Abstract：
:Antiretroviral therapy (ART) does not eliminate HIV-1 from latently infected reservoirs, and this remains the critical obstacle to the eradication of infection. Although ART is effective in suppressing viral load, life-long ART is burdensome in many respects. Given expanding numbers of HIV-infected individuals on ART worldwide, there is an urgent need to examine the possibility that innovative therapies might eradicate infection, and obviate the need for life-long medical therapy for HIV-positive people around the world. Several approaches to eradicating the latent HIV reservoir and curing infection have been proposed and are under study. An initial strategy seeks to induce the expression of the latent integrated proviral genomes within resting CD4+ T cells, so that viral proteins or particles may be revealed and allow these cellular reservoirs to be cleared. The inducing agents that have been studied recently are inhibitors of histone deacetylase (HDAC) such as suberoylanilide hydroxamic acid (SAHA). Such induction of viral expression seems unlikely in itself to efficiently clear all latently infected cells. Therefore, it seems likely that parallel efforts to augment the HIV-specific immune response with specific immunotherapies or vaccination may be required. Recently, efforts to achieve immune augmentation by ex vivo expansion of viral specific cytotoxic T-cell lymphocytes derived from HIV-infected patients have yielded an augmented HIV-specific immune response in vivo, as have cellular vaccinations delivered by administration of dendritic cells. As HIV latency and the persistence of infection despite effective ART is multifactorial, the eradication of HIV infection may require multiple approaches.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Margolis DMdoi
10.1007/s11908-014-0392-2subject
Has Abstractpub_date
2014-03-01 00:00:00pages
392issue
3eissn
1523-3847issn
1534-3146journal_volume
16pub_type
杂志文章abstract：:Determining the microbiologic etiology of enteric infection remains an elusive goal. Conventional approaches, including culture, microscopy, and antigen-based tests have significant limitations such as limit of detection and the need for multiple procedures. Molecular diagnostics, especially PCR based tests, are rapid...
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更新日期：2012-02-01 00:00:00
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journal_title：Current infectious disease reports
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更新日期：2008-03-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-004-0053-y
更新日期：2004-08-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0581-x
更新日期：2017-08-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-005-0044-7
更新日期：2005-11-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-001-0090-8
更新日期：2001-12-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-011-0175-y
更新日期：2011-06-01 00:00:00
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journal_title：Current infectious disease reports
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更新日期：2015-12-01 00:00:00
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journal_title：Current infectious disease reports
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doi：10.1007/s11908-015-0496-3
更新日期：2015-08-01 00:00:00
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journal_title：Current infectious disease reports
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更新日期：1999-06-01 00:00:00
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更新日期：2012-02-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0069-1
更新日期：2007-11-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-999-0043-1
更新日期：1999-10-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-005-0007-z
更新日期：2005-09-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-009-0052-0
更新日期：2009-09-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0008-1
更新日期：2007-03-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0061-9
更新日期：2007-09-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0601-x
更新日期：2017-09-19 00:00:00
abstract：:In an era of cost-consciousness in the delivery of medical care, the economics of healthcare delivery for HIV-infected persons has been an area of active interest. Interested parties include the payors of HIV care, particularly public insurers, who are paying for an increasing amount of the overall cost of HIV care in...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0018-8
更新日期：2000-08-01 00:00:00
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journal_title：Current infectious disease reports
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更新日期：2013-02-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0047-7
更新日期：2007-07-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-002-0041-z
更新日期：2002-12-01 00:00:00
abstract：:Vaginal discharge, vulvar pruritus, and dyspareunia are among the most common symptoms that prompt women to seek medical advice. They are frequently assumed to be due to vaginitis resulting from infection and are treated with anti-infective agents without further investigation. Such empirical treatment may be successf...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-008-0079-7
更新日期：2008-11-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-003-0020-z
更新日期：2003-10-01 00:00:00
abstract：:Pyoderma gangrenosum (PG) is a rare cause of purulent vulvovaginal ulceration. Six recent cases of vulvovaginal pyoderma gangrenosum associated with rituximab are described. All cases were seen in the setting of rituximab used for the treatment of B cell non Hodgkin's lymphoma (NHL). Age range was 50-74; symptoms were...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0478-5
更新日期：2015-05-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0017-0
更新日期：2007-01-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-012-0269-1
更新日期：2012-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Modern advances in malaria rapid diagnostic test (RDT) technology have increased demand for low-cost, easy-to-use assays in areas endemic for malaria. Substantial developments in diagnostic sensitivity and specificity, improvements in non-falciparum RDTs, and novel biotechnological innovations are gra...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-018-0655-4
更新日期：2018-10-23 00:00:00
