Abstract:
:It is well established that the immunological response to the seasonal trivalent influenza vaccine is attenuated in cancer patients. Furthermore, rates of seroprotection and seroconversion vary by malignancy type and are higher in patients with solid tumors, as compared either with those with hematologic malignancies or with allogeneic hematopoietic stem cell recipients. In 2009, a novel influenza strain prompted development of new vaccines and evaluation of alternative dosing strategies in an attempt to increase the rates of seroconversion in immunocompromised patients, further complicating this issue. Recent literature has demonstrated that the use of myeloablative chemotherapy regimens and biologics is correlated with decreased immunogenicity and response to influenza vaccines. Much debate still exists as to the optimal timing of influenza vaccination. Delaying vaccination from 1 week following standard chemotherapy up to 6 months following rituximab is increasingly supported by studies in this heterogeneous population.
journal_name
Curr Infect Dis Repjournal_title
Current infectious disease reportsauthors
Baluch A,Pasikhova Ydoi
10.1007/s11908-013-0368-7subject
Has Abstractpub_date
2013-12-01 00:00:00pages
486-90issue
6eissn
1523-3847issn
1534-3146journal_volume
15pub_type
杂志文章abstract::High-risk human papillomaviruses (HPVs) are now recognized as the etiologic agents of invasive cervical cancer, a major cancer in women. A single HPV type (type 16) is responsible for about 50% of the cancers. The major capsid protein of papillomaviruses, L1, when expressed by recombinant DNA technology, has the intri...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-005-0072-3
更新日期:2005-03-01 00:00:00
abstract::Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes, mostly Aedes aegypti and Aedes albopictus. After half a century of focal outbreaks of acute febrile polyarthralgia in Africa and Asia, the disease unexpectedly spread in the past decade with large outbreaks in Africa and around the Indian Ocean and ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0180-1
更新日期:2011-06-01 00:00:00
abstract::Community-acquired pneumonia (CAP) is one of the most common causes of morbidity and mortality in elderly and children. Vitamin C is known as a physiological antioxidant, regulating innate immune system in the lung. Vitamin C has been used to prevent and treat CAP. However, the use of vitamin C for preventing and trea...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-016-0530-0
更新日期:2016-08-01 00:00:00
abstract::Cyclosporiasis is a food- and water-borne infection that affects healthy and immunocompromised individuals. Awareness of the disease has increased, and outbreaks continue to be reported among vulnerable hosts and now among local residents in endemic areas. Advances in molecular techniques have improved identification ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-009-0016-4
更新日期:2009-03-01 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0175-y
更新日期:2011-06-01 00:00:00
abstract::Hepatitis C virus (HCV) infection is a significant cause of chronic liver disease with substantial long-term sequelae. Until very recently, therapies to cure HCV were hindered by high nonresponse rates and severe side effects. The first-generation protease inhibitor-containing regimens provided superior cure rates for...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0413-1
更新日期:2014-08-01 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-996-0021-9
更新日期:1999-06-01 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0442-9
更新日期:2014-12-01 00:00:00
abstract::Transmissible spongiform encephalopathies (TSEs) are a group of progressive, fatal neurodegenerative disorders that share a common spongiform histopathology. TSEs may be transmitted in a sporadic, familial, iatrogenic, or zoonotic fashion. The putative infectious agent of TSE, the prion, represents a novel paradigm of...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-004-0053-y
更新日期:2004-08-01 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-996-0032-6
更新日期:2001-04-01 00:00:00
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journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-001-0090-8
更新日期:2001-12-01 00:00:00
abstract::Colonization with Staphylococcus aureus is a risk factor for invasive S. aureus infections. Intranasal mupirocin has effectively eradicated S. aureus colonization and appears to prevent S. aureus nosocomial infections in some patient populations. In hospitals and communities where mupirocin use has been widespread, re...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-004-0062-x
更新日期:2004-12-01 00:00:00
abstract::All of the endemic mycoses have cutaneous and mucocutaneous manifestations that are most commonly seen when patients have disseminated infection. Biopsy of skin lesions is simple and safe and can assist in making a timely diagnosis of disseminated infection. Primary cutaneous inoculation infection has been reported wi...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-013-0352-2
更新日期:2013-10-01 00:00:00
abstract::Neisseria gonorrhoeae is a common cause of genitourinary sexually transmitted infections. N. gonorrhoeae is an obligate human pathogen that has evidence of tissue-specific host interactions and diverse extragenital manifestations of infection both in adult and pediatric populations. The clinical presentation of extrag...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-006-0009-5
更新日期:2006-03-01 00:00:00
abstract::Oral triazole therapy is well established for the treatment of invasive aspergillosis (IPA), allergic aspergillosis (ABPA), and chronic pulmonary aspergillosis (CPA), and is often long-term. Resistance to triazole azole antifungal drugs in Aspergillus fumigatus is now a major clinical problem in a number of European l...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-011-0218-4
更新日期:2011-12-01 00:00:00
