Abstract：
:The first description of acute respiratory distress syndrome (ARDS) in adults appeared in 1967 and was characterized by dyspnea, hypoxemia, diffuse alveolar infiltrates, and reduced respiratory system compliance. ARDS and acute lung injury (ALI) syndrome have no specific treatment, only supportive care: treating the underlying cause, when possible, and using mechanical ventilation. Historically, mechanical ventilation applied normal/large tidal volumes and low levels of positive end-expiratory pressure (PEEP). Experimental data showed that a high-volume, high-pressure ventilation strategy may lead to lung lesions indistinguishable from ARDS. Subsequent randomized clinical trials showed improved survival using low tidal volumes (6 vs 12 mL/kg ideal body weight) and limiting plateau pressure to 30 cm H(2)O, although the optimal level of PEEP remains controversial. Prone positioning should be reserved for severely ill patients. Inhaled nitric oxide, which is a pulmonary vasodilator with anti-inflammatory properties, is associated with limited improvement in oxygenation without improvement in survival.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Chiumello D,Cressoni Mdoi
10.1007/s11908-009-0052-0subject
Has Abstractpub_date
2009-09-01 00:00:00pages
365-71issue
5eissn
1523-3847issn
1534-3146journal_volume
11pub_type
杂志文章abstract：:The ability to predict efficacy and toxicity during antiretroviral therapy for HIV would be of obvious advantage. The substantial variability between patients in terms of bioavailability and distribution of current regimens is likely driven by genetic and environmental factors. Protease inhibitors and nucleoside/nucle...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-006-0052-2
更新日期：2006-09-01 00:00:00
abstract：:Candida species are an important cause of health care-related bloodstream infections (BSI). Understanding the current Candida BSI incidence trends, the dominant species causing disease, and the mortality associated with this infection are important to help guide therapeutic and prophylaxis measures. In this review, tr...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-005-0044-7
更新日期：2005-11-01 00:00:00
abstract：:Vaginal discharge, vulvar pruritus, and dyspareunia are among the most common symptoms that prompt women to seek medical advice. They are frequently assumed to be due to vaginitis resulting from infection and are treated with anti-infective agents without further investigation. Such empirical treatment may be successf...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-008-0079-7
更新日期：2008-11-01 00:00:00
abstract：:Immunization against the most common meningeal pathogens is the leading factor associated with decreased incidence of bacterial meningitis in countries where routine vaccination is available. This is most dramatically illustrated by the reduction in the incidence of Haemophilus influenzae type b meningitis. The incide...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0047-7
更新日期：2007-07-01 00:00:00
abstract：:Oral triazole therapy is well established for the treatment of invasive aspergillosis (IPA), allergic aspergillosis (ABPA), and chronic pulmonary aspergillosis (CPA), and is often long-term. Resistance to triazole azole antifungal drugs in Aspergillus fumigatus is now a major clinical problem in a number of European l...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-011-0218-4
更新日期：2011-12-01 00:00:00
abstract：:Neuroimaging studies have revealed that neurocysticercosis is a major cause of neurologic disease in most developing countries and is an emerging disease in industrialized areas. Patients with neurocysticercosis present mainly with seizures (parenchymal form) or intracranial hypertension (ventricular/subarachnoid form...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-999-0055-x
更新日期：1999-12-01 00:00:00
abstract：:Skin lesions provide an important clue to the diagnoses of many infections in returned travelers. New information related to epidemiology, recognition, diagnosis, or management is described for the systemic infections--dengue fever, several of the rickettsial infections, African trypanosomiasis, and coccidioidomycosis...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-004-0025-2
更新日期：2004-02-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this paper is to review therapies with new mechanisms of action for the treatment of HIV that are at least in phase 2 clinical trials. RECENT FINDINGS:There are several new mechanisms of action being represented within clinical development, including histone deacetylase (HDAC) inhibito...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0601-x
更新日期：2017-09-19 00:00:00
abstract：:The deadly combination of tuberculosis (TB) and human immunodeficiency virus (HIV) currently ravaging the world, taking a toll of about 0.35 million people every year, is one of the major public health crises of the decade. Throughout the course of HIV infection, the risk of acquisition, reactivation, and reinfection ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-012-0311-3
更新日期：2013-02-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-010-0156-6
更新日期：2011-02-01 00:00:00
abstract：:During much of the past century, the microbe itself stood at the heart of microbial pathogenesis. Little thought was devoted to the host per se, though it was granted that differences in susceptibility to certain infections did exist between individuals, and between different ethnic groups. During the past 20 years, e...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-1009-9
更新日期：2007-10-01 00:00:00
abstract：:Group A streptococcus is a widespread human pathogen that causes a broad spectrum of human disease. The persistent high burden and severity of illness in developing and industrialized countries speaks to the need for a safe and effective vaccine. Modern approaches to vaccine construction include M protein type-specifi...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-008-0032-9
更新日期：2008-05-01 00:00:00
abstract：:Healthcare-associated bacterial meningitis may occur after neurosurgical procedures, head trauma, and following placement of external or internal ventricular catheters. The likely microorganisms that cause meningitis in this setting (ie, staphylococci and gram-negative bacilli) are different from those that cause meni...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-011-0190-z
