Abstract：
:Bacterial meningitis is a complex disorder in which neurologic injury is caused, in part, by the causative organism and, in part, by the host's own inflammatory response. In studies of experimental bacterial meningitis, adjuvant treatment with corticosteroids, specifically dexamethasone, has beneficial effects. On the basis of these experimental studies, several clinical trials were undertaken to determine the effects of adjunctive corticosteroids in patients with bacterial meningitis. On the basis of overall benefit without detrimental effects by subgroup analysis, dexamethasone therapy should be initiated before or with the first dose of antibiotic and should be continued in most patients with community-acquired acute bacterial meningitis. For patients with a low suspicion of meningitis but an urgent need for antibiotics before cerebrospinal fluid can be obtained, we recommend initiation of treatment with dexamethasone, with discontinuation of dexamethasone therapy as soon as the diagnosis has been excluded.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
van de Beek D,de Gans Jdoi
10.1007/s11908-005-0061-6keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
285-291issue
4eissn
1523-3847issn
1534-3146journal_volume
7pub_type
杂志文章abstract：:During much of the past century, the microbe itself stood at the heart of microbial pathogenesis. Little thought was devoted to the host per se, though it was granted that differences in susceptibility to certain infections did exist between individuals, and between different ethnic groups. During the past 20 years, e...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-1009-9
更新日期：2007-10-01 00:00:00
abstract：:Infections due to community-associated methicillin---resistant Staphylococcus aureus (CA-MRSA) are becoming more prevalent. CA-MRSA infections have unique epidemiologic features and virulence factors. Compared with health care-associated MRSA (HA-MRSA), most CA-MRSA is clonal type USA300 or 400 and has the Staphylococ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-008-0005-z
更新日期：2008-03-01 00:00:00
abstract：:Neurocysticercosis, caused by infection with the pork tapeworm Taenia solium, is increasingly recognized as a cause of neurologic disease worldwide. Because the clinical presentation is nonspecific, diagnosis has been difficult. Advances in imaging studies and serodiagnostic techniques are facilitating the diagnosis o...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-005-0022-0
更新日期：2005-01-01 00:00:00
abstract：:A broad range of disorders can cause inflammation of the thyroid gland. True thyroid infections are rare and can result from a variety of microorganisms, of which bacteria are the most common. Other rarer pathogens include fungi, parasites, and viruses. Gram-positive bacteria, especially staphylococci, predominate as ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0027-7
更新日期：2000-04-01 00:00:00
abstract：:Hepatic failure due to hepatitis C is the leading indicator for orthotopic liver transplantation (OLT) in the United States. Unfortunately, recurrent hepatitis C virus infection is essentially universal following orthotopic liver transplantation. Although significant advances have been made in the past decade for the ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-002-0049-4
更新日期：2002-04-01 00:00:00
abstract：:Bacterial vaginosis (BV) is a common cause of vaginal discharge in women of childbearing age. In some individuals, it recurs frequently after treatment, frustrating both the patient and the physician. Standard BV treatment--metronidazole or clindamycin, administered either intravaginally or orally--is followed by rela...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0053-5
更新日期：2000-12-01 00:00:00
abstract：:Ventilator-associated pneumonia (VAP), an infection of the lower respiratory tract which occurs in association with mechanical ventilation, is one of the most common causes of nosocomial infection in the intensive care unit (ICU). VAP causes significant morbidity and mortality in critically ill patients including incr...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0496-3
更新日期：2015-08-01 00:00:00
abstract：:Cyclosporiasis is a food- and water-borne infection that affects healthy and immunocompromised individuals. Awareness of the disease has increased, and outbreaks continue to be reported among vulnerable hosts and now among local residents in endemic areas. Advances in molecular techniques have improved identification ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-009-0016-4
更新日期：2009-03-01 00:00:00
abstract：:Solid organ and hematopoietic stem cell transplant recipients may be exposed to diseases which may be prevented through live attenuated virus vaccines (LAVV). Because of their immunosuppression, these diseases can lead to severe complications in transplant recipients. Despite increasing evidence regarding the safety a...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0472-y
更新日期：2015-04-01 00:00:00
abstract：:Group A streptococcus is a widespread human pathogen that causes a broad spectrum of human disease. The persistent high burden and severity of illness in developing and industrialized countries speaks to the need for a safe and effective vaccine. Modern approaches to vaccine construction include M protein type-specifi...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-008-0032-9
更新日期：2008-05-01 00:00:00
abstract：:In the United States each year, influenza accounts for an estimated 20,000 to 40,000 deaths, nearly 300,000 hospitalizations, and millions of days lost from work. In the past few years, there has been an explosion of information in the medical literature related to influenza. This paper reviews these latest developmen...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0039-3
更新日期：2000-06-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this article is to perform a systematic review over the past 5 years on the role and effectiveness of clinical decision support systems (CDSSs) on antibiotic stewardship. RECENT FINDINGS:CDDS interventions found a significant impact on multiple outcomes relevant to antibiotic stewardsh...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-019-0683-8
更新日期：2019-07-24 00:00:00
abstract：:The dogma is that the higher risk of pyelonephritis in pregnant women is explained entirely by anatomic/obstructive changes. If so, gestational pyelonephritis should be caused by random, nonpathogenic bacteria. Instead, gestational pyelonephritis is associated with a narrow group of genetically related Escherichia col...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-002-0041-z
更新日期：2002-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system most often characterized by clinical relapses and periods of remission. RECENT FINDINGS:The past decade has seen a dramatic increase in disease-modifying therapies for MS. Fourteen FDA-approved immunomodulato...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0562-0
