Clinical Pharmacologic Considerations for HIV-1 Protease Inhibitors.

abstract：:Although waterborne pathogens are relatively uncommon causes of cutaneous infections, these agents are being recognized with increasing frequency. Humans are exposed to water through a variety of recreational and occupational activities. Poor sanitary conditions in developing nations place the human populations at con...

journal_title：Current infectious disease reports

authors： Elko L,Rosenbach K,Sinnott J

更新日期：2003-10-01 00:00:00

abstract：:Patients with sepsis may require mechanical ventilation due to the acute respiratory distress syndrome (ARDS). It has become increasingly accepted that mechanical ventilation can contribute to lung injury in these patients. The modern concept of ventilator-induced lung injury is described in the context of alveolar ov...

journal_title：Current infectious disease reports

authors： Hess DR,Thompson BT

更新日期：2005-09-01 00:00:00

abstract：:Antimicrobial resistance is a growing problem globally. The appearance and spread of bacteria that are resistant to most or all commonly available antibiotics has raised the specter of untreatable bacterial infections. The New Delhi metallo-beta-lactamase-1 (NDM-1) has received wide attention because of the extreme re...

journal_title：Current infectious disease reports

authors： Wilson ME,Chen LH

更新日期：2012-06-01 00:00:00

abstract：:Urinary tract infection (UTI) is a common clinical syndrome in women. Most UTIs are caused by Escherichia coli. UTI has become a productive and accessible model system for studying the molecular details of how bacteria interact with mucosal surfaces and the nature of the host response. Important advances in the past y...

journal_title：Current infectious disease reports

authors： Stapleton AE

更新日期：2006-11-01 00:00:00

abstract：:In an era of cost-consciousness in the delivery of medical care, the economics of healthcare delivery for HIV-infected persons has been an area of active interest. Interested parties include the payors of HIV care, particularly public insurers, who are paying for an increasing amount of the overall cost of HIV care in...

journal_title：Current infectious disease reports

authors： Moore RD

更新日期：2000-08-01 00:00:00

abstract：:Arthroplasty of the knee and hip is a common procedure. There is a risk of infection with primary arthroplasty, with an incidence of 1% to 2%. Significant cost and morbidity are associated with infection of the prosthetic joint. Most infections (60% to 70%) are caused by staphylococci, but approximately 10% are caused...

journal_title：Current infectious disease reports

authors： Lentino JR

更新日期：2004-10-01 00:00:00

abstract：:Clostridium difficile is a major cause of antibiotic-associated diarrhea. While treatment regimens for C. difficile have been available for decades, they remain less than optimal due to the frequent recurrences that occur after therapy is completed. Moreover, the morbidity and expense associated with C. difficile have...

journal_title：Current infectious disease reports

authors： Ciesla WP,Bobak DA

更新日期：2001-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The global emergence of antifungal resistance among Candida spp. and Aspergillus spp. is a growing threat to public health, driven largely by the expanding use of antifungals in both the clinical and agricultural settings. As treatment options remain limited, understanding mechanisms and risk factors ...

journal_title：Current infectious disease reports

authors： Hendrickson JA,Hu C,Aitken SL,Beyda N

更新日期：2019-11-16 00:00:00

abstract：:Community-acquired pneumonia (CAP) is one of the most common causes of morbidity and mortality in elderly and children. Vitamin C is known as a physiological antioxidant, regulating innate immune system in the lung. Vitamin C has been used to prevent and treat CAP. However, the use of vitamin C for preventing and trea...

journal_title：Current infectious disease reports

authors： Li Y,Li G

更新日期：2016-08-01 00:00:00

abstract：:Infections due to community-associated methicillin---resistant Staphylococcus aureus (CA-MRSA) are becoming more prevalent. CA-MRSA infections have unique epidemiologic features and virulence factors. Compared with health care-associated MRSA (HA-MRSA), most CA-MRSA is clonal type USA300 or 400 and has the Staphylococ...

