Lack of association of the polymorphic locus in the 5'-flanking region of the human insulin gene and diabetes in American blacks.

abstract：:A simple method for the elimination of labile glycohemoglobin in the chromatographic quantitation of glycosylated hemoglobin is described. Use is made of the instability of Schiff base adducts in acidic solution. Erythrocytes are lysed with a pH 5 buffer. At this pH dissociation reaches completion during sample prepar...

journal_title：Diabetes

authors： Bissé E,Berger W,Flückiger R

更新日期：1982-07-01 00:00:00

abstract：:Receptors for bradykinin (BK) were characterized in primary cultures of beating neonatal rat cardiomyocytes using [3H]BK was radioligand. Degradation studies demonstrated that [3H]BK was stable for at least 2 h when incubated with cardiomyocytes at 2 and 37 degrees C in the presence of bacitracin in combination with c...

journal_title：Diabetes

authors： Kasel AM,Faussner A,Pfeifer A,Müller U,Werdan K,Roscher AA

更新日期：1996-01-01 00:00:00

abstract：:The presence of the enzyme aldose reductase is increasingly being linked to diabetic complications. The distribution of this enzyme in human cornea, lens, retina, and optic nerve has been studied using specific antibodies against purified human placental aldose reductase raised in both rabbit and goat. The antisera fr...

journal_title：Diabetes

authors： Akagi Y,Yajima Y,Kador PF,Kuwabara T,Kinoshita JH

更新日期：1984-06-01 00:00:00

abstract：:Growth hormone (GH) and IGFs have a long distinguished history in diabetes, with possible participation in the development of renal complications. The implicated effect of GH in diabetic end-stage organ damage may be mediated by growth hormone receptor (GHR) or postreceptor events in GH signal transduction. The presen...

journal_title：Diabetes

authors： Thirone AC,Scarlett JA,Gasparetti AL,Araujo EP,Lima MH,Carvalho CR,Velloso LA,Saad MJ

更新日期：2002-07-01 00:00:00

abstract：:Effects of epinephrine (Epi) infusion on the absorption of subcutaneously injected 125I-labeled soluble human insulin (10 U) from the thigh or the abdomen were studied in 16 healthy subjects and from the thigh in 10 insulin-dependent diabetic (IDDM) patients. Epi was infused at 0.3 (high dose) or 0.1 (low dose; health...

journal_title：Diabetes

authors： Fernqvist E,Gunnarsson R,Linde B

更新日期：1988-06-01 00:00:00

abstract：:The enzyme activities of mitochondrial glycerol phosphate dehydrogenase (mGPD) (EC 1.1.99.5) and pyruvate carboxylase (PC) (EC 6.4.1.1) have been reported to be low in the pancreatic islet of several rodent models of NIDDM. The present study was undertaken to discern whether mGPD is abnormal in the Zucker diabetic fat...

journal_title：Diabetes

authors： MacDonald MJ,Tang J,Polonsky KS

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:Monocytes in childhood-onset type 1 diabetes show distinct gene expression. We hypothesize that monocyte activation in monozygotic (MZ) twin pairs discordant for childhood-onset type 1 diabetes could reflect distinct stages of the disease process including diabetes susceptibility (differences between twins, b...

journal_title：Diabetes

authors： Beyan H,Drexhage RC,van der Heul Nieuwenhuijsen L,de Wit H,Padmos RC,Schloot NC,Drexhage HA,Leslie RD

更新日期：2010-07-01 00:00:00

abstract：:Endothelinlike immunoreactivity was detected by radioimmunoassay in medium conditioned by cultured endothelial cells obtained from bovine retinal microvessels (9.2 +/- 6.5 pM, n = 4). Sephadex G-25 column chromatography and fast-protein liquid chromatography revealed that most of the endothelinlike immunoreactivity wa...

journal_title：Diabetes

authors： Takahashi K,Brooks RA,Kanse SM,Ghatei MA,Kohner EM,Bloom SR

更新日期：1989-09-01 00:00:00

abstract：:We tested the hypothesis that green tea prevents diabetes-related tissue dysfunctions attributable to oxidation. Diabetic rats were treated daily with tap water, vitamins C and E, or fresh Japanese green tea extract. After 12 months, body weights were decreased, whereas glycated lysine in aorta, tendon, and plasma wer...

journal_title：Diabetes

authors： Mustata GT,Rosca M,Biemel KM,Reihl O,Smith MA,Viswanathan A,Strauch C,Du Y,Tang J,Kern TS,Lederer MO,Brownlee M,Weiss MF,Monnier VM

更新日期：2005-02-01 00:00:00

abstract：:Transcription factor expression fluctuates during β-cell ontogeny, and disruptions in this pattern can affect the development or function of those cells. Here we uncovered that murine endocrine pancreatic progenitors express high levels of the homeodomain transcription factor Prox1, whereas both immature and mature β-...

