听力与言语-语言病理学

行为科学

医学伦理学

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  • A High-Fat Diet Attenuates AMPK α1 in Adipocytes to Induce Exosome Shedding and Nonalcoholic Fatty Liver Development In Vivo.

    abstract::Exosomes are important for intercellular communication, but the role of exosomes in the communication between adipose tissue (AT) and the liver remains unknown. The aim of this study is to determine the contribution of AT-derived exosomes in nonalcoholic fatty liver disease (NAFLD). Exosome components, liver fat conte...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0146

    authors: Yan C,Tian X,Li J,Liu D,Ye D,Xie Z,Han Y,Zou MH

    更新日期:2021-02-01 00:00:00

  • Emerging Role of Bone Morphogenetic Protein 4 in Metabolic Disorders.

    abstract::Bone morphogenetic proteins (BMPs) are a group of signaling molecules that belong to the TGF-β superfamily. Initially discovered for their ability to induce bone formation, BMPs are known to play a diverse and critical array of biological roles. We here focus on recent evidence showing that BMP4 is an important regula...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0884

    authors: Baboota RK,Blüher M,Smith U

    更新日期:2021-02-01 00:00:00

  • Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia.

    abstract::Elevation of glucagon levels and increase in α-cell mass are associated with states of hyperglycemia in diabetes. Our previous studies have highlighted the role of nutrient signaling via mTOR complex 1 (mTORC1) regulation that controls glucagon secretion and α-cell mass. In the current studies we investigated the effe...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0440

    authors: Bozadjieva Kramer N,Lubaczeuski C,Blandino-Rosano M,Barker G,Gittes GK,Caicedo A,Bernal-Mizrachi E

    更新日期:2021-02-01 00:00:00

  • TLR9 Deficiency in B Cells Promotes Immune Tolerance via Interleukin-10 in a Type 1 Diabetes Mouse Model.

    abstract::Toll-like receptor 9 (TLR9) is highly expressed in B cells, and B cells are important in the pathogenesis of type 1 diabetes (T1D) development. However, the intrinsic effect of TLR9 in B cells on β-cell autoimmunity is not known. To fill this knowledge gap, we generated NOD mice with a B-cell-specific deficiency of TL...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0373

    authors: Sha S,Pearson JA,Peng J,Hu Y,Huang J,Xing Y,Zhang L,Zhu Y,Zhao H,Wong FS,Chen L,Wen L

    更新日期:2021-02-01 00:00:00

  • One in Ten CD8+ Cells in the Pancreas of Living Individuals With Recent Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI15-24.

    abstract::In type 1 diabetes, a lifelong autoimmune disease, T cells infiltrate the islets and the exocrine pancreas in high numbers. CD8+ T cells are the main cell type found in the insulitic lesion, and CD8+ T cells reactive against beta cell antigens have been detected in the periphery and in the pancreas of subjects with sh...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0908

    authors: Rodriguez-Calvo T,Krogvold L,Amirian N,Dahl-Jørgensen K,von Herrath M

    更新日期:2021-01-07 00:00:00

  • Lung and Kidney ACE2 and TMPRSS2 in Renin Angiotensin System Blocker Treated Comorbid Diabetic Mice Mimicking Host Factors That Have Been Linked to Severe COVID-19.

    abstract::The causes of the increased risk of severe COVID-19 in persons with diabetes are unclear. It has been speculated that renin angiotensin system (RAS) blockers may promote COVID-19 by increasing ACE2, which SARS-CoV-2 uses to enter host cells, along with the host protease TMPRSS2. Taking a reverse translational approach...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0765

    authors: Batchu SN,Kaur H,Yerra VG,Advani SL,Kabir MG,Liu Y,Klein T,Advani A

    更新日期:2020-12-11 00:00:00

  • Deciphering the Plasma Proteome of Type 2 Diabetes.

    abstract::With an estimated prevalence of 463 million affected, type 2 diabetes represents a major challenge to health care systems worldwide. Analyzing the plasma proteomes of individuals with type 2 diabetes may illuminate hitherto unknown functional mechanisms underlying disease pathology. We assessed the associations betwee...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0296

    authors: Elhadad MA,Jonasson C,Huth C,Wilson R,Gieger C,Matias P,Grallert H,Graumann J,Gailus-Durner V,Rathmann W,von Toerne C,Hauck SM,Koenig W,Sinner MF,Oprea TI,Suhre K,Thorand B,Hveem K,Peters A,Waldenberger M

