Abstract:
:Exploring coagulation in newborns and children is a challenge due to the low levels of both procoagulant factors and inhibitors. Conventional coagulation tests might be inadequate to explore all of these changes. The aim of the study is to evaluate the thrombin generation assay, a global test to explore coagulation, in a pediatric population (n=586) compared to an adult population (n=166). The thrombin generation assays were performed using Calibrated Automated Thrombography with two different tissue factor concentrations (1 and 5 pM), with and without thrombomodulin (TM). In the absence of TM, the endogenous thrombin potential (ETP) is significantly lower in the pediatric population, reflecting the decrease in procoagulant factors. In the presence of TM, ETP values in pediatric subjects are within the reference range of adult values. The thrombin generation assay demonstrates that coagulation balance is maintained in the pediatric population.
journal_name
Ann Biol Clin (Paris)journal_title
Annales de biologie cliniqueauthors
Talon L,Sapin AF,Fourneyron V,Senectaire S,Tardieu M,Tillier M,Trapani A,Trayaud A,Vaissade A,Lebreton A,Sinegre Tdoi
10.1684/abc.2020.1607subject
Has Abstractpub_date
2020-12-01 00:00:00pages
629-638issue
6eissn
0003-3898issn
1950-6112pii
abc.2020.1607journal_volume
78pub_type
杂志文章abstract::The authors describe an automatic method of estimation of uric acid based on the colour obtained in the presence of Gaiac resin and peroxidase, and the hydrogen peroxide produced by the action of urate oxidase on uric acid. ...
journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::Monoclonal antibodies have been raised against porcine LH receptor and allowed to clone the corresponding messenger RNA from testicular cells. Cross hybridisation with the LH receptor clone allowed to isolate a clone corresponding to the human TSH receptor from thyroids. The structure of both receptors have been deter...
journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
pub_type: 杂志文章,评审
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章,评审
doi:
更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
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journal_title:Annales de biologie clinique
pub_type: 杂志文章,多中心研究
doi:
更新日期:2004-09-01 00:00:00
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journal_title:Annales de biologie clinique
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doi:
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journal_title:Annales de biologie clinique
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doi:
更新日期:1988-01-01 00:00:00
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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更新日期:1993-01-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Annales de biologie clinique
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doi:10.1684/abc.2009.0301
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journal_title:Annales de biologie clinique
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doi:
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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doi:
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