journal_title：Diabetes

authors： Paul L,Walker EM,Drosos Y,Cyphert HA,Neale G,Stein R,South J,Grosveld G,Herrera PL,Sosa-Pineda B

更新日期：2016-03-01 00:00:00

abstract：:Alterations in dopaminergic circuitry play a critical role in food reward and may contribute to susceptibility to obesity. Ingestion of sweets releases dopamine in striatum, and both sweet preferences and striatal D2 receptors (D2R) decline with age and may be altered in obesity. Understanding the relationships betwee...

journal_title：Diabetes

authors： Pepino MY,Eisenstein SA,Bischoff AN,Klein S,Moerlein SM,Perlmutter JS,Black KJ,Hershey T

更新日期：2016-09-01 00:00:00

abstract：:Beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) consists of a nonmetabolizable long-chain fatty acid designed to probe the effect exerted by fatty acids on insulin sensitivity. The effect of MEDICA 16 was evaluated in insulin-resistant Zucker (fa/fa) rats in terms of liver, muscle, and adipose tissue re...

journal_title：Diabetes

authors： Mayorek N,Kalderon B,Itach E,Bar-Tana J

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:C57Bl/6 mice develop obesity and mild hyperglycemia when fed a high-fat diet (HFD). Although diet-induced obesity (DIO) is a widely studied model of type 2 diabetes, little is known about beta-cell failure in these mice. RESEARCH DESIGN AND METHODS:DIO mice were separated in two groups according to body weig...

journal_title：Diabetes

authors： Peyot ML,Pepin E,Lamontagne J,Latour MG,Zarrouki B,Lussier R,Pineda M,Jetton TL,Madiraju SR,Joly E,Prentki M

更新日期：2010-09-01 00:00:00

abstract：:Nonketotic, genetically diabetic Cinese hamsters show subnormal pancreatic insulin release and impaired suppression of glucagon in response to glucose. To study the pancreatic effects of other agents, dynamic insulin and glucagon release was measured from the in vitro perfused pancreases of normal and diabetic Chinese...

journal_title：Diabetes

authors： Frankel BJ,Gerich JE,Fanska RE,Gerritsen GC,Grodsky GM

更新日期：1975-03-01 00:00:00

abstract：:Glucose metabolism affects most major signal pathways in pancreatic beta-cells. Multiple protein kinases, including protein kinase C (PKC) isoenzymes, are involved in these effects; however, their role is poorly defined. Moreover, the dynamics of kinase isoenzyme activation in reference to the biphasic insulin secreti...

journal_title：Diabetes

authors： Warwar N,Efendic S,Ostenson CG,Haber EP,Cerasi E,Nesher R

更新日期：2006-03-01 00:00:00

abstract：:The insulin resistance syndrome is characterized by several risk factors for cardiovascular disease. Chronic chemical activation of AMP-activated protein kinase by the adenosine analog 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside (AICAR) has been shown to augment insulin action, upregulate mitochondrial enz...

journal_title：Diabetes

authors： Buhl ES,Jessen N,Pold R,Ledet T,Flyvbjerg A,Pedersen SB,Pedersen O,Schmitz O,Lund S

更新日期：2002-07-01 00:00:00

abstract：:To examine the biochemical mechanisms by which hyperglycemia produces insulin secretory abnormalities, we studied isolated islets from control rats and rats infused for 48 h with a 50% glucose solution. To preserve the effects of in vivo hyperglycemia during in vitro handling for islet isolation, our standard isolatio...

journal_title：Diabetes

authors： Timmers KI,Powell AM,Voyles NR,Solomon D,Wilkins SD,Bhathena S,Recant L

更新日期：1990-11-01 00:00:00

abstract：:The pancreatic and duodenal homeobox factor-1 (PDX-1), also known as IDX-1/STF-1/IPF1, a homeodomain-containing transcription factor, plays a central role in regulating pancreatic development and insulin gene transcription. Furthermore, even in adults, PDX-1 is associated with islet neogenesis and differentiation of i...

journal_title：Diabetes

authors： Noguchi H,Kaneto H,Weir GC,Bonner-Weir S

更新日期：2003-07-01 00:00:00

abstract：:Pancreatic beta-cell survival is critical in the setting of diabetes as well as in islet transplantation. Transgenic mice overexpressing parathyroid hormone-related protein (PTHrP) targeted to beta-cells using the rat insulin II promoter (RIP) display hyperinsulinemia, hypoglycemia, and islet hyperplasia, without a co...

journal_title：Diabetes

authors： Cebrian A,García-Ocaña A,Takane KK,Sipula D,Stewart AF,Vasavada RC

更新日期：2002-10-01 00:00:00

abstract：:Oxidative stress is implicated in diabetes complications, during which endogenous antioxidant defenses have important pathophysiological consequences. To date, the significance of endogenous antioxidants such as metallothioneins I and II (MT-I+II) in type 2 diabetes remains unclear. To examine the MT-I+II-mediated ant...

