Abstract：
:High-risk human papillomaviruses (HPVs) are now recognized as the etiologic agents of invasive cervical cancer, a major cancer in women. A single HPV type (type 16) is responsible for about 50% of the cancers. The major capsid protein of papillomaviruses, L1, when expressed by recombinant DNA technology, has the intrinsic ability to assemble into virus-like particles (VLPs). In a recent study, a vaccine based on HPV 16 VLPs was tested in a placebo-controlled proof-of-principle trial in young women in the United States. The vaccine was found to prevent 100% of incident persistent HPV 16 infections and HPV 16-associated cervical intraepithelial neoplasia. These results offer promise that cervical cancer will be preventable by an HPV-based vaccine. Studies planned or in progress are examining the efficacy of the vaccine in men, in HIV-infected individuals, and in other parts of the world. Attempts are being made to prepare vaccines that can be administered more easily to large populations.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Gravitt PE,Shah KVdoi
10.1007/s11908-005-0072-3keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
125-131issue
2eissn
1523-3847issn
1534-3146journal_volume
7pub_type
杂志文章abstract：:Drotrecogin alfa (activated) (DrotAA) has been approved for therapy of severe sepsis and septic shock for 7 years, but controversy persists regarding efficacy and safety. Only a single randomized, controlled trial (Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis; PROWESS) has shown evidence...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-008-0060-5
更新日期：2008-09-01 00:00:00
abstract：:Although modern medicine has improved survival in congenital heart disease dramatically, the long-term course carries a risk of late complications. The incidence of infective endocarditis in adults with congenital heart disease is more than 10 times higher than that of the normal population. Identification of the high...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-003-0006-x
更新日期：2003-08-01 00:00:00
abstract：:Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have been reported with increasing frequency from many parts of the world. Most infections involve the skin and soft tissue structures, and CA-MRSA is now the most commonly identifiable cause of purulent skin and soft tissue infectio...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0061-9
更新日期：2007-09-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-013-0352-2
更新日期：2013-10-01 00:00:00
abstract：:With the causal link between specific types of human papillomavirus (HPV) and cervical cancer firmly established, efforts have turned to assessing the relative merits of offering HPV testing in screening, triage, and posttreatment management. Many unanswered questions remain, but a growing body of evidence supports a ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-996-0054-0
更新日期：2001-04-01 00:00:00
abstract：PURPOSE OF REVIEW:The global emergence of antifungal resistance among Candida spp. and Aspergillus spp. is a growing threat to public health, driven largely by the expanding use of antifungals in both the clinical and agricultural settings. As treatment options remain limited, understanding mechanisms and risk factors ...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-019-0702-9
更新日期：2019-11-16 00:00:00
abstract：PURPOSE OF REVIEW:This review aims to determine the effectiveness of the use of syndrome diagnosis in the evaluation of vaginitis and to make suggestions based on the review findings. RECENT FINDINGS:Vaginal discharge as the main symptom of vaginitis is unspecific. A randomized study of symptom-based diagnosis and tre...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0558-9
更新日期：2017-01-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-014-0444-7
更新日期：2015-01-01 00:00:00
abstract：:Antiretroviral therapy (ART) does not eliminate HIV-1 from latently infected reservoirs, and this remains the critical obstacle to the eradication of infection. Although ART is effective in suppressing viral load, life-long ART is burdensome in many respects. Given expanding numbers of HIV-infected individuals on ART ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-014-0392-2
更新日期：2014-03-01 00:00:00
abstract：:The immune reconstitution inflammatory syndrome (IRIS) is a well-described phenomenon in HIV-infected patients following initiation of antiretroviral therapy and can lead to significant morbidity and mortality in some patients. Risk for IRIS is enhanced in those with low CD4 counts and preexisting opportunistic infect...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-012-0308-y
更新日期：2013-02-01 00:00:00
abstract：:Clostridium difficile is a major cause of antibiotic-associated diarrhea. While treatment regimens for C. difficile have been available for decades, they remain less than optimal due to the frequent recurrences that occur after therapy is completed. Moreover, the morbidity and expense associated with C. difficile have...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-996-0032-6
更新日期：2001-04-01 00:00:00
abstract：:Colonization with Staphylococcus aureus is a risk factor for invasive S. aureus infections. Intranasal mupirocin has effectively eradicated S. aureus colonization and appears to prevent S. aureus nosocomial infections in some patient populations. In hospitals and communities where mupirocin use has been widespread, re...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-004-0062-x
更新日期：2004-12-01 00:00:00
abstract：PURPOSE OF THE REVIEW:Community-acquired pneumonia (CAP) is still associated with a large burden and causes significant morbidity and mortality. Besides universal vaccination and antibiotic treatment, statins as adjunctive therapy may also have a beneficial role in the prevention and treatment of CAP. Our goal from thi...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0581-x