    更新日期:2020-12-01 00:00:00

  • Implications of Integrated Pancreatic Microcirculation: Crosstalk between Endocrine and Exocrine Compartments.

    abstract::The endocrine and exocrine pancreas have been studied separately by endocrinologists and gastroenterologists as two organ systems. The pancreatic islet, consisting of 1-2% mass of the whole pancreas, has long been believed to be regulated independently from the surrounding exocrine tissues. Particularly, islet blood f...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0810

    authors: Dybala MP,Gebien LR,Reyna ME,Yu Y,Hara M

    更新日期:2020-12-01 00:00:00

  • Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance.

    abstract::Skeletal muscle insulin resistance is a prominent early feature in the pathogenesis of type 2 diabetes. In attempt to overcome this defect, we generated mice overexpressing insulin receptors (IR) specifically in skeletal muscle (IRMOE). On normal chow, IRMOE mice have body weight similar to that of controls but an inc...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0439

    authors: Wang G,Yu Y,Cai W,Batista TM,Suk S,Noh HL,Hirshman M,Nigro P,Li ME,Softic S,Goodyear L,Kim JK,Kahn CR

    更新日期:2020-11-01 00:00:00

  • Noninvasive Monitoring of Glycemia-Induced Regulation of GLP-1R Expression in Murine and Human Islets of Langerhans.

    abstract::Glucagon-like peptide 1 receptor (GLP-1R) imaging with radiolabeled exendin has proven to be a powerful tool to quantify β-cell mass (BCM) in vivo. As GLP-1R expression is thought to be influenced by glycemic control, we examined the effect of blood glucose (BG) levels on GLP-1R-mediated exendin uptake in both murine ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0616

    authors: Buitinga M,Cohrs CM,Eter WA,Claessens-Joosten L,Frielink C,Bos D,Sandker G,Brom M,Speier S,Gotthardt M

    更新日期:2020-11-01 00:00:00

  • Mechanisms Underlying Absent Training-Induced Improvement in Insulin Action in Lean, Hyperandrogenic Women With Polycystic Ovary Syndrome.

    abstract::Women with polycystic ovary syndrome (PCOS) have been shown to be less insulin sensitive compared with control (CON) women, independent of BMI. Training is associated with molecular adaptations in skeletal muscle, improving glucose uptake and metabolism in both healthy individuals and patients with type 2 diabetes. In...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0062

    authors: Hansen SL,Bojsen-Møller KN,Lundsgaard AM,Hendrich FL,Nilas L,Sjøberg KA,Hingst JR,Serup AK,Olguín CH,Carl CS,Wernblad LF,Henneberg M,Lustrup KM,Hansen C,Jensen TE,Madsbad S,Wojtaszewski JFP,Richter EA,Kiens B

    更新日期:2020-11-01 00:00:00

  • Protection of Pancreatic Islets Using Theranostic Silencing Nanoparticles in a Baboon Model of Islet Transplantation.

    abstract::The long-term success of pancreatic islet transplantation (Tx) as a cure for type 1 diabetes remains limited. Islet loss after Tx related to apoptosis, inflammation, and other factors continues to limit Tx efficacy. In this project, we demonstrate a novel approach aimed at protecting islets before Tx in nonhuman prima...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0517

    authors: Pomposelli T,Wang P,Takeuchi K,Miyake K,Ariyoshi Y,Watanabe H,Chen X,Shimizu A,Robertson N,Yamada K,Moore A

    更新日期:2020-11-01 00:00:00

  • Association of the 1q25 Diabetes-Specific Coronary Heart Disease Locus With Alterations of the γ-Glutamyl Cycle and Increased Methylglyoxal Levels in Endothelial Cells.

    abstract::A chromosome 1q25 variant (rs10911021) has been associated with coronary heart disease (CHD) in type 2 diabetes. In human umbilical vein endothelial cells (HUVECs), the risk allele "C" is associated with lower expression of the adjacent gene GLUL encoding glutamine synthase, converting glutamic acid to glutamine. To f...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0475

    authors: Pipino C,Shah H,Prudente S,Di Pietro N,Zeng L,Park K,Trischitta V,Pennathur S,Pandolfi A,Doria A

