pappas PG

    更新日期:2007-11-01 00:00:00

  • Recent advances in the treatment of mucormycosis.

    abstract::In recent years, substantial advances have been achieved in the treatment of mucormycosis. It is now clear that early initiation of therapy results in substantially better outcomes, underscoring the need to maintain a high index of suspicion and aggressively biopsy potential lesions. Increasing data support the need f...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-010-0129-9

    authors: Spellberg B,Ibrahim AS

    更新日期:2010-11-01 00:00:00

  • Antipsychotic drug use and community-acquired pneumonia.

    abstract::Antipsychotics are generally distinguished as atypical and typical agents, which are indicated in the treatment of acute and chronic psychoses and other psychiatric disorders. In April 2005, the US Food and Drug Administration issued a warning about the increased risk of all-cause mortality associated with atypical an...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-011-0175-y

    authors: Trifirò G

    更新日期:2011-06-01 00:00:00