更新日期：2017-08-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to investigate the evolution and epidemiology of Klebsiella pneumoniae carbapenemase (KPC)-producing organisms and the current and future treatment options for infections caused by KPC-producing isolates. RECENT FINDINGS:The emergence of resistance in Enterobacteriaceae ...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-018-0617-x
更新日期：2018-05-05 00:00:00
abstract：PURPOSE OF REVIEW:The infectious complications of transplantation can have devastating consequences for patients. Early and accurate diagnosis is essential to good outcomes. This review describes recent advances in pathogen-directed diagnostic testing and discusses the role of new methods for transplant infectious dise...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-019-0704-7
更新日期：2019-11-26 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-005-0044-7
更新日期：2005-11-01 00:00:00
abstract：:This article reviews techniques of rapid testing and the effective diagnosis of streptococcal pharyngitis. Despite 50 years' study of streptococcal pharyngitis and 20 years' experience with rapid tests for its diagnosis, the subject continues to evolve. Rapid diagnostic tests have become more sensitive. Experts now co...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-004-0006-5
更新日期：2004-06-01 00:00:00
abstract：:Prosthetic valve endocarditis (PVE) due to mycobacteria is a rare but frequently fatal complication that may occur early after the surgical procedure, or even years later. Infection has been described with both mechanical and biologic valvular prosthesis. The most commonly implicated mycobacterial species belong to th...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-010-0108-1
更新日期：2010-07-01 00:00:00
abstract：:Intensive care unit (ICU) patients present several unusual pharmacokinetic (PK) characteristics compared with less seriously ill patients, including increased distribution volume and variable clearance. Interpatient PK variability is often considerable and can produce a wide range of values for PK parameters and major...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-009-0003-9
更新日期：2009-01-01 00:00:00
abstract：:Healthcare-associated bacterial meningitis may occur after neurosurgical procedures, head trauma, and following placement of external or internal ventricular catheters. The likely microorganisms that cause meningitis in this setting (ie, staphylococci and gram-negative bacilli) are different from those that cause meni...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-011-0190-z
更新日期：2011-08-01 00:00:00
abstract：:It is well established that the immunological response to the seasonal trivalent influenza vaccine is attenuated in cancer patients. Furthermore, rates of seroprotection and seroconversion vary by malignancy type and are higher in patients with solid tumors, as compared either with those with hematologic malignancies ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-013-0368-7
更新日期：2013-12-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0039-3
更新日期：2000-06-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0496-3
更新日期：2015-08-01 00:00:00
abstract：:Many data associate low protease inhibitor plasma concentrations with suboptimal virologic responses, whereas relatively few data associate high plasma concentrations with increased likelihood of toxicity. Knowledge of relationships between concentrations and virologic response is important because significant variabi...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-001-0079-3
更新日期：2001-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Community-acquired pneumonia (CAP) is the cause of a considerable burden of morbidity and mortality among HIV-infected patients. The purpose of this study was to review recent literature for epidemiological trends and management of CAP in HIV patients. RECENT FINDINGS:While the specific infectious et...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0559-8
更新日期：2017-01-01 00:00:00
abstract：:Group A streptococcus is a widespread human pathogen that causes a broad spectrum of human disease. The persistent high burden and severity of illness in developing and industrialized countries speaks to the need for a safe and effective vaccine. Modern approaches to vaccine construction include M protein type-specifi...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-008-0032-9
更新日期：2008-05-01 00:00:00
abstract：:Skin and soft tissue infections vary widely in their nature and severity, and their nomenclature is complex. Most are readily recognized and easily treated, but more severe infections may masquerade in forms similar to those of more innocent infections, causing delay in diagnosis and treatment that may result in loss ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-002-0010-6
更新日期：2002-10-01 00:00:00
abstract：:Determining the microbiologic etiology of enteric infection remains an elusive goal. Conventional approaches, including culture, microscopy, and antigen-based tests have significant limitations such as limit of detection and the need for multiple procedures. Molecular diagnostics, especially PCR based tests, are rapid...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-011-0223-7
更新日期：2012-02-01 00:00:00
abstract：:Oral triazole therapy is well established for the treatment of invasive aspergillosis (IPA), allergic aspergillosis (ABPA), and chronic pulmonary aspergillosis (CPA), and is often long-term. Resistance to triazole azole antifungal drugs in Aspergillus fumigatus is now a major clinical problem in a number of European l...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-011-0218-4
更新日期：2011-12-01 00:00:00
abstract：:Contact precautions are routinely employed for the control of multidrug-resistant organisms. Robust measures, however, for the incremental benefit of contact precautions, gowns, gloves, and active detection and isolation strategies for the prevention of cross-transmission in endemic settings are lacking. Unintended co...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-012-0299-8
更新日期：2012-12-01 00:00:00
