Abstract:
:Elderly are at high risk for hospitalization for community-acquired pneumonia (CAP), especially due to Streptococcus pneumoniae, and seasonal influenza viruses. Data suggest PPV23's influence on various CAP-related outcomes among the elderly may depend upon how many years have elapsed since they received this vaccine. PPV23's protection against invasive pneumococcal disease and CAP hospitalizations are often limited to moderately ill elderly, who are less than 75 years old, or female. PCV13 demonstrates broad protection against a variety of CAPs, but ultimately, its influence on their outcomes among the elderly may be limited by herd immunity from PCV7 use. Influenza vaccine's indirect protective effect against all-cause and non-invasive pneumococcal CAP in the elderly is difficult to ascertain. The use of both PPV23 and influenza vaccine shortens length of stay in hospitalized elderly with CAP, but whether that benefit would be realized in the presence of herd immunity is unknown.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Gubbins PO,Li Cdoi
10.1007/s11908-015-0505-6subject
Has Abstractpub_date
2015-12-01 00:00:00pages
49issue
12eissn
1523-3847issn
1534-3146pii
10.1007/s11908-015-0505-6journal_volume
17pub_type
杂志文章abstract:PURPOSE OF REVIEW:The increase in drug-resistant community-acquired pneumonia (CAP) is an important problem all over the world. This article explores the current state of antimicrobial resistance of different bacteria that cause CAP and also assesses risk factors to identify those pathogens. RECENT FINDINGS:In the las...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0565-x
更新日期:2017-03-01 00:00:00
abstract::Candida species remain the most frequently isolated fungi in intensive care unit (ICU) patients with severe sepsis or septic shock. Delayed antifungal therapy in these patients is a recognized risk factor for mortality. However, the diagnosis of invasive candidiasis remains difficult and is frequently delayed. Clinica...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0204-x
更新日期:2011-10-01 00:00:00
abstract::In an era of cost-consciousness in the delivery of medical care, the economics of healthcare delivery for HIV-infected persons has been an area of active interest. Interested parties include the payors of HIV care, particularly public insurers, who are paying for an increasing amount of the overall cost of HIV care in...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0018-8
更新日期:2000-08-01 00:00:00
abstract::During much of the past century, the microbe itself stood at the heart of microbial pathogenesis. Little thought was devoted to the host per se, though it was granted that differences in susceptibility to certain infections did exist between individuals, and between different ethnic groups. During the past 20 years, e...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-007-1009-9
更新日期:2007-10-01 00:00:00
abstract::Increases in sexually transmitted diseases (STDs) among men who have sex with men (MSM) have coincided with recent increases in sexual risk behaviors across the United States and Europe. The identification of same-sex sexual risk behavior in men and the subsequent risk for certain bacterial and viral infections requir...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-003-0050-6
更新日期:2003-04-01 00:00:00
abstract::Cervical lymphadenopathy is a common problem in children. The condition most commonly represents a transient response to a benign local or generalized infection. Acute bilateral cervical lymphadenitis is usually caused by a viral upper respiratory tract infection or streptococcal pharyngitis. Acute unilateral cervical...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-009-0028-0
更新日期:2009-05-01 00:00:00
abstract::In the United States each year, influenza accounts for an estimated 20,000 to 40,000 deaths, nearly 300,000 hospitalizations, and millions of days lost from work. In the past few years, there has been an explosion of information in the medical literature related to influenza. This paper reviews these latest developmen...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0039-3
更新日期:2000-06-01 00:00:00
abstract::Although mixed infections are known to be clinically relevant in conditions such as nosocomial pneumonia and ventilator-related pneumonia, it is increasingly recognized that a substantial number of community-acquired lower respiratory tract infections may also be attributed to more than one pathogenic organism. A bett...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-007-0017-0
更新日期:2007-01-01 00:00:00
abstract::Nontuberculous mycobacteria (NTM) are ubiquitous in the environment and cause a wide range of diseases in humans. Pulmonary involvement, the most common disease manifestation of NTM infection, is being increasingly encountered in clinical settings. In addition, specific phenotypic and genetic characteristics of person...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-010-0103-6
更新日期:2010-05-01 00:00:00
abstract::Immunization against the most common meningeal pathogens is the leading factor associated with decreased incidence of bacterial meningitis in countries where routine vaccination is available. This is most dramatically illustrated by the reduction in the incidence of Haemophilus influenzae type b meningitis. The incide...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-007-0047-7
更新日期:2007-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Acinetobacter baumannii (AB) is an infamous nosocomial pathogen with a seemingly limitless capacity for antimicrobial resistance, leading to few treatment options and poor clinical outcomes. The debatably low pathogenicity and virulence of AB are juxtaposed by its exceptionally high rate of infection-...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-019-0706-5
更新日期:2019-11-16 00:00:00
abstract::Necrotizing enterocolitis (NEC) continues to be a major cause of morbidity and mortality in premature infants. Although the pathogenesis of NEC remains unclear, abnormal bacterial colonization has been postulated as playing a central role. Various factors impact bacterial colonization following delivery. Compared to t...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-010-0156-6
更新日期:2011-02-01 00:00:00
abstract::Group A streptococcus is a widespread human pathogen that causes a broad spectrum of human disease. The persistent high burden and severity of illness in developing and industrialized countries speaks to the need for a safe and effective vaccine. Modern approaches to vaccine construction include M protein type-specifi...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-008-0032-9
更新日期:2008-05-01 00:00:00
abstract:Purpose of Review:In December 2019, outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected pneumonia patients were discovered in Wuhan City, Hubei Province, China. With the spread of the epidemic, new cases have been found in other regions of China and abroad. This review summarizes the curr...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-020-00738-7
