Abstract：
PURPOSE OF REVIEW:Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system most often characterized by clinical relapses and periods of remission. RECENT FINDINGS:The past decade has seen a dramatic increase in disease-modifying therapies for MS. Fourteen FDA-approved immunomodulatory drugs are currently available, and more medications are in development. A growing number of reported opportunistic infections, including progressive multifocal leukoencephalopathy (PML), highlight the serious complications of these new drugs and the need for specific screening guidelines. Using data from Phase II and III randomized controlled trials, case reports, drug manufacturing data, and clinical experience, we outline the most common and serious infections associated with novel MS therapies.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Levin SN,Kaplan TBdoi
10.1007/s11908-017-0562-0subject
Has Abstractpub_date
2017-02-01 00:00:00pages
7issue
2eissn
1523-3847issn
1534-3146pii
10.1007/s11908-017-0562-0journal_volume
19pub_type
杂志文章,评审abstract：:Antimicrobial resistance is a growing problem globally. The appearance and spread of bacteria that are resistant to most or all commonly available antibiotics has raised the specter of untreatable bacterial infections. The New Delhi metallo-beta-lactamase-1 (NDM-1) has received wide attention because of the extreme re...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-012-0252-x
更新日期：2012-06-01 00:00:00
abstract：PURPOSE OF REVIEW:The infectious complications of transplantation can have devastating consequences for patients. Early and accurate diagnosis is essential to good outcomes. This review describes recent advances in pathogen-directed diagnostic testing and discusses the role of new methods for transplant infectious dise...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-019-0704-7
更新日期：2019-11-26 00:00:00
abstract：:Ventilator-associated pneumonia (VAP), an infection of the lower respiratory tract which occurs in association with mechanical ventilation, is one of the most common causes of nosocomial infection in the intensive care unit (ICU). VAP causes significant morbidity and mortality in critically ill patients including incr...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0496-3
更新日期：2015-08-01 00:00:00
abstract：:Transmissible spongiform encephalopathies (TSEs) are a group of progressive, fatal neurodegenerative disorders that share a common spongiform histopathology. TSEs may be transmitted in a sporadic, familial, iatrogenic, or zoonotic fashion. The putative infectious agent of TSE, the prion, represents a novel paradigm of...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-004-0053-y
更新日期：2004-08-01 00:00:00
abstract：:Pulmonary nocardiosis is an uncommon but serious infection that is increasingly found in immunosuppressed persons, especially transplant recipients and persons with AIDS. The Nocardia species are denizens of soil and decaying plants that gain entry to humans through inhalation or inoculation. Pulmonary nocardiosis typ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-001-0032-5
更新日期：2001-06-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to discuss the unique pathways of biofilm formation utilized by respiratory pathogens and current and future therapeutic strategies to inhibit biofilm formation or eradicate established biofilm in the context of these pathogens. Both nonselective and selective strategies ...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-019-0657-x
更新日期：2019-03-02 00:00:00
abstract：:Although mixed infections are known to be clinically relevant in conditions such as nosocomial pneumonia and ventilator-related pneumonia, it is increasingly recognized that a substantial number of community-acquired lower respiratory tract infections may also be attributed to more than one pathogenic organism. A bett...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0017-0
更新日期：2007-01-01 00:00:00
abstract：:The immune reconstitution inflammatory syndrome (IRIS) is a well-described phenomenon in HIV-infected patients following initiation of antiretroviral therapy and can lead to significant morbidity and mortality in some patients. Risk for IRIS is enhanced in those with low CD4 counts and preexisting opportunistic infect...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-012-0308-y
更新日期：2013-02-01 00:00:00
abstract：:The deadly combination of tuberculosis (TB) and human immunodeficiency virus (HIV) currently ravaging the world, taking a toll of about 0.35 million people every year, is one of the major public health crises of the decade. Throughout the course of HIV infection, the risk of acquisition, reactivation, and reinfection ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-012-0311-3
更新日期：2013-02-01 00:00:00
abstract：:Skin lesions provide an important clue to the diagnoses of many infections in returned travelers. New information related to epidemiology, recognition, diagnosis, or management is described for the systemic infections--dengue fever, several of the rickettsial infections, African trypanosomiasis, and coccidioidomycosis...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-004-0025-2
更新日期：2004-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Acinetobacter baumannii (AB) is an infamous nosocomial pathogen with a seemingly limitless capacity for antimicrobial resistance, leading to few treatment options and poor clinical outcomes. The debatably low pathogenicity and virulence of AB are juxtaposed by its exceptionally high rate of infection-...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-019-0706-5
更新日期：2019-11-16 00:00:00
abstract：:In an era of cost-consciousness in the delivery of medical care, the economics of healthcare delivery for HIV-infected persons has been an area of active interest. Interested parties include the payors of HIV care, particularly public insurers, who are paying for an increasing amount of the overall cost of HIV care in...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0018-8
更新日期：2000-08-01 00:00:00
abstract：:Before the advent of antiretroviral therapy (ART), CMV retinitis was a common, debilitating opportunistic infection in the HIV-infected population. ART has had such a favorable impact on the prevention and management of CMV retinitis that it can be considered in some ways to be CMV therapy. Currently available CMV dir...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-012-0269-1
更新日期：2012-08-01 00:00:00
abstract：:Candida species remain the most frequently isolated fungi in intensive care unit (ICU) patients with severe sepsis or septic shock. Delayed antifungal therapy in these patients is a recognized risk factor for mortality. However, the diagnosis of invasive candidiasis remains difficult and is frequently delayed. Clinica...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-011-0204-x