journal_title：Current infectious disease reports

authors： Paez A,Skiest D

更新日期：2008-03-01 00:00:00

abstract：:Colonization with Staphylococcus aureus is a risk factor for invasive S. aureus infections. Intranasal mupirocin has effectively eradicated S. aureus colonization and appears to prevent S. aureus nosocomial infections in some patient populations. In hospitals and communities where mupirocin use has been widespread, re...

journal_title：Current infectious disease reports

authors： Polgreen PM,Herwaldt LA

更新日期：2004-12-01 00:00:00

abstract：:Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes, mostly Aedes aegypti and Aedes albopictus. After half a century of focal outbreaks of acute febrile polyarthralgia in Africa and Asia, the disease unexpectedly spread in the past decade with large outbreaks in Africa and around the Indian Ocean and ...

journal_title：Current infectious disease reports

authors： Simon F,Javelle E,Oliver M,Leparc-Goffart I,Marimoutou C

更新日期：2011-06-01 00:00:00

abstract：:Determining the microbiologic etiology of enteric infection remains an elusive goal. Conventional approaches, including culture, microscopy, and antigen-based tests have significant limitations such as limit of detection and the need for multiple procedures. Molecular diagnostics, especially PCR based tests, are rapid...

journal_title：Current infectious disease reports

authors： Platts-Mills JA,Operario DJ,Houpt ER

更新日期：2012-02-01 00:00:00

abstract：:A variety of antigen-capture assays are commercially available for the detection of influenza. In addition, real-time multiplex polymerase chain reaction (PCR) has been used to detect influenza A and B in clinical specimens. The commercial assays can be completed in less than 30 minutes and have a sensitivity of at le...

journal_title：Current infectious disease reports

authors： Pachucki CT

更新日期：2005-05-01 00:00:00

abstract：:Chlamydia psittaci, Chlamydia pneumoniae, and Mycoplasma pneumoniae are a group of respiratory pathogens that have similar pulmonary and extrapulmonary manifestations. Recent studies suggest that C. pneumoniae and M. pneumoniae may play a role in the pathogenesis of asthma, but further studies are needed to delineate ...

journal_title：Current infectious disease reports

authors： Atmar RL

更新日期：1999-04-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a significant cause of chronic liver disease with substantial long-term sequelae. Until very recently, therapies to cure HCV were hindered by high nonresponse rates and severe side effects. The first-generation protease inhibitor-containing regimens provided superior cure rates for...

journal_title：Current infectious disease reports

authors： Moore C,Levitsky J

更新日期：2014-08-01 00:00:00

abstract：Purpose of Review:In December 2019, outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected pneumonia patients were discovered in Wuhan City, Hubei Province, China. With the spread of the epidemic, new cases have been found in other regions of China and abroad. This review summarizes the curr...

journal_title：Current infectious disease reports

authors： Wang Y,Wang L,Li X,Gong Z

更新日期：2020-01-01 00:00:00

abstract：:Community-acquired pneumonia is a common reason for hospitalization and leads to significant morbidity and mortality. There are published evidence-based guidelines for the diagnosis, treatment, and management of community-acquired pneumonia. Many countries, including the US, have developed national, publically reporte...

journal_title：Current infectious disease reports

authors： Richey EA,Dudley L,Liu SK

更新日期：2014-02-01 00:00:00

abstract：:Streptococcus bovis is a rare, but important cause of bacterial meningitis in children. Since its discovery in the early 1970s, the pathogen has undergone multiple taxonomic changes producing four distinct subspecies today, the most prevalent of which is S. gallolyticus subsp pasteurianus in infants and children. Whil...

journal_title：Current infectious disease reports

authors： Hede SV

更新日期：2016-03-01 00:00:00

abstract：:Pyoderma gangrenosum (PG) is a rare cause of purulent vulvovaginal ulceration. Six recent cases of vulvovaginal pyoderma gangrenosum associated with rituximab are described. All cases were seen in the setting of rituximab used for the treatment of B cell non Hodgkin's lymphoma (NHL). Age range was 50-74; symptoms were...

