[Usefulness of immature platelet fraction measurement for diagnosis and monitoring of iron deficiency associated thrombocytopenia: about two cases].

Abstract:

:Iron deficiency anemia is frequently associated with thrombocytosis. However, in some rare cases of very severe iron deficiency, a thrombocytopenia may occur. This condition may lead to a misdiagnosis of immune thrombocytopenic purpura and thus to unnecessary tests in this context. Here we report two patients who presented with iron deficiency associated thrombocytopenia rapidly corrected after martial supplementation. We then discuss the value of measuring immature platelet fraction (IPF), which represents the population of newly formed platelets containing a greater amount of residual RNA. For both cases, low IPF values at admission indicated a central origin of thrombocytopenia with decreased platelet production, which is the pathophysiological mechanism of iron deficiency associated thrombocytopenia.

journal_name

Ann Biol Clin (Paris)

authors

Blandinières A,Arlet JB,Gaussem P,Pouchot J,Darnige L

doi

10.1684/abc.2020.1564

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

433-437

issue

4

eissn

0003-3898

issn

1950-6112

pii

abc.2020.1564

journal_volume

78

pub_type

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