Is Vitamin C Beneficial to Patients with CAP?

Abstract:

:Community-acquired pneumonia (CAP) is one of the most common causes of morbidity and mortality in elderly and children. Vitamin C is known as a physiological antioxidant, regulating innate immune system in the lung. Vitamin C has been used to prevent and treat CAP. However, the use of vitamin C for preventing and treating CAP has been a subject of controversy. We aim to review the most significant findings about vitamin C supplementation in patients with pneumonia based on literature from the PubMed. First, we reviewed recent advances about the role of oxidative stress in CAP. Oxidative stress is a crucial component of the host defense system and inflammatory response. However, excessive oxidative stress can cause a systemic inflammatory response leading to tissue damage. The degree of oxidative stress has been associated with the severity of CAP. Vitamin C is beneficial to the host defense system by regulating the innate immunity in the lungs. We also discuss the prophylactic use of vitamin C for pneumonia. Vitamin C supplementation decreased the pneumonia risk in patients with vitamin C deficiency. However, it is not beneficial for prophylactic use of vitamin C to prevent pneumonia in the well-nourished population. Finally, we summarize the effect of vitamin C on mechanical ventilation used during respiratory failure. Administration of vitamin C decreases the duration of mechanical ventilation by decreasing oxidative stress.

journal_name

Curr Infect Dis Rep

authors

Li Y,Li G

doi

10.1007/s11908-016-0530-0

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

24

issue

8

eissn

1523-3847

issn

1534-3146

pii

10.1007/s11908-016-0530-0

journal_volume

18

pub_type

杂志文章,评审
  • Diagnosis and Management of Infectious Thyroiditis.

    abstract::A broad range of disorders can cause inflammation of the thyroid gland. True thyroid infections are rare and can result from a variety of microorganisms, of which bacteria are the most common. Other rarer pathogens include fungi, parasites, and viruses. Gram-positive bacteria, especially staphylococci, predominate as ...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-000-0027-7

    authors: Shah SS,Baum SG

    更新日期:2000-04-01 00:00:00

  • Management of HIV-infected Patients with Multidrug-resistant Virus.

    abstract::Heavily pretreated HIV-infected patients with multidrug-resistant virus remain a clinical challenge to the treating physician. While the goal of therapy in such patients is still controversial, sustained immunologic and clinical benefit have only been demonstrated with complete suppression of plasma viral load below d...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-002-0089-9

    authors: Montaner JS,Harris M

    更新日期:2002-06-01 00:00:00

  • The Influence of Influenza and Pneumococcal Vaccines on Community-Acquired Pneumonia (CAP) Outcomes Among Elderly Patients.

    abstract::Elderly are at high risk for hospitalization for community-acquired pneumonia (CAP), especially due to Streptococcus pneumoniae, and seasonal influenza viruses. Data suggest PPV23's influence on various CAP-related outcomes among the elderly may depend upon how many years have elapsed since they received this vaccine....

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-015-0505-6

    authors: Gubbins PO,Li C

    更新日期:2015-12-01 00:00:00

  • Bacterial meningitis vaccines: not just for kids.

    abstract::Bacterial meningitis remains a feared diagnosis that may lead to significant mortality and morbidity in both the developed and developing world; case fatality rates range from 10% to 50% among all age groups. Several vaccines are available (including the Haemophilus influenzae type B polysaccharide conjugate vaccine) ...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-009-0045-z

    authors: Verma R,Fisher MC

    更新日期:2009-07-01 00:00:00

  • Live virus vaccines in transplantation: friend or foe?

    abstract::Solid organ and hematopoietic stem cell transplant recipients may be exposed to diseases which may be prevented through live attenuated virus vaccines (LAVV). Because of their immunosuppression, these diseases can lead to severe complications in transplant recipients. Despite increasing evidence regarding the safety a...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-015-0472-y

    authors: Verolet CM,Posfay-Barbe KM

    更新日期:2015-04-01 00:00:00

  • Rotavirus Vaccines: Current Controversies and Future Directions.

