Abstract:
:Endocarditis pathogens colonize valves with pre-existing sterile vegetations or valves with minimal endothelial lesions. Inflamed endothelia produce cytokines, integrins, and tissue factor, which in turn attract fibronectin, monocytes, and platelets. Bacteria attaching to such structures further activate the cascade, becoming embedded and protected from host defenses. Staphylococcus aureus also actively invade the endothelium, causing apoptosis and endothelial damage. Knowledge of this interplay identifies host factors as potential therapeutic targets. Blocking infection by modulating host factors might be opportune because host factors are conserved. In contrast, interfering with bacterial virulence factors might be more complicated because they vary among different bacteria.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Widmer E,Que YA,Entenza JM,Moreillon Pdoi
10.1007/s11908-006-0071-zsubject
Has Abstractpub_date
2006-06-01 00:00:00pages
271-9issue
4eissn
1523-3847issn
1534-3146journal_volume
8pub_type
杂志文章abstract::All of the endemic mycoses have cutaneous and mucocutaneous manifestations that are most commonly seen when patients have disseminated infection. Biopsy of skin lesions is simple and safe and can assist in making a timely diagnosis of disseminated infection. Primary cutaneous inoculation infection has been reported wi...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-013-0352-2
更新日期:2013-10-01 00:00:00
abstract::Streptococcus bovis is a rare, but important cause of bacterial meningitis in children. Since its discovery in the early 1970s, the pathogen has undergone multiple taxonomic changes producing four distinct subspecies today, the most prevalent of which is S. gallolyticus subsp pasteurianus in infants and children. Whil...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-016-0519-8
更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The increase in drug-resistant community-acquired pneumonia (CAP) is an important problem all over the world. This article explores the current state of antimicrobial resistance of different bacteria that cause CAP and also assesses risk factors to identify those pathogens. RECENT FINDINGS:In the las...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0565-x
更新日期:2017-03-01 00:00:00
abstract::Skin lesions provide an important clue to the diagnoses of many infections in returned travelers. New information related to epidemiology, recognition, diagnosis, or management is described for the systemic infections--dengue fever, several of the rickettsial infections, African trypanosomiasis, and coccidioidomycosis...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-004-0025-2
更新日期:2004-02-01 00:00:00
abstract::Neurocysticercosis, caused by infection with the pork tapeworm Taenia solium, is increasingly recognized as a cause of neurologic disease worldwide. Because the clinical presentation is nonspecific, diagnosis has been difficult. Advances in imaging studies and serodiagnostic techniques are facilitating the diagnosis o...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-005-0022-0
更新日期:2005-01-01 00:00:00
abstract::The deadly combination of tuberculosis (TB) and human immunodeficiency virus (HIV) currently ravaging the world, taking a toll of about 0.35 million people every year, is one of the major public health crises of the decade. Throughout the course of HIV infection, the risk of acquisition, reactivation, and reinfection ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-012-0311-3
更新日期:2013-02-01 00:00:00
abstract::Urinary tract infections are common, especially among women, and cause significant morbidity. While prognosis is probably more dependent on whether or not an episode of urinary tract infection is complicated (ie, associated with functional, metabolic, or anatomic abnormalities of the urinary tract) or uncomplicated, a...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-001-0090-8
更新日期:2001-12-01 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0180-1
更新日期:2011-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this article is to perform a systematic review over the past 5 years on the role and effectiveness of clinical decision support systems (CDSSs) on antibiotic stewardship. RECENT FINDINGS:CDDS interventions found a significant impact on multiple outcomes relevant to antibiotic stewardsh...
