Abstract:
:Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes, mostly Aedes aegypti and Aedes albopictus. After half a century of focal outbreaks of acute febrile polyarthralgia in Africa and Asia, the disease unexpectedly spread in the past decade with large outbreaks in Africa and around the Indian Ocean and rare autochthonous transmission in temperate areas. This emergence brought new insights on its pathogenesis, notably the role of the A226V mutation that improved CHIKV fitness in Ae. albopictus and the possible CHIKV persistence in deep tissue sanctuaries for months after infection. Massive outbreaks also revealed new aspects of the acute stage: the high number of symptomatic cases, unexpected complications, mother-to-child transmission, and low lethality in debilitated patients. The follow-up of patients in epidemic areas has identified frequent, long-lasting, rheumatic disorders, including rare inflammatory joint destruction, and common chronic mood changes associated with quality-of-life impairment. Thus, the globalization of CHIKV exposes countries with Aedes mosquitoes both to brutal outbreaks of acute incapacitating episodes and endemic long-lasting disorders.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Simon F,Javelle E,Oliver M,Leparc-Goffart I,Marimoutou Cdoi
10.1007/s11908-011-0180-1subject
Has Abstractpub_date
2011-06-01 00:00:00pages
218-28issue
3eissn
1523-3847issn
1534-3146journal_volume
13pub_type
杂志文章abstract::Fungi are common inhabitants of the oral and nasal mucosa, and therefore the differentiation between colonization and pathogenicity in the setting of upper respiratory tract infection symptoms can be difficult. Fungal head and neck infections occur in both immunocompetent and immunocompromised persons, and patients wi...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0078-z
更新日期:2002-06-01 00:00:00
abstract::The outcome for HIV-infected patients with cancer has dramatically improved in the highly active antiretroviral therapy (HAART) era, probably due to improvements in immune status and bone marrow function that allow the possibility of increased drug-dose intensity with a higher complete remission rate. Although data re...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-008-0026-7
更新日期:2008-05-01 00:00:00
abstract::Antiretroviral therapy (ART) does not eliminate HIV-1 from latently infected reservoirs, and this remains the critical obstacle to the eradication of infection. Although ART is effective in suppressing viral load, life-long ART is burdensome in many respects. Given expanding numbers of HIV-infected individuals on ART ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0392-2
更新日期:2014-03-01 00:00:00
abstract::The deadly combination of tuberculosis (TB) and human immunodeficiency virus (HIV) currently ravaging the world, taking a toll of about 0.35 million people every year, is one of the major public health crises of the decade. Throughout the course of HIV infection, the risk of acquisition, reactivation, and reinfection ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-012-0311-3
更新日期:2013-02-01 00:00:00
abstract::In recent years, substantial advances have been achieved in the treatment of mucormycosis. It is now clear that early initiation of therapy results in substantially better outcomes, underscoring the need to maintain a high index of suspicion and aggressively biopsy potential lesions. Increasing data support the need f...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-010-0129-9
更新日期:2010-11-01 00:00:00
abstract::In most high-income countries, fewer children now acquire meningitis, and many of those who do will survive. Globally, however, meningitis still remains a significant cause of child morbidity and mortality. In this article, the authors review recent evidence on the morbidity faced by childhood survivors of bacterial m...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-013-0332-6
更新日期:2013-06-01 00:00:00
abstract::Myocarditis is an acquired form inflammatory heart muscle disease, manifested as acute and chronic conditions. While many etiologies have been reported, the most common cause of this disease is infection, primarily viral. Typically, the specific causative agent(s) and mechanism(s) are elusive. Over the past several ye...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0008-x
更新日期:2000-08-01 00:00:00
abstract::In an era of cost-consciousness in the delivery of medical care, the economics of healthcare delivery for HIV-infected persons has been an area of active interest. Interested parties include the payors of HIV care, particularly public insurers, who are paying for an increasing amount of the overall cost of HIV care in...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0018-8
更新日期:2000-08-01 00:00:00
abstract::Neisseria gonorrhoeae is a common cause of genitourinary sexually transmitted infections. N. gonorrhoeae is an obligate human pathogen that has evidence of tissue-specific host interactions and diverse extragenital manifestations of infection both in adult and pediatric populations. The clinical presentation of extrag...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-006-0009-5
更新日期:2006-03-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Community-acquired pneumonia (CAP) is still associated with a large burden and causes significant morbidity and mortality. Besides universal vaccination and antibiotic treatment, statins as adjunctive therapy may also have a beneficial role in the prevention and treatment of CAP. Our goal from thi...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0581-x
更新日期:2017-08-01 00:00:00
abstract::In the United States each year, influenza accounts for an estimated 20,000 to 40,000 deaths, nearly 300,000 hospitalizations, and millions of days lost from work. In the past few years, there has been an explosion of information in the medical literature related to influenza. This paper reviews these latest developmen...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0039-3
更新日期:2000-06-01 00:00:00
abstract::A variety of antigen-capture assays are commercially available for the detection of influenza. In addition, real-time multiplex polymerase chain reaction (PCR) has been used to detect influenza A and B in clinical specimens. The commercial assays can be completed in less than 30 minutes and have a sensitivity of at le...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-005-0033-x
更新日期:2005-05-01 00:00:00
abstract::Determining the microbiologic etiology of enteric infection remains an elusive goal. Conventional approaches, including culture, microscopy, and antigen-based tests have significant limitations such as limit of detection and the need for multiple procedures. Molecular diagnostics, especially PCR based tests, are rapid...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0223-7
更新日期:2012-02-01 00:00:00