    更新日期:2020-10-01 00:00:00

  • Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel.

    abstract::A substantial proportion of patients with adult-onset diabetes share features of both type 1 diabetes (T1D) and type 2 diabetes (T2D). These individuals, at diagnosis, clinically resemble T2D patients by not requiring insulin treatment, yet they have immunogenetic markers associated with T1D. Such a slowly evolving fo...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/dbi20-0017

    authors: Buzzetti R,Tuomi T,Mauricio D,Pietropaolo M,Zhou Z,Pozzilli P,Leslie RD

    更新日期:2020-10-01 00:00:00

  • Novel Long Noncoding RNA lnc-URIDS Delays Diabetic Wound Healing by Targeting Plod1.

    abstract::Impaired wound healing is one of the main causes of diabetic foot ulcerations. However, the exact mechanism of delayed wound healing in diabetes is not fully understood. Long noncoding RNAs (lncRNAs) are widely involved in a variety of biological processes and diseases, including diabetes and its associated complicati...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0147

    authors: Hu M,Wu Y,Yang C,Wang X,Wang W,Zhou L,Zeng T,Zhou J,Wang C,Lao G,Yan L,Ren M

    更新日期:2020-10-01 00:00:00

  • Managing Hyperglycemia in the COVID-19 Inflammatory Storm.

    abstract::A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019 [COVID-19]) is now at global pandemic levels causing significant morbidity and mortality. Patients with diabetes are particularly vulnerable and more likely to get severe complications when infected with this vi...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/dbi20-0022

    authors: Gianchandani R,Esfandiari NH,Ang L,Iyengar J,Knotts S,Choksi P,Pop-Busui R

    更新日期:2020-10-01 00:00:00

  • 3-Hydroxyisobutyrate, A Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism.

    abstract::Circulating branched-chain amino acids (BCAAs) associate with insulin resistance and type 2 diabetes. 3-Hydroxyisobutyrate (3-HIB) is a catabolic intermediate of the BCAA valine. In this study, we show that in a cohort of 4,942 men and women, circulating 3-HIB is elevated according to levels of hyperglycemia and estab...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-1174

    authors: Nilsen MS,Jersin RÅ,Ulvik A,Madsen A,McCann A,Svensson PA,Svensson MK,Nedrebø BG,Gudbrandsen OA,Tell GS,Kahn CR,Ueland PM,Mellgren G,Dankel SN

    更新日期:2020-09-01 00:00:00

  • Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19.

    abstract::Coronavirus disease 2019 (COVID-19) is a novel threat that seems to result from the collusion between a new pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and an existing pandemic of metabolic disease driven by obesity. This Perspective explores the evolving epidemiological, clinical, biologi...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/dbi19-0023

    authors: Mauvais-Jarvis F

    更新日期:2020-09-01 00:00:00

  • m6A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.

    abstract::The N6-methyladenosine (m6A) RNA modification is essential during embryonic development of various organs. However, its role in embryonic and early postnatal islet development remains unknown. Mice in which RNA methyltransferase-like 3/14 (Mettl3/14) were deleted in Ngn3+ endocrine progenitors (Mettl3/14 ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0906

    authors: Wang Y,Sun J,Lin Z,Zhang W,Wang S,Wang W,Wang Q,Ning G

    更新日期:2020-08-01 00:00:00

  • Longitudinal Analysis of Serum Cytokine Levels and Gut Microbial Abundance Links IL-17/IL-22 With Clostridia and Insulin Sensitivity in Humans.

    abstract::Recent studies using mouse models suggest that interaction between the gut microbiome and IL-17/IL-22-producing cells plays a role in the development of metabolic diseases. We investigated this relationship in humans using data from the prediabetes study of the Integrated Human Microbiome Project (iHMP). Specifically,...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0592

    authors: Zhou X,Johnson JS,Spakowicz D,Zhou W,Zhou Y,Sodergren E,Snyder M,Weinstock GM

    更新日期:2020-08-01 00:00:00

  • Pericyte Bridges in Homeostasis and Hyperglycemia.

