Abstract:
:Intensive care unit (ICU) patients present several unusual pharmacokinetic (PK) characteristics compared with less seriously ill patients, including increased distribution volume and variable clearance. Interpatient PK variability is often considerable and can produce a wide range of values for PK parameters and major differences in drug exposure. These analyses have led to the development of simulation techniques and population PK models to assess dosing regimens in specific patient subsets. Plasma concentrations may frequently overestimate target-site concentrations and therefore clinical efficacy. The unbound drug concentration at the infection site should be preferred. Although renal replacement therapy techniques are commonly used in ICU patients, data concerning antibiotic dosing in this setting remain limited. Administration of antibacterial agents by continuous infusion is becoming a common technique to avoid undesirable high peak concentrations and low trough concentrations and to optimize PK-pharmacodynamic indices.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Dufour G,Montravers Pdoi
10.1007/s11908-009-0003-9subject
Has Abstractpub_date
2009-01-01 00:00:00pages
14-20issue
1eissn
1523-3847issn
1534-3146journal_volume
11pub_type
杂志文章abstract::The ability to predict efficacy and toxicity during antiretroviral therapy for HIV would be of obvious advantage. The substantial variability between patients in terms of bioavailability and distribution of current regimens is likely driven by genetic and environmental factors. Protease inhibitors and nucleoside/nucle...
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更新日期:2017-03-01 00:00:00
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更新日期:2004-08-01 00:00:00
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更新日期:2014-03-01 00:00:00
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journal_title:Current infectious disease reports
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