Abstract：
:Patients with sepsis may require mechanical ventilation due to the acute respiratory distress syndrome (ARDS). It has become increasingly accepted that mechanical ventilation can contribute to lung injury in these patients. The modern concept of ventilator-induced lung injury is described in the context of alveolar over-distention (volutrauma), alveolar de-recruitment (atelectrauma), and biochemical injury and inflammation to the lung parenchyma (biotrauma). To avoid over-distention lung injury, the tidal volume should be set at 6 mL/kg predicted body weight and plateau pressure should be limited to 30 cm H2O. This has been shown to afford a survival benefit. Although setting positive end-expiratory pressure (PEEP) to zero is likely harmful during mechanical ventilation of patients with ARDS, evidence is lacking for a survival benefit if a high PEEP level is set compared with a modest level of PEEP. Although adjunctive measures such as recruitment maneuvers, prone position, and inhaled nitric oxide may improve oxygenation, evidence is lacking that these measures improve survival.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Hess DR,Thompson BTdoi
10.1007/s11908-005-0007-zkeywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
342-8issue
5eissn
1523-3847issn
1534-3146journal_volume
7pub_type
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journal_title：Current infectious disease reports
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更新日期：1999-04-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
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更新日期：2019-03-02 00:00:00
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journal_title：Current infectious disease reports
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更新日期：2005-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2002-10-01 00:00:00
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更新日期：2008-11-01 00:00:00
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更新日期：2009-03-01 00:00:00
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更新日期：2006-03-01 00:00:00
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更新日期：2007-11-01 00:00:00
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更新日期：2002-04-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2004-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11908-004-0038-x
更新日期：2004-10-01 00:00:00