    abstract::Diabetic retinopathy is a potentially blinding eye disease that threatens the vision of one-ninth of patients with diabetes. Progression of the disease has long been attributed to an initial dropout of pericytes that enwrap the retinal microvasculature. Revealed through retinal vascular digests, a subsequent increase ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0471

    authors: Corliss BA,Ray HC,Doty RW,Mathews C,Sheybani N,Fitzgerald K,Prince R,Kelly-Goss MR,Murfee WL,Chappell J,Owens GK,Yates PA,Peirce SM

    更新日期:2020-07-01 00:00:00

  • Genetic Causes of Severe Childhood Obesity: A Remarkably High Prevalence in an Inbred Population of Pakistan.

    abstract::Monogenic forms of obesity have been identified in ≤10% of severely obese European patients. However, the overall spectrum of deleterious variants (point mutations and structural variants) responsible for childhood severe obesity remains elusive. In this study, we genetically screened 225 severely obese children from ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-1238

    authors: Saeed S,Arslan M,Manzoor J,Din SM,Janjua QM,Ayesha H,Ain QT,Inam L,Lobbens S,Vaillant E,Durand E,Derhourhi M,Amanzougarene S,Badreddine A,Berberian L,Gaget S,Khan WI,Butt TA,Bonnefond A,Froguel P

    更新日期:2020-07-01 00:00:00

  • T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal.

    abstract::The autoimmune disease type 1 diabetes is characterized by effector T-cell responses to pancreatic β-cell-derived peptides presented by HLA class I and class II molecules, leading ultimately to β-cell demise and insulin insufficiency. Although a given HLA molecule presents a vast array of peptides, only those recogniz...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/dbi19-0022

    authors: James EA,Mallone R,Kent SC,DiLorenzo TP

    更新日期:2020-07-01 00:00:00

  • Glucose-Stimulated Insulin Secretion Fundamentally Requires H2O2 Signaling by NADPH Oxidase 4.

    abstract::NADPH facilitates glucose-stimulated insulin secretion (GSIS) in pancreatic islets (PIs) of β-cells through an as yet unknown mechanism. We found NADPH oxidase isoform 4 (NOX4) to be the main producer of cytosolic H2O2, which is essential for GSIS; an increase in ATP alone was insufficient for GSIS. The fast GSIS phas...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-1130

    authors: Plecitá-Hlavatá L,Jabůrek M,Holendová B,Tauber J,Pavluch V,Berková Z,Cahová M,Schröder K,Brandes RP,Siemen D,Ježek P

    更新日期:2020-07-01 00:00:00

  • Hyperuricemia Predisposes to the Onset of Diabetes via Promoting Pancreatic β-Cell Death in Uricase-Deficient Male Mice.

    abstract::Clinical studies have shown a link between hyperuricemia (HU) and diabetes, while the exact effect of soluble serum urate on glucose metabolism remains elusive. This study aims to characterize the glucose metabolic phenotypes and investigate the underlying molecular mechanisms using a novel spontaneous HU mouse model ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0704

    authors: Lu J,He Y,Cui L,Xing X,Liu Z,Li X,Zhang H,Li H,Sun W,Ji A,Wang Y,Yin H,Li C

    更新日期:2020-06-01 00:00:00

  • Central KATP Channels Modulate Glucose Effectiveness in Humans and Rodents.

    abstract::Hyperglycemia is a potent regulator of endogenous glucose production (EGP). Loss of this "glucose effectiveness" is a major contributor to elevated plasma glucose concentrations in type 2 diabetes (T2D). KATP channels in the central nervous system have been shown to regulate EGP in humans and rodents. We examined the ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-1256

    authors: Carey M,Lontchi-Yimagou E,Mitchell W,Reda S,Zhang K,Kehlenbrink S,Koppaka S,Maginley SR,Aleksic S,Bhansali S,Huffman DM,Hawkins M

    更新日期:2020-06-01 00:00:00

  • DLL1- and DLL4-Mediated Notch Signaling Is Essential for Adult Pancreatic Islet Homeostasis.