journal_title:Current infectious disease reports
pub_type: 杂志文章
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更新日期:2019-07-24 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章
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更新日期:2003-12-01 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0579-4
更新日期:2017-07-01 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-009-0028-0
更新日期:2009-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Acinetobacter baumannii (AB) is an infamous nosocomial pathogen with a seemingly limitless capacity for antimicrobial resistance, leading to few treatment options and poor clinical outcomes. The debatably low pathogenicity and virulence of AB are juxtaposed by its exceptionally high rate of infection-...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-019-0706-5
更新日期:2019-11-16 00:00:00
abstract::Two million of the 15 million (13.3%) new cases of sexually transmitted infections (STIs) among persons 15 to 49 years old occur in pregnant women. Access to care and a provider's ability to assess risk, screen, and treat STIs are critical factors in preventing adverse pregnancy outcomes. Significant variations in pro...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-007-0008-1
更新日期:2007-03-01 00:00:00
abstract::Hepatitis delta virus (HDV) is a unique human virus, showing similarities with plant viroids. Although impressive knowledge on virus structure and replication has been achieved, several questions like HBV/HDV interaction and post translational modifications of HD antigens remain to be answered. Potential targets for t...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0233-5
更新日期:2012-02-01 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-009-0061-z
更新日期:2009-11-01 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-999-0013-7
更新日期:1999-04-01 00:00:00
abstract::Noroviruses are among the most common cause of diarrhea in transplant recipients. The clinical spectrum of norovirus infection after transplant is increasingly being recognized. As substantial morbidity is now associated with norovirus infections in this population; the quest for rapid diagnostic modalities and newer ...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-016-0524-y
更新日期:2016-06-01 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0600-y
更新日期:2017-09-23 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-005-0044-7
更新日期:2005-11-01 00:00:00
abstract::Antiretroviral therapy (ART) does not eliminate HIV-1 from latently infected reservoirs, and this remains the critical obstacle to the eradication of infection. Although ART is effective in suppressing viral load, life-long ART is burdensome in many respects. Given expanding numbers of HIV-infected individuals on ART ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0392-2
更新日期:2014-03-01 00:00:00
abstract::In most high-income countries, fewer children now acquire meningitis, and many of those who do will survive. Globally, however, meningitis still remains a significant cause of child morbidity and mortality. In this article, the authors review recent evidence on the morbidity faced by childhood survivors of bacterial m...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-013-0332-6
更新日期:2013-06-01 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0395-z
更新日期:2014-02-01 00:00:00
abstract::Although most cases of rhinosinusitis are benign, the disruption of quality of life due to disease symptoms leads patients to seek early medical care. Ongoing debates dispute the definition, bacteriology, and medical management of chronic sinusitis, while the criteria for acute sinusitis are relatively well establishe...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-001-0022-7
更新日期:2001-06-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Patients with COPD are at increased risk for community-acquired pneumonia (CAP). COPD has been reported as a comorbidity in at least one third of the hospitalized patients with CAP. There is a controversy that the pre...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0444-7
更新日期:2015-01-01 00:00:00
abstract::Antimicrobial resistance is a growing problem globally. The appearance and spread of bacteria that are resistant to most or all commonly available antibiotics has raised the specter of untreatable bacterial infections. The New Delhi metallo-beta-lactamase-1 (NDM-1) has received wide attention because of the extreme re...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-012-0252-x
更新日期:2012-06-01 00:00:00
abstract::Although modern medicine has improved survival in congenital heart disease dramatically, the long-term course carries a risk of late complications. The incidence of infective endocarditis in adults with congenital heart disease is more than 10 times higher than that of the normal population. Identification of the high...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-003-0006-x
更新日期:2003-08-01 00:00:00
abstract::Starting from 2010, the 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in several countries. This paper discusses some of the problems recently emerged after PCV13 use and their clinical impact. The impact of PCV13 has been relevant and has saved millions of children and adults by severe infectious di...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-018-0607-z
更新日期:2018-01-24 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-018-0655-4
更新日期:2018-10-23 00:00:00
abstract::Three newer oral antifungal agents, itraconazole, terbinafine and fluconazole, have revolutionized treatment of superficial mycoses. The tissue pharmacokinetics of itraconazole and terbinafine allow much shorter courses of therapy- with higher efficacy-in the treatment of onychomycosis, compared to other oral agents. ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-000-0074-0
更新日期:2000-10-01 00:00:00