journal_title：Current infectious disease reports

authors： Selva-Nayagam P,Fischer G,Hamann I,Sobel J,James C

更新日期：2015-05-01 00:00:00

abstract：:Nontuberculous mycobacteria (NTM) are ubiquitous in the environment and cause a wide range of diseases in humans. Pulmonary involvement, the most common disease manifestation of NTM infection, is being increasingly encountered in clinical settings. In addition, specific phenotypic and genetic characteristics of person...

journal_title：Current infectious disease reports

authors： Saleeb P,Olivier KN

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Acinetobacter baumannii (AB) is an infamous nosocomial pathogen with a seemingly limitless capacity for antimicrobial resistance, leading to few treatment options and poor clinical outcomes. The debatably low pathogenicity and virulence of AB are juxtaposed by its exceptionally high rate of infection-...

journal_title：Current infectious disease reports

authors： Butler DA,Biagi M,Tan X,Qasmieh S,Bulman ZP,Wenzler E

更新日期：2019-11-16 00:00:00

abstract：:Clinical toxinology is a specialized area of clinical medicine focused on the pathophysiology, diagnosis, treatment, and prevention of diseases caused by animal, plant, and fungal toxins. This review focuses on recent developments in snakebite. Snakebite is newly recognized as a Neglected Tropical Disease by the World...

journal_title：Current infectious disease reports

authors： White J

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this paper is to review therapies with new mechanisms of action for the treatment of HIV that are at least in phase 2 clinical trials. RECENT FINDINGS:There are several new mechanisms of action being represented within clinical development, including histone deacetylase (HDAC) inhibito...

journal_title：Current infectious disease reports

authors： Gravatt LAH,Leibrand CR,Patel S,McRae M

更新日期：2017-09-19 00:00:00

abstract：:Combination antifungal therapy has been an area of great research and clinical interest since antifungals became available decades ago, in part driven by the severe morbidity and mortality associated with invasive fungal infections. Because of the availability of newer antifungal agents including echinocandins and exp...

journal_title：Current infectious disease reports

authors： Baddley JW,Pappas PG

更新日期：2007-11-01 00:00:00

abstract：:Coronary heart disease (CHD) is an inflammatory process that takes decades to develop. In HIV-seronegative persons, high-sensitivity C-reactive protein is a biologic marker of CHD risk. HIV infection induces chronic inflammation, despite adequate suppression of HIV replication with antiretroviral therapy, resulting in...

journal_title：Current infectious disease reports

authors： Fichtenbaum CJ

更新日期：2011-02-01 00:00:00

abstract：:The first description of acute respiratory distress syndrome (ARDS) in adults appeared in 1967 and was characterized by dyspnea, hypoxemia, diffuse alveolar infiltrates, and reduced respiratory system compliance. ARDS and acute lung injury (ALI) syndrome have no specific treatment, only supportive care: treating the u...

journal_title：Current infectious disease reports

authors： Chiumello D,Cressoni M

更新日期：2009-09-01 00:00:00

abstract：:Although highly active antiretroviral therapy suppresses HIV replication resulting in extraordinary clinical benefits, toxicity, adherence difficulties, and the monetary cost of medications limit the long-term effectiveness and availability of therapy for many HIV-infected individuals. Strategies to interrupt therapy ...

journal_title：Current infectious disease reports

authors： Dybul M

更新日期：2002-04-01 00:00:00

abstract：:The pathogenesis of vulvovaginal candidiasis, which is caused by Candida albicans, is poorly understood. Despite a strong protective role for cell-mediated immunity (CMI) against other mucosal candidal infections, numerous studies in humans and most animal models have revealed little to no role for CMI or other forms ...

journal_title：Current infectious disease reports

authors： Fidel PL

更新日期：2003-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Post-transplant infections present a formidable challenge to the physician due to their varied presentation. Many of these infections begin by inoculation following skin compromise or disseminate to the skin hematogenously, making cutaneous manifestations of infection an important diagnostic clue in t...

journal_title：Current infectious disease reports

authors： Pettit CJ,Mazurek K,Kaffenberger B

更新日期：2018-05-22 00:00:00