    abstract::Genes of the Notch signaling pathway are expressed in different cell types and organs at different time points during embryonic development and adulthood. The Notch ligand Delta-like 1 (DLL1) controls the decision between endocrine and exocrine fates of multipotent progenitors in the developing pancreas, and loss of D...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0795

    authors: Rubey M,Chhabra NF,Gradinger D,Sanz-Moreno A,Lickert H,Przemeck GKH,Hrabě de Angelis M

    更新日期:2020-05-01 00:00:00

  • Protection Against Insulin Resistance by Apolipoprotein M/Sphingosine-1-Phosphate.

    abstract::Subjects with low serum HDL cholesterol levels are reported to be susceptible to diabetes, with insulin resistance believed to be the underlying pathological mechanism. Apolipoprotein M (apoM) is a carrier of sphingosine-1-phosphate (S1P), a multifunctional lipid mediator, on HDL, and the pleiotropic effects of HDL ar...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0811

    authors: Kurano M,Tsukamoto K,Shimizu T,Kassai H,Nakao K,Aiba A,Hara M,Yatomi Y

    更新日期:2020-05-01 00:00:00

  • The Peripheral Peril: Injected Insulin Induces Insulin Insensitivity in Type 1 Diabetes.

    abstract::Insulin resistance is an underappreciated facet of type 1 diabetes that occurs with remarkable consistency and considerable magnitude. Although therapeutic innovations are continuing to normalize dysglycemia, a sizable body of data suggests a second metabolic abnormality-iatrogenic hyperinsulinemia-principally drives ...

    journal_title:Diabetes

    pub_type: 杂志文章,评审

    doi:10.2337/dbi19-0026

    authors: Gregory JM,Cherrington AD,Moore DJ

    更新日期:2020-05-01 00:00:00

  • A Primary Role for α-Cells as Amino Acid Sensors.

    abstract::Glucagon and its partner insulin are dually linked in both their secretion from islet cells and their action in the liver. Glucagon signaling increases hepatic glucose output, and hyperglucagonemia is partly responsible for the hyperglycemia in diabetes, making glucagon an attractive target for therapeutic interventio...

    journal_title:Diabetes

    pub_type: 杂志文章,评审

    doi:10.2337/dbi19-0021

    authors: Dean ED

    更新日期:2020-04-01 00:00:00

  • Troponin T Parallels Structural Nerve Damage in Type 2 Diabetes: A Cross-sectional Study Using Magnetic Resonance Neurography.

    abstract::Clinical studies have suggested that changes in peripheral nerve microcirculation may contribute to nerve damage in diabetic polyneuropathy (DN). High-sensitivity troponin T (hsTNT) assays have been recently shown to provide predictive values for both cardiac and peripheral microangiopathy in type 2 diabetes (T2D). Th...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-1094

    authors: Jende JME,Groener JB,Kender Z,Hahn A,Morgenstern J,Heiland S,Nawroth PP,Bendszus M,Kopf S,Kurz FT

    更新日期:2020-04-01 00:00:00

  • Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health.

    abstract::Human but not mouse islets transplanted into immunodeficient NSG mice effectively accumulate lipid droplets (LDs). Because chronic lipid exposure is associated with islet β-cell dysfunction, we investigated LD accumulation in the intact human and mouse pancreas over a range of ages and states of diabetes. Very few LDs...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0281

    authors: Tong X,Dai C,Walker JT,Nair GG,Kennedy A,Carr RM,Hebrok M,Powers AC,Stein R

    更新日期:2020-03-01 00:00:00

  • Tacrolimus-Induced BMP/SMAD Signaling Associates With Metabolic Stress-Activated FOXO1 to Trigger β-Cell Failure.

    abstract::Active maintenance of β-cell identity through fine-tuned regulation of key transcription factors ensures β-cell function. Tacrolimus, a widely used immunosuppressant, accelerates onset of diabetes after organ transplantation, but underlying molecular mechanisms are unclear. Here we show that tacrolimus induces loss of...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0828

    authors: Triñanes J,Ten Dijke P,Groen N,Hanegraaf M,Porrini E,Rodriguez-Rodriguez AE,Drachenberg C,Rabelink TJ,de Koning E,Carlotti F,de Vries APJ

    更新日期:2020-02-01 00:00:00

  • Immunomodulation Followed by Antigen-Specific Treg Infusion Controls Islet Autoimmunity.

