The Use of Statins and Risk of Community-Acquired Pneumonia.

Abstract:

PURPOSE OF THE REVIEW:Community-acquired pneumonia (CAP) is still associated with a large burden and causes significant morbidity and mortality. Besides universal vaccination and antibiotic treatment, statins as adjunctive therapy may also have a beneficial role in the prevention and treatment of CAP. Our goal from this review is to discuss the epidemiology of CAP, and role of statins as adjunctive therapy in the development of CAP. RECENT FINDINGS:Statins are lipid-lowering medications characterized by their ability to control hypercholesterolemia in addition to other pleiotropic effects that could explain their role in the pathogenesis of CAP. While most observational studies have shown that statins reduce risk of pneumonia in the general population, patients with diabetes, and recently in patients with myocardial infarction, no randomized controlled trial (RCT) to date has been conducted to assess the efficacy of statins to prevent development of CAP. Given the paucity of robust randomized evidence to assess statin use and the development of CAP, and considering conflicting results of the observational studies, we are not in favor of initiation of statins for either the prevention or treatment of CAP.

journal_name

Curr Infect Dis Rep

authors

Batais MA,Khan AR,Bin Abdulhak AA

doi

10.1007/s11908-017-0581-x

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

26

issue

8

eissn

1523-3847

issn

1534-3146

pii

10.1007/s11908-017-0581-x

journal_volume

19

pub_type

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