更新日期：2011-10-01 00:00:00
abstract：:A variety of antigen-capture assays are commercially available for the detection of influenza. In addition, real-time multiplex polymerase chain reaction (PCR) has been used to detect influenza A and B in clinical specimens. The commercial assays can be completed in less than 30 minutes and have a sensitivity of at le...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-005-0033-x
更新日期：2005-05-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to investigate the evolution and epidemiology of Klebsiella pneumoniae carbapenemase (KPC)-producing organisms and the current and future treatment options for infections caused by KPC-producing isolates. RECENT FINDINGS:The emergence of resistance in Enterobacteriaceae ...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-018-0617-x
更新日期：2018-05-05 00:00:00
abstract：:In most high-income countries, fewer children now acquire meningitis, and many of those who do will survive. Globally, however, meningitis still remains a significant cause of child morbidity and mortality. In this article, the authors review recent evidence on the morbidity faced by childhood survivors of bacterial m...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-013-0332-6
更新日期：2013-06-01 00:00:00
abstract：:Although most cases of rhinosinusitis are benign, the disruption of quality of life due to disease symptoms leads patients to seek early medical care. Ongoing debates dispute the definition, bacteriology, and medical management of chronic sinusitis, while the criteria for acute sinusitis are relatively well establishe...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-001-0022-7
更新日期：2001-06-01 00:00:00
abstract：:Although waterborne pathogens are relatively uncommon causes of cutaneous infections, these agents are being recognized with increasing frequency. Humans are exposed to water through a variety of recreational and occupational activities. Poor sanitary conditions in developing nations place the human populations at con...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-003-0020-z
更新日期：2003-10-01 00:00:00
abstract：:In the United States each year, influenza accounts for an estimated 20,000 to 40,000 deaths, nearly 300,000 hospitalizations, and millions of days lost from work. In the past few years, there has been an explosion of information in the medical literature related to influenza. This paper reviews these latest developmen...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0039-3
更新日期：2000-06-01 00:00:00
abstract：:Two million of the 15 million (13.3%) new cases of sexually transmitted infections (STIs) among persons 15 to 49 years old occur in pregnant women. Access to care and a provider's ability to assess risk, screen, and treat STIs are critical factors in preventing adverse pregnancy outcomes. Significant variations in pro...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0008-1
更新日期：2007-03-01 00:00:00
abstract：:Coronary heart disease (CHD) is an inflammatory process that takes decades to develop. In HIV-seronegative persons, high-sensitivity C-reactive protein is a biologic marker of CHD risk. HIV infection induces chronic inflammation, despite adequate suppression of HIV replication with antiretroviral therapy, resulting in...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-010-0153-9
更新日期：2011-02-01 00:00:00
abstract：PURPOSE OF REVIEW:The global emergence of antifungal resistance among Candida spp. and Aspergillus spp. is a growing threat to public health, driven largely by the expanding use of antifungals in both the clinical and agricultural settings. As treatment options remain limited, understanding mechanisms and risk factors ...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-019-0702-9
更新日期：2019-11-16 00:00:00
abstract：:Community-acquired pneumonia is a common reason for hospitalization and leads to significant morbidity and mortality. There are published evidence-based guidelines for the diagnosis, treatment, and management of community-acquired pneumonia. Many countries, including the US, have developed national, publically reporte...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-014-0395-z
更新日期：2014-02-01 00:00:00
abstract：:Combination antifungal therapy has been an area of great research and clinical interest since antifungals became available decades ago, in part driven by the severe morbidity and mortality associated with invasive fungal infections. Because of the availability of newer antifungal agents including echinocandins and exp...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0069-1
更新日期：2007-11-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Patients with COPD are at increased risk for community-acquired pneumonia (CAP). COPD has been reported as a comorbidity in at least one third of the hospitalized patients with CAP. There is a controversy that the pre...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-014-0444-7
更新日期：2015-01-01 00:00:00
abstract：:Rates of syphilis continue to increase in the United States and HIV-infected patients make up a large proportion of cases. The interaction between syphilis and HIV is complex and still incompletely understood. Although diagnosis and management of HIV-infected patients with syphilis is, in general, similar to HIV-uninf...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-010-0083-6
更新日期：2010-03-01 00:00:00
abstract：:Human herpesvirus 8 (HHV-8) or Kaposi's sarcoma (KS)-associated herpesvirus is a recently identified virus that is associated with KS, multicentric Castleman's disease, and body cavity-based lymphomas. KS is the most common kind of cancer in AIDS patients and the initial AIDS-defining condition in over 20% of patients...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-999-0031-5
更新日期：1999-08-01 00:00:00
abstract：:Fungal endocarditis (FE) is an increasingly prevalent and devastating disease in today's highly advancing medical practice. With more patients receiving broad-spectrum antibiotics or invasive interventions including long-term central venous catheters or prosthetic heart valve placements, FE is increasingly reported. R...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-008-0045-4
更新日期：2008-07-01 00:00:00
abstract：:There is strong evidence that preoperative nasal S. aureus screening/decolonization will significantly reduce surgical site infections (SSIs) after joint prostheses implantation. There is some evidence that antibiotic-containing bone cement may lower SSI rates. Timely administration of perioperative systemic antibioti...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-012-0278-0
更新日期：2012-10-01 00:00:00
