Abstract:
PURPOSE OF THE REVIEW:Community-acquired pneumonia (CAP) is still associated with a large burden and causes significant morbidity and mortality. Besides universal vaccination and antibiotic treatment, statins as adjunctive therapy may also have a beneficial role in the prevention and treatment of CAP. Our goal from this review is to discuss the epidemiology of CAP, and role of statins as adjunctive therapy in the development of CAP. RECENT FINDINGS:Statins are lipid-lowering medications characterized by their ability to control hypercholesterolemia in addition to other pleiotropic effects that could explain their role in the pathogenesis of CAP. While most observational studies have shown that statins reduce risk of pneumonia in the general population, patients with diabetes, and recently in patients with myocardial infarction, no randomized controlled trial (RCT) to date has been conducted to assess the efficacy of statins to prevent development of CAP. Given the paucity of robust randomized evidence to assess statin use and the development of CAP, and considering conflicting results of the observational studies, we are not in favor of initiation of statins for either the prevention or treatment of CAP.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Batais MA,Khan AR,Bin Abdulhak AAdoi
10.1007/s11908-017-0581-xsubject
Has Abstractpub_date
2017-08-01 00:00:00pages
26issue
8eissn
1523-3847issn
1534-3146pii
10.1007/s11908-017-0581-xjournal_volume
19pub_type
杂志文章,评审abstract::Rates of syphilis continue to increase in the United States and HIV-infected patients make up a large proportion of cases. The interaction between syphilis and HIV is complex and still incompletely understood. Although diagnosis and management of HIV-infected patients with syphilis is, in general, similar to HIV-uninf...
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pub_type: 杂志文章,评审
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