Abstract：
:Hepatitis C virus (HCV) infection is a significant cause of chronic liver disease with substantial long-term sequelae. Until very recently, therapies to cure HCV were hindered by high nonresponse rates and severe side effects. The first-generation protease inhibitor-containing regimens provided superior cure rates for many HCV-infected patients, although their side-effect profile proved to be quite burdensome. We are now witnessing the emergence of therapies with superior cure rates, limited side effects, and broad genotypic activity. Two therapies, sofosbuvir (an NS5b polymerase inhibitor) and simeprevir (a second-generation NS3/4A protease inhibitor), were approved by the Food and Drug Administration in late 2013 for use in a number of HCV populations. This review focuses primarily upon these therapies and the key studies that support their use in practice. Furthermore, representative novel antiviral therapies, in advanced stages of testing, are also reviewed.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Moore C,Levitsky Jdoi
10.1007/s11908-014-0413-1subject
Has Abstractpub_date
2014-08-01 00:00:00pages
413issue
8eissn
1523-3847issn
1534-3146journal_volume
16pub_type
杂志文章abstract：:Bacterial meningitis is a complex disorder in which neurologic injury is caused, in part, by the causative organism and, in part, by the host's own inflammatory response. In studies of experimental bacterial meningitis, adjuvant treatment with corticosteroids, specifically dexamethasone, has beneficial effects. On the...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-005-0061-6
更新日期：2005-07-01 00:00:00
abstract：PURPOSE OF THE REVIEW:Community-acquired pneumonia (CAP) is still associated with a large burden and causes significant morbidity and mortality. Besides universal vaccination and antibiotic treatment, statins as adjunctive therapy may also have a beneficial role in the prevention and treatment of CAP. Our goal from thi...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0581-x
更新日期：2017-08-01 00:00:00
abstract：:Elderly are at high risk for hospitalization for community-acquired pneumonia (CAP), especially due to Streptococcus pneumoniae, and seasonal influenza viruses. Data suggest PPV23's influence on various CAP-related outcomes among the elderly may depend upon how many years have elapsed since they received this vaccine....
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0505-6
更新日期：2015-12-01 00:00:00
abstract：:The incidence of end-stage liver disease (ESLD) is increasing and many of these patients may be considered for orthotopic liver transplantation. As patients with ESLD are at risk of a number of infections, infectious disease physicians should be aware of the management of these infections in order to provide optimal p...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0514-5
更新日期：2016-01-01 00:00:00
abstract：:Intensive care unit (ICU) patients present several unusual pharmacokinetic (PK) characteristics compared with less seriously ill patients, including increased distribution volume and variable clearance. Interpatient PK variability is often considerable and can produce a wide range of values for PK parameters and major...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-009-0003-9
更新日期：2009-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Suppressive therapy and periodic presumptive treatment (PPT) are distinct but related strategies that have been used to reduce the incidence of bacterial vaginosis (BV). Here, we review clinical trial evidence of the effectiveness of suppressive therapy and PPT to reduce BV, and discuss their roles fo...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-019-0688-3
更新日期：2019-08-31 00:00:00
abstract：:The first description of acute respiratory distress syndrome (ARDS) in adults appeared in 1967 and was characterized by dyspnea, hypoxemia, diffuse alveolar infiltrates, and reduced respiratory system compliance. ARDS and acute lung injury (ALI) syndrome have no specific treatment, only supportive care: treating the u...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-009-0052-0
更新日期：2009-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Post-transplant infections present a formidable challenge to the physician due to their varied presentation. Many of these infections begin by inoculation following skin compromise or disseminate to the skin hematogenously, making cutaneous manifestations of infection an important diagnostic clue in t...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-018-0621-1
更新日期：2018-05-22 00:00:00
abstract：:Skin lesions provide an important clue to the diagnoses of many infections in returned travelers. New information related to epidemiology, recognition, diagnosis, or management is described for the systemic infections--dengue fever, several of the rickettsial infections, African trypanosomiasis, and coccidioidomycosis...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-004-0025-2
更新日期：2004-02-01 00:00:00
abstract：:Although modern medicine has improved survival in congenital heart disease dramatically, the long-term course carries a risk of late complications. The incidence of infective endocarditis in adults with congenital heart disease is more than 10 times higher than that of the normal population. Identification of the high...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-003-0006-x
更新日期：2003-08-01 00:00:00
abstract：:Although mixed infections are known to be clinically relevant in conditions such as nosocomial pneumonia and ventilator-related pneumonia, it is increasingly recognized that a substantial number of community-acquired lower respiratory tract infections may also be attributed to more than one pathogenic organism. A bett...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0017-0
更新日期：2007-01-01 00:00:00
abstract：:Bacterial vaginosis (BV) is a common cause of vaginal discharge in women of childbearing age. In some individuals, it recurs frequently after treatment, frustrating both the patient and the physician. Standard BV treatment--metronidazole or clindamycin, administered either intravaginally or orally--is followed by rela...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0053-5
更新日期：2000-12-01 00:00:00
abstract：PURPOSE OF REVIEW:This review attempts to understand the reasons for the successes and failures of the two novel strategies that have slowly begun to emerge as potential counters for anti-malarial drug resistance-"Triple Combination Therapy" and "Drug Cycling." RECENT FINDINGS:Recent reports have suggested that increa...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0579-4
更新日期：2017-07-01 00:00:00
abstract：:Solid organ and hematopoietic stem cell transplant recipients may be exposed to diseases which may be prevented through live attenuated virus vaccines (LAVV). Because of their immunosuppression, these diseases can lead to severe complications in transplant recipients. Despite increasing evidence regarding the safety a...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0472-y