    abstract::Rotaviruses are the most important cause of pediatric gastroenteritis worldwide. In August 1998, a new rotavirus vaccine was licensed for general use in the United States. However, 14 months later, the vaccine was withdrawn from the market because of serious gastrointestinal side effects. This paper discusses the need...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-000-0090-0

    authors: Coffin SE

    更新日期:2000-02-01 00:00:00

  • Antifungal Resistance: a Concerning Trend for the Present and Future.

    abstract:PURPOSE OF REVIEW:The global emergence of antifungal resistance among Candida spp. and Aspergillus spp. is a growing threat to public health, driven largely by the expanding use of antifungals in both the clinical and agricultural settings. As treatment options remain limited, understanding mechanisms and risk factors ...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11908-019-0702-9

    authors: Hendrickson JA,Hu C,Aitken SL,Beyda N

    更新日期:2019-11-16 00:00:00

  • Combination antifungal therapy for the treatment of invasive yeast and mold infections.

    abstract::Combination antifungal therapy has been an area of great research and clinical interest since antifungals became available decades ago, in part driven by the severe morbidity and mortality associated with invasive fungal infections. Because of the availability of newer antifungal agents including echinocandins and exp...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-007-0069-1

    authors: Baddley JW,Pappas PG

    更新日期:2007-11-01 00:00:00

  • Will New Human Papillomavirus Diagnostics Improve Cervical Cancer Control Efforts?

    abstract::With the causal link between specific types of human papillomavirus (HPV) and cervical cancer firmly established, efforts have turned to assessing the relative merits of offering HPV testing in screening, triage, and posttreatment management. Many unanswered questions remain, but a growing body of evidence supports a ...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-996-0054-0

    authors: Kulasingam SL,Koutsky LA

    更新日期:2001-04-01 00:00:00

  • Azole antifungal resistance today: focus on Aspergillus.

    abstract::Oral triazole therapy is well established for the treatment of invasive aspergillosis (IPA), allergic aspergillosis (ABPA), and chronic pulmonary aspergillosis (CPA), and is often long-term. Resistance to triazole azole antifungal drugs in Aspergillus fumigatus is now a major clinical problem in a number of European l...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-011-0218-4

    authors: Bowyer P,Moore CB,Rautemaa R,Denning DW,Richardson MD

    更新日期:2011-12-01 00:00:00

  • A 2015 Update on Ventilator-Associated Pneumonia: New Insights on Its Prevention, Diagnosis, and Treatment.

    abstract::Ventilator-associated pneumonia (VAP), an infection of the lower respiratory tract which occurs in association with mechanical ventilation, is one of the most common causes of nosocomial infection in the intensive care unit (ICU). VAP causes significant morbidity and mortality in critically ill patients including incr...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-015-0496-3

    authors: Waters B,Muscedere J

    更新日期:2015-08-01 00:00:00

  • Recent Developments in the Epidemiology, Diagnosis, Treatment, and Prevention of Neurocysticercosis.

    abstract::Neuroimaging studies have revealed that neurocysticercosis is a major cause of neurologic disease in most developing countries and is an emerging disease in industrialized areas. Patients with neurocysticercosis present mainly with seizures (parenchymal form) or intracranial hypertension (ventricular/subarachnoid form...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-999-0055-x

    authors: White AC,Garcia HH

    更新日期:1999-12-01 00:00:00

  • Community-acquired pneumonia in patients with chronic obstructive pulmonary disease.

    abstract::Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Patients with COPD are at increased risk for community-acquired pneumonia (CAP). COPD has been reported as a comorbidity in at least one third of the hospitalized patients with CAP. There is a controversy that the pre...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-014-0444-7

    authors: Cilli A

    更新日期:2015-01-01 00:00:00

  • Evaluation and Management of Syphilis in the HIV-Infected Patient.

