Abstract：
:Candida species remain the most frequently isolated fungi in intensive care unit (ICU) patients with severe sepsis or septic shock. Delayed antifungal therapy in these patients is a recognized risk factor for mortality. However, the diagnosis of invasive candidiasis remains difficult and is frequently delayed. Clinical scores have been proposed to assess the risk of development of invasive candidiasis or candidemia. Laboratory tools for early diagnosis are disappointing or still under development. Triazoles, polyenes, and echinocandins are the key drugs used to treat invasive candidiasis in ICU patients with similar efficacy, but very variable tolerability. The increasing incidence of fluconazole-resistant and susceptible-dose dependent strains and the safety profile of antifungal agents must be taken into account when selecting empiric therapy, frequently leading to the initial use of echinocandins in ICU patients with severe sepsis or septic shock.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Allou N,Allyn J,Montravers Pdoi
10.1007/s11908-011-0204-xsubject
Has Abstractpub_date
2011-10-01 00:00:00pages
426-32issue
5eissn
1523-3847issn
1534-3146journal_volume
13pub_type
杂志文章abstract：PURPOSE OF REVIEW:Community-acquired pneumonia (CAP) is the cause of a considerable burden of morbidity and mortality among HIV-infected patients. The purpose of this study was to review recent literature for epidemiological trends and management of CAP in HIV patients. RECENT FINDINGS:While the specific infectious et...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0559-8
更新日期：2017-01-01 00:00:00
abstract：:Although mixed infections are known to be clinically relevant in conditions such as nosocomial pneumonia and ventilator-related pneumonia, it is increasingly recognized that a substantial number of community-acquired lower respiratory tract infections may also be attributed to more than one pathogenic organism. A bett...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0017-0
更新日期：2007-01-01 00:00:00
abstract：:The outcome for HIV-infected patients with cancer has dramatically improved in the highly active antiretroviral therapy (HAART) era, probably due to improvements in immune status and bone marrow function that allow the possibility of increased drug-dose intensity with a higher complete remission rate. Although data re...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-008-0026-7
更新日期：2008-05-01 00:00:00
abstract：:This article reviews techniques of rapid testing and the effective diagnosis of streptococcal pharyngitis. Despite 50 years' study of streptococcal pharyngitis and 20 years' experience with rapid tests for its diagnosis, the subject continues to evolve. Rapid diagnostic tests have become more sensitive. Experts now co...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-004-0006-5
更新日期：2004-06-01 00:00:00
abstract：:Bacterial meningitis is a complex disorder in which neurologic injury is caused, in part, by the causative organism and, in part, by the host's own inflammatory response. In studies of experimental bacterial meningitis, adjuvant treatment with corticosteroids, specifically dexamethasone, has beneficial effects. On the...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-005-0061-6
更新日期：2005-07-01 00:00:00
abstract：:Drotrecogin alfa (activated) (DrotAA) has been approved for therapy of severe sepsis and septic shock for 7 years, but controversy persists regarding efficacy and safety. Only a single randomized, controlled trial (Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis; PROWESS) has shown evidence...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-008-0060-5
更新日期：2008-09-01 00:00:00
abstract：:Immunization against the most common meningeal pathogens is the leading factor associated with decreased incidence of bacterial meningitis in countries where routine vaccination is available. This is most dramatically illustrated by the reduction in the incidence of Haemophilus influenzae type b meningitis. The incide...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0047-7
更新日期：2007-07-01 00:00:00
abstract：:In an era of cost-consciousness in the delivery of medical care, the economics of healthcare delivery for HIV-infected persons has been an area of active interest. Interested parties include the payors of HIV care, particularly public insurers, who are paying for an increasing amount of the overall cost of HIV care in...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0018-8
更新日期：2000-08-01 00:00:00
abstract：:Three newer oral antifungal agents, itraconazole, terbinafine and fluconazole, have revolutionized treatment of superficial mycoses. The tissue pharmacokinetics of itraconazole and terbinafine allow much shorter courses of therapy- with higher efficacy-in the treatment of onychomycosis, compared to other oral agents. ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0074-0
更新日期：2000-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Suppressive therapy and periodic presumptive treatment (PPT) are distinct but related strategies that have been used to reduce the incidence of bacterial vaginosis (BV). Here, we review clinical trial evidence of the effectiveness of suppressive therapy and PPT to reduce BV, and discuss their roles fo...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-019-0688-3
更新日期：2019-08-31 00:00:00
abstract：:Carbapenems are the broadest spectrum antimicrobials utilized in the treatment of serious infections since the 1980s. Soon after their introduction, the discovery of carbapenem-resistant Enterobacteriaceae (CRE) was reported in the 1990s. Invasive CRE infections are associated with high mortality and limited treatment...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-016-0548-3
更新日期：2016-12-01 00:00:00
abstract：:Infections due to community-associated methicillin---resistant Staphylococcus aureus (CA-MRSA) are becoming more prevalent. CA-MRSA infections have unique epidemiologic features and virulence factors. Compared with health care-associated MRSA (HA-MRSA), most CA-MRSA is clonal type USA300 or 400 and has the Staphylococ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-008-0005-z
更新日期：2008-03-01 00:00:00
abstract：Purpose of Review:In December 2019, outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected pneumonia patients were discovered in Wuhan City, Hubei Province, China. With the spread of the epidemic, new cases have been found in other regions of China and abroad. This review summarizes the curr...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-020-00738-7
更新日期：2020-01-01 00:00:00
abstract：:Rates of syphilis continue to increase in the United States and HIV-infected patients make up a large proportion of cases. The interaction between syphilis and HIV is complex and still incompletely understood. Although diagnosis and management of HIV-infected patients with syphilis is, in general, similar to HIV-uninf...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-010-0083-6