更新日期:2020-01-01 00:00:00
abstract::This article reviews techniques of rapid testing and the effective diagnosis of streptococcal pharyngitis. Despite 50 years' study of streptococcal pharyngitis and 20 years' experience with rapid tests for its diagnosis, the subject continues to evolve. Rapid diagnostic tests have become more sensitive. Experts now co...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-004-0006-5
更新日期:2004-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Modern advances in malaria rapid diagnostic test (RDT) technology have increased demand for low-cost, easy-to-use assays in areas endemic for malaria. Substantial developments in diagnostic sensitivity and specificity, improvements in non-falciparum RDTs, and novel biotechnological innovations are gra...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-018-0655-4
更新日期:2018-10-23 00:00:00
abstract::Infectious myositis is defined as an infection of a skeletal muscle. Infectious myositis is most commonly caused by bacteria; however, a variety of viral, parasitic, and fungal agents may also cause myositis. The pathogenesis of nonbacterial infectious myositis is via direct or hematogenous infection of the musculatur...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-010-0118-z
更新日期:2010-09-01 00:00:00
abstract::The possibility that infection with Chlamydia pneumoniae may somehow contribute to the pathogenesis of atherosclerosis continues to be explored by researchers worldwide. A direct cause-and-effect relationship between the bacterium and subsequent development of atherosclerosis has yet to be proved. However, compelling ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-996-0021-9
更新日期:1999-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This review highlights current knowledge in travel-related neuroinfectious diseases, providing insight on approaches to prevention, diagnosis, and treatment of infections of the central nervous system (CNS) in travelers and immigrants. RECENT FINDINGS:Updates on travel vaccine recommendations includi...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0594-5
更新日期:2017-10-03 00:00:00
abstract::Lower respiratory tract infections (LRTIs) are a global burden to public health and are frequently caused by respiratory viruses. Advances in molecular diagnostic techniques have allowed the identification of previously undetected viral pathogens and have improved our understanding of respiratory virus infections. Her...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-012-0258-4
更新日期:2012-06-01 00:00:00
abstract::Combination antifungal therapy has been an area of great research and clinical interest since antifungals became available decades ago, in part driven by the severe morbidity and mortality associated with invasive fungal infections. Because of the availability of newer antifungal agents including echinocandins and exp...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-007-0069-1
更新日期:2007-11-01 00:00:00
abstract::Although most cases of rhinosinusitis are benign, the disruption of quality of life due to disease symptoms leads patients to seek early medical care. Ongoing debates dispute the definition, bacteriology, and medical management of chronic sinusitis, while the criteria for acute sinusitis are relatively well establishe...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-001-0022-7
更新日期:2001-06-01 00:00:00
abstract::Clostridium difficile is a major cause of antibiotic-associated diarrhea. While treatment regimens for C. difficile have been available for decades, they remain less than optimal due to the frequent recurrences that occur after therapy is completed. Moreover, the morbidity and expense associated with C. difficile have...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-996-0032-6
更新日期:2001-04-01 00:00:00
abstract::Pyoderma gangrenosum (PG) is a rare cause of purulent vulvovaginal ulceration. Six recent cases of vulvovaginal pyoderma gangrenosum associated with rituximab are described. All cases were seen in the setting of rituximab used for the treatment of B cell non Hodgkin's lymphoma (NHL). Age range was 50-74; symptoms were...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-015-0478-5
更新日期:2015-05-01 00:00:00
abstract::Hepatic failure due to hepatitis C is the leading indicator for orthotopic liver transplantation (OLT) in the United States. Unfortunately, recurrent hepatitis C virus infection is essentially universal following orthotopic liver transplantation. Although significant advances have been made in the past decade for the ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0049-4
更新日期:2002-04-01 00:00:00
abstract::Rates of syphilis continue to increase in the United States and HIV-infected patients make up a large proportion of cases. The interaction between syphilis and HIV is complex and still incompletely understood. Although diagnosis and management of HIV-infected patients with syphilis is, in general, similar to HIV-uninf...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-010-0083-6
更新日期:2010-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The global emergence of antifungal resistance among Candida spp. and Aspergillus spp. is a growing threat to public health, driven largely by the expanding use of antifungals in both the clinical and agricultural settings. As treatment options remain limited, understanding mechanisms and risk factors ...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-019-0702-9
更新日期:2019-11-16 00:00:00
abstract::Community-acquired pneumonia is a common reason for hospitalization and leads to significant morbidity and mortality. There are published evidence-based guidelines for the diagnosis, treatment, and management of community-acquired pneumonia. Many countries, including the US, have developed national, publically reporte...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0395-z
更新日期:2014-02-01 00:00:00
abstract::Hepatitis delta virus (HDV) is a unique human virus, showing similarities with plant viroids. Although impressive knowledge on virus structure and replication has been achieved, several questions like HBV/HDV interaction and post translational modifications of HD antigens remain to be answered. Potential targets for t...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0233-5
更新日期:2012-02-01 00:00:00
abstract::Antipsychotics are generally distinguished as atypical and typical agents, which are indicated in the treatment of acute and chronic psychoses and other psychiatric disorders. In April 2005, the US Food and Drug Administration issued a warning about the increased risk of all-cause mortality associated with atypical an...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0175-y
更新日期:2011-06-01 00:00:00