Abstract:
:Carbapenems are the broadest spectrum antimicrobials utilized in the treatment of serious infections since the 1980s. Soon after their introduction, the discovery of carbapenem-resistant Enterobacteriaceae (CRE) was reported in the 1990s. Invasive CRE infections are associated with high mortality and limited treatment options making care for patients with these infections challenging for clinicians. Current practice has reverted back to the use of "older" antimicrobials, such as the polymyxins, tigecycline, and fosfomycin, to combat invasive CRE infections. However, recent approval of ceftazidime-avibactam has added another treatment option to the current antimicrobial armamentarium. Resistance among the "older" agents is still rare but has been reported. Currently, there are numerous agents that are under investigation as well as combination therapy that looks promising in the treatment of CRE infections.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Bowers DR,Huang Vdoi
10.1007/s11908-016-0548-3subject
Has Abstractpub_date
2016-12-01 00:00:00pages
48issue
12eissn
1523-3847issn
1534-3146pii
10.1007/s11908-016-0548-3journal_volume
18pub_type
杂志文章,评审abstract::In the United States each year, influenza accounts for an estimated 20,000 to 40,000 deaths, nearly 300,000 hospitalizations, and millions of days lost from work. In the past few years, there has been an explosion of information in the medical literature related to influenza. This paper reviews these latest developmen...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0039-3
更新日期:2000-06-01 00:00:00
abstract::Contact precautions are routinely employed for the control of multidrug-resistant organisms. Robust measures, however, for the incremental benefit of contact precautions, gowns, gloves, and active detection and isolation strategies for the prevention of cross-transmission in endemic settings are lacking. Unintended co...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-012-0299-8
更新日期:2012-12-01 00:00:00
abstract::In most high-income countries, fewer children now acquire meningitis, and many of those who do will survive. Globally, however, meningitis still remains a significant cause of child morbidity and mortality. In this article, the authors review recent evidence on the morbidity faced by childhood survivors of bacterial m...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-013-0332-6
更新日期:2013-06-01 00:00:00
abstract::Starting from 2010, the 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in several countries. This paper discusses some of the problems recently emerged after PCV13 use and their clinical impact. The impact of PCV13 has been relevant and has saved millions of children and adults by severe infectious di...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-018-0607-z
更新日期:2018-01-24 00:00:00
abstract::In recent years, substantial advances have been achieved in the treatment of mucormycosis. It is now clear that early initiation of therapy results in substantially better outcomes, underscoring the need to maintain a high index of suspicion and aggressively biopsy potential lesions. Increasing data support the need f...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-010-0129-9
更新日期:2010-11-01 00:00:00
abstract::Hepatitis delta virus (HDV) is a unique human virus, showing similarities with plant viroids. Although impressive knowledge on virus structure and replication has been achieved, several questions like HBV/HDV interaction and post translational modifications of HD antigens remain to be answered. Potential targets for t...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0233-5
更新日期:2012-02-01 00:00:00
abstract::Fungi are common inhabitants of the oral and nasal mucosa, and therefore the differentiation between colonization and pathogenicity in the setting of upper respiratory tract infection symptoms can be difficult. Fungal head and neck infections occur in both immunocompetent and immunocompromised persons, and patients wi...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0078-z
更新日期:2002-06-01 00:00:00
abstract::Therapy of cryptococcal meningitis has been focused primarily on optimizing the antifungal regimen to improve the previously high treatment failure rates. Until recently, relatively little attention has been paid to the impact of increased intracranial pressure, which is a frequent problem that complicates management ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0026-y
更新日期:2002-08-01 00:00:00
abstract::High-risk human papillomaviruses (HPVs) are now recognized as the etiologic agents of invasive cervical cancer, a major cancer in women. A single HPV type (type 16) is responsible for about 50% of the cancers. The major capsid protein of papillomaviruses, L1, when expressed by recombinant DNA technology, has the intri...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-005-0072-3
更新日期:2005-03-01 00:00:00
abstract::Increases in sexually transmitted diseases (STDs) among men who have sex with men (MSM) have coincided with recent increases in sexual risk behaviors across the United States and Europe. The identification of same-sex sexual risk behavior in men and the subsequent risk for certain bacterial and viral infections requir...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-003-0050-6
更新日期:2003-04-01 00:00:00
abstract::Before the advent of antiretroviral therapy (ART), CMV retinitis was a common, debilitating opportunistic infection in the HIV-infected population. ART has had such a favorable impact on the prevention and management of CMV retinitis that it can be considered in some ways to be CMV therapy. Currently available CMV dir...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-012-0269-1
更新日期:2012-08-01 00:00:00
abstract::Rotaviruses are the most important cause of pediatric gastroenteritis worldwide. In August 1998, a new rotavirus vaccine was licensed for general use in the United States. However, 14 months later, the vaccine was withdrawn from the market because of serious gastrointestinal side effects. This paper discusses the need...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0090-0
更新日期:2000-02-01 00:00:00
abstract:PURPOSE OF REVIEW:This review aims to determine the effectiveness of the use of syndrome diagnosis in the evaluation of vaginitis and to make suggestions based on the review findings. RECENT FINDINGS:Vaginal discharge as the main symptom of vaginitis is unspecific. A randomized study of symptom-based diagnosis and tre...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0558-9
更新日期:2017-01-01 00:00:00
abstract::Hepatic failure due to hepatitis C is the leading indicator for orthotopic liver transplantation (OLT) in the United States. Unfortunately, recurrent hepatitis C virus infection is essentially universal following orthotopic liver transplantation. Although significant advances have been made in the past decade for the ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0049-4
