Metallothionein-mediated antioxidant defense system and its response to exercise training are impaired in human type 2 diabetes.

Abstract:

:Oxidative stress is implicated in diabetes complications, during which endogenous antioxidant defenses have important pathophysiological consequences. To date, the significance of endogenous antioxidants such as metallothioneins I and II (MT-I+II) in type 2 diabetes remains unclear. To examine the MT-I+II-mediated antioxidant capacity and its response to exercise training in the skeletal muscle of patients with type 2 diabetes, biopsies and blood samples were taken from 13 matched subjects (type 2 diabetes n = 8, control subjects n = 5) both before and after 8 weeks of exercise training. Immunohistochemical analysis revealed reduced MT-I+II levels in the skeletal muscle of type 2 diabetic subjects compared with control subjects. Control subjects produced a robust increase of MT-I+II in response to training; however, in type 2 diabetes, MT-I+II levels remained essentially unchanged. Significantly lower levels of MT-I+II were also detected in the plasma of type 2 diabetic subjects compared with control subjects. These results suggest that, in control subjects, the MT-I+II defense system is active and inducible within skeletal muscle tissue and plasma. In type 2 diabetes, reduced levels of MT-I+II in muscle and plasma, as well as the deficient MT-I+II response to exercise, indicate that this antioxidant defense is impaired. This study presents a novel candidate in the pathogenesis of complications related to oxidative stress in type 2 diabetes.

journal_name

Diabetes

journal_title

Diabetes

authors

Scheede-Bergdahl C,Penkowa M,Hidalgo J,Olsen DB,Schjerling P,Prats C,Boushel R,Dela F

doi

10.2337/diabetes.54.11.3089

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

3089-94

issue

11

eissn

0012-1797

issn

1939-327X

pii

54/11/3089

journal_volume

54

pub_type

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