    abstract::Rates of syphilis continue to increase in the United States and HIV-infected patients make up a large proportion of cases. The interaction between syphilis and HIV is complex and still incompletely understood. Although diagnosis and management of HIV-infected patients with syphilis is, in general, similar to HIV-uninf...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-010-0083-6

    authors: Ghanem KG

    更新日期:2010-03-01 00:00:00

  • New concepts in the pathophysiology of infective endocarditis.

    abstract::Endocarditis pathogens colonize valves with pre-existing sterile vegetations or valves with minimal endothelial lesions. Inflamed endothelia produce cytokines, integrins, and tissue factor, which in turn attract fibronectin, monocytes, and platelets. Bacteria attaching to such structures further activate the cascade, ...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-006-0071-z

    authors: Widmer E,Que YA,Entenza JM,Moreillon P

    更新日期:2006-06-01 00:00:00

  • Urinary Tract Infection in Postmenopausal Women.

    abstract::Urinary tract infection (UTI) is common in postmenopausal women; the estimated incidence ranges from 4% to 15%. The clinical presentation of UTI is somewhat different in postmenopausal older women than it is in younger women: postmenopausal women are less likely to report frequency, dysuria, hematuria, and fever, but ...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-999-0043-1

    authors: Foxman B

    更新日期:1999-10-01 00:00:00

  • Dermatologic Infectious Diseases in International Travelers.

    abstract::Skin lesions provide an important clue to the diagnoses of many infections in returned travelers. New information related to epidemiology, recognition, diagnosis, or management is described for the systemic infections--dengue fever, several of the rickettsial infections, African trypanosomiasis, and coccidioidomycosis...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-004-0025-2

    authors: Wilson ME,Chen LH

    更新日期:2004-02-01 00:00:00

  • Infectious Considerations in the Pre-Transplant Evaluation of Cirrhotic Patients Awaiting Orthotopic Liver Transplantation.

    abstract::The incidence of end-stage liver disease (ESLD) is increasing and many of these patients may be considered for orthotopic liver transplantation. As patients with ESLD are at risk of a number of infections, infectious disease physicians should be aware of the management of these infections in order to provide optimal p...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-015-0514-5

    authors: Mah A,Wright A

    更新日期:2016-01-01 00:00:00

  • Global trends in candidemia: review of reports from 1995-2005.

    abstract::Candida species are an important cause of health care-related bloodstream infections (BSI). Understanding the current Candida BSI incidence trends, the dominant species causing disease, and the mortality associated with this infection are important to help guide therapeutic and prophylaxis measures. In this review, tr...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-005-0044-7

    authors: Morgan J

    更新日期:2005-11-01 00:00:00

  • The immune reconstitution inflammatory syndrome: a clinical update.

    abstract::The immune reconstitution inflammatory syndrome (IRIS) is a well-described phenomenon in HIV-infected patients following initiation of antiretroviral therapy and can lead to significant morbidity and mortality in some patients. Risk for IRIS is enhanced in those with low CD4 counts and preexisting opportunistic infect...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-012-0308-y

    authors: Armstrong WS

    更新日期:2013-02-01 00:00:00

  • Update on varicella zoster virus vasculopathy.

    abstract::Primary infection of humans with varicella zoster virus (VZV) causes varicella (chickenpox), after which the virus becomes latent in cranial nerve ganglia, dorsal root ganglia and autonomic ganglia along the entire neuraxis. As VZV-specific cell-mediated immunity declines in elderly and immunocompromised individuals, ...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-014-0407-z

    authors: Nagel MA,Gilden D

    更新日期:2014-06-01 00:00:00

  • Chikungunya virus infection.

    abstract::Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes, mostly Aedes aegypti and Aedes albopictus. After half a century of focal outbreaks of acute febrile polyarthralgia in Africa and Asia, the disease unexpectedly spread in the past decade with large outbreaks in Africa and around the Indian Ocean and ...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-011-0180-1

    authors: Simon F,Javelle E,Oliver M,Leparc-Goffart I,Marimoutou C

    更新日期:2011-06-01 00:00:00

  • Clinical Decision Support Systems and Their Role in Antibiotic Stewardship: a Systematic Review.

