Abstract:
:Determining the microbiologic etiology of enteric infection remains an elusive goal. Conventional approaches, including culture, microscopy, and antigen-based tests have significant limitations such as limit of detection and the need for multiple procedures. Molecular diagnostics, especially PCR based tests, are rapidly changing research and practice in infectious diseases. Diarrheal disease, with its broad range of potential infectious etiologies, is well suited for multiplex molecular testing. This review highlights examples of currently employed molecular tests, as well as ways in which these tests can be applied in the future. The absence of a gold standard for the microbiologic cause of diarrhea means that the clinical significance of detected organisms may not always be clear. Conventional wisdom is that there should be one main pathogen causing diarrhea, however our thinking is challenged by increased detection of mixed infections. Thus, the successful incorporation of molecular diagnostics for diarrheal disease into practice will require both a careful understanding of the technical aspects and research to define their clinical utility.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Platts-Mills JA,Operario DJ,Houpt ERdoi
10.1007/s11908-011-0223-7subject
Has Abstractpub_date
2012-02-01 00:00:00pages
41-6issue
1eissn
1523-3847issn
1534-3146journal_volume
14pub_type
杂志文章abstract::Cyclosporiasis is a food- and water-borne infection that affects healthy and immunocompromised individuals. Awareness of the disease has increased, and outbreaks continue to be reported among vulnerable hosts and now among local residents in endemic areas. Advances in molecular techniques have improved identification ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-009-0016-4
更新日期:2009-03-01 00:00:00
abstract::Although mixed infections are known to be clinically relevant in conditions such as nosocomial pneumonia and ventilator-related pneumonia, it is increasingly recognized that a substantial number of community-acquired lower respiratory tract infections may also be attributed to more than one pathogenic organism. A bett...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-007-0017-0
更新日期:2007-01-01 00:00:00
abstract::Intensive care unit (ICU) patients present several unusual pharmacokinetic (PK) characteristics compared with less seriously ill patients, including increased distribution volume and variable clearance. Interpatient PK variability is often considerable and can produce a wide range of values for PK parameters and major...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-009-0003-9
更新日期:2009-01-01 00:00:00
abstract::Although modern medicine has improved survival in congenital heart disease dramatically, the long-term course carries a risk of late complications. The incidence of infective endocarditis in adults with congenital heart disease is more than 10 times higher than that of the normal population. Identification of the high...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-003-0006-x
更新日期:2003-08-01 00:00:00
abstract::Elderly are at high risk for hospitalization for community-acquired pneumonia (CAP), especially due to Streptococcus pneumoniae, and seasonal influenza viruses. Data suggest PPV23's influence on various CAP-related outcomes among the elderly may depend upon how many years have elapsed since they received this vaccine....
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-015-0505-6
更新日期:2015-12-01 00:00:00
abstract::Arthroplasty of the knee and hip is a common procedure. There is a risk of infection with primary arthroplasty, with an incidence of 1% to 2%. Significant cost and morbidity are associated with infection of the prosthetic joint. Most infections (60% to 70%) are caused by staphylococci, but approximately 10% are caused...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-004-0038-x
更新日期:2004-10-01 00:00:00
abstract::Human herpesvirus 8 (HHV-8) or Kaposi's sarcoma (KS)-associated herpesvirus is a recently identified virus that is associated with KS, multicentric Castleman's disease, and body cavity-based lymphomas. KS is the most common kind of cancer in AIDS patients and the initial AIDS-defining condition in over 20% of patients...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-999-0031-5
更新日期:1999-08-01 00:00:00
abstract::Three newer oral antifungal agents, itraconazole, terbinafine and fluconazole, have revolutionized treatment of superficial mycoses. The tissue pharmacokinetics of itraconazole and terbinafine allow much shorter courses of therapy- with higher efficacy-in the treatment of onychomycosis, compared to other oral agents. ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0074-0
更新日期:2000-10-01 00:00:00
abstract::Community-acquired pneumonia is a common reason for hospitalization and leads to significant morbidity and mortality. There are published evidence-based guidelines for the diagnosis, treatment, and management of community-acquired pneumonia. Many countries, including the US, have developed national, publically reporte...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0395-z
更新日期:2014-02-01 00:00:00
abstract::Hepatic failure due to hepatitis C is the leading indicator for orthotopic liver transplantation (OLT) in the United States. Unfortunately, recurrent hepatitis C virus infection is essentially universal following orthotopic liver transplantation. Although significant advances have been made in the past decade for the ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0049-4
更新日期:2002-04-01 00:00:00
abstract:Purpose of Review:In December 2019, outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected pneumonia patients were discovered in Wuhan City, Hubei Province, China. With the spread of the epidemic, new cases have been found in other regions of China and abroad. This review summarizes the curr...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-020-00738-7
更新日期:2020-01-01 00:00:00
abstract::Diarrhea is one of the most common health problems among travelers. Although enterotoxigenic Escherichia coli is implicated most commonly, enteroaggregative E. coli has recently been described as a major pathogen. Shigella, Campylobacter, and Salmonella organisms are less common causes of acute diarrhea, and intestina...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0070-7
更新日期:2002-02-01 00:00:00
abstract::Solid organ and hematopoietic stem cell transplant recipients may be exposed to diseases which may be prevented through live attenuated virus vaccines (LAVV). Because of their immunosuppression, these diseases can lead to severe complications in transplant recipients. Despite increasing evidence regarding the safety a...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-015-0472-y
更新日期:2015-04-01 00:00:00
