[Accreditation of the toxicological screening: recommendations of the SFBC-SFTA group].

Abstract:

:Toxicological screening is a specific approach to analytical toxicology that uses analytical tools such as GC-MS, LC-UV (diode array) or LC-MS. Toxicological screening allows the detection and simultaneous identification of a large number of compounds. The results may be based on the use of one or more techniques. As part of the accreditation process for medical biology examinations according to standard NF EN ISO 15189, the group from SFTA and SFBC recommends an approach to accredit toxicological screening. Indeed, the complexity of the accreditation of this analysis comes in particular from the high number of compounds that can be detected. Validation parameters are discussed in the specific context of toxicological screening by considering two distinct approaches: the simple identification of compounds, or the identification and estimation of a range of concentration related to clinical outcomes.

journal_name

Ann Biol Clin (Paris)

authors

Guitton J,Gaulier JM,Citterio-Quentin A,Abe E,Allibé N,Bartoli M,Cohen S,Monteil-Ganiere C,Garcia-Hejl C,Grosjean J,Richard D,Roman E,Saint-Marcoux F,Wendremaire M

doi

10.1684/abc.2019.1422

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

219-224

issue

2

eissn

0003-3898

issn

1950-6112

pii

abc.2019.1422

journal_volume

77

pub_type

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