abstract::About 1% of all patients with end-stage renal disease in the United States are infected with HIV. With the introduction of highly active antiretroviral therapy (HAART), HIV death rates have declined 80%, and chronic diseases resulting from HIV have replaced opportunistic infections as the leading cause of death among ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-009-0078-3
更新日期:2010-01-01 00:00:00
abstract::The deadly combination of tuberculosis (TB) and human immunodeficiency virus (HIV) currently ravaging the world, taking a toll of about 0.35 million people every year, is one of the major public health crises of the decade. Throughout the course of HIV infection, the risk of acquisition, reactivation, and reinfection ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-012-0311-3
更新日期:2013-02-01 00:00:00
abstract::Carbapenems are the broadest spectrum antimicrobials utilized in the treatment of serious infections since the 1980s. Soon after their introduction, the discovery of carbapenem-resistant Enterobacteriaceae (CRE) was reported in the 1990s. Invasive CRE infections are associated with high mortality and limited treatment...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-016-0548-3
更新日期:2016-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this paper is to review therapies with new mechanisms of action for the treatment of HIV that are at least in phase 2 clinical trials. RECENT FINDINGS:There are several new mechanisms of action being represented within clinical development, including histone deacetylase (HDAC) inhibito...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0601-x
更新日期:2017-09-19 00:00:00
abstract::Rates of syphilis continue to increase in the United States and HIV-infected patients make up a large proportion of cases. The interaction between syphilis and HIV is complex and still incompletely understood. Although diagnosis and management of HIV-infected patients with syphilis is, in general, similar to HIV-uninf...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-010-0083-6
更新日期:2010-03-01 00:00:00
abstract::The ability to predict efficacy and toxicity during antiretroviral therapy for HIV would be of obvious advantage. The substantial variability between patients in terms of bioavailability and distribution of current regimens is likely driven by genetic and environmental factors. Protease inhibitors and nucleoside/nucle...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-006-0052-2
更新日期:2006-09-01 00:00:00
abstract::Although highly active antiretroviral therapy suppresses HIV replication resulting in extraordinary clinical benefits, toxicity, adherence difficulties, and the monetary cost of medications limit the long-term effectiveness and availability of therapy for many HIV-infected individuals. Strategies to interrupt therapy ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0059-2
更新日期:2002-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This review aims to determine the effectiveness of the use of syndrome diagnosis in the evaluation of vaginitis and to make suggestions based on the review findings. RECENT FINDINGS:Vaginal discharge as the main symptom of vaginitis is unspecific. A randomized study of symptom-based diagnosis and tre...
journal_title:Current infectious disease reports
pub_type: 杂志文章,评审
doi:10.1007/s11908-017-0558-9
更新日期:2017-01-01 00:00:00
abstract::Antimicrobial resistance is a growing problem globally. The appearance and spread of bacteria that are resistant to most or all commonly available antibiotics has raised the specter of untreatable bacterial infections. The New Delhi metallo-beta-lactamase-1 (NDM-1) has received wide attention because of the extreme re...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-012-0252-x
更新日期:2012-06-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Patients with COPD are at increased risk for community-acquired pneumonia (CAP). COPD has been reported as a comorbidity in at least one third of the hospitalized patients with CAP. There is a controversy that the pre...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0444-7
更新日期:2015-01-01 00:00:00
abstract::Patients with sepsis may require mechanical ventilation due to the acute respiratory distress syndrome (ARDS). It has become increasingly accepted that mechanical ventilation can contribute to lung injury in these patients. The modern concept of ventilator-induced lung injury is described in the context of alveolar ov...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-005-0007-z
更新日期:2005-09-01 00:00:00
abstract::Skin and soft tissue infections vary widely in their nature and severity, and their nomenclature is complex. Most are readily recognized and easily treated, but more severe infections may masquerade in forms similar to those of more innocent infections, causing delay in diagnosis and treatment that may result in loss ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-002-0010-6
更新日期:2002-10-01 00:00:00
abstract::Before the advent of antiretroviral therapy (ART), CMV retinitis was a common, debilitating opportunistic infection in the HIV-infected population. ART has had such a favorable impact on the prevention and management of CMV retinitis that it can be considered in some ways to be CMV therapy. Currently available CMV dir...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-012-0269-1
更新日期:2012-08-01 00:00:00
abstract::Antiretroviral therapy (ART) does not eliminate HIV-1 from latently infected reservoirs, and this remains the critical obstacle to the eradication of infection. Although ART is effective in suppressing viral load, life-long ART is burdensome in many respects. Given expanding numbers of HIV-infected individuals on ART ...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-014-0392-2
更新日期:2014-03-01 00:00:00
abstract::Bacterial meningitis is a complex disorder in which neurologic injury is caused, in part, by the causative organism and, in part, by the host's own inflammatory response. In studies of experimental bacterial meningitis, adjuvant treatment with corticosteroids, specifically dexamethasone, has beneficial effects. On the...
journal_title:Current infectious disease reports
pub_type: 杂志文章
doi:10.1007/s11908-005-0061-6
更新日期:2005-07-01 00:00:00