Abstract:
:Coronavirus disease 2019 (COVID-19) is a novel threat that seems to result from the collusion between a new pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and an existing pandemic of metabolic disease driven by obesity. This Perspective explores the evolving epidemiological, clinical, biological, and molecular evidence to propose an unfolding paradigm in which old age, chronic metabolic disease (such as obesity, type 2 diabetes, and metabolic syndrome), and male biological sex produce a deadly symbiosis of dysregulated immunometabolism and chronic systemic inflammation that intensifies virally induced hyperinflammation associated with SARS-CoV-2 infection. It is intended to inspire new research directions and stimulate funding in this field.
journal_name
Diabetesjournal_title
Diabetesauthors
Mauvais-Jarvis Fdoi
10.2337/dbi19-0023subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1857-1863issue
9eissn
0012-1797issn
1939-327Xpii
dbi19-0023journal_volume
69pub_type
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