abstract：:Exploring coagulation in newborns and children is a challenge due to the low levels of both procoagulant factors and inhibitors. Conventional coagulation tests might be inadequate to explore all of these changes. The aim of the study is to evaluate the thrombin generation assay, a global test to explore coagulation, i...

journal_title：Annales de biologie clinique

authors： Talon L,Sapin AF,Fourneyron V,Senectaire S,Tardieu M,Tillier M,Trapani A,Trayaud A,Vaissade A,Lebreton A,Sinegre T

更新日期：2020-12-01 00:00:00

abstract：:Biochemical diagnosis of hereditary metabolic diseases requires the detection and simultaneous identification of a large number of compounds, hence the interest in metabolic profiles. Acylcarnitine profile allows the identification and quantification of more than thirty compounds. As part of the accreditation process ...

journal_title：Annales de biologie clinique

authors： Nowoczyn M,Acquaviva-Bourdain C,Corne C,Minet-Quinard R,Van Noolen L,Garnotel R,Dessein AF

更新日期：2020-10-01 00:00:00

abstract：:Biochemical diagnosis of hereditary metabolic diseases requires the detection and simultaneous identification of a large number of compounds, hence the interest in metabolic profiles. Amino acid chromatography allows the identification and quantification of more than forty compounds. As part of the accreditation proce...

journal_title：Annales de biologie clinique

authors： Veauville A,Acquaviva-Bourdain C,Nowoczyn M,Read MH,Corne C,Dessein AF,Van Noolen L,Garnotel R,Minet-Quinard R

更新日期：2020-10-01 00:00:00

abstract：:Iron deficiency anemia is frequently associated with thrombocytosis. However, in some rare cases of very severe iron deficiency, a thrombocytopenia may occur. This condition may lead to a misdiagnosis of immune thrombocytopenic purpura and thus to unnecessary tests in this context. Here we report two patients who pres...

journal_title：Annales de biologie clinique

authors： Blandinières A,Arlet JB,Gaussem P,Pouchot J,Darnige L

更新日期：2020-08-01 00:00:00

abstract：:Anti-citrullinated cyclic peptide antibodies (ACPA) were initially considered very specific for the diagnosis of rheumatoid arthritis (RA), and can predict the prognosis of the disease. However, these antibodies can be detected in other autoimmune diseases, including systemic lupus erythematosus (SLE), the most common...

journal_title：Annales de biologie clinique

authors： Bouchedoub Y,Djenouhat K,Rachedi N,Babasaci R,Ould Ali L,Salah K,Kherrache R,Kherbeche M,Khlifati A,Guernou FZ,Benzitouni A,Semmana M,Meghlaoui A

更新日期：2020-04-01 00:00:00

abstract：:This article aims to place the phosphatidylethanol (PEth) blood test in the detection area of ethanol consumption causing alcohol-related disorders, to present the current methods of analysis, data on interpretation, some practical applications and the prospects of use of this biomarker. PEth is a minor metabolite of ...

journal_title：Annales de biologie clinique

authors： Hakim F,Wiart JF,Ménard O,Allorge D,Gaulier JM

更新日期：2019-12-01 00:00:00

abstract：:The SFBC working group aimed to deal with biological tests outside the French nomenclature that may be useful for the follow-up of dialysis patients. Our discussion was divided into 3 parts: 1) evaluation of peritoneal membrane characteristics; 2) monitoring of renal replacement therapy using regional citrate anticoag...

journal_title：Annales de biologie clinique

authors： Bargnoux AS,Barguil Y,Zaoui E,Jean G,Cristol JP

更新日期：2019-08-01 00:00:00

abstract：:Type 2 diabetes (T2DM) associated with non-alcoholic fatty liver disease (NAFLD) increases cardiovascular risk. Complex and subtle connections are established between hepatic dysfunction and adipose tissue hyperactivity. This relationship is mediated by insulin resistance, dyslipidemia and inflammation. Recently incre...

journal_title：Annales de biologie clinique

authors： Chellali S,Boudiba A,Griene L,Koceir EA

更新日期：2019-06-01 00:00:00

abstract：:The aim of this study is to evaluate the anomalies of coagulation (by assaying the factor VIII, fibrinogen, D-dimer and resistance to activated protein C) in patients with lung cancer. METHODS:101 patients newly diagnosed with lung cancer before treatment and 72 control blood donors were included in the study after i...

journal_title：Annales de biologie clinique

authors： Hammouda A,Souilah S,Ferhat-Hamida MY,Amir ZC,Aouichat-Bouguerra S,Hariti G

更新日期：2019-06-01 00:00:00

abstract：:Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disorder caused by circulating autoantibodies directed against factor (F) VIII. Apart from idiopathic cases, AHA is associated with autoimmune diseases, cancers, use of medications, pregnancy and the post-partum period. We report the case of a 78-ye...