    abstract::Optimal immune-based therapies for type 1 diabetes (T1D) should restore self-tolerance without inducing chronic immunosuppression. CD4+Foxp3+ regulatory T cells (Tregs) are a key cell population capable of facilitating durable immune tolerance. However, clinical trials with expanded Tregs in T1D and solid-organ transp...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0061

    authors: Cabello-Kindelan C,Mackey S,Sands A,Rodriguez J,Vazquez C,Pugliese A,Bayer AL

    更新日期:2020-02-01 00:00:00

  • Fat-Specific Knockout of Mecp2 Upregulates Slpi to Reduce Obesity by Enhancing Browning.

    abstract::Abnormalities of methyl-CpG binding protein 2 (Mecp2) cause neurological disorders with metabolic dysfunction; however, its role in adipose tissues remains unclear. Here, we report upregulated Mecp2 in white adipose tissues (WAT) of obese humans, as well as in obese mice and during in vitro adipogenesis. Normal chow-f...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0502

    authors: Liu C,Wang J,Wei Y,Zhang W,Geng M,Yuan Y,Chen Y,Sun Y,Chen H,Zhang Y,Xiong M,Li Y,Zheng L,Huang K

    更新日期:2020-01-01 00:00:00

  • Brain and Body: A Review of Central Nervous System Contributions to Movement Impairments in Diabetes.

    abstract::Diabetes is associated with a loss of somatosensory and motor function, leading to impairments in gait, balance, and manual dexterity. Data-driven neuroimaging studies frequently report a negative impact of diabetes on sensorimotor regions in the brain; however, relationships with sensorimotor behavior are rarely cons...

    journal_title:Diabetes

    pub_type: 杂志文章,评审

    doi:10.2337/db19-0321

    authors: Ferris JK,Inglis JT,Madden KM,Boyd LA

    更新日期:2020-01-01 00:00:00

  • Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell-Derived Insulin-Expressing Cells Require NEUROD1.

    abstract::Inactivation of the β-cell transcription factor NEUROD1 causes diabetes in mice and humans. In this study, we uncovered novel functions of NEUROD1 during murine islet cell development and during the differentiation of human embryonic stem cells (HESCs) into insulin-producing cells. In mice, we determined that Neurod1 ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0117

    authors: Romer AI,Singer RA,Sui L,Egli D,Sussel L

    更新日期:2019-12-01 00:00:00

  • Cellular Origins of Beige Fat Cells Revisited.

    abstract::Activated beige adipocytes have therapeutic potential due to their ability to improve glucose and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether beige cells arise through de novo differentiation from resident precursors or through reprogramming of mature white adipocytes has been...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0308

    authors: Shao M,Wang QA,Song A,Vishvanath L,Busbuso NC,Scherer PE,Gupta RK

    更新日期:2019-10-01 00:00:00

  • Early Detection of Peripheral Blood Cell Signature in Children Developing β-Cell Autoimmunity at a Young Age.

    abstract::The appearance of type 1 diabetes (T1D)-associated autoantibodies is the first and only measurable parameter to predict progression toward T1D in genetically susceptible individuals. However, autoantibodies indicate an active autoimmune reaction, wherein the immune tolerance is already broken. Therefore, there is a cl...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0287

    authors: Kallionpää H,Somani J,Tuomela S,Ullah U,de Albuquerque R,Lönnberg T,Komsi E,Siljander H,Honkanen J,Härkönen T,Peet A,Tillmann V,Chandra V,Anagandula MK,Frisk G,Otonkoski T,Rasool O,Lund R,Lähdesmäki H,Knip M,Lahes

    更新日期:2019-10-01 00:00:00

  • HDL Cholesterol Efflux Predicts Incident New-Onset Diabetes After Transplantation (NODAT) in Renal Transplant Recipients Independent of HDL Cholesterol Levels.

    abstract::In renal transplant recipients (RTRs), new-onset diabetes after transplantation (NODAT) is a frequent and serious complication limiting survival of graft and patient. However, the underlying pathophysiology remains incompletely understood. In vitro and in preclinical models, HDL can preserve β-cell function, largely b...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db18-1267

    authors: Szili-Torok T,Annema W,Anderson JLC,Bakker SJL,Tietge UJF

    更新日期:2019-10-01 00:00:00

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