Abstract:
:The aim of the study was to check if a slight and non visible hemolysis to naked eye such as that induced by blood coagulation could interfere in the immunonephelometric measurement of haptoglobin, and if this interference was dependent on the protein phenotype. Results confirmed that blood coagulation induced a non visible hemolysis whose intensity markedly varied from one specimen to another. Under our conditions (kinetic measurement with a Beckman Coulter immunonephelometer), we observed with the sera a negative interference linked to the hemolysis induced by blood coagulation when compared to corresponding plasmas obtained with lithium heparinate (p < 0,005). It was checked also that this anticoagulant did not induce a positive interference. Hemolysis interference was not found phenotype dependent. These results lead us to recommend to perform haptoglobin measurements on heparinised plasmas.
journal_name
Ann Biol Clin (Paris)journal_title
Annales de biologie cliniqueauthors
Guéye PM,Sall I,Lessinger JM,Férard Gsubject
Has Abstractpub_date
2004-11-01 00:00:00pages
701-5issue
6eissn
0003-3898issn
1950-6112journal_volume
62pub_type
杂志文章abstract::The aim of this article is to describe the processes involved in the organisation and function of the medical laboratory to fulfill the needs of the users. The knowledge of the different interfaces and relationship is a condition for the control of the processes according to the quality management system. ...
journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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pub_type: 杂志文章,评审
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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pub_type: 杂志文章,评审
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