Abstract：
:Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disorder that must be correctly diagnose because it is a chronic disease with a real impact on the quality of life and the survival of the patients. PNH screening of all patients with anemia or thrombosis is not recommended. We report the case of a 71-year-old male patient referred for chronic anemia. Anemia work-up revealed a misunderstood association of a hemolytic anemia with a negative direct antiglobulin test and iron deficiency. The patient exhibits biological signs of intravascular hemolysis, as well as a recent history of two episodes of deep vein thrombosis. Screening for PNH by flow cytometry shown a PNH clone with a size of approximately 33% of the granulocytes and 11% of the red blood cells. An interstitial deletion of the chromosome 13 was found in the medullar karyotype. PNH through chronic intravascular hemolysis induces an urinary iron loss. This is the only cause of hemolytic anemia inducing iron deficiency.
journal_name
Ann Biol Clin (Paris)journal_title
Annales de biologie cliniqueauthors
Gendron N,Arlet JB,Gaussem P,Radford-Weiss I,Dupeux S,Rosain J,La Tour RP,Darnige Ldoi
10.1684/abc.2017.1277subject
Has Abstractpub_date
2017-10-01 00:00:00pages
580-588issue
5eissn
0003-3898issn
1950-6112pii
abc.2017.1277journal_volume
75pub_type
杂志文章abstract：:Diagnosis of haematological malignancies is based on multiparametric analysis such as morphology, phenotype and genotype studies. Some entities are only defined by one of these approach. Flow-cytometry (FCM) is useful to determined the normal counterpart of the tumoral process and its differentiation status within the...
journal_title：Annales de biologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：2002-11-01 00:00:00
abstract：:The oculo-cerebro-renal syndrome of Lowe is a rare X-linked disorder, caused by the inositol biphosphate 5-phosphatase deficiency, localized to the Golgi complex. Several mutations were reported in patient's OCRL gene leading to enzyme deficiency. We report a Moroccan case of OCRL syndrome of Lowe with a neo mutation ...
journal_title：Annales de biologie clinique
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doi：
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journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：10.1684/abc.2013.0809
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journal_title：Annales de biologie clinique
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doi：
更新日期：1984-01-01 00:00:00
abstract：:Blood histamine proved to be important for the immune homeostasis. By its direct action or by means of H-2 receptors it end or prevents the excessive immune response. Recent studies revealed changes in cell mediated immunity in subjects with atopia, with increased histaminemia and their obvious protection against canc...
journal_title：Annales de biologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-01 00:00:00
abstract：:In this report, the authors have studied the plasma and red blood cell concentrations of both zinc and copper in 90 uremic patients treated by intermittent hemodialysis. They found that plasmatic and erythrocytic levels of zinc together with the copper red blood cell concentrations determined before and after the hemo...
journal_title：Annales de biologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1989-01-01 00:00:00
abstract：:The proliferation of commercial immunoassays for the determination of apolipoproteins AI and B as parameters of risk for coronary heart disease and the discordance between the values obtained with the systems have made more urgent than ever the need for standardization of these assays. The authors report here the resu...
journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
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journal_title：Annales de biologie clinique
pub_type： 杂志文章,实务指引
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journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
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journal_title：Annales de biologie clinique
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doi：10.1684/abc.2008.0210
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journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：
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journal_title：Annales de biologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1998-09-01 00:00:00
abstract：:Second generation hepatitis C virus (HCV) Elisas are currently in use in Europe and have been submitted for approval in the United States. These new assays contain additional antigens from the putative nucleocapsid and NS-3 regions of the HCV genome in addition to the c100-3 antigen present in first generation Elisas....
journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
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journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：10.1684/abc.2020.1564
更新日期：2020-08-01 00:00:00
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journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：10.1684/abc.2020.1607
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journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
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journal_title：Annales de biologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1986-01-01 00:00:00
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journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：10.1684/abc.2012.0765
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journal_title：Annales de biologie clinique
pub_type： 杂志文章
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journal_title：Annales de biologie clinique
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doi：
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journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
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journal_title：Annales de biologie clinique
pub_type： 杂志文章
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journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：10.1684/abc.2010.0459
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journal_title：Annales de biologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
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journal_title：Annales de biologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：2005-03-01 00:00:00
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journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：10.1684/abc.2011.0598
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journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:A fluorimetric, authomatical method for determination of free and total cholesterol in serum is described. Cholesterol esters are splitted into free cholesterol and fatty acids by cholesterol esterase. In the presence of oxygen free cholesterol will be transformed by cholesterol oxydase in delta 4 cholestenone with fo...
journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:Gas-liquid chromatography has been used directly on clinical specimens as a method for presumptive diagnosis of anaerobic infections. This technique proved to be valuable and reliable. Combined with a Gram stain, it offers the possibility to differentiate in less than 1 hour aerobic from anaerobic infections by means ...
journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
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journal_title：Annales de biologie clinique
pub_type： 杂志文章
doi：10.1684/abc.2017.1283
更新日期：2017-12-01 00:00:00