    abstract:PURPOSE OF REVIEW:The purpose of this article is to perform a systematic review over the past 5 years on the role and effectiveness of clinical decision support systems (CDSSs) on antibiotic stewardship. RECENT FINDINGS:CDDS interventions found a significant impact on multiple outcomes relevant to antibiotic stewardsh...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-019-0683-8

    authors: Rittmann B,Stevens MP

    更新日期:2019-07-24 00:00:00

  • Healthcare Economics in HIV.

    abstract::In an era of cost-consciousness in the delivery of medical care, the economics of healthcare delivery for HIV-infected persons has been an area of active interest. Interested parties include the payors of HIV care, particularly public insurers, who are paying for an increasing amount of the overall cost of HIV care in...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-000-0018-8

    authors: Moore RD

    更新日期:2000-08-01 00:00:00

  • Infections Associated with Prosthetic Knee and Prosthetic Hip.

    abstract::Arthroplasty of the knee and hip is a common procedure. There is a risk of infection with primary arthroplasty, with an incidence of 1% to 2%. Significant cost and morbidity are associated with infection of the prosthetic joint. Most infections (60% to 70%) are caused by staphylococci, but approximately 10% are caused...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-004-0038-x

    authors: Lentino JR

    更新日期:2004-10-01 00:00:00

  • Pharmacokinetics of antibiotics or antifungal drugs in intensive care units.

    abstract::Intensive care unit (ICU) patients present several unusual pharmacokinetic (PK) characteristics compared with less seriously ill patients, including increased distribution volume and variable clearance. Interpatient PK variability is often considerable and can produce a wide range of values for PK parameters and major...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-009-0003-9

    authors: Dufour G,Montravers P

    更新日期:2009-01-01 00:00:00

  • Management and Prevention of Clostridium difficile-Associated Diarrhea.

    abstract::Clostridium difficile is a major cause of antibiotic-associated diarrhea. While treatment regimens for C. difficile have been available for decades, they remain less than optimal due to the frequent recurrences that occur after therapy is completed. Moreover, the morbidity and expense associated with C. difficile have...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-996-0032-6

    authors: Ciesla WP,Bobak DA

    更新日期:2001-04-01 00:00:00

  • Prevention of surgical site infections in bone and joint procedures.

    abstract::There is strong evidence that preoperative nasal S. aureus screening/decolonization will significantly reduce surgical site infections (SSIs) after joint prostheses implantation. There is some evidence that antibiotic-containing bone cement may lower SSI rates. Timely administration of perioperative systemic antibioti...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-012-0278-0

    authors: Vonberg RP,Gastmeier P

    更新日期:2012-10-01 00:00:00

  • The prospect of vaccination against group A beta-hemolytic streptococci.

    abstract::Group A streptococcus is a widespread human pathogen that causes a broad spectrum of human disease. The persistent high burden and severity of illness in developing and industrialized countries speaks to the need for a safe and effective vaccine. Modern approaches to vaccine construction include M protein type-specifi...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章

    doi:10.1007/s11908-008-0032-9

    authors: Kotloff KL

    更新日期:2008-05-01 00:00:00

  • An Update on Malaria Rapid Diagnostic Tests.

    abstract:PURPOSE OF REVIEW:Modern advances in malaria rapid diagnostic test (RDT) technology have increased demand for low-cost, easy-to-use assays in areas endemic for malaria. Substantial developments in diagnostic sensitivity and specificity, improvements in non-falciparum RDTs, and novel biotechnological innovations are gra...

    journal_title:Current infectious disease reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11908-018-0655-4

    authors: Mukkala AN,Kwan J,Lau R,Harris D,Kain D,Boggild AK

    更新日期:2018-10-23 00:00:00