abstract::The first description of acute respiratory distress syndrome (ARDS) in adults appeared in 1967 and was characterized by dyspnea, hypoxemia, diffuse alveolar infiltrates, and reduced respiratory system compliance. ARDS and acute lung injury (ALI) syndrome have no specific treatment, only supportive care: treating the u...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-009-0052-0
更新日期:2009-09-01 00:00:00
abstract::Lower respiratory tract infections (LRTIs) are a global burden to public health and are frequently caused by respiratory viruses. Advances in molecular diagnostic techniques have allowed the identification of previously undetected viral pathogens and have improved our understanding of respiratory virus infections. Her...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-012-0258-4
更新日期:2012-06-01 00:00:00
abstract::A broad range of disorders can cause inflammation of the thyroid gland. True thyroid infections are rare and can result from a variety of microorganisms, of which bacteria are the most common. Other rarer pathogens include fungi, parasites, and viruses. Gram-positive bacteria, especially staphylococci, predominate as ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0027-7
更新日期:2000-04-01 00:00:00
abstract::Necrotizing enterocolitis (NEC) continues to be a major cause of morbidity and mortality in premature infants. Although the pathogenesis of NEC remains unclear, abnormal bacterial colonization has been postulated as playing a central role. Various factors impact bacterial colonization following delivery. Compared to t...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-010-0156-6
更新日期:2011-02-01 00:00:00
abstract::Pouchitis is an inflammatory complication after restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA). IPAA is the surgical treatment of choice in patients with ulcerative colitis (UC) who require colectomy. Initial episodes of acute pouchitis generally respond to antibiotics but significant numbers of c...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0442-9
更新日期:2014-12-01 00:00:00
abstract::Ventilator-associated pneumonia (VAP), an infection of the lower respiratory tract which occurs in association with mechanical ventilation, is one of the most common causes of nosocomial infection in the intensive care unit (ICU). VAP causes significant morbidity and mortality in critically ill patients including incr...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-015-0496-3
更新日期:2015-08-01 00:00:00
abstract::Coronary heart disease (CHD) is an inflammatory process that takes decades to develop. In HIV-seronegative persons, high-sensitivity C-reactive protein is a biologic marker of CHD risk. HIV infection induces chronic inflammation, despite adequate suppression of HIV replication with antiretroviral therapy, resulting in...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-010-0153-9
更新日期:2011-02-01 00:00:00
abstract::Patients with sepsis may require mechanical ventilation due to the acute respiratory distress syndrome (ARDS). It has become increasingly accepted that mechanical ventilation can contribute to lung injury in these patients. The modern concept of ventilator-induced lung injury is described in the context of alveolar ov...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-005-0007-z
更新日期:2005-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Suppressive therapy and periodic presumptive treatment (PPT) are distinct but related strategies that have been used to reduce the incidence of bacterial vaginosis (BV). Here, we review clinical trial evidence of the effectiveness of suppressive therapy and PPT to reduce BV, and discuss their roles fo...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-019-0688-3
更新日期:2019-08-31 00:00:00
abstract::Many data associate low protease inhibitor plasma concentrations with suboptimal virologic responses, whereas relatively few data associate high plasma concentrations with increased likelihood of toxicity. Knowledge of relationships between concentrations and virologic response is important because significant variabi...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-001-0079-3
更新日期:2001-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Modern advances in malaria rapid diagnostic test (RDT) technology have increased demand for low-cost, easy-to-use assays in areas endemic for malaria. Substantial developments in diagnostic sensitivity and specificity, improvements in non-falciparum RDTs, and novel biotechnological innovations are gra...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-018-0655-4
更新日期:2018-10-23 00:00:00
abstract::All of the endemic mycoses have cutaneous and mucocutaneous manifestations that are most commonly seen when patients have disseminated infection. Biopsy of skin lesions is simple and safe and can assist in making a timely diagnosis of disseminated infection. Primary cutaneous inoculation infection has been reported wi...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-013-0352-2
更新日期:2013-10-01 00:00:00
abstract::Infections due to community-associated methicillin---resistant Staphylococcus aureus (CA-MRSA) are becoming more prevalent. CA-MRSA infections have unique epidemiologic features and virulence factors. Compared with health care-associated MRSA (HA-MRSA), most CA-MRSA is clonal type USA300 or 400 and has the Staphylococ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-008-0005-z
更新日期:2008-03-01 00:00:00
abstract::Rotaviruses are the most important cause of pediatric gastroenteritis worldwide. In August 1998, a new rotavirus vaccine was licensed for general use in the United States. However, 14 months later, the vaccine was withdrawn from the market because of serious gastrointestinal side effects. This paper discusses the need...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0090-0
更新日期:2000-02-01 00:00:00
abstract::Three newer oral antifungal agents, itraconazole, terbinafine and fluconazole, have revolutionized treatment of superficial mycoses. The tissue pharmacokinetics of itraconazole and terbinafine allow much shorter courses of therapy- with higher efficacy-in the treatment of onychomycosis, compared to other oral agents. ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0074-0
更新日期:2000-10-01 00:00:00
abstract::Although highly active antiretroviral therapy suppresses HIV replication resulting in extraordinary clinical benefits, toxicity, adherence difficulties, and the monetary cost of medications limit the long-term effectiveness and availability of therapy for many HIV-infected individuals. Strategies to interrupt therapy ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0059-2
更新日期:2002-04-01 00:00:00
abstract::Urinary tract infection (UTI) is a common clinical syndrome in women. Most UTIs are caused by Escherichia coli. UTI has become a productive and accessible model system for studying the molecular details of how bacteria interact with mucosal surfaces and the nature of the host response. Important advances in the past y...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-006-0021-9
更新日期:2006-11-01 00:00:00