更新日期：2015-04-01 00:00:00
abstract：:Streptococcus bovis is a rare, but important cause of bacterial meningitis in children. Since its discovery in the early 1970s, the pathogen has undergone multiple taxonomic changes producing four distinct subspecies today, the most prevalent of which is S. gallolyticus subsp pasteurianus in infants and children. Whil...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-016-0519-8
更新日期：2016-03-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this article is to perform a systematic review over the past 5 years on the role and effectiveness of clinical decision support systems (CDSSs) on antibiotic stewardship. RECENT FINDINGS:CDDS interventions found a significant impact on multiple outcomes relevant to antibiotic stewardsh...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-019-0683-8
更新日期：2019-07-24 00:00:00
abstract：:Urinary tract infection (UTI) is common in postmenopausal women; the estimated incidence ranges from 4% to 15%. The clinical presentation of UTI is somewhat different in postmenopausal older women than it is in younger women: postmenopausal women are less likely to report frequency, dysuria, hematuria, and fever, but ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-999-0043-1
更新日期：1999-10-01 00:00:00
abstract：:Treatment of chronic rhinosinusitis still represents an unmet medical need. Presently, the US Food and Drug Administration has not approved any drugs for the treatment of this common condition. Various inflammatory processes are involved in the pathogenesis of chronic rhinosinusitis. Treatment of infection and surgica...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-007-0031-2
更新日期：2007-05-01 00:00:00
abstract：:Pyoderma gangrenosum (PG) is a rare cause of purulent vulvovaginal ulceration. Six recent cases of vulvovaginal pyoderma gangrenosum associated with rituximab are described. All cases were seen in the setting of rituximab used for the treatment of B cell non Hodgkin's lymphoma (NHL). Age range was 50-74; symptoms were...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-015-0478-5
更新日期：2015-05-01 00:00:00
abstract：:Bacterial meningitis remains a feared diagnosis that may lead to significant mortality and morbidity in both the developed and developing world; case fatality rates range from 10% to 50% among all age groups. Several vaccines are available (including the Haemophilus influenzae type B polysaccharide conjugate vaccine) ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-009-0045-z
更新日期：2009-07-01 00:00:00
abstract：:Therapy of cryptococcal meningitis has been focused primarily on optimizing the antifungal regimen to improve the previously high treatment failure rates. Until recently, relatively little attention has been paid to the impact of increased intracranial pressure, which is a frequent problem that complicates management ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-002-0026-y
更新日期：2002-08-01 00:00:00
abstract：:Coronary heart disease (CHD) is an inflammatory process that takes decades to develop. In HIV-seronegative persons, high-sensitivity C-reactive protein is a biologic marker of CHD risk. HIV infection induces chronic inflammation, despite adequate suppression of HIV replication with antiretroviral therapy, resulting in...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-010-0153-9
更新日期：2011-02-01 00:00:00
abstract：PURPOSE OF REVIEW:The increase in drug-resistant community-acquired pneumonia (CAP) is an important problem all over the world. This article explores the current state of antimicrobial resistance of different bacteria that cause CAP and also assesses risk factors to identify those pathogens. RECENT FINDINGS:In the las...
journal_title：Current infectious disease reports
pub_type： 杂志文章,评审
doi：10.1007/s11908-017-0565-x
更新日期：2017-03-01 00:00:00
abstract：:Prosthetic valve endocarditis (PVE) due to mycobacteria is a rare but frequently fatal complication that may occur early after the surgical procedure, or even years later. Infection has been described with both mechanical and biologic valvular prosthesis. The most commonly implicated mycobacterial species belong to th...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-010-0108-1
更新日期：2010-07-01 00:00:00
abstract：:Necrotizing enterocolitis (NEC) continues to be a major cause of morbidity and mortality in premature infants. Although the pathogenesis of NEC remains unclear, abnormal bacterial colonization has been postulated as playing a central role. Various factors impact bacterial colonization following delivery. Compared to t...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-010-0156-6
更新日期：2011-02-01 00:00:00
abstract：:Three newer oral antifungal agents, itraconazole, terbinafine and fluconazole, have revolutionized treatment of superficial mycoses. The tissue pharmacokinetics of itraconazole and terbinafine allow much shorter courses of therapy- with higher efficacy-in the treatment of onychomycosis, compared to other oral agents. ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-000-0074-0
更新日期：2000-10-01 00:00:00
abstract：:Hepatic failure due to hepatitis C is the leading indicator for orthotopic liver transplantation (OLT) in the United States. Unfortunately, recurrent hepatitis C virus infection is essentially universal following orthotopic liver transplantation. Although significant advances have been made in the past decade for the ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-002-0049-4
更新日期：2002-04-01 00:00:00
abstract：:Antimicrobial resistance is a growing problem globally. The appearance and spread of bacteria that are resistant to most or all commonly available antibiotics has raised the specter of untreatable bacterial infections. The New Delhi metallo-beta-lactamase-1 (NDM-1) has received wide attention because of the extreme re...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-012-0252-x
更新日期：2012-06-01 00:00:00
abstract：:Drotrecogin alfa (activated) (DrotAA) has been approved for therapy of severe sepsis and septic shock for 7 years, but controversy persists regarding efficacy and safety. Only a single randomized, controlled trial (Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis; PROWESS) has shown evidence...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-008-0060-5
更新日期：2008-09-01 00:00:00
abstract：:Chlamydia psittaci, Chlamydia pneumoniae, and Mycoplasma pneumoniae are a group of respiratory pathogens that have similar pulmonary and extrapulmonary manifestations. Recent studies suggest that C. pneumoniae and M. pneumoniae may play a role in the pathogenesis of asthma, but further studies are needed to delineate ...
journal_title：Current infectious disease reports
pub_type： 杂志文章
doi：10.1007/s11908-999-0013-7
更新日期：1999-04-01 00:00:00