journal_title：Annales de biologie clinique

authors： Sourdeau É,Clauser S,Prud'Homme R,Bardet V,Calmette L

更新日期：2019-04-01 00:00:00

abstract：:We report the case of an 83-year-old woman admitted to the accident and emergency unit for pneumopathy. The blood cell count on the DXH automaton (Coulter® ™ UniCel® DxH) found a normochromic and normocytic anemia, anormal platelet count and subnormal leukocyte formula. The only alarm raised by the automaton was the p...

journal_title：Annales de biologie clinique

authors： Gatignol A,Amirault M,Legac É,Decker J

更新日期：2019-04-01 00:00:00

abstract：:Toxicological screening is a specific approach to analytical toxicology that uses analytical tools such as GC-MS, LC-UV (diode array) or LC-MS. Toxicological screening allows the detection and simultaneous identification of a large number of compounds. The results may be based on the use of one or more techniques. As ...

journal_title：Annales de biologie clinique

authors： Guitton J,Gaulier JM,Citterio-Quentin A,Abe E,Allibé N,Bartoli M,Cohen S,Monteil-Ganiere C,Garcia-Hejl C,Grosjean J,Richard D,Roman E,Saint-Marcoux F,Wendremaire M

更新日期：2019-04-01 00:00:00

abstract：:Today, medical prescriptions of proteinuria or albuminuria, which are depending on medical status of patients, still depend on doctors. Indeed, according to their medical specialty or to the recommendations they are following, they could prescribe either proteinuria or albuminuria. The consequences are practical for l...

journal_title：Annales de biologie clinique

authors： Perrier F,Piéroni L,groupe de travail SFBC, SFNDT, SNP.

更新日期：2019-02-01 00:00:00

abstract：:Lymphoplasmacytic lymphoma is rare. Although most cases of LPL are Waldenström macroglobulinemia associated with an immunoglobulin M, there are exceptions. Indeed, few cases are immunoglobulin A-secreting or immunoglobulin G-secreting. These cases are poorly described and raise diagnostic difficulties. The purpose of ...

journal_title：Annales de biologie clinique

authors： Vergnolle I,Sigur N,Corre J

更新日期：2018-12-01 00:00:00

abstract：:Adult neutropenia, defined as a blood neutrophil count below 1.5 G/L, is a common condition. The most common cause of acute neutropenia is a drug-related reaction or an acute infectious disease. In chronic forms many etiologies are possible, sometimes poorly-defined, requiring precise explorations. The purpose of this...

journal_title：Annales de biologie clinique

authors： Bonnin A,Vignon G,Mottaz P,Labrousse J,Carrere F,Augereau PF,Aucher P,Lellouche F

更新日期：2018-12-01 00:00:00

abstract：:Shwachman-Diamond syndrome is a constitutional disorder characterized by exocrine pancreatic failure and neutropenia with dysgranulopoiesis. It is a rare disease, with less than 100 cases reported in France. Here we report the case of a 23-year-old woman with this syndrome. The clinical feature and the diagnostic step...

journal_title：Annales de biologie clinique

authors： Kaabar M,Lemaire P,Cussac V,Besancon A,Martin-Coignard D,Fenneteau O,Laribi K,Pineau-Vincent F

更新日期：2018-08-01 00:00:00

abstract：:Premature rupture of the membranes (PROM) is a frequent event affecting 3% of pregnancies. PROM causes 30% of premature deliveries and 20% of perinatal mortality. The diagnosis relies mainly on the clinical visualization of the amniotic fluid flow in the vagina. If not, clinicians can use bedside tests detecting eithe...

journal_title：Annales de biologie clinique

authors： Julien M,N'guema L,Bouzerara A,Toro B,Lecarpentier E,Guibourdenche J

更新日期：2018-06-01 00:00:00

abstract：:We quantify the impact of several variables including site of blood draw, delay in measurement, and use of the cyanide antidote hydroxocobalamin on detection of both normal (<2 mmol/L) and elevated (>6 mmol/L) human plasma lactate. An in vivo study assessed effects of venous or arterial origin of blood samples. Two in...

journal_title：Annales de biologie clinique

authors： Houzé P,Laforge M,Baud FJ

更新日期：2018-01-01 00:00:00

abstract：:Blood gas analyzers are able to provide information on a wide range of oxygenation parameters. Some of these data are complex. Their biological significance or clinical consistency are not always well known. This article aims to define these parameters, their reference values according to the type of sample; and to ou...

journal_title：Annales de biologie clinique

authors： Godignon M,Costes F,Sapin V,Bouvier D

更新日期：2017-12-01 00:00:00

abstract：:The hospital environment is a potential source of microbial contamination. Thus, the magazines in hospital's waiting rooms are handled by patients and visitors whose health and hygiene conditions can vary widely. In this context, we had measured the microbial load on the surface of magazines. Fifteen magazines from 5 ...