更新日期：2017-02-01 00:00:00
abstract：:In recent years, substantial advances have been achieved in the treatment of mucormycosis. It is now clear that early initiation of therapy results in substantially better outcomes, underscoring the need to maintain a high index of suspicion and aggressively biopsy potential lesions. Increasing data support the need f...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-010-0129-9
更新日期：2010-11-01 00:00:00
abstract：:Carbapenems are the broadest spectrum antimicrobials utilized in the treatment of serious infections since the 1980s. Soon after their introduction, the discovery of carbapenem-resistant Enterobacteriaceae (CRE) was reported in the 1990s. Invasive CRE infections are associated with high mortality and limited treatment...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-016-0548-3
更新日期：2016-12-01 00:00:00
abstract：:Pulmonary nocardiosis is an uncommon but serious infection that is increasingly found in immunosuppressed persons, especially transplant recipients and persons with AIDS. The Nocardia species are denizens of soil and decaying plants that gain entry to humans through inhalation or inoculation. Pulmonary nocardiosis typ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-001-0032-5
更新日期：2001-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Suppressive therapy and periodic presumptive treatment (PPT) are distinct but related strategies that have been used to reduce the incidence of bacterial vaginosis (BV). Here, we review clinical trial evidence of the effectiveness of suppressive therapy and PPT to reduce BV, and discuss their roles fo...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-019-0688-3
更新日期：2019-08-31 00:00:00
abstract：:Immunization against the most common meningeal pathogens is the leading factor associated with decreased incidence of bacterial meningitis in countries where routine vaccination is available. This is most dramatically illustrated by the reduction in the incidence of Haemophilus influenzae type b meningitis. The incide...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0047-7
更新日期：2007-07-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to discuss the unique pathways of biofilm formation utilized by respiratory pathogens and current and future therapeutic strategies to inhibit biofilm formation or eradicate established biofilm in the context of these pathogens. Both nonselective and selective strategies ...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-019-0657-x
更新日期：2019-03-02 00:00:00
abstract：:Although most cases of rhinosinusitis are benign, the disruption of quality of life due to disease symptoms leads patients to seek early medical care. Ongoing debates dispute the definition, bacteriology, and medical management of chronic sinusitis, while the criteria for acute sinusitis are relatively well establishe...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-001-0022-7
更新日期：2001-06-01 00:00:00
abstract：:About 1% of all patients with end-stage renal disease in the United States are infected with HIV. With the introduction of highly active antiretroviral therapy (HAART), HIV death rates have declined 80%, and chronic diseases resulting from HIV have replaced opportunistic infections as the leading cause of death among ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-009-0078-3
更新日期：2010-01-01 00:00:00
abstract：:Urinary tract infection (UTI) is a common clinical syndrome in women. Most UTIs are caused by Escherichia coli. UTI has become a productive and accessible model system for studying the molecular details of how bacteria interact with mucosal surfaces and the nature of the host response. Important advances in the past y...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-006-0021-9
更新日期：2006-11-01 00:00:00
abstract：:Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have been reported with increasing frequency from many parts of the world. Most infections involve the skin and soft tissue structures, and CA-MRSA is now the most commonly identifiable cause of purulent skin and soft tissue infectio...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0061-9
更新日期：2007-09-01 00:00:00
abstract：PURPOSE OF THE REVIEW:Community-acquired pneumonia (CAP) is still associated with a large burden and causes significant morbidity and mortality. Besides universal vaccination and antibiotic treatment, statins as adjunctive therapy may also have a beneficial role in the prevention and treatment of CAP. Our goal from thi...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0581-x
更新日期：2017-08-01 00:00:00
abstract：:Colonization with Staphylococcus aureus is a risk factor for invasive S. aureus infections. Intranasal mupirocin has effectively eradicated S. aureus colonization and appears to prevent S. aureus nosocomial infections in some patient populations. In hospitals and communities where mupirocin use has been widespread, re...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-004-0062-x
更新日期：2004-12-01 00:00:00
abstract：:Rates of syphilis continue to increase in the United States and HIV-infected patients make up a large proportion of cases. The interaction between syphilis and HIV is complex and still incompletely understood. Although diagnosis and management of HIV-infected patients with syphilis is, in general, similar to HIV-uninf...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-010-0083-6
更新日期：2010-03-01 00:00:00
abstract：:Starting from 2010, the 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in several countries. This paper discusses some of the problems recently emerged after PCV13 use and their clinical impact. The impact of PCV13 has been relevant and has saved millions of children and adults by severe infectious di...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-018-0607-z
更新日期：2018-01-24 00:00:00
abstract：:Candida species are an important cause of health care-related bloodstream infections (BSI). Understanding the current Candida BSI incidence trends, the dominant species causing disease, and the mortality associated with this infection are important to help guide therapeutic and prophylaxis measures. In this review, tr...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-005-0044-7
更新日期：2005-11-01 00:00:00
abstract：:Although mixed infections are known to be clinically relevant in conditions such as nosocomial pneumonia and ventilator-related pneumonia, it is increasingly recognized that a substantial number of community-acquired lower respiratory tract infections may also be attributed to more than one pathogenic organism. A bett...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0017-0
更新日期：2007-01-01 00:00:00