abstract::Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes, mostly Aedes aegypti and Aedes albopictus. After half a century of focal outbreaks of acute febrile polyarthralgia in Africa and Asia, the disease unexpectedly spread in the past decade with large outbreaks in Africa and around the Indian Ocean and ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0180-1
更新日期:2011-06-01 00:00:00
abstract::The deadly combination of tuberculosis (TB) and human immunodeficiency virus (HIV) currently ravaging the world, taking a toll of about 0.35 million people every year, is one of the major public health crises of the decade. Throughout the course of HIV infection, the risk of acquisition, reactivation, and reinfection ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-012-0311-3
更新日期:2013-02-01 00:00:00
abstract::Bacterial vaginosis (BV) is a common cause of vaginal discharge in women of childbearing age. In some individuals, it recurs frequently after treatment, frustrating both the patient and the physician. Standard BV treatment--metronidazole or clindamycin, administered either intravaginally or orally--is followed by rela...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0053-5
更新日期:2000-12-01 00:00:00
abstract::Combination antifungal therapy has been an area of great research and clinical interest since antifungals became available decades ago, in part driven by the severe morbidity and mortality associated with invasive fungal infections. Because of the availability of newer antifungal agents including echinocandins and exp...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-007-0069-1
更新日期:2007-11-01 00:00:00
abstract::Antipsychotics are generally distinguished as atypical and typical agents, which are indicated in the treatment of acute and chronic psychoses and other psychiatric disorders. In April 2005, the US Food and Drug Administration issued a warning about the increased risk of all-cause mortality associated with atypical an...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0175-y
更新日期:2011-06-01 00:00:00
abstract::Urinary tract infections are common, especially among women, and cause significant morbidity. While prognosis is probably more dependent on whether or not an episode of urinary tract infection is complicated (ie, associated with functional, metabolic, or anatomic abnormalities of the urinary tract) or uncomplicated, a...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-001-0090-8
更新日期:2001-12-01 00:00:00
abstract::Although highly active antiretroviral therapy suppresses HIV replication resulting in extraordinary clinical benefits, toxicity, adherence difficulties, and the monetary cost of medications limit the long-term effectiveness and availability of therapy for many HIV-infected individuals. Strategies to interrupt therapy ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0059-2
更新日期:2002-04-01 00:00:00
abstract::Infections due to community-associated methicillin---resistant Staphylococcus aureus (CA-MRSA) are becoming more prevalent. CA-MRSA infections have unique epidemiologic features and virulence factors. Compared with health care-associated MRSA (HA-MRSA), most CA-MRSA is clonal type USA300 or 400 and has the Staphylococ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-008-0005-z
更新日期:2008-03-01 00:00:00
abstract::Many data associate low protease inhibitor plasma concentrations with suboptimal virologic responses, whereas relatively few data associate high plasma concentrations with increased likelihood of toxicity. Knowledge of relationships between concentrations and virologic response is important because significant variabi...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-001-0079-3
更新日期:2001-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to investigate the evolution and epidemiology of Klebsiella pneumoniae carbapenemase (KPC)-producing organisms and the current and future treatment options for infections caused by KPC-producing isolates. RECENT FINDINGS:The emergence of resistance in Enterobacteriaceae ...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-018-0617-x
更新日期:2018-05-05 00:00:00
abstract::Healthcare-associated bacterial meningitis may occur after neurosurgical procedures, head trauma, and following placement of external or internal ventricular catheters. The likely microorganisms that cause meningitis in this setting (ie, staphylococci and gram-negative bacilli) are different from those that cause meni...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0190-z
更新日期:2011-08-01 00:00:00
abstract::Neuroimaging studies have revealed that neurocysticercosis is a major cause of neurologic disease in most developing countries and is an emerging disease in industrialized areas. Patients with neurocysticercosis present mainly with seizures (parenchymal form) or intracranial hypertension (ventricular/subarachnoid form...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-999-0055-x
更新日期:1999-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system most often characterized by clinical relapses and periods of remission. RECENT FINDINGS:The past decade has seen a dramatic increase in disease-modifying therapies for MS. Fourteen FDA-approved immunomodulato...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0562-0
更新日期:2017-02-01 00:00:00
abstract::Endocarditis pathogens colonize valves with pre-existing sterile vegetations or valves with minimal endothelial lesions. Inflamed endothelia produce cytokines, integrins, and tissue factor, which in turn attract fibronectin, monocytes, and platelets. Bacteria attaching to such structures further activate the cascade, ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-006-0071-z
更新日期:2006-06-01 00:00:00
abstract::Primary infection of humans with varicella zoster virus (VZV) causes varicella (chickenpox), after which the virus becomes latent in cranial nerve ganglia, dorsal root ganglia and autonomic ganglia along the entire neuraxis. As VZV-specific cell-mediated immunity declines in elderly and immunocompromised individuals, ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0407-z
更新日期:2014-06-01 00:00:00
abstract::In most high-income countries, fewer children now acquire meningitis, and many of those who do will survive. Globally, however, meningitis still remains a significant cause of child morbidity and mortality. In this article, the authors review recent evidence on the morbidity faced by childhood survivors of bacterial m...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-013-0332-6
更新日期:2013-06-01 00:00:00
abstract::With the causal link between specific types of human papillomavirus (HPV) and cervical cancer firmly established, efforts have turned to assessing the relative merits of offering HPV testing in screening, triage, and posttreatment management. Many unanswered questions remain, but a growing body of evidence supports a ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-996-0054-0
更新日期:2001-04-01 00:00:00