更新日期:2002-04-01 00:00:00
abstract::A variety of antigen-capture assays are commercially available for the detection of influenza. In addition, real-time multiplex polymerase chain reaction (PCR) has been used to detect influenza A and B in clinical specimens. The commercial assays can be completed in less than 30 minutes and have a sensitivity of at le...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-005-0033-x
更新日期:2005-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Post-transplant infections present a formidable challenge to the physician due to their varied presentation. Many of these infections begin by inoculation following skin compromise or disseminate to the skin hematogenously, making cutaneous manifestations of infection an important diagnostic clue in t...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-018-0621-1
更新日期:2018-05-22 00:00:00
abstract::The 2009 pandemic influenza A (H1N1) was responsible for the first influenza pandemic of the 21st century. The virus- a previously unknown triple-reassortant virus containing segments of avian, human, and swine origins- generally caused mild disease. Unlike seasonal influenza, 2009 pandemic influenza A (H1N1) primaril...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-010-0157-5
更新日期:2011-04-01 00:00:00
abstract::Endocarditis pathogens colonize valves with pre-existing sterile vegetations or valves with minimal endothelial lesions. Inflamed endothelia produce cytokines, integrins, and tissue factor, which in turn attract fibronectin, monocytes, and platelets. Bacteria attaching to such structures further activate the cascade, ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-006-0071-z
更新日期:2006-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Modern advances in malaria rapid diagnostic test (RDT) technology have increased demand for low-cost, easy-to-use assays in areas endemic for malaria. Substantial developments in diagnostic sensitivity and specificity, improvements in non-falciparum RDTs, and novel biotechnological innovations are gra...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-018-0655-4
更新日期:2018-10-23 00:00:00
abstract::Candida species are an important cause of health care-related bloodstream infections (BSI). Understanding the current Candida BSI incidence trends, the dominant species causing disease, and the mortality associated with this infection are important to help guide therapeutic and prophylaxis measures. In this review, tr...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-005-0044-7
更新日期:2005-11-01 00:00:00
abstract:Purpose of Review:In December 2019, outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected pneumonia patients were discovered in Wuhan City, Hubei Province, China. With the spread of the epidemic, new cases have been found in other regions of China and abroad. This review summarizes the curr...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-020-00738-7
更新日期:2020-01-01 00:00:00
abstract::Urinary tract infection (UTI) is common in postmenopausal women; the estimated incidence ranges from 4% to 15%. The clinical presentation of UTI is somewhat different in postmenopausal older women than it is in younger women: postmenopausal women are less likely to report frequency, dysuria, hematuria, and fever, but ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-999-0043-1
更新日期:1999-10-01 00:00:00
abstract::Cyclosporiasis is a food- and water-borne infection that affects healthy and immunocompromised individuals. Awareness of the disease has increased, and outbreaks continue to be reported among vulnerable hosts and now among local residents in endemic areas. Advances in molecular techniques have improved identification ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-009-0016-4
更新日期:2009-03-01 00:00:00
abstract::The ability to predict efficacy and toxicity during antiretroviral therapy for HIV would be of obvious advantage. The substantial variability between patients in terms of bioavailability and distribution of current regimens is likely driven by genetic and environmental factors. Protease inhibitors and nucleoside/nucle...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-006-0052-2
更新日期:2006-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this article is to perform a systematic review over the past 5 years on the role and effectiveness of clinical decision support systems (CDSSs) on antibiotic stewardship. RECENT FINDINGS:CDDS interventions found a significant impact on multiple outcomes relevant to antibiotic stewardsh...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-019-0683-8
更新日期:2019-07-24 00:00:00
abstract::Elderly are at high risk for hospitalization for community-acquired pneumonia (CAP), especially due to Streptococcus pneumoniae, and seasonal influenza viruses. Data suggest PPV23's influence on various CAP-related outcomes among the elderly may depend upon how many years have elapsed since they received this vaccine....
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-015-0505-6
更新日期:2015-12-01 00:00:00
abstract::Transmissible spongiform encephalopathies (TSEs) are a group of progressive, fatal neurodegenerative disorders that share a common spongiform histopathology. TSEs may be transmitted in a sporadic, familial, iatrogenic, or zoonotic fashion. The putative infectious agent of TSE, the prion, represents a novel paradigm of...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-004-0053-y
更新日期:2004-08-01 00:00:00
abstract::Invasive fungal infection (IFI) is an important cause of morbidity and mortality in patients with hematologic malignancy, prolonged neutropenia, or after hematopoietic stem cell transplant. Antifungal prophylaxis prevents IFI in high-risk hematology patients. This article discusses recent developments in antifungal pr...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-009-0061-z
更新日期:2009-11-01 00:00:00
abstract::Africa carries a disproportionate burden of the global HIV endemic, accounting for two thirds of the global 33.3 million people living with HIV. While tremendous advances have been made in addressing the HIV epidemic in Africa, considerable challenges remain. Testing for HIV increased by 86% from 2007 to 2009 but more...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0230-8
更新日期:2012-02-01 00:00:00
abstract::The incidence of end-stage liver disease (ESLD) is increasing and many of these patients may be considered for orthotopic liver transplantation. As patients with ESLD are at risk of a number of infections, infectious disease physicians should be aware of the management of these infections in order to provide optimal p...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-015-0514-5
更新日期:2016-01-01 00:00:00