journal_title：Diabetes

authors： Scheede-Bergdahl C,Penkowa M,Hidalgo J,Olsen DB,Schjerling P,Prats C,Boushel R,Dela F

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:The catabasis of inflammation is an active process directed by n-3 derived pro-resolving lipid mediators. We aimed to determine whether high-fat (HF) diet-induced n-3 deficiency compromises the resolution capacity of obese mice and thereby contributes to obesity-linked inflammation and insulin resistance. RE...

journal_title：Diabetes

authors： White PJ,Arita M,Taguchi R,Kang JX,Marette A

更新日期：2010-12-01 00:00:00

abstract：:We studied the effects of short-term (5 days) and long-term (2 wk) high carbohydrate (75%) feedings on insulin binding to isolated adipocytes and insulin sensitivity in vivo in normal subjects. Ingestion of the high carbohydrate diet led to daylong hyperinsulinemia in both short- and long-term groups. Insulin binding ...

journal_title：Diabetes

authors： Kolterman OG,Greenfield M,Reaven GM,Saekow M,Olefsky JM

更新日期：1979-08-01 00:00:00

abstract：:Concentrations of glycosylated hemoglobin (GHb) are elevated in diabetes mellitus and are believed to reflect previous metabolic control. To better define possible determinants of GHb in man, we investigated the relationship between GHb and both fasting plasma glucose (FPG) and basal insulin (IRI) in 42 normal subject...

journal_title：Diabetes

authors： Graf RJ,Halter JB,Porte D Jr

更新日期：1978-08-01 00:00:00

abstract：:Although decreased levels of circulating insulinlike growth factor I (IGF-I) and hepatic IGF-I mRNA in diabetic animal models support a role for insulin in IGF-I regulation, it has been difficult to study the effects of insulin in vitro. Few immortal cell lines exhibit hormone-responsive production of IGF-I, and studi...

journal_title：Diabetes

authors： Phillips LS,Goldstein S,Pao CI

更新日期：1991-11-01 00:00:00

abstract：:Microinflammation is a common major mechanism in the pathogenesis of diabetic vascular complications, including diabetic nephropathy. Macrophage scavenger receptor-A (SR-A) is a multifunctional receptor expressed on macrophages. This study aimed to determine the role of SR-A in diabetic nephropathy using SR-A-deficien...

journal_title：Diabetes

authors： Usui HK,Shikata K,Sasaki M,Okada S,Matsuda M,Shikata Y,Ogawa D,Kido Y,Nagase R,Yozai K,Ohga S,Tone A,Wada J,Takeya M,Horiuchi S,Kodama T,Makino H

更新日期：2007-02-01 00:00:00

abstract：:Non-insulin-dependent diabetes mellitus (NIDDM) is a heterogenous disorder characterized by defects in insulin action and secretion. This study was aimed at developing a rat model in which these pathogenic factors might be studied. Male Wistar rats were injected at 2 days of age with 45 or 30 mg/kg streptozocin (STZ) ...

journal_title：Diabetes

authors： Pascoe WS,Storlien LH

更新日期：1990-02-01 00:00:00

abstract：:To investigate whether insulin reduces platelet aggregability through a modulation of the guanosine-3',5'-cyclic monophosphate (cGMP) concentrations, we determined by a radioimmunoassay the cGMP values in the platelet-rich plasma (PRP) obtained from 17 healthy volunteers and incubated for 3 min with different concentr...

journal_title：Diabetes

authors： Trovati M,Massucco P,Mattiello L,Mularoni E,Cavalot F,Anfossi G

更新日期：1994-08-01 00:00:00

abstract：:To elucidate the direct effect of rosiglitazone (RSG), a new thiazolidinedione antihyperglycemic agent, on pancreatic insulin secretion, an in situ investigation by rat pancreatic perfusion was performed. At a basal glucose concentration of 6 mmol/l, RSG (0.045-4.5 micromol/l) stimulated insulin release in a dose-depe...

journal_title：Diabetes

authors： Yang C,Chang TJ,Chang JC,Liu MW,Tai TY,Hsu WH,Chuang LM

更新日期：2001-11-01 00:00:00

abstract：:Twelve type I (insulin-dependent) diabetic subjects in stable metabolic control for at least 3 mo received a controlled diet containing 50% carbohydrate, 35% fat, and 15% protein. Calorie intake varied from 1800 to 2200 calories, depending on individual needs. Part of the polyunsaturated omega-6 fatty acids (omega 6FA...

journal_title：Diabetes

authors： Rillaerts EG,Engelmann GJ,Van Camp KM,De Leeuw I

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVE:Many of the effects of angiotensin (Ang) II are mediated through specific plasma membrane receptors. However, Ang II also elicits biological effects from the interior of the cell (intracrine), some of which are not inhibited by Ang receptor blockers (ARBs). Recent in vitro studies have identified high glucose...

journal_title：Diabetes

authors： Singh VP,Le B,Khode R,Baker KM,Kumar R

更新日期：2008-12-01 00:00:00