Abstract:
:Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disorder that must be correctly diagnose because it is a chronic disease with a real impact on the quality of life and the survival of the patients. PNH screening of all patients with anemia or thrombosis is not recommended. We report the case of a 71-year-old male patient referred for chronic anemia. Anemia work-up revealed a misunderstood association of a hemolytic anemia with a negative direct antiglobulin test and iron deficiency. The patient exhibits biological signs of intravascular hemolysis, as well as a recent history of two episodes of deep vein thrombosis. Screening for PNH by flow cytometry shown a PNH clone with a size of approximately 33% of the granulocytes and 11% of the red blood cells. An interstitial deletion of the chromosome 13 was found in the medullar karyotype. PNH through chronic intravascular hemolysis induces an urinary iron loss. This is the only cause of hemolytic anemia inducing iron deficiency.
journal_name
Ann Biol Clin (Paris)journal_title
Annales de biologie cliniqueauthors
Gendron N,Arlet JB,Gaussem P,Radford-Weiss I,Dupeux S,Rosain J,La Tour RP,Darnige Ldoi
10.1684/abc.2017.1277subject
Has Abstractpub_date
2017-10-01 00:00:00pages
580-588issue
5eissn
0003-3898issn
1950-6112pii
abc.2017.1277journal_volume
75pub_type
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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doi:
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journal_title:Annales de biologie clinique
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更新日期:1993-01-01 00:00:00
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journal_title:Annales de biologie clinique
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更新日期:1999-05-01 00:00:00
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journal_title:Annales de biologie clinique
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pub_type: 杂志文章,评审
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journal_title:Annales de biologie clinique
pub_type: 杂志文章,多中心研究
doi:
更新日期:2007-03-01 00:00:00
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
pub_type: 杂志文章,评审
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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