journal_title：Annales de biologie clinique

authors： Adé M,Burger S,Cuntzmann A,Exinger J,Meunier O

更新日期：2017-12-01 00:00:00

abstract：:For the reliable urinary measurement of calcium, phosphate and uric acid, a pre-analytical process by adding acid or base to urine samples at laboratory is recommended in order to dissolve precipitated solutes. Several studies on different kind of samples and analysers have previously shown that a such pre-analytical ...

journal_title：Annales de biologie clinique

authors： Petit M,Beaudeux JL,Majoux S,Hennequin C

更新日期：2017-10-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disorder that must be correctly diagnose because it is a chronic disease with a real impact on the quality of life and the survival of the patients. PNH screening of all patients with anemia or thrombosis is not recommended. We report...

journal_title：Annales de biologie clinique

authors： Gendron N,Arlet JB,Gaussem P,Radford-Weiss I,Dupeux S,Rosain J,La Tour RP,Darnige L

更新日期：2017-10-01 00:00:00

abstract：:Myoadenylate deaminase deficit (MAD, MIM#615511) is the most common cause of metabolic myopathies with an estimated prevalence of 1-2% in the general population. We report the case of a 39-year-old man suffering from severe skeletal muscle pain that had developed gradually for 4 years. A moderate increase in creatine ...

journal_title：Annales de biologie clinique

authors： Lim L,Palayer M,Bruneau A,Letournel F,Le Maréchal C,Simard G,Reynier P,Homedan C,Nadaj-Pakleza A

更新日期：2017-08-01 00:00:00

abstract：:Testing for natriuretic peptides (BNP, NT-proBNP or MR-proANP) is recommended by the European Society of Cardiology (ESC) since 2005 for the exclusion diagnosis of acute and chronic heart failure because of very high predictive values. Natriuretic peptides are produced by the heart in response to high transmural press...

journal_title：Annales de biologie clinique

authors： Favresse J,Gruson D

更新日期：2017-06-01 00:00:00

abstract：:Legislation and ISO 15189 international standard provide that the clinical laboratories shall organize the communication of the biological assay results, especially with the establishment of a list of critical assays, whose results shall be reported during doctor's on call period but also through restricting result tr...

journal_title：Annales de biologie clinique

authors： Hoffmann P

更新日期：2017-06-01 00:00:00

abstract：:The aim of this study was to evaluate the pre-analytical factors contributing to uncertainty in thyroglobulin measurement in fluids from fine-needle aspiration (FNA) washout of cervical lymph nodes. We studied pre-analytical stability, in different conditions, of 41 samples prepared with concentrated solutions of thyr...

journal_title：Annales de biologie clinique

authors： Casson FB,Moal V,Gauchez AS,Moineau MP,Sault C,Schlageter MH,Massart C

更新日期：2017-04-01 00:00:00

abstract：:Urinary protein electrophoresis analysis (UPE) is an essential investigation for the study of abnormal proteins in urines. The interpretation of this analysis must be comprehensive and relevant. Indeed, UPE is often requested by clinicians and may have an important impact in patient's management. This paper presents t...

journal_title：Annales de biologie clinique

authors： Nel I,Thiolières JM,Ghillani-Dalbin P,Jacquiaud C,Piéroni L

更新日期：2017-02-01 00:00:00

abstract：:The diagnosis of double hit lymphoma remains a challenge for the biologist for a good management of the patient. This new category of lymphoma "double hit" (DH) is part of a new entity of the WHO classification 2008: « Unclassifiable B lymphoma with features intermediate between diffuse large cell B lymphoma and Burki...

journal_title：Annales de biologie clinique

authors： Wyrwas M,Michel J,Guibaud I,Lesesve JF,Bénet B

更新日期：2016-12-01 00:00:00

abstract：:Acquired recurrent cytogenetic abnormalities are frequent in chronic lymphocytic leukaemia (CLL). They can be associated with good or poor prognostic factors, and also with gene mutations. Chromosomal abnormalities could be clonal or sub-clonal. Assessing the TP53 status (deletion/mutation) is currently mandatory befo...

journal_title：Annales de biologie clinique

authors： Nguyen-Khac F,Borie C,Callet-Bauchu E,Eclache V,Struski S

更新日期：2016-10-01 00:00:00

abstract：:In a control population, we filed the 24-hour urinary calcium to set normal values, based on weight, BMI and menopause. By assessing calcium intake, 25OHD, PTH, CTX, GFR, we wanted to study how these could influence calcium excretion. A total of 317 subjects of 55.82 ± 12.6 years were studied: 249 women (210 were post...