更新日期：2011-08-01 00:00:00
abstract：:Increases in sexually transmitted diseases (STDs) among men who have sex with men (MSM) have coincided with recent increases in sexual risk behaviors across the United States and Europe. The identification of same-sex sexual risk behavior in men and the subsequent risk for certain bacterial and viral infections requir...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-003-0050-6
更新日期：2003-04-01 00:00:00
abstract：:Hepatitis delta virus (HDV) is a unique human virus, showing similarities with plant viroids. Although impressive knowledge on virus structure and replication has been achieved, several questions like HBV/HDV interaction and post translational modifications of HD antigens remain to be answered. Potential targets for t...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-011-0233-5
更新日期：2012-02-01 00:00:00
abstract：:Myocarditis is an acquired form inflammatory heart muscle disease, manifested as acute and chronic conditions. While many etiologies have been reported, the most common cause of this disease is infection, primarily viral. Typically, the specific causative agent(s) and mechanism(s) are elusive. Over the past several ye...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0008-x
更新日期：2000-08-01 00:00:00
abstract：:In an era of cost-consciousness in the delivery of medical care, the economics of healthcare delivery for HIV-infected persons has been an area of active interest. Interested parties include the payors of HIV care, particularly public insurers, who are paying for an increasing amount of the overall cost of HIV care in...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0018-8
更新日期：2000-08-01 00:00:00
abstract：:Two million of the 15 million (13.3%) new cases of sexually transmitted infections (STIs) among persons 15 to 49 years old occur in pregnant women. Access to care and a provider's ability to assess risk, screen, and treat STIs are critical factors in preventing adverse pregnancy outcomes. Significant variations in pro...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0008-1
更新日期：2007-03-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-016-0524-y
更新日期：2016-06-01 00:00:00
abstract：:Neisseria gonorrhoeae is a common cause of genitourinary sexually transmitted infections. N. gonorrhoeae is an obligate human pathogen that has evidence of tissue-specific host interactions and diverse extragenital manifestations of infection both in adult and pediatric populations. The clinical presentation of extrag...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-006-0009-5
更新日期：2006-03-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-014-0442-9
更新日期：2014-12-01 00:00:00
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journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-002-0049-4
更新日期：2002-04-01 00:00:00
abstract：:Reduction of microbial contamination of the hospital environment is a challenge, yet has potential impacts on infection prevention efforts. Fumigation and UV light devices for environmental cleaning have expanded into the health care setting with the goal of decontamination of difficult to clean or overlooked surfaces...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0498-1
更新日期：2015-09-01 00:00:00
abstract：:In the United States each year, influenza accounts for an estimated 20,000 to 40,000 deaths, nearly 300,000 hospitalizations, and millions of days lost from work. In the past few years, there has been an explosion of information in the medical literature related to influenza. This paper reviews these latest developmen...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0039-3
更新日期：2000-06-01 00:00:00
abstract：:Arthroplasty of the knee and hip is a common procedure. There is a risk of infection with primary arthroplasty, with an incidence of 1% to 2%. Significant cost and morbidity are associated with infection of the prosthetic joint. Most infections (60% to 70%) are caused by staphylococci, but approximately 10% are caused...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-004-0038-x
更新日期：2004-10-01 00:00:00
abstract：:Although most cases of rhinosinusitis are benign, the disruption of quality of life due to disease symptoms leads patients to seek early medical care. Ongoing debates dispute the definition, bacteriology, and medical management of chronic sinusitis, while the criteria for acute sinusitis are relatively well establishe...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-001-0022-7
更新日期：2001-06-01 00:00:00
abstract：:Prosthetic valve endocarditis (PVE) due to mycobacteria is a rare but frequently fatal complication that may occur early after the surgical procedure, or even years later. Infection has been described with both mechanical and biologic valvular prosthesis. The most commonly implicated mycobacterial species belong to th...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-010-0108-1
更新日期：2010-07-01 00:00:00
abstract：:Clinical toxinology is a specialized area of clinical medicine focused on the pathophysiology, diagnosis, treatment, and prevention of diseases caused by animal, plant, and fungal toxins. This review focuses on recent developments in snakebite. Snakebite is newly recognized as a Neglected Tropical Disease by the World...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-011-0172-1
更新日期：2011-06-01 00:00:00
abstract：:Skin and soft tissue infections vary widely in their nature and severity, and their nomenclature is complex. Most are readily recognized and easily treated, but more severe infections may masquerade in forms similar to those of more innocent infections, causing delay in diagnosis and treatment that may result in loss ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-002-0010-6
更新日期：2002-10-01 00:00:00
abstract：:Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes, mostly Aedes aegypti and Aedes albopictus. After half a century of focal outbreaks of acute febrile polyarthralgia in Africa and Asia, the disease unexpectedly spread in the past decade with large outbreaks in Africa and around the Indian Ocean and ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-011-0180-1
更新日期：2011-06-01 00:00:00