更新日期：2010-03-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection is a significant cause of chronic liver disease with substantial long-term sequelae. Until very recently, therapies to cure HCV were hindered by high nonresponse rates and severe side effects. The first-generation protease inhibitor-containing regimens provided superior cure rates for...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-014-0413-1
更新日期：2014-08-01 00:00:00
abstract：:Patients with sepsis may require mechanical ventilation due to the acute respiratory distress syndrome (ARDS). It has become increasingly accepted that mechanical ventilation can contribute to lung injury in these patients. The modern concept of ventilator-induced lung injury is described in the context of alveolar ov...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-005-0007-z
更新日期：2005-09-01 00:00:00
abstract：:Determining the microbiologic etiology of enteric infection remains an elusive goal. Conventional approaches, including culture, microscopy, and antigen-based tests have significant limitations such as limit of detection and the need for multiple procedures. Molecular diagnostics, especially PCR based tests, are rapid...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-011-0223-7
更新日期：2012-02-01 00:00:00
abstract：:Bacterial vaginosis (BV) is a common cause of vaginal discharge in women of childbearing age. In some individuals, it recurs frequently after treatment, frustrating both the patient and the physician. Standard BV treatment--metronidazole or clindamycin, administered either intravaginally or orally--is followed by rela...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0053-5
更新日期：2000-12-01 00:00:00
abstract：:Therapy of cryptococcal meningitis has been focused primarily on optimizing the antifungal regimen to improve the previously high treatment failure rates. Until recently, relatively little attention has been paid to the impact of increased intracranial pressure, which is a frequent problem that complicates management ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-002-0026-y
更新日期：2002-08-01 00:00:00
abstract：:Antimicrobial resistance is a growing problem globally. The appearance and spread of bacteria that are resistant to most or all commonly available antibiotics has raised the specter of untreatable bacterial infections. The New Delhi metallo-beta-lactamase-1 (NDM-1) has received wide attention because of the extreme re...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-012-0252-x
更新日期：2012-06-01 00:00:00
abstract：:A broad range of disorders can cause inflammation of the thyroid gland. True thyroid infections are rare and can result from a variety of microorganisms, of which bacteria are the most common. Other rarer pathogens include fungi, parasites, and viruses. Gram-positive bacteria, especially staphylococci, predominate as ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0027-7
更新日期：2000-04-01 00:00:00
abstract：:Solid organ and hematopoietic stem cell transplant recipients may be exposed to diseases which may be prevented through live attenuated virus vaccines (LAVV). Because of their immunosuppression, these diseases can lead to severe complications in transplant recipients. Despite increasing evidence regarding the safety a...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0472-y
更新日期：2015-04-01 00:00:00
abstract：:Transmissible spongiform encephalopathies (TSEs) are a group of progressive, fatal neurodegenerative disorders that share a common spongiform histopathology. TSEs may be transmitted in a sporadic, familial, iatrogenic, or zoonotic fashion. The putative infectious agent of TSE, the prion, represents a novel paradigm of...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-004-0053-y
更新日期：2004-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Since the treatment of acute diverticulitis has become more conservative over the last years, knowledge of conservative treatment strategies is increasingly important. RECENT FINDINGS:Several treatment strategies that previously have been imposed as routine treatment are now obsolete. Uncomplicated d...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0600-y
更新日期：2017-09-23 00:00:00
abstract：:Eosinophilia in patients exposed to tropical or subtropical environments is caused most commonly by helminth (worm) infections. Besides a detailed exposure history, the diagnostic approach must consider other infections and noninfectious causes of eosinophilia, as treatments for many of these disorders differ. ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-006-0034-4
更新日期：2006-01-01 00:00:00
abstract：:Streptococcus bovis is a rare, but important cause of bacterial meningitis in children. Since its discovery in the early 1970s, the pathogen has undergone multiple taxonomic changes producing four distinct subspecies today, the most prevalent of which is S. gallolyticus subsp pasteurianus in infants and children. Whil...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-016-0519-8
更新日期：2016-03-01 00:00:00
abstract：PURPOSE OF REVIEW:The infectious complications of transplantation can have devastating consequences for patients. Early and accurate diagnosis is essential to good outcomes. This review describes recent advances in pathogen-directed diagnostic testing and discusses the role of new methods for transplant infectious dise...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-019-0704-7
更新日期：2019-11-26 00:00:00
abstract：:Africa carries a disproportionate burden of the global HIV endemic, accounting for two thirds of the global 33.3 million people living with HIV. While tremendous advances have been made in addressing the HIV epidemic in Africa, considerable challenges remain. Testing for HIV increased by 86% from 2007 to 2009 but more...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-011-0230-8
更新日期：2012-02-01 00:00:00
abstract：:The incidence of end-stage liver disease (ESLD) is increasing and many of these patients may be considered for orthotopic liver transplantation. As patients with ESLD are at risk of a number of infections, infectious disease physicians should be aware of the management of these infections in order to provide optimal p...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0514-5
更新日期：2016-01-01 00:00:00
abstract：PURPOSE OF REVIEW:The increase in drug-resistant community-acquired pneumonia (CAP) is an important problem all over the world. This article explores the current state of antimicrobial resistance of different bacteria that cause CAP and also assesses risk factors to identify those pathogens. RECENT FINDINGS:In the las...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0565-x
更新日期：2017-03-01 00:00:00