journal_title：Annales de biologie clinique

authors： Laroche M,Nigon D,Gennero I,Lassoued S,Pouilles JM,Trémolières F,Vallet M,Tack I

更新日期：2016-08-01 00:00:00

abstract：:The discovery of free fetal DNA in the maternal circulation has inaugurated the era of non-invasive prenatal diagnosis. The latter has the advantage of avoiding the use of conventional obstetric procedures, such as chorionic villus sampling or aspiration of amniotic fluid, thus limiting the risks of miscarriage they i...

journal_title：Annales de biologie clinique

authors： Orhant L,Rondeau S,Vasson A,Anselem O,Goffinet F,Allach El Khattabi L,Leturcq F,Vidaud D,Bienvenu T,Tsatsaris V,Nectoux J

更新日期：2016-06-01 00:00:00

abstract：:SFBC working group on critical care testing describes in this paper guideline for the management of laboratory medicine examination process in emergency conditions. After a summary on French standards and regulations, the critical care testing perimeter and definitions of stat levels are presented in different context...

journal_title：Annales de biologie clinique

authors： Vaubourdolle M,Alvarez JC,Barbé F,Beaudeux JL,Boissier É,Caillon H,Chatron P,Joly-Guillou ML,Mailloux A

更新日期：2016-03-01 00:00:00

abstract：:Direct oral anticoagulants (DAO), anti-IIa or anti-Xa, are intended to be widely used for the treatment and prevention of thrombotic disorders in venous thromboembolic disease and atrial fibrillation as an alternative of vitamin K antagonists (VKA). Despite predictable pharmacological properties, spontaneous or provok...

journal_title：Annales de biologie clinique

authors： Gendron N,Smadja DM

更新日期：2016-01-01 00:00:00

abstract：:Hemolysis should lead to changes in test results. Our study evaluated the impact of hemolysis on 26 blood measurements of stat biochemistry markers (sodium, potassium, chloride, urea, creatinine, glucose, total protein, calcium, magnesium, inorganic phosphorus, uric acid, C-reactive protein, total bilirubin, ASAT, ALA...

journal_title：Annales de biologie clinique

authors： Poupon C,Lefèvre G,Ngo-François S,Alibeu C,Barbé F,Bourbonneux V,Cartier R,Morin C,Szymanowicz A,Vuillaume I,Groupe de travail du Collège national de biochimie des hôpitaux.

更新日期：2015-11-01 00:00:00

abstract：:Recent advances in the characterization of microcrystals in tissue samples based on physico-chemical techniques are reviewed. It is a new opportunity for the physician to access early a diagnosis of rare but severe pathologies and to start a specific therapy able to delay or to stop an irreversible alteration of the o...

journal_title：Annales de biologie clinique

authors： Bazin D,Daudon M

更新日期：2015-09-01 00:00:00

abstract：:Nowadays, physiological amino acids profiling is based primarily on ion exchange chromatography (IEC) coupled to a post-column derivatization with ninhydrin and UV detection at two wavelengths. Unfortunately, this technique suffers various drawbacks such as long analysis time, high sample volume and specific costs rel...

journal_title：Annales de biologie clinique

authors： Boemer F,Schoos R,Deberg M

更新日期：2015-07-01 00:00:00

abstract：:In the perspective of a future request of accreditation according to the NF EN 15189 standard of the sector of prenatal diagnosis of the trisomy 21 foetal, we compared the results obtained for AFP, hCG, free hCG, PAPP-A and for the risks, according to 2 types of blood collection tubes: sterile tube and sterile tube wi...

journal_title：Annales de biologie clinique

authors： Laudat A,Girard P,Burc-Struxiano L

更新日期：2015-05-01 00:00:00

abstract：:Direct and indirect ion selective electrodes (ISEs) are two methods commonly used in biochemistry laboratories in order to measure the electrolytes such as sodium. In the clinical practice, it's the sodium concentration in plasma water -measured by direct ISE- which is important to consider as it is responsible of wat...

journal_title：Annales de biologie clinique

authors： Zelmat MS

更新日期：2015-05-01 00:00:00

abstract：:The identification of polymorphism A4059V associated with the 12276 A>G at exon 45 of the PKD1 gene in a Tunisian polycystic patient. ...

journal_title：Annales de biologie clinique

authors： Sahnoun S,Barbouch S,Hadj Fredj S,Khedher A,Messaoud T

更新日期：2015-03-01 00:00:00

abstract：:Blood testing using the dried blood spot (DBS) is used since the 1960s in clinical analysis, mainly within the framework of the neonatal screening (Guthrie test). Since then numerous analytes such as nucleic acids, small molecules or lipids, were successfully measured on the DBS. While this pre-analytical method repre...

journal_title：Annales de biologie clinique

authors： Hirtz C,Lehmann S

更新日期：2015-01-01 00:00:00